UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                   ----------


                                    FORM 11-K


                              FOR ANNUAL REPORTS OF
               EMPLOYEE STOCK REPURCHASE SAVINGS AND SIMILAR PLANS
                        PURSUANT TO SECTION 15(d) OF THE
                         SECURITIES EXCHANGE ACT OF 1934


(MARK ONE)


|X|  ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES
     EXCHANGE ACT OF 1934

                   FOR THE FISCAL YEAR ENDED DECEMBER 31, 2007

                                       OR

|_|  TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES
     EXCHANGE ACT OF 1934

FOR THE TRANSITION PERIOD FROM ______________ TO ______________


                        COMMISSION FILE NUMBER 001-09974


                               Enzo Biochem, Inc.
                      Salary Reduction Profit Sharing Plan

              (Full title of the plan and the address of the plan,
               if different from that of the issuer named below:)


             Enzo Biochem, Inc, 527 Madison Ave. New York, NY 10022

         (Name of issuer of the securities held pursuant to the plan and
                 the address of its principal executive office)





                               ENZO BIOCHEM, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN

                                TABLE OF CONTENTS







                                                                       PAGE
                                                                       ----

Report of Independent Registered Public Accounting Firm                  1

FINANCIAL STATEMENTS:

      Statements of Net Assets Available for Benefits
      December 31, 2007 and 2006                                         2

      Statement of Changes in Net Assets Available
      for Benefits For the year ended December 31, 2007                  3

      Notes to Financial Statements                                     4-8

SUPPLEMENTAL SCHEDULE AS OF DECEMBER 31, 2007:

      Schedule H, Item 4i -
      Schedule of Assets Held at End of Year                             9

Signatures                                                              10

Consent of Independent Registered Public Accounting Firm             Exhibit 23





             REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM



To the Trustees of
Enzo Biochem, Inc. Salary Reduction Profit Sharing Plan


We have audited the accompanying statements of net assets available for benefits
of Enzo Biochem,  Inc. Salary  Reduction  Profit Sharing Plan (the "Plan") as of
December 31, 2007 and 2006,  and the related  statement of changes in net assets
available  for benefits for the year ended  December 31, 2007.  These  financial
statements are the responsibility of the Plan's  management.  Our responsibility
is to express an opinion on these financial statements based on our audit.

We conducted our audit in accordance with generally  accepted auditing standards
as established by the Auditing Standards Board (United States) and in accordance
with the  standards of the Public  Company  Accounting  Oversight  Board (United
States).  Those  standards  require that we plan and perform the audit to obtain
reasonable assurance about whether the financial statements are free of material
misstatement.  The Plan is not required to have, nor were we engaged to perform,
an audit of its internal  control over financial  reporting.  Our audit included
consideration  of  internal  control  over  financial  reporting  as a basis for
designing audit  procedures that are appropriate in the  circumstances,  but not
for the  purpose of  expressing  an opinion on the  effectiveness  of the Plan's
internal  control  over  financial  reporting.  Accordingly,  we express no such
opinion. An audit also includes examining,  on a test basis, evidence supporting
the  amounts  and  disclosures  in  the  financial  statements,   assessing  the
accounting principles used and significant estimates made by management, as well
as evaluating the overall financial statement presentation.  We believe that our
audit provides a reasonable basis for our opinion.

In our opinion,  the financial  statements  referred to above present fairly, in
all material  respects,  the net assets available for benefits of the Plan as of
December 31, 2007 and 2006, and the changes in net assets available for benefits
for the year ended December 31, 2007 in conformity  with  accounting  principles
generally accepted in the United States of America.

Our audit was  conducted  for the  purpose  of  forming  an opinion on the basic
financial statements taken as a whole. The supplemental  schedule of assets held
for investment  purposes at the end of the year, is presented for the purpose of
additional analysis and is not a required part of the basic financial statements
but is supplementary information required by the Department of Labor's Rules and
Regulations for Reporting and Disclosure  under the Employee  Retirement  Income
Security Act of 1974. The  supplemental  schedule is the  responsibility  of the
Plan's management.  The supplemental schedule has been subjected to the auditing
procedures  applied in the audit of the basic  financial  statements and, in our
opinion,  is fairly  stated in all  material  respects  in relation to the basic
financial statements taken as a whole.


