UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  SCHEDULE 13D

                    UNDER THE SECURITIES EXCHANGE ACT OF 1934
                                 AMENDMENT NO. 2

                            Interpharm Holdings, Inc.

 ------------------------------------------------------------------------------
                                (Name of Company)

                          Common Stock, $0.01 par value

 ------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                    460588106

 ------------------------------------------------------------------------------
                      (CUSIP Number of Class of Securities)

           Joan P. Neuscheler                          Gloria M. Skigen
 Tullis-Dickerson Capital Focus III, L.P.     Law Offices of Gloria M. Skigen
 c/o Tullis-Dickerson Partners III, L.L.C.        51 Boulder Brook Drive
       Two Greenwich Plaza, 4th Fl.                 Stamford, CT 06830
           Greenwich, CT 06830                         (203)861-1717
            (203) 629-8700




                  (Name, Address and Telephone Number of Person
                Authorized to Receive Notices and Communications)

                                February 28, 2008



                          (Date of Event which Requires
                            Filing of this Schedule)

If the filing person has previously filed a statement on Schedule 13G to report
the acquisition that is the subject of this Schedule 13D, and is filing this
schedule because of Sections 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check
the following box. [ ]

NOTE: Schedules filed in paper format shall include a signed original and five
copies of the schedule, including all exhibits. See ss.240.13d-7 for other
parties to whom copies are to be sent. * The remainder of this cover page shall
be filled out for a reporting person's initial filing on this form with respect
to the subject class of securities, and for any subsequent amendment containing
information which would alter disclosures provided in a prior cover page. The
information required on the remainder of this cover page shall not be deemed to
be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934
("ACT") or otherwise subject to the liabilities of that section of the Act but
shall be subject to all other provisions of the Act (however, SEE the NOTES).





                                 SCHEDULE 13D/A

--------------------------------------------------------------------------------
CUSIP NO.      460588106                               PAGE 2 OF 14 PAGES
--------------------------------------------------------------------------------
     1     NAME OF REPORTING PERSON
           I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

           Tullis-Dickerson Capital Focus III, L.P. IRS # 06-1621801
-------------------------------------------------------------------------------
     2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP         (a) [x]
                                                                    (b) [ ]

-------------------------------------------------------------------------------
     3     SEC USE ONLY

-------------------------------------------------------------------------------
     4     SOURCE OF FUNDS*

           WC
-------------------------------------------------------------------------------
     5     CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED
           PURSUANT TO ITEMS 2(d) or 2(e)                               [ ]

-------------------------------------------------------------------------------
     6     CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware, United States of America
-------------------------------------------------------------------------------
                  7      SOLE VOTING POWER

                         0
                 ---------------------------------------------------------------
 NUMBER OF        8      SHARED VOTING POWER
 SHARES
 BENEFICIALLY            568,647 shares of Common Stock;
 OWNED BY
 EACH                    2,281,914 shares of Common Stock issuable upon exercise
 REPORTING               of the Amended and Restated Warrants;
 PERSON WITH
                         10,526,316 shares of Common Stock issuable upon
                         conversion of the Series D-1 Preferred Stock;

                         877,194 shares of Common Stock issuable upon
                         conversion of the Convertible Notes; and

                         307,017 shares of Common Stock issuable upon
                         conversion of the Note Warrants (1)
                 ---------------------------------------------------------------
                  9      SOLE DISPOSITIVE POWER

                         0
                 ---------------------------------------------------------------
                  10     SHARED DISPOSITIVE POWER

                         568,647 shares of Common Stock;

                         2,281,914 shares of Common Stock issuable upon exercise
                         of the Amended and Restated Warrants; and

                         10,526,316 shares of Common Stock issuable upon
                         conversion of the Series D-1 Preferred Stock;

                         877,194 shares of Common Stock issuable upon
                         conversion of the Convertible Notes; and

