FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person * ASTRAZENECA PLC   2. Issuer Name and Ticker or Trading Symbol PhaseBio Pharmaceuticals Inc [PHAS] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director __X__ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) 1 FRANCIS CRICK AVENUE,  3. Date of Earliest Transaction (Month/Day/Year) 10/22/2018 (Street) CAMBRIDGE, X0 CB2 0AA 4. If Amendment, Date Original Filed(Month/Day/Year) 6. Individual or Joint/Group Filing(Check Applicable Line) ___ Form filed by One Reporting Person _X_ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 10/22/2018   C   2,404,554 A (1) 2,404,554 I By Zeneca, Inc. (2) Common Stock 10/22/2018   P   600,000 A $ 5 3,004,554 I By Zeneca, Inc. (2)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Underlying Securities (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Warrants to Purchase Series C-1 Preferred Stock	$ 0.12	10/22/2018		X(3)			113,891	(4)	(4)	Series C-1 Preferred Stock (1)	113,891	$ 0	0	I	By Zeneca, Inc. (2)
Series C-1 Preferred Stock	(1)	10/22/2018		X(3)		113,891		(1)	(1)	Common Stock	113,891	$ 0.12	1,666,951	I	By Zeneca, Inc. (2)
Series C-1 Preferred Stock	(1)	10/22/2018		S(3)			2,734	(1)	(1)	Common Stock	2,734	$ 5	1,664,217	I	By Zeneca, Inc. (2)
Series C-1 Preferred Stock	(1)	10/22/2018		C			1,664,217	(1)	(1)	Common Stock	1,664,217	$ 0	0	I	By Zeneca, Inc. (2)
Series D Preferred Stock	(1)	10/22/2018		C			740,337	(1)	(1)	Common Stock	740,337	$ 0	0	I	By Zeneca, Inc. (2)

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
ASTRAZENECA PLC 1 FRANCIS CRICK AVENUE CAMBRIDGE, X0 CB2 0AA		X
Zeneca, Inc. C/O ASTRAZENECA PLC 1 FRANCIS CRICK AVENUE CAMBRIDGE, X0 CB2 0AA		X

Signatures

/s/ Adrian Kemp, on behalf of AstraZeneca PLC		10/24/2018
**Signature of Reporting Person		Date
/s/ David E. White, on behalf of Zeneca Inc.		10/24/2018
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	Each share of Preferred Stock converted into Common Stock on a one-for-one basis upon the closing of the Issuer's initial public offering and has no expiration date.
(2)	Zeneca Inc. is a wholly-owned subsidiary of AstraZeneca PLC. AstraZeneca PLC may be deemed to beneficially own the securities held by Zeneca Inc., but disclaims beneficial ownership over such securities except to the extent of its pecuniary interest therein, if any.
(3)	Represents the net exercise of the warrants immediately prior to, and contingent upon, the closing of the Issuer's initial public offering.
(4)	The warrants were exercisable until, and were scheduled to expire upon, the closing of the Issuer's initial public offering.

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