The markets opened sharply lower with the Dow tumbling 94 points to 15,544 ahead of the Institute for Supply Management's services industry report. Nasdaq fell 19 points 3916.

On the upside

Endo Health (Nasdaq: ENDP) will acquire Paladin Labs for approximately $1.5 billion in cash and stock.

GT Advanced Technologies (Nasdaq: GTAT) announced a multiyear agreement to supply Apple (Nasdaq: AAPL) with sapphire material.

Cytori Therapeutics (Nasdaq: CYTX) licensed its Cytori Cell Therapy to Lorem Vascular for up to $531 million.

On the downside

BroadSoft (Nasdaq: BSFT) fell to a greater than expected loss for the third quarter prompting downgrades.

ImmunoGen (Nasdaq: IMGN) halted a Phase II study of its IMGN901 in treating small cell lung cancer.

Orbitz Worldwide (NYSE: OWW) disappointed with lower third quarter earnings that fell short of expectations.

In the broad market, declining issues outpaced advancers by a margin of 5 to 1 on the NYSE and by more than 5 to 2 on Nasdaq. The broader S&P 500 fell 9 points to 1758.