Marks Paneth & Shron LLP



Woodbury, New York
July 2, 2008


                                       1



                               ENZO BIOCHEM, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN

                 STATEMENTS OF NET ASSETS AVAILABLE FOR BENEFITS

                                  DECEMBER 31,



                                                       2007              2006
                                                   -----------       -----------

ASSETS

Cash                                               $    57,832       $    54,129
                                                   -----------       -----------

Investments at fair value:
    Mutual funds                                    10,288,151         9,583,819
    Common stock                                     2,003,849         2,251,720
    Insurance contract                               1,263,245         1,062,804
                                                   -----------       -----------
                                                    13,555,245        12,898,343
                                                   -----------       -----------
Receivables:
    Employer's contributions                           465,640           415,536
    Participants' contributions                          3,156            31,404
                                                   -----------       -----------
                                                       468,796           446,940
                                                   -----------       -----------

Loans receivable - participants                        218,993           175,842
                                                   -----------       -----------

TOTAL ASSETS                                        14,300,866        13,575,254
                                                   -----------       -----------

NET ASSETS AVAILABLE FOR BENEFITS                  $14,300,866       $13,575,254
                                                   ===========       ===========



See notes to financial statements.


                                       2



                               ENZO BIOCHEM, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN

            STATEMENT OF CHANGES IN NET ASSETS AVAILABLE FOR BENEFITS

                      FOR THE YEAR ENDED DECEMBER 31, 2007




                                                                                                      
Additions to net assets attributed to:
  Participants' contributions                                                                              $    1,267,255
  Employer's contributions                                                                                        465,640
  Rollover contributions                                                                                           63,497
  Transfer of assets from Axxora, LLC. 401(k) plan                                                                153,570
  Interest on loans to participants                                                                                14,121
  Net appreciation (depreciation) in fair value of investments:
      Mutual funds                                                                   $  1,043,634
      Common stock                                                                       (212,477)                831,157
                                                                                     -------------         --------------

         Total additions                                                                                        2,795,240
                                                                                                           --------------

Deductions from net assets attributed to:
  Benefits paid to participants                                                                                 2,029,258
  Administrative expenses                                                                                          40,370
                                                                                                           --------------

         Total deductions                                                                                       2,069,628
                                                                                                           --------------

Net increase in net assets available for benefits                                                                 725,612

Net assets available for benefits, beginning of year                                                           13,575,254
                                                                                                           --------------

Net assets available for benefits, end of year                                                             $   14,300,866
                                                                                                           ==============



See notes to financial statements.


                                       3




                               ENZO BIOCHEM, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN
                          NOTES TO FINANCIAL STATEMENTS

NOTE 1: PLAN DESCRIPTION

        The following  description of the Enzo Biochem,  Inc.  Salary  Reduction
        Profit  Sharing Plan ("the  Plan")  provides  only general  information.
        Participants should refer to the Plan Agreement,  as amended, for a more
        complete description of the Plan's provisions.

        GENERAL

        The Plan is a defined  contribution  plan  covering all eligible  United
        States based  full-time  employees  of Enzo  Biochem,  Inc.,  (the "Plan
        Sponsor"), and its wholly owned subsidiaries,  Enzo Clinical Labs, Inc.,
        Enzo  Therapeutics,  Inc.,  Enzo Life  Sciences,  Inc.,  and Axxora Life
        Sciences,  Inc ("ALS")  which was acquired in June 2007,  (collectively,
        the  "Company")  who have  completed  three  months of service  and have
        attained age twenty-one.

        The Plan is subject to the provisions of the Employee  Retirement Income
        Security Act of 1974 ("ERISA").

        CONTRIBUTIONS

        Eligible  employee  participants  can  elect to defer up to the  maximum
        amount  permitted by the Internal Revenue Code for each year ($15,500 in
        2007  and  $15,000  in  2006).   Effective  January  1,  2002,  catch-up
        contributions  are also permitted for participants who have attained age
        50 by December  31st, in accordance  with Section 414(v) of the Code, in
        an  amount up to a maximum  of $5,000 in 2007 and 2006,  bringing  those
        participants'  statutory  limitation  to $20,500 in 2007 and $20,000 for
        2006. In 2007 participant contributions totaled $1,267,255.  Included in
        participant  contributions  is  a  qualified  non-elective  contribution
        totaling $3,156 that had not been received as of December 31, 2007. This
        qualified non-elective contribution was paid by the Plan Sponsor on June
        25, 2008.