                         307,017 shares of Common Stock issuable upon
                         conversion of the Note Warrants (1)
--------------------------------------------------------------------------------
     11    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH PERSON

                         568,647 shares of Common Stock;

                         2,281,914 shares of Common Stock issuable upon exercise
                         of the Amended and Restated Warrants; and

                         10,526,316 shares of Common Stock issuable upon
                         conversion of the Series D-1 Preferred Stock;

                         877,194 shares of Common Stock issuable upon
                         conversion of the Convertible Notes; and

                         307,017 shares of Common Stock issuable upon
                         conversion of the Note Warrants (1))
-------------------------------------------------------------------------------
     12    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
           CERTAIN SHARES*                                                [ ]
-------------------------------------------------------------------------------
     13    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           18.2% (see Item 5)(1)
-------------------------------------------------------------------------------
     14    TYPE OF REPORTING PERSON*

           PN
-------------------------------------------------------------------------------

----------------
(1) Does not include shares of Common Stock (including shares of Common Stock
and shares of Common Stock issuable upon the conversion of preferred stock and
exercise of warrants and options) held by parties to the Irrevocable Proxy
Agreement other than the Reporting Persons, as discussed in Item 4 of the
Amendment No. 1.




                                 SCHEDULE 13D/A

--------------------------------------------------------------------------------
CUSIP NO.      460588106                               PAGE 3 OF 14 PAGES
--------------------------------------------------------------------------------
     1     NAME OF REPORTING PERSON
           I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

           Tullis-Dickerson Partners III, L.L.C. IRS # 06-1621800
--------------------------------------------------------------------------------
     2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP         (a) [x]
                                                                    (b) [ ]

--------------------------------------------------------------------------------
     3     SEC USE ONLY

--------------------------------------------------------------------------------
     4     SOURCE OF FUNDS*

           AF
--------------------------------------------------------------------------------
     5     CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED
           PURSUANT TO ITEMS 2(d) or 2(e)                               [ ]

--------------------------------------------------------------------------------
     6     CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware, United States of America
--------------------------------------------------------------------------------
                  7      SOLE VOTING POWER

                         0
                 ---------------------------------------------------------------
 NUMBER OF        8      SHARED VOTING POWER
 SHARES
 BENEFICIALLY            568,647 shares of Common Stock;
 OWNED BY
 EACH                    2,281,914 shares of Common Stock issuable upon exercise
 REPORTING               of the Amended and Restated Warrants;
 PERSON WITH
                         10,526,316 shares of Common Stock issuable upon
                         conversion of the Series D-1 Preferred Stock;

                         877,194 shares of Common Stock issuable upon
                         conversion of the Convertible Notes; and

                         307,017 shares of Common Stock issuable upon
                         conversion of the Note Warrants (1)
                 ---------------------------------------------------------------
                  9      SOLE DISPOSITIVE POWER

                         0
                 ---------------------------------------------------------------
                  10     SHARED DISPOSITIVE POWER

                         568,647 shares of Common Stock;

                         2,281,914 shares of Common Stock issuable upon exercise
                         of the Amended and Restated Warrants; and

                         10,526,316 shares of Common Stock issuable upon
                         conversion of the Series D-1 Preferred Stock;

                         877,194 shares of Common Stock issuable upon
                         conversion of the Convertible Notes; and

                         307,017 shares of Common Stock issuable upon
                         conversion of the Note Warrants (1)
 ------------------------------------------------------------------------------
     11    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH PERSON

                         568,647 shares of Common Stock;

                         2,281,914 shares of Common Stock issuable upon exercise
                         of the Amended and Restated Warrants; and

                         10,526,316 shares of Common Stock issuable upon
                         conversion of the Series D-1 Preferred Stock;

                         877,194 shares of Common Stock issuable upon
                         conversion of the Convertible Notes; and

