European and Asian stocks fell Friday after economic reports suggested growth will weaken in the world's major economies. Downbeat data on Germany, China and the U.S. came on top of uncertainty over whether European leaders will make progress in tackling their debt crisis at key meetings. Germany's Ifo institute reported that business optimism fell for a second straight month in Europe's largest economy, which has been growing more strongly than the 17-member eurozone as a whole. The survey index dipped to 105.3 from 106.9 in May. That followed a U.S. Labor Department report from Thursday that the four-week average of applications for unemployment benefits jumped to the highest level in nine months. Appetite for financial assets such as stocks was also dented by the results of a monthly HSBC survey, which showed that manufacturing in China has continued to contract. China's growth has been a pillar of the global economy in recent years, so its slowdown has been of particular concern to investors. Meanwhile, infighting over Europe's heavy debt burden continued, leading IMF head Christine Lagarde to warn that the euro is under "acute stress" and to urge leaders of the 17 countries that use the currency to consider steps such as jointly issuing debt. The leaders of Germany, France, Italy and Spain will meet in Rome on Friday to seek common ground ahead of an EU summit on June 28-29 in Brussels, but there is no clear sense that they can agree on any of the several proposals to address the debt crisis. Against that background, Britain's FTSE 100 fell 0.6% to 5,532.76, while the French CAC 40 eased 0.2% to 3,105.52 and the German DAX 30 blue chips index fell 0.5% to 6,312.81. US share index futures pointed higher ahead of the opening of trading in New York. The Dow industrials future rose 0.4% to 12,552.00 and the Standard & Poor's 500 future rose 0.5% to 1,324.80 The chief European piece of bad news was the Ifo report. It follows downbeat readings from the ZEW survey of investors and a poll of purchasing managers that also suggest the Germany economy is lagging. "The survey echoes the other indicators in suggesting that the German economy is doing little more than stagnating at the moment, and may even be contracting," wrote Jonathan Loynes, chief European economist at Capital Economics in London. "In short, another blow to hopes that strong growth and higher inflation in Germany would help to solve the euro-zone crisis." Traders also reacted to several negative U.S. indicators. On top of the jobs figures, sales of previously-owned homes fell 1.5% in May. A further sign of weakness in the world's No. 1 economy came from the Philadelphia branch of the Federal Reserve, which issued a report showing that manufacturing in the northeast had experienced a sharp decrease due to a steep fall in company orders. "With signs of weakness in the U.S. economy, the persistence of the eurozone debt crisis and the threat of a hard landing in China looming, the prospect of a synchronized economic slowdown is real," analysts at DBS Bank Ltd. in Singapore said in a market commentary. Sentiment was also shaken after Moody's Investors Service lowered the credit ratings of 15 major banks, including Bank of America, JPMorgan Chase and Goldman Sachs, saying their long-term prospects for profitability and growth are shrinking. Downgrades generally make it more costly for banks to raise money by selling debt because investors demand higher interest in return for taking on riskier debt. "Of course, they deserve it for years of mismanagement and speculative trading activities ... and also the exposure to sovereign bank debt," said Francis Lun, managing director of Lyncean Holdings in Hong Kong. "So, as a result, all these major international banks are being downgraded to a more realistic level." Benchmark oil for August delivery was up 48 cents to $78.68 per barrel in electronic trading on the New York Mercantile Exchange. The euro rose 0.1% to $1.2555. The dollar rose 0.1% to 80.31 yen.