        In addition,  the Company will  contribute  to the Plan a  discretionary
        matching   contribution  equal  to  50%  of  the  participant's   401(k)
        contribution,  not to  exceed  50% of  10% of the  participant's  annual
        compensation.  Participants  who have completed a year of service during
        the plan year and are  actively  employed as of the last day of the plan
        year shall be deemed eligible to share in the matching  contribution for
        the  year.  In 2007 and  2006,  the total  matching  contributions  were
        $465,640 and  $415,536,  respectively,  in the form of Enzo Biochem Inc.
        common stock.

        Effective  June 1, 2006,  the Company  amended the Plan's  participant's
        salary reduction election.  The amendment requires  participants to make
        an initial salary deferral  election,  or an election to receive cash in
        lieu of a salary  deferral  election,  within 30 days after entering the
        Plan. A participant's  compensation will automatically be reduced by 3%,
        which  will  be  considered  to be the  Participant's  salary  reduction
        election  if the  Participant  does  not  elect to  defer a  portion  of
        compensation  or  elect  to  receive  cash in lieu of  making  a  salary
        deferral election.

        PARTICIPANTS' ACCOUNTS

        Contributions  are  invested  in a choice  of  mutual  funds,  a benefit
        responsive  investment  contract,  and the common stock of Enzo Biochem,
        Inc.  Contribution  selections are designated by the participants.  Each
        participant's  account is credited with the  participant's  contribution
        and allocations of (a) the Company's matching contribution and, (b) Plan
        earnings,  and charged with an  allocation of  administrative  expenses.
        Allocations are based on participant  compensation or account  balances,
        as  defined.  The  benefit to which a  participant  is  entitled  is the
        benefit that can be provided from the participant's vested account.


                                       4


                               ENZO BIOCHEM, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN
                          NOTES TO FINANCIAL STATEMENTS


NOTE 1: PLAN DESCRIPTION (CONTINUED)

        Effective  April 15, 2006, the Company  amended the Plan to allow a Plan
        participant  to elect  to  classify  all or part of his or her  elective
        deferrals as a Roth 401(k) deferral.

        VESTING

        Participants'  contributed  funds arising from salary reductions and the
        earnings  thereon,  are  fully  vested  at  all  times.  Vesting  in the
        Company's  matching  contribution and earnings thereon,  is ratable over
        four years of service.

        FORFEITURES

        Any forfeited  amounts  shall be applied to reduce the Company's  future
        contributions.  For the years  ended  December  31,  2007 and 2006,  the
        Company's  contributions  were reduced by forfeitures  of  approximately
        $17,600 and $13,700, respectively.

        LOANS TO PARTICIPANTS

        Participants  may borrow from their 401(k)  accounts a minimum of $1,000
        up to a maximum  of 50% of their  vested  account  balance  or  $50,000.
        Participants  are  entitled to borrow  from their  account for a maximum
        loan  term of five  years  unless  the  proceeds  are used to  acquire a
        principal  residence  in which case it may exceed five years.  The loans
        are  secured by the  participant's  vested  account  balance  and bear a
        reasonable  rate of  interest.  Principal  and  interest is paid ratably
        through payroll deductions.

        PAYMENT OF BENEFITS

        On  termination  of  service  due to death,  disability  or  retirement,
        participants  may elect to receive  an amount  equal to the value of the
        vested  interest  in their  account  in  either a lump sum  amount or in
        various  annuity  options.  For  termination  of  service  due to  other
        reasons,  a participant  may receive the value of the vested interest in
        their  account as a lump sum  distribution.  Benefits are payable in the
        form of cash or property.

        OPERATING EXPENSES

        Certain operating expenses of the Plan are paid by the Plan Sponsor.


NOTE 2: SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

        The Plan's  financial  statements  have been prepared in conformity with
        accounting principles generally accepted in the United States of America
        and under the accrual basis method of accounting.

        The Plan's investments are stated at fair value. Investment earnings are
        reinvested in the  respective  funds.  Investment  earnings  include the
        Plan's  proportionate share of realized gains and losses on the disposal
        of  investments,  and  appreciation or depreciation in the fair value of
        the underlying  investments  comprising the respective mutual funds. All
        purchases and sales are recorded on a trade date basis.


                                       5



                               ENZO BIOCHEM, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN
                          NOTES TO FINANCIAL STATEMENTS


NOTE 2: SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (CONTINUED)

        The Plan presents in the statement of changes in net asset available for
        benefits,  the net  appreciation  (depreciation)  in fair  value  of its
        investments,  which  consists  of the  realized  gains or losses and the
        unrealized appreciation (depreciation) on those investments.