                         307,017 shares of Common Stock issuable upon
                         conversion of the Note Warrants (1)
--------------------------------------------------------------------------------
     12    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
           CERTAIN SHARES*                                                [ ]
--------------------------------------------------------------------------------
     13    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           18.2% (see Item 5)(1)
--------------------------------------------------------------------------------
     14    TYPE OF REPORTING PERSON*

           OO
--------------------------------------------------------------------------------

-----------------------
(1) Does not include shares of Common Stock (including shares of Common Stock
and shares of Common Stock issuable upon the conversion of preferred stock and
exercise of warrants and options) held by parties to the Irrevocable Proxy
Agreement other than the Reporting Persons, as discussed in Item 4 of the
Amendment No. 1.




                                 SCHEDULE 13D/A

--------------------------------------------------------------------------------
CUSIP NO.      460588106                               PAGE 4 OF 14 PAGES
--------------------------------------------------------------------------------
     1     NAME OF REPORTING PERSON
           I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

           Joan P. Neuscheler
--------------------------------------------------------------------------------
     2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP         (a) [x]
                                                                    (b) [ ]

--------------------------------------------------------------------------------
     3     SEC USE ONLY

--------------------------------------------------------------------------------
     4     SOURCE OF FUNDS*

           AF
--------------------------------------------------------------------------------
     5     CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED
           PURSUANT TO ITEMS 2(d) or 2(e)                               [ ]

--------------------------------------------------------------------------------
     6     CITIZENSHIP OR PLACE OF ORGANIZATION

           United States of America
--------------------------------------------------------------------------------
                  7      SOLE VOTING POWER

                         0
                 ---------------------------------------------------------------
 NUMBER OF        8      SHARED VOTING POWER
 SHARES
 BENEFICIALLY            568,647 shares of Common Stock;
 OWNED BY
 EACH                    2,281,914 shares of Common Stock issuable upon exercise
 REPORTING               of the Amended and Restated Warrants;
 PERSON WITH
                         10,526,316 shares of Common Stock issuable upon
                         conversion of the Series D-1 Preferred Stock;

                         877,194 shares of Common Stock issuable upon
                         conversion of the Convertible Notes; and

                         307,017 shares of Common Stock issuable upon
                         conversion of the Note Warrants (1)
                 ---------------------------------------------------------------
                  9      SOLE DISPOSITIVE POWER

                         0
                 ---------------------------------------------------------------
                  10     SHARED DISPOSITIVE POWER

                         568,647 shares of Common Stock;

                         2,281,914 shares of Common Stock issuable upon exercise
                         of the Amended and Restated Warrants; and

                         10,526,316 shares of Common Stock issuable upon
                         conversion of the Series D-1 Preferred Stock;

                         877,194 shares of Common Stock issuable upon
                         conversion of the Convertible Notes; and

                         307,017 shares of Common Stock issuable upon
                         conversion of the Note Warrants (1)
-------------------------------------------------------------------------------
     11    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH PERSON

                         568,647 shares of Common Stock;

                         2,281,914 shares of Common Stock issuable upon exercise
                         of the Amended and Restated Warrants; and

                         10,526,316 shares of Common Stock issuable upon
                         conversion of the Series D-1 Preferred Stock;

                         877,194 shares of Common Stock issuable upon
                         conversion of the Convertible Notes; and

                         307,017 shares of Common Stock issuable upon
                         conversion of the Note Warrants (1)
--------------------------------------------------------------------------------
     12    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
           CERTAIN SHARES*                                                [ ]
--------------------------------------------------------------------------------
     13    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           18.2% (see Item 5)(1)
--------------------------------------------------------------------------------
     14    TYPE OF REPORTING PERSON*

           IN
--------------------------------------------------------------------------------

-----------------------
(1) Does not include shares of Common Stock (including shares of Common Stock
and shares of Common Stock issuable upon the conversion of preferred stock and
exercise of warrants and options) held by parties to the Irrevocable Proxy
Agreement other than the Reporting Persons, as discussed in Item 4 of the
Amendment No. 1.




