FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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(Print or Type Responses)

1. Name and Address of Reporting Person * Isabelle Warren John   2. Issuer Name and Ticker or Trading Symbol SENESCO TECHNOLOGIES INC [SNT] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) __X__ Director _____ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) 303 GEORGE STREET, SUITE 420 3. Date of Earliest Transaction (Month/Day/Year) 02/19/2010 (Street) NEW BRUNSWICK, NJ 08901 4. If Amendment, Date Original Filed(Month/Day/Year) 6. Individual or Joint/Group Filing(Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 02/19/2010   P   16,745 A $ 0 (1) 18,967 D

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code (Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date (Month/Day/Year)

7. Title and Amount of Underlying Securities (Instr. 3 and 4)

8. Price of Derivative Security (Instr. 5)

9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)

11. Nature of Indirect Beneficial Ownership (Instr. 4)

Code

V

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

Common Stock Warrant

$ 1.01

02/19/2010

P

9,691

02/19/2010

06/30/2012

Common Stock

9,691

$ 0 (1)

13,719

D

Common Stock Warrant

$ 1.01

02/19/2010

P

16,152

02/19/2010

12/20/2012

Common Stock

16,152

$ 0 (1)

29,871

D

Common Stock Warrant

$ 1.01

02/19/2010

P

10,768

02/19/2010

06/30/2013

Common Stock

10,768

$ 0 (1)

40,639

D

Common Stock Warrant

$ 0.83

02/19/2010

P

16,152

02/19/2010

12/20/2012

Common Stock

16,152

$ 0 (1)

56,791

D

Common Stock Warrant

$ 0.83

02/19/2010

P

10,768

02/19/2010

06/30/2013

Common Stock

10,768

$ 0 (1)

67,559

D

Convertible Debenture Due 12/31/2010

$ 0.22 (2)

02/19/2010

P

$ 64,607

02/19/2010

12/31/2010

Common Stock

287,626

$ 0 (1)

287,626

D

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
Isabelle Warren John 303 GEORGE STREET SUITE 420 NEW BRUNSWICK, NJ 08901	X

Signatures

Warren J. Isabelle		02/23/2010
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	Mr. Isabelle entered into agreements to purchase an aggregate of 16,745 shares of common stock, 63,531 common stock warrants and $64,607 of convertible debentures. The total purchase price was $11,500, which was not allocated among the various components.
(2)	The conversion rate used is the rate that the convertible debentures may convert at as of February 19, 2010. However, the conversion rate may change as the convertible debentures convert at a floating conversion rate equal to the lower of $0.83, subject to adjustment, or 80% of the lowest daily VWAP for the five day period immediately preceding the conversion date.

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