A downward revision of the nation's gross domestic product weighed the markets down to a lower open with the Dow losing 20 points to 18,193. Nasdaq lost 6 points to 4,981.

On the upside

Shares of Cytori Therapeutics (Nasdaq: CYTX) continued climbing.

Clean Energy Fuels (Nasdaq: CLNE) swung to a greater than expected profit for the fourth quarter.

Horizon Pharma (Nasdaq: HZNP) narrowed fourth quarter losses more than expected as revenue surged prompting the biopharmaceutical to lift its full year guidance.

On the downside

Weight Watchers (NYSE: WTW) fell to a loss for the fourth quarter and forecast full year earnings below expectations.

J.C. Penney (NYSE: JCP) fell to an unexpected loss for the fourth quarter.

TubeMogul (Nasdaq: TUBE) fell to a loss for the fourth quarter and forecast current quarter revenue that missed analyst estimates.

In the broad market, declining issues outpaced advancers by a margin of more than 10 to 9 on the NYSE and by 7 to 5 on Nasdaq. The broader S&P 500 eased a point to 2109. Bitcoin gained $15 to $248.