        The   preparation  of  the  financial   statements  in  conformity  with
        accounting principles generally accepted in the United States of America
        requires  management  to make  estimates  and  assumptions  that  affect
        reported  amounts and  disclosures in the financial  statements.  Actual
        results could differ from those estimates.


NOTE 3: INVESTMENTS

        The following  table  presents the fair values,  as determined by quoted
        market  price,  of the  investments  at  December  31,  except  for  the
        Metropolitan Life Stable Value Contract,  which is presented at contract
        value, which approximates fair value:

                                                       2007             2006
                                                       -----            ----

Enzo Biochem,  Inc.* (157,288 shares at 2007,
  157,794 shares at 2006)                           $2,003,849       $2,251,720
American Century Government Bond                    $  288,250       $  290,796
American Funds AMCAP Fund CL A                      $  710,006       $  754,629
American Funds American Balanced Fund CL A*         $1,339,162       $1,327,293
American Funds Europacific Growth CL A*             $1,893,613       $1,709,274
American Funds Washington Mutual
  Investors Fund CL A*                              $2,589,711       $2,610,689
Baron Growth Fund                                   $  223,969       $  148,728
Calamos Growth Fund CL A                            $  559,349       $  493,974
Fidelity Contrafund*                                $1,148,803       $  974,288
Fidelity Spartan US Equity Index Fund               $  284,363       $  194,843
Freemont Bond Fund                                  $  228,029       $  163,272
Hotchkis & Wiley Mid Cap Value CL 1                 $  253,786       $  340,975
Neuberger & Berman Genesis Fund Trust               $  550,820       $  422,533
Metropolitan Life Stable Value Contract (Note 4)*   $1,263,245       $1,062,804
Royce Total Return                                  $  140,800       $  151,114
American Funds US Gov't Securities Fund CL A        $    1,499       $    1,411
Principal Investors High Yield                      $   65,831       $       --
Frank Russell 2010 Strategy Fund                    $      931       $       --
Frank Russell 2020 Strategy Fund                    $    4,373       $       --
Frank Russell 2030 Strategy Fund                    $    1,986       $       --
Frank Russell 2040 Strategy Fund                    $    2,870       $       --

*  Denotes  investments  representing  5% or more of net  assets  available  for
   benefits at December 31, 2007.


                                       6




                               ENZO BIOCHEM, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN
                          NOTES TO FINANCIAL STATEMENTS


NOTE 4: INVESTMENT CONTRACT WITH INSURANCE COMPANY

        The Plan has a benefit-responsive investment contract with MetLife Trust
        Company,   National   Association   (MetLife).   MetLife  maintains  the
        contributions  in separate  accounts.  The accounts  are  credited  with
        earnings on the  underlying  investments  and  charged  for  participant
        withdrawals and administrative expenses. The contract is included in the
        financial  statements  at  contract  value  as  reported  to the Plan by
        Counsel Trust Company.  Contract  value  represents  contributions  made
        under the contract,  plus earnings,  less  participant  withdrawals  and
        administrative   expenses.   Participants  may  ordinarily   direct  the
        withdrawal  or  transfer  of all or a  portion  of their  investment  at
        contract value.

        There are no  reserves  against  contract  value for credit  risk of the
        contract  issuer or otherwise  and contract is estimated to  approximate
        fair  value.   The  average  yield  and  crediting   interest  rate  was
        approximately 4.2% and 4.5% for 2007 and 2006, respectively.

NOTE 5: TRANSFER OF ASSETS

        On November  15, 2007,  the assets of the 401(k) Plan of Axxora,  LLC (a
        United  States based wholly owned  subsidiary  of ALS) were  transferred
        into the Plan. The  transferred  net assets have been  recognized in the
        accounts of Enzo Biochem, Inc. Salary Reduction Profit Sharing Plan. The
        transferred  assets  consisted  of  investments  at fair value  totaling
        $153,570.

NOTE 6: RIGHT TO TERMINATE PLAN

        Although it has not  expressed  any intent to do so, the Company has the
        right under the Plan to discontinue its contributions at any time and to
        terminate the Plan subject to the provisions of ERISA.

NOTE 7: TAX STATUS

        The Plan  obtained its latest  determination  letter in February 2002 in
        which  the  Internal  Revenue  Service  stated  that  the  Plan  was  in
        compliance  with the  applicable  requirements  of the Internal  Revenue
        Code.  The Plan has  been  amended  since  receiving  the  determination
        letter.  However,  the  plan  administrator  believes  that  the Plan is
        currently  designed and being operated in compliance with the applicable
        requirements of the Internal Revenue Code.