                                 SCHEDULE 13D/A

--------------------------------------------------------------------------------
CUSIP NO.      460588106                               PAGE 5 OF 14 PAGES
--------------------------------------------------------------------------------
     1     NAME OF REPORTING PERSON
           I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

           James L.L. Tullis
--------------------------------------------------------------------------------
     2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP         (a) [x]
                                                                    (b) [ ]

--------------------------------------------------------------------------------
     3     SEC USE ONLY

--------------------------------------------------------------------------------
     4     SOURCE OF FUNDS*

           AF
--------------------------------------------------------------------------------
     5     CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED
           PURSUANT TO ITEMS 2(d) or 2(e)                               [ ]

--------------------------------------------------------------------------------
     6     CITIZENSHIP OR PLACE OF ORGANIZATION

           United States of America
--------------------------------------------------------------------------------
                  7      SOLE VOTING POWER

                         0
                 ---------------------------------------------------------------
 NUMBER OF        8      SHARED VOTING POWER
 SHARES
 BENEFICIALLY            568,647 shares of Common Stock;
 OWNED BY
 EACH                    2,281,914 shares of Common Stock issuable upon exercise
 REPORTING               of the Amended and Restated Warrants;
 PERSON WITH
                         10,526,316 shares of Common Stock issuable upon
                         conversion of the Series D-1 Preferred Stock;

                         877,194 shares of Common Stock issuable upon
                         conversion of the Convertible Notes; and

                         307,017 shares of Common Stock issuable upon
                         conversion of the Note Warrants (1)
                 ---------------------------------------------------------------
                  9      SOLE DISPOSITIVE POWER

                         0
                 ---------------------------------------------------------------
                  10     SHARED DISPOSITIVE POWER

                         568,647 shares of Common Stock;

                         2,281,914 shares of Common Stock issuable upon exercise
                         of the Amended and Restated Warrants; and

                         10,526,316 shares of Common Stock issuable upon
                         conversion of the Series D-1 Preferred Stock;

                         877,194 shares of Common Stock issuable upon
                         conversion of the Convertible Notes; and

                         307,017 shares of Common Stock issuable upon
                         conversion of the Note Warrants (1)
------------------------------------------------------------------------------
     11    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH PERSON

                         568,647 shares of Common Stock;

                         2,281,914 shares of Common Stock issuable upon exercise
                         of the Amended and Restated Warrants; and

                         10,526,316 shares of Common Stock issuable upon
                         conversion of the Series D-1 Preferred Stock;

                         877,194 shares of Common Stock issuable upon
                         conversion of the Convertible Notes; and

                         307,017 shares of Common Stock issuable upon
                         conversion of the Note Warrants (1)
--------------------------------------------------------------------------------
     12    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
           CERTAIN SHARES*                                                [ ]
 -------------------------------------------------------------------------------
     13    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           18.2% (see Item 5)(1)
 -------------------------------------------------------------------------------
     14    TYPE OF REPORTING PERSON*

           IN
 -------------------------------------------------------------------------------

 -----------------------

 (1) Does not include shares of Common Stock (including shares of Common Stock
 and shares of Common Stock issuable upon the conversion of preferred stock and
 exercise of warrants and options) held by parties to the Irrevocable Proxy
 Agreement other than the Reporting Persons, as discussed in Item 4 of the
 Amendment No. 1.




