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                                 UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  SCHEDULE 14A

          Proxy Statement Pursuant to Section 14(a) of the Securities
                     Exchange Act of 1934 (Amendment No.  )

Filed by the Registrant [X]
Filed by a Party other than the Registrant [ ]

Check the appropriate box:

[ ]  Preliminary Proxy Statement
[ ]  CONFIDENTIAL, FOR USE OF THE COMMISSION ONLY (AS PERMITTED BY
     RULE 14a-6(e)(2))
[X]  Definitive Proxy Statement
[ ]  Definitive Additional Materials
[ ]  Soliciting Material Pursuant to Section 240.14a-12

                             LEXICON GENETICS INC.
--------------------------------------------------------------------------------
                (Name of Registrant as Specified In Its Charter)

--------------------------------------------------------------------------------
    (Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (check the appropriate box):

[X]  No fee required.

[ ]  Fee computed on table below per Exchange Act Rules 14a-6(i)(4) and 0-11.

     1) Title of each class of securities to which transaction applies:

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        pursuant to Exchange Act Rule 0-11 (set forth the amount on which the
        filing fee is calculated and state how it was determined):

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[ ]  Fee paid previously with preliminary materials.

[ ]  Check box if any part of the fee is offset as provided by Exchange Act
     Rule 0-11(a)(2) and identify the filing for which the offsetting fee was
     paid previously. Identify the previous filing by registration statement
     number, or the Form or Schedule and the date of its filing.

     1) Amount Previously Paid:

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     2) Form, Schedule or Registration Statement No.:

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SEC 1913 (02-02)




                                 [LEXICON LOGO]

                                 April 15, 2004

TO OUR STOCKHOLDERS:

         I am pleased to invite you to attend the 2004 annual meeting of
stockholders of Lexicon Genetics Incorporated to be held on Wednesday, May 19,
2004 at 1:30 p.m., local time, at The Marriott Woodlands Waterway Hotel and
Convention Center, 1601 Lake Robbins Drive, The Woodlands, Texas. We have
enclosed with this letter:

-        an official notice of the annual meeting;

-        a proxy statement that describes the matters to be considered and acted
         upon at the annual meeting; and

-        a form of proxy that we are asking you to complete and return to us,
         indicating your vote with respect to the matters described in the proxy
         statement.

         Your vote is important, regardless of the number of shares that you
hold. Whether or not you plan to attend the annual meeting, I hope you will vote
as soon as possible by signing and returning the enclosed form of proxy in the
postage-paid envelope we have provided for that purpose.

         Thank you for your ongoing support of and continued interest in Lexicon
Genetics. We look forward to seeing you at the annual meeting.

                                   Sincerely,

                                   /s/ Arthur T. Sands, M.D., Ph.D.

                                   Arthur T. Sands, M.D., Ph.D.
                                   President and Chief Executive Officer



                          LEXICON GENETICS INCORPORATED
                          8800 TECHNOLOGY FOREST PLACE
                           THE WOODLANDS, TEXAS 77381
                                 (281) 863-3000

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                             TO BE HELD MAY 19, 2004

TO OUR STOCKHOLDERS:

         The annual meeting of stockholders of Lexicon Genetics Incorporated
will be held on Wednesday, May 19, 2004 at 1:30 p.m., local time, at The
Marriott Woodlands Waterway Hotel and Convention Center, 1601 Lake Robbins
Drive, The Woodlands, Texas, to:

     -   elect two Class I directors;

     -   ratify and approve our existing 2000 Equity Incentive Plan so that
         grants under the plan will remain exempt from a cap on deductible
         compensation imposed by Section 162(m) of the Internal Revenue Code;

     -   ratify and approve the appointment of Ernst & Young LLP as our
         independent auditors for the fiscal year ending December 31, 2004; and

     -   act on any other business that properly comes before the annual
         meeting.

         You are entitled to vote at the annual meeting only if you are the
record owner of shares of our common stock at the close of business on March 30,
2004.

         It is important that your shares be represented at the annual meeting
whether or not you plan to attend. PLEASE MARK, SIGN AND DATE THE ENCLOSED PROXY
AND RETURN IT IN THE ACCOMPANYING POSTPAID ENVELOPE AS PROMPTLY AS POSSIBLE. If
you are present at the annual meeting, and wish to do so, you may revoke the
proxy and vote in person.

                                             By order of the Board of Directors,

                                             /s/ Jeffrey L. Wade

                                             Jeffrey L. Wade
                                             Secretary

The Woodlands, Texas
April 15, 2004



                          LEXICON GENETICS INCORPORATED
                          8800 TECHNOLOGY FOREST PLACE
                           THE WOODLANDS, TEXAS 77381
                                 (281) 863-3000

                                 PROXY STATEMENT
                                       FOR
                         ANNUAL MEETING OF STOCKHOLDERS

                             TO BE HELD MAY 19, 2004

                               GENERAL INFORMATION

PURPOSE OF THIS PROXY STATEMENT

         We have prepared this proxy statement to solicit proxies on behalf of
our Board of Directors for use at our 2004 annual meeting of stockholders and
any adjournment or postponement thereof. We are mailing this proxy statement and
the accompanying notice of annual meeting of stockholders and form of proxy to
our stockholders on or about April 15, 2004.

TIME AND PLACE OF ANNUAL MEETING

         The annual meeting will be held on Wednesday, May 19, 2004 at 1:30
p.m., local time, at The Marriott Woodlands Waterway Hotel and Convention
Center, 1601 Lake Robbins Drive, The Woodlands, Texas.

