Illumina Reports Financial Results for Fourth Quarter and Fiscal Year 2008

Illumina, Inc. (NASDAQ:ILMN) today announced its financial results for the fourth quarter and fiscal year 2008.

For the fourth quarter of 2008, Illumina reported revenue of $160.9 million, a 43% increase over the $112.6 million reported in the fourth quarter of 2007 and a 7% increase over revenue of $150.3 million in the third quarter of 2008. This represents the Company's 30th consecutive quarter of revenue growth. The Company reported GAAP net income for the quarter of $28.9 million, or $0.22 per diluted share, compared to a GAAP net loss of $4.1 million, or ($0.04) per basic and diluted share in the comparable period of 2007. The GAAP net loss in the fourth quarter of 2007 was attributable to the recognition of litigation settlement expenses. GAAP net income for the fourth quarter of 2008 included non-cash charges of $11.8 million in stock compensation expense associated with SFAS No. 123R, $2.7 million attributable to the amortization of intangible assets and $0.9 million of accrued contingent compensation associated with the acquisition of Avantome, Inc. Excluding the impact of these specified items, and net of pro forma tax expense, Illumina’s net income on a non-GAAP basis for the fourth quarter of 2008 was $39.4 million, or $0.31 per diluted share, compared to $22.5 million, or $0.19 per diluted share, for the fourth quarter of 2007.

Gross margin in the fourth quarter of 2008 was 64.4% compared to 63.8% in the comparable period of 2007. Excluding the effect of the amortization of intangibles and non-cash charges associated with stock compensation, non-GAAP gross margin was 66.7% for the fourth quarter of 2008 compared to 65.5% in the prior year period.

Research and development (R&D) expenses for the fourth quarter of 2008 were $28.3 million compared to $20.1 million in the fourth quarter of 2007. R&D expenses include $3.8 million and $3.0 million of non-cash stock compensation expense in the fourth quarter of 2008 and 2007, respectively, as well as $0.9 million of accrued contingent compensation associated with the Avantome acquisition completed during the third quarter of 2008. Excluding these charges, R&D expenses as a percentage of revenues were 14.7% compared to 15.2% in the prior year period.

Selling, general, and administrative (SG&A) expenses for the quarter were $39.2 million compared to $30.0 million for the fourth quarter of 2007. SG&A expenses include $6.9 million and $5.4 million of non-cash stock compensation expense in the fourth quarter of 2008 and 2007, respectively. Excluding these charges, SG&A expenses as a percentage of revenues were 20.1% compared to 21.9% in the prior year period.

The Company generated $49.4 million in cash flow from operations during the fourth quarter of 2008, compared to $11.9 million in the comparable quarter of 2007. Depreciation and amortization expenses were $7.7 million and capital expenditures were $14.6 million during the quarter. During the quarter, the Company repurchased 3.1 million shares of common stock outstanding for a total of $70.8 million. Net of this repurchase, the Company ended the quarter with $687.3 million in cash and investments compared to $701.2 million as of September 28, 2008.

Fiscal 2008

For the fiscal year 2008, the Company reported revenue of $573.2 million, a 56% increase over the $366.8 million reported in fiscal 2007. On a GAAP basis, the Company reported net income of $50.5 million or $0.38 per diluted share compared to a GAAP net loss of $278.4 million or $2.57 per share in 2007. 2008 GAAP net income included non-cash charges of $47.7 million related to stock compensation expense, $24.7 million for the write off of in-process research and development associated with the acquisition of Avantome, Inc., $10.4 million attributable to the amortization of intangible assets, $4.1 million associated with the write-off of manufacturing equipment, and $1.5 million of accrued contingent compensation associated with the acquisition of Avantome, Inc. Excluding the impact of the non-cash items listed above and net of pro forma tax expense, Illumina's non-GAAP net income was $118.0 million, or $0.93 per diluted share, compared to $71.9 million, or $0.62 per diluted share in fiscal 2007.

Gross margin for fiscal 2008 was 61.6%, compared to 63.2% in fiscal 2007. Excluding non-cash charges associated with stock compensation, the amortization of intangible assets, the write-off of manufacturing equipment, and certain acquisition related expenses, non-GAAP gross margin was 65.0% in fiscal 2008 compared to 65.3% in fiscal 2007.