                                 SCHEDULE 13D/A

--------------------------------------------------------------------------------
CUSIP NO.      460588106                               PAGE 6 OF 14 PAGES
--------------------------------------------------------------------------------
     1     NAME OF REPORTING PERSON
           I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

           Thomas P. Dickerson
--------------------------------------------------------------------------------
     2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP         (a) [x]
                                                                    (b) [ ]

--------------------------------------------------------------------------------
     3     SEC USE ONLY

--------------------------------------------------------------------------------
     4     SOURCE OF FUNDS*

           AF
--------------------------------------------------------------------------------
     5     CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED
           PURSUANT TO ITEMS 2(d) or 2(e)                               [ ]

--------------------------------------------------------------------------------
     6     CITIZENSHIP OR PLACE OF ORGANIZATION

           United States of America
--------------------------------------------------------------------------------
                  7      SOLE VOTING POWER

                         0
                 ---------------------------------------------------------------
 NUMBER OF        8      SHARED VOTING POWER
 SHARES
 BENEFICIALLY            568,647 shares of Common Stock;
 OWNED BY
 EACH                    2,281,914 shares of Common Stock issuable upon exercise
 REPORTING               of the Amended and Restated Warrants;
 PERSON WITH
                         10,526,316 shares of Common Stock issuable upon
                         conversion of the Series D-1 Preferred Stock;

                         877,194 shares of Common Stock issuable upon
                         conversion of the Convertible Notes; and

                         307,017 shares of Common Stock issuable upon
                         conversion of the Note Warrants (1)
                 ---------------------------------------------------------------
                  9      SOLE DISPOSITIVE POWER

                         0
                 ---------------------------------------------------------------
                  10     SHARED DISPOSITIVE POWER

                         568,647 shares of Common Stock;

                         2,281,914 shares of Common Stock issuable upon exercise
                         of the Amended and Restated Warrants; and

                         10,526,316 shares of Common Stock issuable upon
                         conversion of the Series D-1 Preferred Stock;

                         877,194 shares of Common Stock issuable upon
                         conversion of the Convertible Notes; and

                         307,017 shares of Common Stock issuable upon
                         conversion of the Note Warrants (1)
-------------------------------------------------------------------------------
     11    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH PERSON

                         568,647 shares of Common Stock;

                         2,281,914 shares of Common Stock issuable upon exercise
                         of the Amended and Restated Warrants; and

                         10,526,316 shares of Common Stock issuable upon
                         conversion of the Series D-1 Preferred Stock;

                         877,194 shares of Common Stock issuable upon
                         conversion of the Convertible Notes; and

                         307,017 shares of Common Stock issuable upon
                         conversion of the Note Warrants (1)
--------------------------------------------------------------------------------
     12    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
           CERTAIN SHARES*                                                [ ]
--------------------------------------------------------------------------------
     13    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           18.2% (see Item 5)(1)
--------------------------------------------------------------------------------
     14    TYPE OF REPORTING PERSON*

           IN
--------------------------------------------------------------------------------

-----------------------
(1) Does not include shares of Common Stock (including shares of Common Stock
and shares of Common Stock issuable upon the conversion of preferred stock and
exercise of warrants and options) held by parties to the Irrevocable Proxy
Agreement other than the Reporting Persons, as discussed in Item 4 of the
Amendment No. 1.



                                 SCHEDULE 13D/A

--------------------------------------------------------------------------------
CUSIP NO.      460588106                               PAGE 7 OF 14 PAGES
--------------------------------------------------------------------------------

     1     NAME OF REPORTING PERSON
           I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

           Lyle A. Hohnke
--------------------------------------------------------------------------------
     2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP         (a) [x]
                                                                    (b) [ ]

--------------------------------------------------------------------------------
     3     SEC USE ONLY

--------------------------------------------------------------------------------
     4     SOURCE OF FUNDS*

           AF
--------------------------------------------------------------------------------
     5     CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED
           PURSUANT TO ITEMS 2(d) or 2(e)                               [ ]

--------------------------------------------------------------------------------
     6     CITIZENSHIP OR PLACE OF ORGANIZATION

           United States of America
--------------------------------------------------------------------------------
                  7      SOLE VOTING POWER