MATTERS TO BE CONSIDERED AT THE ANNUAL MEETING

         At the annual meeting, our stockholders will be asked to consider and
act upon the following matters:

                  -        the election of two Class I directors;

                  -        a proposal to ratify and approve our existing 2000
                           Equity Incentive Plan so that grants under the plan
                           will remain exempt from a cap on deductible
                           compensation imposed by Section 162(m) of the
                           Internal Revenue Code; and

                  -        a proposal to ratify and approve the appointment of
                           Ernst & Young LLP as our independent auditors for the
                           fiscal year ending December 31, 2004.

         Our Board of Directors does not intend to bring any other matters
before the annual meeting and has not been informed that any other matters are
to be presented by others. Our bylaws contain several requirements that must be
satisfied in order for any of our stockholders to bring a proposal before one of
our annual meetings, including a requirement of delivering proper advance notice
to us. Stockholders are advised to review our bylaws if they intend to present a
proposal at any of our annual meetings.

RECORD DATE FOR DETERMINING ENTITLEMENT TO VOTE

         You are entitled to vote at the annual meeting if you were the record
owner of shares of our common stock as of the close of business on March 30,
2004, the record date for the annual meeting established by our Board of
Directors.

HOW TO VOTE YOUR SHARES

         You may vote in person at the annual meeting or by proxy. To ensure
that your shares are represented at the annual meeting, we recommend you vote by
proxy even if you plan to attend the annual meeting in person. Even if you

                                       1


vote by proxy, if you wish, you can revoke your proxy and vote in person at the
annual meeting. If you want to vote at the annual meeting but your shares are
held by an intermediary, such as a broker or bank, you will need to obtain from
the intermediary either proof of your ownership of such shares as of March 30,
2004 or a proxy to vote your shares.

         You may receive more than one proxy depending on how you hold your
shares. If you hold your shares through someone else, such as a broker or a
bank, you may get materials from them asking you how you want your shares to be
voted at the annual meeting.

QUORUM

         We must have a quorum to conduct any business at the annual meeting.
This means that at least a majority of our outstanding shares eligible to vote
at the annual meeting must be represented at the annual meeting, either in
person or by proxy. Abstentions are counted for purposes of determining whether
a quorum is present. In addition, shares of our common stock held by
intermediaries that are voted for at least one matter at the annual meeting will
be counted as being present for purposes of determining a quorum for all
matters, even if the beneficial owner's discretion has been withheld for voting
on some or all other matters (commonly referred to as a "broker non-vote").

OUTSTANDING SHARES

         On the record date, we had 63,313,965 shares of our common stock
outstanding. If you were the record owner of shares of our common stock on the
record date, you will be entitled to one vote for each share of stock that you
own on each matter that is called to vote at the annual meeting.

VOTE NEEDED TO APPROVE PROPOSALS

         Our Class I directors will be elected by a plurality vote. As a result,
if a quorum is present at the annual meeting, the two persons receiving the
greatest number of votes will be elected to serve as our Class I directors.
Withholding authority to vote for a director nominee will not affect the outcome
of the election of directors.

         The ratification and approval of our existing 2000 Equity Incentive
Plan, the appointment of Ernst & Young LLP as our independent auditors for the
year ending December 31, 2004 and any other business that may properly come
before the annual meeting for a vote, will require a majority of the votes cast
with respect to such matter (unless a greater vote is required by law or our
charter or bylaws). On any such matter, an abstention from voting will have the
same effect as a vote against the proposal. Broker non-votes do not count as
votes for or against these proposals and are not considered in calculating the
number of votes necessary for approval.

HOW YOUR PROXY WILL BE VOTED

         Giving us your proxy means that you are authorizing us to vote your
shares at the annual meeting in the manner you direct. You may vote for our
nominees for election as Class I directors or withhold your vote for any one or
more of those nominees. You may vote for or against the proposals to ratify and
approve our existing 2000 Equity Incentive Plan and the appointment of Ernst &
Young LLP as our independent auditors for the year ending December 31, 2004, or
abstain from voting on those proposals.

         If you sign and return the enclosed proxy card and do not withhold
authority to vote for the election of our nominees for election as Class I
directors, all of your shares will be voted for the election of those nominees.
If you withhold authority to vote for one or more of our nominees for election
as Class I directors, none of your shares will be voted for those nominees.

         If any of our nominees for election as Class I directors become
unavailable for any reason before the election, we may reduce the number of
directors serving on our Board of Directors, or our Board of Directors may
designate substitute nominees, as necessary. We have no reason to believe that
any of our nominees for election as Class I directors will be unavailable. If
our Board of Directors designates any substitute nominees, the persons named in
the enclosed proxy card will vote your shares for such substitute(s) if they are
instructed to do so by our Board of Directors or, in the absence of any such
instructions, in accordance with their own best judgment.

         If you sign and return the enclosed proxy but do not specify how you
want your shares voted, your shares will be voted in favor of our nominees for
election as Class I directors and in favor of the proposals to ratify and
approve our

                                       2


existing 2000 Equity Incentive Plan and the appointment of Ernst & Young LLP as
our independent auditors for the year ending December 31, 2004.

         If you sign and return the enclosed proxy and any additional business
properly comes before the annual meeting, the persons named in the enclosed
proxy will vote your shares on those matters as instructed by our Board of
Directors or, in the absence of any such instructions, in accordance with their
own best judgment. As of the date of this proxy statement, we are not aware of
any other matter to be raised at the annual meeting.

HOW TO REVOKE YOUR PROXY

         You may revoke your proxy at any time before your shares are voted by
providing our Corporate Secretary with either a new proxy with a later date or a
written notice of your desire to revoke your proxy at the following address:

         Lexicon Genetics Incorporated
         8800 Technology Forest Place
         The Woodlands, Texas 77381
         Attention: Corporate Secretary

         You may also revoke your proxy at any time prior to your shares having
been voted by attending the annual meeting in person and notifying the inspector
of election of your desire to revoke your proxy. Your proxy will not
automatically be revoked merely because you attend the annual meeting.