R&D expenses for fiscal 2008 were $100.0 million compared to $73.9 million in fiscal 2007. R&D expenses for 2008 included non-cash stock compensation expense of $14.1 million compared to $10.0 million in 2007. 2008 R&D expenses also included $1.5 million of accrued contingent compensation associated with the acquisition of Avantome, Inc. SG&A expenses for fiscal 2008 were $148.0 million compared to $101.3 million in 2007 and included $28.5 million and $19.4 million of non-cash stock compensation expense respectively.

The Company generated $51.1 million in cash from operations in 2008 which included $90.5 million in litigation settlement payments. Excluding these payments, the Company generated $141.7 million in cash from operations. Depreciation and amortization expenses for the year were $27.7 million and capital expenditures were $59.7 million.

Highlights since our last earnings release:

• Forbes ranked Illumina #1 on its list of Fastest-Growing American Technology Companies for the second time in the past three years.
• Entered into a strategic alliance with Oxford Nanopore Technologies (“Oxford Nanopore”) including a commercialization agreement under which Illumina will exclusively market, sell, distribute, and service BASE(TM) Technology products developed by Oxford Nanopore for DNA sequencing into the research and diagnostic markets on a worldwide basis. In addition to the commercialization agreement, Illumina also made an $18 million equity investment into Oxford Nanopore.
• Launched the Infinium HD HumanCytoSNP-12 BeadChip, a 12 sample BeadChip priced as low as $125 per sample that enables researchers to analyze nearly 300,000 genetic markers per sample that target all known cytogenetic abnormalities.
• Launched the Infinium HD iSelect Custom Genotyping platform which enables researchers to screen between 3,000 to 200,000 custom SNPs in human or non-human species across 12 samples on one BeadChip. The first commercially available products made with the Infinium HD iSelect technology include the OvineSNP50 and PorcineSNP60 BeadChips. The new panels were developed in collaboration with leading researchers at international consortia and utilized Illumina's Genome Analyzer, public databases, and other marker discovery approaches for content selection.
• Announced that researchers at Duke University Medical Center will utilize Illumina's Genome Analyzer to study the resistance to HIV infection among 50 individuals that were highly exposed to the virus, but who remain uninfected. As part of this study, Duke University researchers will sequence the complete genome of at least 50 individuals.
• Announced that researchers at the Beijing Genomics Institute (BGI), Shenzhen completed the de novo sequence of the giant panda genome. Exclusively using Illumina's Genome Analyzer, a small team of scientists--in one month--produced 150 gigabases of sequence that was used to assemble the three gigabase genome.
• Launched the Infinium HD Human660W-Quad BeadChip, a four sample BeadChip that features 2.6 million genetic markers and was developed in collaboration with The Centre for Applied Genomics at the Hospital for Sick Children in Toronto and the Wellcome Trust Sanger Institute. This BeadChip adds markers to the HumanHap550+ to target over 5,000 regions in the human genome known to be associated with copy number variation (CNV).
• Shipped 11 additional Genome Analyzers (GA) to the Wellcome Trust Sanger Institute, bringing their total number of GAs to 37. The additional systems will support the Sanger Institute's many initiatives, such as its contribution to the 1000 Genome Project, which requires economical, accurate, and rapid sequence generation.
• The Company was added to the NASDAQ-100 Index and Illumina stock was added to the PowerShares QQQ Trust (NasdaqGM: QQQQ).
• Appointed Mark Lewis to Senior Vice President of Development and appointed Bill Bonnar to Senior Vice President of Operations.

Financial Outlook and Guidance

The non-GAAP financial guidance discussed below excludes non-cash charges resulting from stock compensation expense, the incremental interest expense of the Company’s convertible debt associated with the adoption on January 1, 2009 of FASB Staff Position No. APB 14-1 “Accounting for convertible debt instruments that may be settled in cash upon conversion” (including partial cash settlement)(FSP APB 14-1), amortization expense related to intangible assets, the accrual of contingent compensation related to the Avantome acquisition, and the double dilution associated with the accounting treatment of the Company’s convertible debt outstanding and the corresponding call option overlay (see table which reconciles these non-GAAP financial measures to the related GAAP measures).