NOTE 8: PARTY IN INTEREST TRANSACTIONS

        During 2007, the Plan purchased  shares of common stock in Enzo Biochem,
        Inc., the parent company of the Plan sponsor,  at market prices totaling
        approximately  $559,000. In addition,  shares were sold at market prices
        totaling approximately $571,000. At December 31, 2007 and 2006, the Plan
        held Enzo Biochem, Inc. common stock with a fair value of $2,003,849 and
        $2,251,720, respectively.

        Fees paid by the Plan to the third party Plan administrators amounted to
        $40,370 for the year ended December 31, 2007.


                                       7



                               ENZO BIOCHEM, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN
                          NOTES TO FINANCIAL STATEMENTS


NOTE 9: RISKS AND UNCERTAINTIES

        The Plan invests in various investment securities. Investment securities
        are exposed to various risk such as interest  rate,  market,  and credit
        risks.  Due to the  level of risk  associated  with  certain  investment
        securities,  it is at least  reasonably  possible  that  changes  in the
        values of  investment  securities  will  occur in the near term and that
        such changes could materially affect participants'  account balances and
        the  amounts  reported  in the  statement  of net assets  available  for
        benefits.


                                       8



                               ENZO BIOCHEM, INC.
                              SALARY REDUCTION PLAN

                               SCHEDULE H, ITEM 4i
                     SCHEDULE OF ASSETS HELD AT END OF YEAR

                               E.I.N. # 13-2866202
                                   PLAN # 001

                                DECEMBER 31, 2007




                                                                       DESCRIPTION OF
                                                                    INVESTMENT INCLUDING
                          IDENTITY OF ISSUE,                        MATURITY DATE, RATE
                         BORROWER, LESSOR OR                      OF INTEREST, COLLATERAL,
                            SIMILAR PARTY                          PAR OR MATURITY VALUE         COST       CURRENT VALUE
 (a)                             (b)                                         (c)                  (d)             (e)
 ---    ------------------------------------------               --------------------------     ------     ---------------
                                                                                               
  *     Enzo Biochem, Inc.                                            Common Stock                         $    2,003,849
        American Century Government Bond                              Mutual Fund                          $      288,250
        American Funds AMCAP Fund CL A                                Mutual Fund                          $      710,006
        American Funds American Balanced Fund CL A                    Mutual Fund                          $    1,339,162
        American Funds Europacific Growth CL A                        Mutual Fund                          $    1,893,613
        American Funds Washington Mutual
          Investors Fund CL A                                         Mutual Fund                          $    2,589,711
        Baron Growth Fund                                             Mutual Fund                          $      223,969
        Calamos Growth Fund CL A                                      Mutual Fund                          $      559,349
        Fidelity Contrafund                                           Mutual Fund                          $    1,148,803
        Fidelity Spartan US Equity Index Fund                         Mutual Fund                          $      284,363
        Freemont Bond Fund                                            Mutual Fund                          $      228,029
        Hotchkis & Wiley Mid Cap Value CL 1                           Mutual Fund                          $      253,786
        Neuberger & Berman Genesis Fund Trust                         Mutual Fund                          $      550,820
                                                                    Guaranteed Investment
        Metropolitan Life Stable Value Contract                           Contract                         $    1,263,245
        Royce Total Return                                            Mutual Fund                          $      140,800
        American Funds US Gov't Securities Fund CL A                  Mutual Fund                          $        1,499
        Principal Investors High Yield                                Mutual Fund                          $       65,831
        Frank Russell 2010 Strategy Fund                              Mutual Fund                          $          931
        Frank Russell 2020 Strategy Fund                              Mutual Fund                          $        4,373
        Frank Russell 2030 Strategy Fund                              Mutual Fund                          $        1,986
        Frank Russell 2040 Strategy Fund                              Mutual Fund                          $        2,870
        Participant Loans                                             5.00% - 11.00%               -0-     $      218,993


* Party-in-interest


See Independent Auditors' Report.


                                       9


                                   SIGNATURES

THE PLAN. Pursuant to the requirements of the Securities Exchange Act of 1934, a
trustee of the below  named  employee  benefit  plan has duly caused this annual
report to be signed on its behalf by the undersigned hereunto duly authorized.

Enzo Biochem, Inc. Salary Reduction Profit Sharing Plan

                                  Date: July 2, 2008

                                  /s/ Herbert Bass
                                  -----------------------------
                                  By: Herbert Bass
                                  Trustee



                                       10