INSPECTOR OF ELECTION

         Mellon Investor Services L.L.C., our transfer agent and registrar, will
count votes and provide a representative who will serve as an inspector of
election for the annual meeting.

LIST OF STOCKHOLDERS ENTITLED TO VOTE

         A list of our stockholders entitled to vote at the annual meeting will
be available for inspection at the annual meeting. The stockholder list will
also be available for inspection for ten days prior to the annual meeting at our
corporate offices located at 8800 Technology Forest Place, The Woodlands, Texas.
Any inspection of this list at our offices will need to be conducted during
ordinary business hours. If you wish to conduct an inspection of the stockholder
list, we request that you please contact our Corporate Secretary before coming
to our offices.

SOLICITATION OF PROXIES AND EXPENSES

         We are asking for your proxy on behalf of our Board of Directors. We
will bear the entire cost of preparing, printing and soliciting proxies. We will
send proxy solicitation materials to all of our stockholders of record as of the
record date and to all intermediaries, such as brokers and banks, that held any
of our shares on that date on behalf of others. These intermediaries will then
forward solicitation materials to the beneficial owners of our shares, and we
will reimburse them for their reasonable out-of-pocket expenses for forwarding
such materials. Our directors, officers and employees may solicit proxies by
mail, in person or by telephone or other electronic communication. Our
directors, officers and employees will not receive additional compensation for
their solicitation efforts, but they will be reimbursed for any out-of-pocket
expenses they incur.

HOUSEHOLDING OF ANNUAL DISCLOSURE DOCUMENTS

         The Securities and Exchange Commission has approved a rule allowing us
to send a single set of our annual report and proxy statement to any household
at which two or more stockholders reside if we believe the stockholders are
members of the same family. This rule benefits both you and us by reducing the
volume of duplicate information received at your household and helping to reduce
our expenses. The rule applies to our annual reports, proxy statements and
information statements. Each stockholder will continue to receive a separate
proxy card or voting instruction card.

         If your household received a single set of disclosure documents for
this year, but you would prefer to receive your own copy, please contact our
transfer agent, Mellon Investor Services L.L.C., by calling their toll-free
number, (800) 635-9270. If you would like to receive your own set of our annual
disclosure documents in future years, follow the instructions described below.
Similarly, if you share an address with another stockholder and together both of
you would like to receive only a single set of our annual disclosure documents,
follow these instructions:

                                       3


                  -        If your shares are registered in your own name,
                           please contact our transfer agent, Mellon Investor
                           Services, and inform them of your request by calling
                           them at (800) 635-9270 or writing them at 85
                           Challenger Road, Ridgefield Park, New Jersey 07660.

                  -        If a broker or other nominee holds your shares,
                           please contact ADP and inform them of your request by
                           calling them at (888) 603-5847 or writing them at
                           Householding Department, 51 Mercedes Way, Edgewood,
                           New York 11717. Be sure to include your name, the
                           name of your brokerage firm and your account number.

         STOCK OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

         The following table presents information regarding the beneficial
ownership of our common stock as of March 30, 2004 by:

                  -        each of the individuals listed in "Executive
                           Compensation - Summary Compensation Table";

                  -        each of our directors;

                  -        each person, or group of affiliated persons, who is
                           known by us to own beneficially five percent or more
                           of our common stock; and

                  -        all current directors and executive officers as a
                           group.

         Beneficial ownership is determined in accordance with the rules of the
Securities and Exchange Commission computing the number of shares beneficially
owned by a person and the percentage ownership of that person. Shares of common
stock under options held by that person that are currently exercisable or
exercisable within 60 days of March 30, 2004 are considered outstanding. These
shares, however, are not considered outstanding when computing the percentage
ownership of each other person.

         Except as indicated in the footnotes to this table and pursuant to
state community property laws, each stockholder named in the table has sole
voting and investment power for the shares shown as beneficially owned by them.
Percentage of ownership is based on 63,313,965 shares of common stock
outstanding on March 30, 2004. Unless otherwise indicated in the footnotes, the
address of each of the individuals named below is: c/o Lexicon Genetics
Incorporated, 8800 Technology Forest Place, The Woodlands, Texas 77381.



                                                                             BENEFICIAL OWNERSHIP
                                                      ------------------------------------------------------------------
                                                                                  SHARES ISSUABLE
                                                                               PURSUANT TO OPTIONS
                                                       NUMBER OF SHARES         EXERCISABLE WITHIN            PERCENTAGE
                                                      BENEFICIALLY OWNED     60 DAYS OF MARCH 30, 2004        OWNERSHIP
                                                      ------------------     -------------------------        ----------
                                                                                                     
Royce & Associates, LLC (1)...............                 7,815,400                         -                 12.3%
Robert C. McNair (2)......................                 5,949,400                         -                  9.4%
Mary H. Cain, James D. Weaver and
   William A. McMinn (3) .................                 5,561,091                     8,500                  8.8%
Baylor College of Medicine (4)............                 4,055,960                         -                  6.4%
Acqua Wellington
   Opportunity I Limited (5)..............                 3,500,000                         -                  5.5%
Arthur T. Sands, M.D., Ph.D. (6)..........                 1,032,300                 2,656,600                  5.6%
Julia P. Gregory (7)......................                    75,047                   586,895                  1.0%
Jeffrey L. Wade, J.D......................                     3,000                   601,579                     *
Brian P. Zambrowicz, Ph.D. ...............                         -                   977,517                  1.5%
Alan J. Main, Ph.D........................                         -                   330,588                     *
C. Thomas Caskey, M.D (8) ................                 1,683,200                   195,500                  3.0%
Sam L. Barker, Ph.D.......................                     7,000                    43,000                     *
Patricia M. Cloherty......................                         -                    38,000                     *
Robert J. Lefkowitz, M.D..................                         -                    31,000                     *
Alan S. Nies, M.D.........................                         -                     3,625                     *
All directors and executive officers
   as a group (6)(7)(8) (13 persons)......                 2,807,847                 6,140,008                 12.9%


                                       4


------------------
* Represents beneficial ownership of less than 1 percent.

