Mixed open as Brexit officially begins

The markets opened mixed with the Dow falling 47 points to 20,654 while Nasdaq rose 11 points to 5,886 after British Prime Minister Theresa May officially triggered the United Kingdom's separation from the European Union.


On the upside


Tonix Pharmaceuticals Holdings (Nasdaq: TNXP) will present at The MicroCap Conference on April 4, 2017.


Exar (NYSE: EXAR) will be acquired by MaxLinear (NYSE: MXL) in an all cash transaction valued at approximately $700 million.


Vertex Pharmaceuticals (Nasdaq: VRTX) reported positive results from two Phase 3 studies of the tezacaftor (VX-661)/ivacaftor combination treatment for cystic fibrosis.


On the downside


Investors locked in profits on Diffusion Pharmaceuticals (Nasdaq: DFFN).

Ritter Pharmaceuticals (Nasdaq: RTTR) reported upbeat results from a Phase 2b/3 study of its lactose intolerance treatment RP-G28 but the stock price fell.

Profit taking weighed down shares of Catalyst Biosciences (Nasdaq: CBIO).


In the broad market, declining issues outpaced advancers by a margin of 5 to 4 on the NYSE and by nearly 9 to 7 on Nasdaq. The broader S&P 500 index eased a fraction to 2,357. Bitcoin gained $8 to $1043.


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