The markets closed lower with the Dow losing 19 points to 20,914 despite an increase in March consumer sentiment. Nasdaq edged up a fraction to 5,901.

On the upside

Shares of MuleSoft (NYSE: MULE) surged in its market debut.

Viveve Medical (Nasdaq: VIVE) priced its public offering of 7.5 million common shares at $4.00 per share.

AveXis (Nasdaq: AVXS) reported positive results from a Phase 1 trial of AVXS-101 in spinal muscular atrophy Type 1.

On the downside

Profit taking weighed down shares of Innocoll Holdings (Nasdaq: INNL).

AmTrust Financial Services (Nasdaq: AFSI) delayed filing its annual report due to errors in previous financial statements dating back to 2014.

An electrical fire shut down AXT's (Nasdaq: AXTI) Beijing manufacturing facility.

In the broad market, advancing issues outpaced decliners by a margin of nearly 3 to 2 on the NYSE and by 7 to 5 on Nasdaq. The broader S&P 500 index slipped 3 points to 2,378. Bitcoin fell $6 to $1,110.