The markets opened lower with the Dow slipping 12 points to 17,964 even as home prices rose. Nasdaq lost 5 points to 4,890.

On the upside

Shares of OncoGenex Pharmaceuticals (Nasdaq: OGXI) rose for the fourth day in a row.

Knowles (NYSE: KN) reported a smaller than expected loss for the first quarter as revenue rose.

The Container Store (NYSE: TCS) reported higher fourth quarter revenue that topped analyst estimates.

On the downside

A Food and Drug Administration advisory panel voted against approval for Sarepta Therapeutics' (Nasdaq: SRPT) Duchenne muscular dystrophy treatment eteplirsen.

The Food and Drug Administration requested that Catalyst Pharmaceuticals (Nasdaq: CPRX) submit positive data from an additional study of Firdapse in Lambert-Eaton myasthenia syndrome patients.

First quarter earnings slipped for Capital Product Partners (Nasdaq: CPLP) and the company lowered its quarterly cash distribution.

In the broad market, advancing issues outpaced decliners by a margin of 3 to 1 on the NYSE and by more than 7 to 5 on Nasdaq. The broader S&P 500 edged up a fraction to 2,088. Bitcoin added $1 to $462.