(1)  Based upon a Schedule 13G filed with the SEC on February 4, 2004,
     reflecting the beneficial ownership of our common stock by Royce &
     Associates, LLC. The address for Royce & Associates, LLC is 1414 Avenue of
     the Americas, New York, New York 10019.

(2)  Based upon a Schedule 13D filed with the SEC on July 18, 2003, reflecting
     the beneficial ownership of our common stock by RCM Financial Services,
     L.P. (4,250,000 shares), Cogene Biotech Ventures, L.P. (1,679,400 shares)
     and Palmetto Partners, Ltd. (20,000 shares). Mr. McNair has sole voting and
     investment power with respect to all of such shares. The address for Mr.
     McNair is 4400 Post Oak Parkway, Suite 1400, Houston, Texas 77027.

(3)  Based upon a Schedule 13D/A filed with the SEC on January 2, 2004,
     reflecting the beneficial ownership of our common stock by the Estate of
     Gordon A. Cain (3,787,000 shares), the Gordon and Mary Cain Foundation
     (700,000 shares), Mr. Weaver (15,000 shares) and Mr. McMinn (1,059,091
     shares). Mrs. Cain and Mr. Weaver are co-executors of the Estate of Gordon
     A. Cain and share investment power with respect to the shares held by it.
     The shares held by or issuable to the Estate of Gordon A. Cain are subject
     to a proxy granted to Mr. McMinn by Mr. Cain to vote these shares in the
     event of Mr. Cain's incapacity or death. The proxy will terminate upon the
     distribution of the shares from Mr. Cain's estate. Mr. McMinn disclaims
     beneficial ownership of these shares. Mrs. Cain is Chairman and Mr. Weaver
     is President of the Gordon and Mary Cain Foundation and share voting and
     investment power with respect to the shares held by it. The address for
     Mrs. Cain, Mr. Weaver and Mr. McMinn is c/o Gordon Cain and Associates, 8
     Greenway Plaza, Suite 702, Houston, Texas 77046.

(4)  Based upon a Schedule 13G/A filed with the SEC on January 7, 2004,
     reflecting the beneficial ownership of our common stock by Baylor College
     of Medicine and BCM Technologies Inc., a wholly owned subsidiary of Baylor
     College of Medicine. The number of shares beneficially owned includes
     28,940 shares owned by BCM Technologies, Inc. The address of Baylor College
     of Medicine is One Baylor Plaza, T-128, Houston, Texas 77030-3498.

(5)  Based upon a Schedule 13G filed with the SEC on January 9, 2004, reflecting
     the beneficial ownership of our common stock by Acqua Wellington
     Opportunity I Limited. The address for Acqua Wellington Opportunity I
     Limited is Shirlaw House, 87 Shirley Street, Nassau, Bahamas.

(6)  The number of shares beneficially owned by Dr. Sands includes 60,000 shares
     held in the name of minor children and 817,500 shares owned by Sands
     Associates LP. The general partners of Sands Associates LP are ATS
     Associates, L.L.C., owned by Dr. Sands, and MES Associates, L.L.C., owned
     by Dr. Sands' wife.

(7)  The number of shares beneficially owned by Ms. Gregory includes 6,647
     shares held in the name of dependent children and trusts for their benefit
     of which she serves as a trustee.

(8)  The number of shares beneficially owned by Dr. Caskey includes 1,679,400
     shares owned by Cogene Biotech Ventures, L.P., of which Dr. Caskey is
     President and Chief Executive Officer. Dr. Caskey disclaims beneficial
     ownership of these shares.

SECTION 16(a) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE

         Section 16(a) of the Exchange Act requires our directors and officers,
and persons who own more than 10% of our common stock, to file initial reports
of ownership and reports of changes in ownership of our common stock with the
Securities and Exchange Commission. Directors, officers and greater than 10%
stockholders are required by Securities and Exchange Commission regulations to
furnish us with copies of all such forms that they file.

         To our knowledge, based solely on our review of the copies of such
reports received by us and on written representations by certain reporting
persons that no reports on Form 5 were required, we believe that during the
fiscal year ended December 31, 2003, all Section 16(a) filing requirements
applicable to our officers, directors and 10% stockholders were complied with in
a timely manner.

                      EQUITY COMPENSATION PLAN INFORMATION

         The following table presents aggregate summary information as of
December 31, 2003 regarding the common stock that may be issued upon exercise of
options, warrants and rights under all of our existing equity compensation
plans, including our 2000 Equity Incentive Plan, 2000 Non-Employee Directors'
Stock Option Plan and Coelacanth Corporation 1999 Stock Option Plan.

                                       5




                                               (a)                             (b)                              (c)
                                                                             WEIGHTED
                                                                          AVERAGE EXERCISE         NUMBER OF SECURITIES REMAINING
                                        NUMBER OF SECURITIES             PRICE PER SHARE OF     AVAILABLE FOR FUTURE ISSUANCE UNDER
                                    TO BE ISSUED UPON EXERCISE OF            OUTSTANDING             EQUITY COMPENSATION PLANS
                                        OUTSTANDING OPTIONS,             OPTIONS, WARRANTS      (EXCLUDING SECURITIES REFLECTED IN
        PLAN CATEGORY                   WARRANTS AND RIGHTS                   AND RIGHTS                      COLUMN (a))
----------------------------        -----------------------------        ------------------     ------------------------------------
                                                                                       
Equity compensation plans
    approved by security
    holders (1) ...........               12,800,159                            $6.1460                   1,004,763 (3)(4)(5)
Equity compensation plans
    not approved by security
    holders (2) ...........                   89,012                             2.6747                          --
                                        ------------                             ------                   ---------
       Total...............               12,889,171                            $6.1220                   1,004,763


--------------------------
(1)  Consists of shares of our common stock issued or remaining available for
     issuance under our 2000 Equity Incentive Plan and 2000 Non-Employee
     Directors' Stock Option Plan.

