Mixed open as ruble collapses

The markets opened mixed with the Dow rising 26 points to 17,207 while Nasdaq lost 15 points to 4,589 as the ruble collapsed.

On the upside

Repsol offered a premium of approximately $8.3 billion in cash to acquire Talisman Energy (NYSE: TLM).

Novogen (Nasdaq: NVGN) announced that its TRXE-009 has been highly effective against melanoma in pre-clinical studies.

Salix Pharmaceuticals (Nasdaq: SLXP) will work with its wholesale partners to reduce inventories.

On the downside

Share of Yandex (Nasdaq: YNDX) tumbled as the value of the ruble plunged.

Frontline (NYSE: FRO) entered debt-for-equity exchange.

The Data and Safety Monitoring Board determined that Cyclacel Pharmaceuticals' (Nasdaq: CYCC) ongoing Phase 3 study of sapacitabine was not likely to statistically significant improvement in survival.

In the broad market, declining issues outpaced advancers by a margin of 5 to 4 on the NYSE and by nearly 10 to 9 on Nasdaq. The broader S&P 500 eased a point to 1987. Bitcoin fell $11 to $331.
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