The World Bank cut its forecast for global economic growth sending the markets tumbling to a sharply lower close with the Dow plunging 102 points to 16,843. Nasdaq lost 6 points to 4,331.

On the upside

Conatus Pharmaceuticals (Nasdaq: CNAT) stock surged despite a lack of news.

BioDelivery Sciences International (Nasdaq: BDSI) president and chief executive Dr. Mark A. Sirgo was interviewed on Bloomberg TV, TheStreet.com and Business News Network about its opioid dependence treatment BUNAVAIL.

MakeMyTrip (Nasdaq: MMYT) partnered with TrustYou.

On the downside

Shares of NQ Mobile (Nasdaq: NQ) continued falling after the company announced yesterday that it will sell a minority interest in its wholly owned subsidiary Beijing NationSky Network Technology.

Profit taking weighed down share of Doral Financial (NYSE: DRL).

B Riley analyst Scott Tilghman slashed his price target on RadioShack (NYSE: RSH) to $0.

In the broad market, declining issues outpaced advancers by a margin of nearly 5 to 3 on both the NYSE and on Nasdaq. The broader S&P 500 lost 6 points to 1943. Bitcoin slipped $6.44 or 1.00% to $644.66.