(2)  Consists of shares of our common stock issuable upon the exercise of
     options granted under the Coelacanth Corporation 1999 Stock Option Plan,
     which we assumed in connection with our July 2001 acquisition of Coelacanth
     Corporation, but does not include warrants to purchase 16,483 shares of
     common stock at a weighted average exercise price of $11.93 per share,
     which we also assumed in connection with our acquisition of Coelacanth.

(3)  Includes 535,763 shares available for future issuance under our 2000 Equity
     Incentive Plan, some or all of which may be awarded as stock bonuses.

(4)  Our 2000 Equity Incentive Plan provides that on each January 1, the number
     of shares available for issuance under the plan will be automatically
     increased by the greater of (i) five percent of our outstanding shares on a
     fully-diluted basis or (ii) the number of shares that could be issued under
     awards granted under the plan during the prior year. Our Board of Directors
     may provide for a lesser increase in the number of shares available for
     issuance under the plan.

(5)  Our 2000 Non-Employee Directors' Stock Option Plan provides that on the day
     following each annual meeting of stockholders, the number of shares
     available for issuance under the plan will be automatically increased by
     the greater of (i) 0.3% of our outstanding shares on a fully-diluted basis
     or (ii) the number of shares that could be issued under options granted
     under the plan during the prior year. Our Board of Directors may provide
     for a lesser increase in the number of shares available for issuance under
     the plan.

                               PROPOSAL NUMBER 1:
                              ELECTION OF DIRECTORS

         Our Board of Directors, which currently has six members, is divided or
"classified" into three classes. Directors in each class are elected to hold
office for a term ending on the date of the third annual meeting following the
annual meeting at which they were elected. The current term of our Class I
directors will expire at this annual meeting. The current terms of our Class II
and Class III directors will expire at our 2005 and 2006 annual meetings of
stockholders, respectively.

         The Board of Directors has nominated and urges you to vote for the
election of the individuals identified below, who have been nominated to serve
as Class I directors until our 2007 annual meeting of stockholders or until
their successors are duly elected and qualified. Each of these individuals is a
member of our present Board of Directors. Your signed proxy will be voted for
the nominees named below unless you specifically indicate on the proxy that you
are withholding your vote.

         It is our policy to encourage the members of our Board of Directors to
attend all annual meetings of stockholders. Three members of our Board of
Directors attended our 2003 annual meeting of stockholders.

NOMINEES FOR CLASS I DIRECTORS

         The following individuals are nominated for election as Class I
directors:



                                                                                                   YEAR FIRST
           NAME                           AGE       POSITION WITH THE COMPANY                   BECAME A DIRECTOR
           ----                           ---       -------------------------                   -----------------
                                                                                       
Robert J. Lefkowitz, M.D.                  61          Director (Class I)                              2001
Alan S. Nies, M.D.                         66          Director (Class I)                              2003


                                       6


         Robert J. Lefkowitz, M.D. has been a director since February 2001 and a
consultant to our company since March 2003. Dr. Lefkowitz is the James B. Duke
Professor of Medicine, Professor of Biochemistry and a Howard Hughes Medical
Institute investigator at Duke University Medical Center, where he has served on
the faculty since 1973. He is a member of the National Academy of Sciences. Dr.
Lefkowitz received his B.A. from Columbia University and his M.D. from Columbia
University College of Physicians and Surgeons.

         Alan S. Nies, M.D. has been a director since November 2003 and Chairman
of our Medical Advisory Board since March 2003. From 1992 through September
2002, Dr. Nies served in a series of senior management positions at Merck & Co.
Inc., most recently as Senior Vice President, Clinical Sciences from 1999 to
2002. Prior to joining Merck, Dr. Nies spent fifteen years as Professor of
Medicine and Pharmacology and Head of the Division of Clinical Pharmacology at
the University of Colorado Health Sciences Center. Dr. Nies holds a B.S. from
Stanford University and an M.D. from Harvard Medical School.

         THE BOARD OF DIRECTORS RECOMMENDS THAT STOCKHOLDERS VOTE "FOR" THE
FOREGOING NOMINEES FOR ELECTION AS CLASS I DIRECTORS.

CURRENT AND CONTINUING DIRECTORS

         The current directors of the Company are identified below:



             NAME                            AGE                  POSITION WITH THE COMPANY
             ----                            ---                  -------------------------
                                               
Arthur T. Sands, M.D., Ph.D.                  42     President and Chief Executive Officer and Director (Class III)
C. Thomas Caskey, M.D. (1) (3)                65     Chairman of the Board of Directors (Class III)
Sam L. Barker, Ph.D. (1) (2)                  61     Director (Class II)
Patricia M. Cloherty (1) (2)                  61     Director (Class II)
Robert J. Lefkowitz, M.D. (3)                 61     Director (Class I)
Alan S. Nies, M.D.                            66     Director (Class I)


------------------

(1)      Member of the Audit Committee

(2)      Member of the Compensation Committee

(3)      Member of the Corporate Governance Committee

         Information regarding the business experience of Dr. Lefkowitz and Dr.
Nies is set forth above under the heading " -- Nominees for Class I Directors."

