The markets closed mixed with the Dow falling 50 points to 16,662 as tensions in the Ukraine tempered enthusiasm for a strong gain in manufacturing production. Nasdaq rose 11 points to 4464.

On the upside

Bargain hunters lifted shares of Tekmira Pharmaceuticals (Nasdaq: TKMR).

Applied Materials (Nasdaq: AMAT) reported higher third quarter earnings that topped analyst estimates.

An arbitration panel rejected patent infringement claims filed by Roche against Gilead Sciences (Nasdaq: GILD).

On the downside

An appeals court declared that two Vringo (Nasdaq: VRNG) patents were invalid.

Dillard's (NYSE: DDS) disappointed with lower second quarter earnings and revenue that fell short of analyst expectations.

Second quarter earnings fell for Autodesk (Nasdaq: ADSK) and the company forecast current quarter earnings below expectations.

In the broad market, declining issues barely edged out advancers by a slim margin on the NYSE and by more than 4 to 3 on Nasdaq. The broader S&P 500 held steady at 1955. Bitcoin lost $15 to $494.