                         0
                 ---------------------------------------------------------------
 NUMBER OF        8      SHARED VOTING POWER
 SHARES
 BENEFICIALLY            568,647 shares of Common Stock;
 OWNED BY
 EACH                    2,281,914 shares of Common Stock issuable upon exercise
 REPORTING               of the Amended and Restated Warrants;
 PERSON WITH
                         10,526,316 shares of Common Stock issuable upon
                         conversion of the Series D-1 Preferred Stock;

                         877,194 shares of Common Stock issuable upon
                         conversion of the Convertible Notes; and

                         307,017 shares of Common Stock issuable upon
                         conversion of the Note Warrants (1)
                 ---------------------------------------------------------------
                  9      SOLE DISPOSITIVE POWER

                         0
                 ---------------------------------------------------------------
                  10     SHARED DISPOSITIVE POWER

                         568,647 shares of Common Stock;

                         2,281,914 shares of Common Stock issuable upon exercise
                         of the Amended and Restated Warrants; and

                         10,526,316 shares of Common Stock issuable upon
                         conversion of the Series D-1 Preferred Stock;

                         877,194 shares of Common Stock issuable upon
                         conversion of the Convertible Notes; and

                         307,017 shares of Common Stock issuable upon
                         conversion of the Note Warrants (1)
-------------------------------------------------------------------------------
     11    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH PERSON

                         568,647 shares of Common Stock;

                         2,281,914 shares of Common Stock issuable upon exercise
                         of the Amended and Restated Warrants; and

                         10,526,316 shares of Common Stock issuable upon
                         conversion of the Series D-1 Preferred Stock;

                         877,194 shares of Common Stock issuable upon
                         conversion of the Convertible Notes; and

                         307,017 shares of Common Stock issuable upon
                         conversion of the Note Warrants (1)
--------------------------------------------------------------------------------
     12    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
           CERTAIN SHARES*                                                [ ]
--------------------------------------------------------------------------------
     13    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           18.2% (see Item 5)(1)
--------------------------------------------------------------------------------
     14    TYPE OF REPORTING PERSON*

           IN
--------------------------------------------------------------------------------

-----------------------
(1) Does not include shares of Common Stock (including shares of Common Stock
and shares of Common Stock issuable upon the conversion of preferred stock and
exercise of warrants and options) held by parties to the Irrevocable Proxy
Agreement other than the Reporting Persons, as discussed in Item 4 of the
Amendment No. 1.




                                 SCHEDULE 13D/A

--------------------------------------------------------------------------------
CUSIP NO.      460588106                               PAGE 8 OF 14 PAGES
--------------------------------------------------------------------------------

     1     NAME OF REPORTING PERSON
           I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

           Timothy M. Buono
--------------------------------------------------------------------------------
     2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP         (a) [x]
                                                                    (b) [ ]

--------------------------------------------------------------------------------
     3     SEC USE ONLY

--------------------------------------------------------------------------------
     4     SOURCE OF FUNDS*

           AF
--------------------------------------------------------------------------------
     5     CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED
           PURSUANT TO ITEMS 2(d) or 2(e)                               [ ]

--------------------------------------------------------------------------------
     6     CITIZENSHIP OR PLACE OF ORGANIZATION

           United States of America
--------------------------------------------------------------------------------
                  7      SOLE VOTING POWER

                         0
                 ---------------------------------------------------------------
 NUMBER OF        8      SHARED VOTING POWER
 SHARES
 BENEFICIALLY            568,647 shares of Common Stock;
 OWNED BY
 EACH                    2,281,914 shares of Common Stock issuable upon exercise
 REPORTING               of the Amended and Restated Warrants;
 PERSON WITH
                         10,526,316 shares of Common Stock issuable upon
                         conversion of the Series D-1 Preferred Stock;

                         877,194 shares of Common Stock issuable upon
                         conversion of the Convertible Notes; and

                         307,017 shares of Common Stock issuable upon
                         conversion of the Note Warrants (1)
                 ---------------------------------------------------------------
                  9      SOLE DISPOSITIVE POWER