We expect revenue for 2009 between $690 and $720 million, representing year-over-year growth between 20% and 26%. We expect our gross margin percentage to be in the mid 60s. We expect earnings per fully diluted share between $1.10 and $1.20. We expect the full year pro forma tax rate to be approximately 33% and stock compensation expense of approximately $60 million or a tax adjusted amount of $0.30 per fully diluted pro forma share. The Company expects full year weighted average diluted shares outstanding for the measurement of pro forma amounts to be approximately 133 million.

For the first quarter of 2009, we expect revenues between $158 and $164 million. We expect earnings per fully diluted share of $0.23 to $0.26 assuming approximately 131 million shares. We expect stock compensation expense during the first quarter of approximately $14 million or a tax adjusted amount of $0.07 per fully diluted pro forma share.

Quarterly Conference Call Information

The conference call will begin at 2:00pm Pacific Time (5:00pm Eastern Time) on Tuesday, February 3, 2009. Interested parties may listen to the call by dialing 866.713.8562 (passcode: 30515169), or if outside North America, by dialing +1.617.597.5310 (passcode: 30515169). Individuals may access the live teleconference under the "Corporate/Investor Information" tab of Illumina's web site at www.illumina.com.

A replay of the conference call will be available from 4:00pm Pacific Time (7:00pm Eastern Time) on February 3, 2009 through February 10, 2009 by dialing 888.286.8010, or if outside North America, by dialing +1.617.801.6888 (passcode: 80494836).

About Illumina

Illumina is a leading developer, manufacturer, and marketer of next-generation life science tools and integrated systems for the large scale analysis of genetic variation and biological function. Using our proprietary technologies, we provide a comprehensive line of products and services that currently serve the sequencing, genotyping, and gene expression markets, and we expect to enter the market for molecular diagnostics. Our customers include leading genomic research centers, academic institutions, agriculture and livestock companies, pharmaceutical companies, clinical research organizations and biotechnology companies. Our tools provide researchers around the world with the performance, throughput, cost effectiveness and flexibility necessary to perform the billions of genetic tests needed to extract valuable medical information from advances in genomics and proteomics. We believe this information will enable researchers to correlate genetic variation and biological function, which will enhance drug discovery and clinical research, allow diseases to be detected earlier and permit better choices of drugs for individual patients.

Statement Regarding Use of Non-GAAP Financial Measures

The Company reported non-GAAP results for diluted net income per share, net income, gross margins, operating margins, cash flow from operations and free cash flow in addition to, and not as a substitute for, or superior to, financial measures calculated in accordance with GAAP.

The Company’s financial results under GAAP include substantial non-cash charges related to stock compensation expense, a charge for the impairment of manufacturing equipment, the amortization of intangible assets, amortization of inventory revaluation costs on products sold that were previously written-up under purchase accounting rules, acquired in-process research and development expense related to the Company's acquisitions of Avantome, Inc. in August 2008 and Solexa, Inc. in January 2007 and compensation expense related to contingent consideration due to stockholders of Avantome, Inc. Per share amounts exclude the double dilution associated with the accounting treatment of the Company’s convertible debt outstanding and the corresponding call option overlay. Management believes that presentation of operating results that excludes these non-cash charges provides useful supplemental information to investors that facilitates analysis of the Company’s core operating results and comparison of operating results across reporting periods. Management believes that this supplemental non-GAAP information is therefore useful to investors in analyzing and assessing the Company’s past and future operating performance.

The Company encourages investors to carefully consider its results under GAAP, as well as its supplemental non-GAAP information and the reconciliation between these presentations, to more fully understand its business. Reconciliations between GAAP and non-GAAP results are presented in the tables of this release.

"Safe Harbor" Statement under the Private Securities Litigation Reform Act of 1995: this release may contain forward-looking statements that involve risks and uncertainties. Among the important factors that could cause actual results to differ materially from those in any forward-looking statements are Illumina's ability (i) to develop and commercialize further our BeadArray™, VeraCode®, and Solexa® technologies and to deploy new sequencing, gene expression, and genotyping products and applications for our technology platforms, (ii) to manufacture robust instrumentation and reagents technology, together with other factors detailed in our filings with the Securities and Exchange Commission including our recent filings on Forms 10-K and 10-Q or in information disclosed in public conference calls, the date and time of which are released beforehand. We disclaim any intent or obligation to update these forward-looking statements beyond the date of this release.