Shire rebuffs $46 billion takeover bid from AbbVie By: MarketWatch June 20, 2014 at 03:29 AM EDT U.K.-listed drug maker Shire PLC has rejected a £27.2 billion ($46.35 billion) takeover bid from U.S. rival AbbVie Inc. Read More >> Related Stocks: AbbVie Astrazeneca Plc ADR Macy's Pfizer Shire Plc Ads