                         0
                 ---------------------------------------------------------------
                  10     SHARED DISPOSITIVE POWER

                         568,647 shares of Common Stock;

                         2,281,914 shares of Common Stock issuable upon exercise
                         of the Amended and Restated Warrants; and

                         10,526,316 shares of Common Stock issuable upon
                         conversion of the Series D-1 Preferred Stock;

                         877,194 shares of Common Stock issuable upon
                         conversion of the Convertible Notes; and

                         307,017 shares of Common Stock issuable upon
                         conversion of the Note Warrants (1)
-------------------------------------------------------------------------------
     11    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH PERSON

                         568,647 shares of Common Stock;

                         2,281,914 shares of Common Stock issuable upon exercise
                         of the Amended and Restated Warrants; and

                         10,526,316 shares of Common Stock issuable upon
                         conversion of the Series D-1 Preferred Stock;

                         877,194 shares of Common Stock issuable upon
                         conversion of the Convertible Notes; and

                         307,017 shares of Common Stock issuable upon
                         conversion of the Note Warrants (1)
--------------------------------------------------------------------------------
     12    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
           CERTAIN SHARES*                                                [ ]
--------------------------------------------------------------------------------
     13    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           18.2% (see Item 5)(1)
--------------------------------------------------------------------------------
     14    TYPE OF REPORTING PERSON*

           IN
--------------------------------------------------------------------------------

-----------------------

(1) Does not include shares of Common Stock (including shares of Common Stock
and shares of Common Stock issuable upon the conversion of preferred stock and
exercise of warrants and options) held by parties to the Irrevocable Proxy
Agreement other than the Reporting Persons, as discussed in Item 4 of the
Amendment No. 1.




                                 SCHEDULE 13D/A

The Schedule 13D filed on June 6, 2006 (the "SCHEDULE 13D") by  Tullis-Dickerson
Capital Focus III, L.P.  ("CAPITAL FOCUS III"),  Tullis-Dickerson  Partners III,
L.L.C. ("PARTNERS III"), Joan P. Neuscheler  ("NEUSCHELER"),  James L. L. Tullis
("TULLIS"),  Thomas P. Dickerson  ("DICKERSON"),  Lyle A. Hohnke  ("HOHNKE") and
Timothy M. Buono  ("BUONO" and together  with Capital  Focus III,  Partners III,
Neuscheler,  Tullis,  Dickerson and Hohnke, the "REPORTING PERSONS") relating to
the common stock, par value $0.01 per share (the "COMMON STOCK"),  of Interpharm
Holdings, Inc. (the "ISSUER"), as amended by Amendment No. 1 to the Schedule 13D
filed on November  16, 2007 (the  "AMENDMENT  NO. 1"), is hereby  amended as set
forth in this Amendment No. 2.

ITEM 4. PURPOSE OF TRANSACTION.

ITEM 4 OF THE SCHEDULE 13D IS HEREBY AMENDED TO ADD THE FOLLOWING:

On February 28, 2008, the Exchange Event (as defined in the Amendment No. 1) was
consummated.

ITEM 5. INTEREST IN SECURITIES OF THE COMPANY.

ITEM 5 (A) AND (B) OF THE SCHEDULE 13D ARE HEREBY AMENDED AND RESTATED AS
follows:

