Mixed open as jobless claims rise

The markets opened mixed with the Dow falling 58 points to 18,018 while Nasdaq gained 10 points to 4,993 as first time applications for unemployment benefits rose modestly.

On the upside

Amicus Therapeutics (Nasdaq: FOLD) accelerated its regulatory approval timeline.

Coronado Biosciences (Nasdaq: CNDO) entered an exclusive license agreement with NeuPharma to develop and commercialize novel irreversible 3rd Generation EGFR inhibitors.

Guess' (NYSE: GES) reported lower fourth quarter earnings but the results were better than expected.

On the downside

Concert Pharmaceuticals (Nasdaq: CNCE) priced its public offering of 3 million common shares at the discounted price of $15.15 per share.

Freeport-McMoRan (NYSE: FCX) stopped production at its Grasberg copper mine in Indonesia as a roadblock by more than 50 workers entered its fourth day.

Shares of National Bank of Greece (Nasdaq: NBG) fell as negotiations between Greece and its creditors grew strained.

In the broad market, declining issues outpaced advancers by a margin of 3 to 1 on the NYSE and by more than 5 to 4 on Nasdaq. The broader S&P 500 lost 5 points to 2093. Bitcoin added $4 to $256.