         Arthur T. Sands, M.D., Ph.D. co-founded our company and has been our
President and Chief Executive Officer and a director since September 1995. From
1992 to September 1995, Dr. Sands served as an American Cancer Society
postdoctoral fellow in the Department of Human and Molecular Genetics at Baylor
College of Medicine, where he studied the function of the p53 gene in cancer
formation and created the XPC knockout mouse, a model for skin cancer. He
received his B.A. in Economics and Political Science from Yale University and
his M.D. and Ph.D. from Baylor College of Medicine.

         C. Thomas Caskey, M.D. became Chairman of our Board of Directors in
April 2000. Dr. Caskey has been President and Chief Executive Officer of Cogene
Biotech Ventures, Ltd., a venture capital firm, since April 2000. He served as
Senior Vice President, Research at Merck Research Laboratories, a division of
Merck & Co., Inc., from 1995 to March 2000 and as President of the Merck Genome
Research Institute from 1996 to March 2000. Before joining Merck, Dr. Caskey
served 25 years at Baylor College of Medicine in a series of senior positions,
including Chairman, Department of Human and Molecular Genetics and Director,
Human Genome Center. He is a member of the National Academy of Sciences. Dr.
Caskey serves as a director of Luminex Corporation and several private
companies. He received his B.A. from the University of South Carolina and his
M.D. from Duke University Medical School.

         Sam L. Barker, Ph.D. has been a director since March 2000. In March
2001, Dr. Barker co-founded Clearview Projects, Inc., a company engaged in
providing partnering and transaction services to biopharmaceutical companies,
and has served as its President and Chief Executive Officer since July 2003. Dr.
Barker served in a series of senior domestic and international management
positions at Bristol-Myers Squibb Company until his retirement in 1998. His
positions at Bristol-Myers Squibb included service as Executive Vice President,
Worldwide Franchise Management and Strategy

                                       7


during 1998, President, United States Pharmaceutical Group from 1995 to 1997 and
President, United States Pharmaceuticals from 1992 to 1995. Dr. Barker received
his B.S. from Henderson State College, his M.S. from the University of Arkansas
and his Ph.D. from Purdue University.

         Patricia M. Cloherty has been a director since May 1998. Ms. Cloherty
has served as Chairman of the United States Russia Investment Fund, established
by the United States government to invest in Russian companies, since President
Clinton appointed her to that position in 1995. In July 2003, Directors of the
Fund also elected her to the position of Chief Executive Officer, a full-time
position she currently holds in Moscow, Russia. From 1973 through 1999, she was
General Partner of Patricof & Co. Ventures, Inc., an international venture
capital company, and successively served as Senior Vice President, President and
Co-Chairman of that company. Ms. Cloherty served as deputy administrator of the
United States Small Business Administration from 1977 to 1978. She is past
president and chairman of the National Venture Capital Association. Ms. Cloherty
serves as a director of Tessera Technologies, Inc. and several private companies
and philanthropies. She holds a B.A. from the San Francisco College for Women
and an M.A. and an M.I.A. from Columbia University.

INDEPENDENCE OF THE BOARD OF DIRECTORS

         After reviewing all relevant transactions and relationships between
each member of the Board of Directors (and his or her family) and us, our senior
management and our independent auditors, the Board of Directors has
affirmatively determined that C. Thomas Caskey, M.D., Sam L. Barker, Ph.D.,
Patricia M. Cloherty and Robert J. Lefkowitz, M.D. are "independent" in
accordance with the applicable listing standards of The Nasdaq Stock Market,
Inc., subject, in the case of Dr. Caskey, to confirmation that we have requested
from The Nasdaq Stock Market as to our proper interpretation and application of
its rules relating to the form of past compensation paid to Dr. Caskey for his
service as the non-executive Chairman of our Board of Directors. Arthur T.
Sands, M.D., Ph.D., our President and Chief Executive Officer, and Alan S. Nies,
M.D., the Chairman of our Medical Advisory Board, are not "independent" within
the meaning of such listing requirements.

BOARD COMMITTEES

         Audit Committee. Our audit committee monitors the integrity of our
financial statements, reviews our internal accounting procedures and oversees
the qualifications, independence and performance of our independent auditors.
The current members of our audit committee are Sam L. Barker, Ph.D., Patricia M.
Cloherty and C. Thomas Caskey, M.D. The Board of Directors, in its business
judgment, has determined that Dr. Barker, Ms. Cloherty and Dr. Caskey are
"independent" in accordance with the provisions of the Securities Exchange Act
of 1934, including all rules and regulations promulgated thereunder. The Board
of Directors has further determined that Dr. Barker, Ms. Cloherty and Dr. Caskey
are "independent" in accordance with the applicable listing standards of The
Nasdaq Stock Market, Inc., subject, in the case of Dr. Caskey, to confirmation
that we have requested from The Nasdaq Stock Market as to our proper
interpretation and application of its rules relating to the form of past
compensation paid to Dr. Caskey for his service as the non-executive Chairman of
our Board of Directors. The Board of Directors, in its business judgment, has
also determined that Ms. Cloherty is an "audit committee financial expert" as
defined in Item 401(h) of Regulation S-K.

         Compensation Committee. Our compensation committee evaluates the
performance of management, determines the compensation of our executive officers
and reviews general policy relating to compensation and benefits of our
employees. The compensation committee also administers the issuance of stock
options and other awards under our 2000 Equity Incentive Plan. The current
members of the compensation committee are Patricia M. Cloherty and Sam L.
Barker, Ph.D.

         Corporate Governance Committee. Our corporate governance committee
identifies individuals qualified to become members of our Board of Directors,
selects candidates or nominees for director positions to be filled by the Board
of Directors or our stockholders and develops appropriate corporate governance
principles. The corporate governance committee operates pursuant to a charter
that was approved by the Board of Directors on February 11, 2004, a copy of
which is attached to this proxy statement as Appendix A.