(a) As of the date of this Amendment No. 2, the Reporting  Persons may be deemed
to  beneficially  own 14,561,088  shares of Common Stock including (i) 2,281,914
shares of Common  Stock  issuable  to  Capital  Focus III upon  exercise  of the
Amended  and  Restated  Warrants  (as  defined in the  Amendment  No.  1);  (ii)
10,526,316  shares of Common Stock issuable to Capital Focus III upon conversion
of the Series D-1  Preferred  Stock (as defined in the  Amendment  No. 1); (iii)
877,194 shares of Common Stock issuable to Capital Focus III upon  conversion of
the  Convertible  Notes (as defined in the Amendment No. 1); (iv) 307,017 shares
of Common  Stock  issuable  to  Capital  Focus III upon  conversion  of the Note
Warrants (as defined in the Amendment  No. 1); and (v) 568,647  shares of Common
Stock  currently  owned by Capital  Focus III. The  14,561,088  shares of Common
Stock that the  Reporting  Persons may be deemed to  beneficially  own represent
18.2% of the Common  Stock.  The  percentages  used in this  Amendment No. 2 are
calculated  based  upon  66,190,053  shares  of  Common  Stock  reported  to  be
outstanding  by the Issuer in its  Schedule  14C filed with the  Securities  and
Exchage Commission on January 16, 2008. Partners III is the sole general partner
of Capital  Focus III.  Neuscheler,  Tullis,  Dickerson,  Hohnke and Buono share
voting and/or  dispositive power over all shares of Common Stock held by Capital
Focus III. The Reporting Persons disclaim beneficial  ownership of the shares of
Common  Stock  beneficially  owned  except  to the  extent  of  their  pecuniary
interests  therein.  As discussed in Item 4, the Reporting Persons may be deemed
to be a group  within the  meaning of Section  13(d)(3)  of the  Securities  and
Exchange Act of 1934, however,  the Reporting Persons disclaim the creation of a
group with the parties to the  Irrevocable  Proxy  Agreement  (as defined in the
Amendment No. 1).

(b) Partners III is the sole general  partner of Capital Focus III.  Neuscheler,
Tullis,  Dickerson,  Hohnke and Buono share voting and/or dispositive power over
all shares.  These individuals  disclaim  beneficial  ownership of the shares of
Common Stock  beneficially  owned by the above entities  except to the extent of
their pecuniary interests therein.  The Reporting Persons disclaim their ability
to direct the voting of Issuer  shares,  other than those held  directly  by the
Reporting  Persons,  as a result of the Irrevocable Proxy Agreement as discussed
in Item 4.

(c) During the last sixty days there were no  transactions  in the Common  Stock
effected.  The Reporting  Persons disclaim their ability to direct the voting of
the Common Stock as a result of the Irrevocable  Proxy Agreement as discussed in
Item 4.

(d) The partners or members of Capital Focus III and Partners III have the right
to participate indirectly in the receipt of dividends from, or proceeds from the
sale of,  the  shares  of  Common  Stock in  accordance  with  their  respective
ownership interests in their respective entities.

(e) Not applicable.




                                   SIGNATURES

     After reasonable inquiry and to the best of his knowledge and belief,  each
of the undersigned certifies that the information set forth in this statement is
true, complete and correct.


February 29, 2008           TULLIS-DICKERSON CAPITAL  FOCUS III, L.P.

                            BY:    TULLIS-DICKERSON PARTNERS III, L.L.C.,
                            ITS:   GENERAL PARTNER

                            By:    /s/ Joan P. Neuscheler
                                   ----------------------------------------
                                   JOAN P. NEUSCHELER
                                   Principal

February 29, 2008                  TULLIS-DICKERSON PARTNERS III, L.L.C.

                            By:    /s/ Joan P. Neuscheler
                                   ----------------------------------------
                                   JOAN P. NEUSCHELER
                                   Principal


February 29, 2008                  /s/ Joan P. Neuscheler
                                   ----------------------------------------
                                   JOAN P. NEUSCHELER

February 29, 2008                  /s/ James L.l. Tullis
                                   ----------------------------------------
                                   JAMES L.L. TULLIS

February 29, 2008                  /s/ Thomas P. Dickerson
                                   ----------------------------------------
                                   THOMAS P. DICKERSON

February 29, 2008                  /s/ Lyle A. Hohnke
                                   ----------------------------------------
                                   LYLE A. HOHNKE

February 29, 2008                  /s/ Timothy M. Buono
                                   ----------------------------------------
                                   TIMOTHY M. BUONO