The nation's productivity fell in the first quarter to weigh the markets down to a lower open with the Dow losing 37 points to 17,713. Nasdaq fell 19 points to 4,743.

On the upside

Eleven Biotherapeutics (Nasdaq: EBIO) presented new data from post hoc analyses on the influence of Interleukin Genetics' IL-1 genetic patterns on response to isunakinra in patients with severe allergic conjunctivitis and severe dry eye.

Zillow Group (Nasdaq: Z) narrowed losses for the first quarter and lifted its full year revenue guidance.

Glaukos (NYSE: GKOS) reversed year ago losses to post a greater than expected profit for the first quarter and forecast full year revenue ahead of estimates.

On the downside

Glu Mobile (Nasdaq: GLUU) fell to a loss for the first quarter and forecast current quarter as well as full year results that missed expectations.

Mizuho downgraded Relypsa (Nasdaq: RLYP) from a Neutral rating to an Underperform rating.

Rubicon Project (NYSE: RUBI) swung to a profit for the first quarter but the company forecast disappointing full year revenue.

In the broad market, declining issues outpaced advancers by a margin of more than 2 to 1 on the NYSE and by more than 5 to 2 on Nasdaq. The broader S&P 500 dropped 13 points to 2,049. Bitcoin lost $3 to $445.