         The corporate governance committee has not established any specific
minimum qualifications for membership on our Board of Directors. Rather, the
committee will generally consider all relevant factors, which may include
independence, experience, diversity, leadership qualities and strength of
character. The corporate governance committee uses its available network of
contacts when compiling a list of potential director candidates and may also
engage outside

                                       8


consultants when appropriate. The committee also considers potential director
candidates recommended by stockholders and other parties and all potential
director candidates are evaluated based on the above criteria. Because the
corporate governance committee makes no distinction in its evaluation of
candidates based on whether such candidates are recommended by stockholders or
other parties, no formal policy or procedure has been established for the
consideration of director candidates recommended by stockholders.

         Any stockholder wishing to propose a potential director candidate may
submit a recommendation in writing within the timeframe specified in our bylaws.
All such communications should be sent to 8800 Technology Forest Place, The
Woodlands, Texas 77381, Attn: Corporate Governance Committee. Submissions should
include the full name of the proposed candidate and a detailed description of
the candidate's qualifications, business experience and other relevant
biographical information.

         The current members of the corporate governance committee are C. Thomas
Caskey, M.D. and Robert J. Lefkowitz, M.D. The Board of Directors, in its
business judgment, has determined that Dr. Caskey and Dr. Lefkowitz are
"independent" in accordance with the applicable listing standards of The Nasdaq
Stock Market, Inc., subject, in the case of Dr. Caskey, to confirmation that we
have requested from The Nasdaq Stock Market as to our proper interpretation and
application of its rules relating to the form of past compensation paid to Dr.
Caskey for his service as the non-executive Chairman of our Board of Directors.

BOARD AND COMMITTEE MEETINGS IN 2003

         The Board of Directors met seven times in 2003. The audit committee met
six times and the compensation committee met four times and took certain
additional actions by unanimous written consent in 2003. The corporate
governance committee was formed in 2004 and did not hold any meetings in 2003.
During 2003, none of our directors attended fewer than 75 percent of the
meetings of the Board of Directors or committees during the period served.

DIRECTOR COMPENSATION

         Each director other than Arthur T. Sands, M.D., Ph.D. and C. Thomas
Caskey, M.D. currently receives a fee of $2,000 for each meeting of the Board of
Directors that he or she attends in person, and $500 for each committee meeting
(other than a committee meeting held at the same time as a meeting of the full
Board of Directors) or telephonic meeting of the Board of Directors in which he
or she participates. Dr. Sands does not receive additional compensation for his
service as a director. Dr. Caskey receives payment of $150,000 per year for his
service as Chairman of our Board of Directors. Dr. Nies receives payment of
$75,000 per year for his service as Chairman of our Medical Advisory Board. All
directors are reimbursed for expenses in connection with attendance at Board of
Directors and committee meetings.

         Our 2000 Non-Employee Directors' Stock Option Plan provides for the
automatic grant of options to purchase shares of common stock to our directors
who are not employees. Non-employee directors first elected after the closing of
our initial public offering receive an initial option to purchase 30,000 shares
of common stock. In addition, all non-employee directors receive an annual
option to purchase 6,000 shares of common stock. All options granted under the
non-employee directors' plan have an exercise price equal to the fair market
value of our common stock on the date of grant.

         In February 2003, in connection with his appointment as Chairman of our
Medical Advisory Board, Dr. Nies received an option under our 2000 Equity
Incentive Plan to purchase 2,500 shares of common stock at an exercise price of
$4.06 per share, the fair market value of our common stock on the date of grant
as determined in accordance with the plan. At the time of our annual meeting of
stockholders in May 2003, Dr. Caskey received an option under our 2000 Equity
Incentive Plan to purchase 8,000 shares of common stock at an exercise price of
$5.00 per share, the fair market value of our common stock on the date of grant
as determined in accordance with the plan. Also at the time of our annual
meeting of stockholders in May 2003, each of Dr. Barker, Ms. Cloherty and Dr.
Lefkowitz received options under the 2000 Non-Employee Directors' Stock Option
Plan to purchase 6,000 shares of common stock at an exercise price of $5.00 per
share, the fair market value of our common stock on the date of grant as
determined in accordance with the plan. In November 2003, in connection with his
election as a director, Dr. Nies received an initial option under the 2000
Non-Employee Directors' Stock Option Plan to purchase 30,000 shares of common
stock at an exercise price of $5.35 per share, the fair market value of our
common stock on the date of grant as determined in accordance with the plan.

                                       9


STOCKHOLDER COMMUNICATIONS WITH THE BOARD OF DIRECTORS

         We believe that our stockholders are currently provided a reasonable
means to communicate with our Board of Directors or individual directors. As a
result, our Board of Directors has not established a formal process for
stockholders to send communications to the Board of Directors or individual
directors. However, the corporate governance committee will consider, from time
to time, whether adoption of a formal process for such stockholder
communications has become necessary or appropriate. Stockholders may send
communications to the Board of Directors or individual directors by mail at 8800
Technology Forest Place, The Woodlands, Texas 77381, Attn: Board of Directors.

CODE OF BUSINESS CONDUCT AND ETHICS

         We have adopted a code of business conduct and ethics that applies to
all of our directors, officers and employees, the text of which appears on our
website at www.lexicon-genetics.com under the caption "Investor Relations." We
intend to disclose on our website the nature of any amendment to or waiver from
our code of business conduct and ethics that applies to our principal executive
officer, principal financial officer, principal accounting officer or
controller, or persons performing similar functions within five business days
following the date of such amendment or waiver. In the case of any such waiver,
including an implicit waiver, we also intend to disclose the name of the person
to whom the waiver was granted and the date of the waiver.

COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION

         During 2003, Patricia M. Cloherty and Sam L. Barker, Ph.D. served as
members of the compensation committee of our Board of Directors. No member of
the compensation committee serves as a member of the board of directors or
compensation committee of any other entity that has one or more executive
officers serving as a member of our board of directors or compensation
committee.

                               PROPOSAL NUMBER 2:
             RATIFICATION AND APPROVAL OF 2000 EQUITY INCENTIVE PLAN

         We use stock option awards as a part of our overall compensation
program in order to align the long-term interests of our employees with those of
our stockholders. These awards are made principally under our 2000 Equity
Incentive Plan, the purpose of which is to secure and retain the services of
employees, directors and consultants, and to provide them with incentives to
exert maximum efforts for the company's success, by giving them the opportunity
through the granting of stock awards to benefit from increases in the value of
our common stock.

         The predecessor to the 2000 Equity Incentive Plan, our 1995 Stock
Option Plan, was first adopted by our Board of Directors and approved by our
stockholders on September 13, 1995. The current plan, which amended and restated
the 1995 Stock Option Plan, was adopted by our Board of Directors on February 3,
2000 and approved by our stockholders on March 15, 2000, prior to our April 2000
initial public offering.

         We are asking that stockholders ratify and approve the 2000 Equity
Incentive Plan so that grants under the plan will remain exempt from a cap on
deductible compensation imposed by Section 162(m) of the Internal Revenue Code
of 1986. Section 162(m) of the Internal Revenue Code places a $1 million cap on
the deductible compensation that can be paid to certain executives of
publicly-traded corporations. Amounts that qualify as "performance based"
compensation under Section 162(m)(4)(c) of the Internal Revenue Code are exempt
from the cap and do not count toward the $1 million limit. Generally, stock
options granted under a plan approved by stockholders will qualify as
performance based compensation. If a plan is approved by stockholders prior to
the initial public offering of a corporation's common stock, however, as was the
case with our 2000 Equity Incentive Plan, options granted after the first annual
meeting of stockholders after the close of the third calendar year following the
calendar year in which the initial public offering was completed will not
qualify as performance based compensation, and thus will not be exempt from the
cap on the tax deductibility of compensation imposed by Section 162(m) of the
Internal Revenue Code, unless the corporation's stockholders again ratify the
plan at a meeting held subsequent to the initial public offering.

         Because our 2000 Equity Incentive Plan was approved by our stockholders
prior to the initial public offering of our common stock, stock options granted
under the plan prior to the May 19, 2004 date of our annual meeting qualify as
performance based compensation exempt from the Section 162(m) cap. Stock options
granted under the 2000 Equity

                                       10


Incentive Plan after May 19, 2004 will not qualify as performance based
compensation exempt from the Section 162(m) cap unless stockholders ratify the
plan at the annual meeting.

         The terms of the 2000 Equity Incentive Plan are summarized below. The
complete text of the plan is set forth in Appendix B to this proxy statement.

         THE BOARD OF DIRECTORS RECOMMENDS THAT STOCKHOLDERS VOTE "FOR"
RATIFICATION AND APPROVAL OF THE 2000 EQUITY INCENTIVE PLAN.

ADMINISTRATION OF THE PLAN

         The plan is administered by the Board of Directors, or a committee
appointed by the Board, which determines recipients and types of options and
other awards to be granted, including number of shares under the option or other
award and when options may be exercised. The compensation committee of the Board
of Directors presently administers the plan.

AWARDS UNDER THE PLAN

         The 2000 Equity Incentive Plan permits the following types of awards:

                  -        incentive stock options;

                  -        nonstatutory stock options;

                  -        stock bonuses; and

                  -        rights to acquire restricted stock.

         Stock options and other awards granted under the plan are evidenced by
agreements that specify the terms and conditions under which they are granted.
All stock options and other awards granted under the plan are subject to the
terms and conditions contained in the applicable agreement and the plan.

ELIGIBILITY

         Awards other than incentive stock options may be granted to employees,
directors and consultants. Incentive stock options may be granted only to
employees. As of April 1, 2004, approximately 657 persons were eligible to
participate in the plan, including approximately 639 employees, six directors
and 13 consultants.

SHARES SUBJECT TO THE PLAN

         We initially reserved an aggregate of 11,250,000 shares of our common
stock for issuance under the 2000 Equity Incentive Plan. On January 1 of each
year for ten years, beginning in 2001, the number of shares reserved for
issuance under the plan automatically increases by the greater of:

                  -        5% of our outstanding shares on a fully-diluted
                           basis; or

                  -        that number of shares that could be issued under
                           awards granted under the plan during the prior year.

         The Board of Directors may provide for a smaller annual increase in the
number of shares reserved for issuance under the plan, however, and the total
number of shares reserved for issuance under the plan may not exceed 30,000,000
shares over the ten-year period. The Board of Directors has limited the increase
on the number of shares reserved for issuance under the plan in each of the last
four years. Currently, there are 17,000,000 shares of our common stock reserved
for issuance under the plan.

         If any award expires, lapses, or is terminated or forfeited for any
reason, the shares subject to that award will continue to be available for the
grant of awards under the plan. Common stock issued as or on the exercise of
awards under the plan may be either authorized and unissued shares or reacquired
shares.

         As of April 1, 2004, there were options outstanding under the plan to
purchase a total of 13,507,607 shares of our common stock. After accounting for
shares that had been issued upon the exercise of options, 1,198,131 shares
remained available for issuance of new options or awards under the plan at that
date.

                                       11


STOCK OPTIONS

         The stock options granted under the 2000 Equity Incentive Plan are
evidenced by agreements that specify the number of shares of our common stock
which may be purchased at a certain specified price and contain other terms and
conditions, such as vesting and termination provisions. All stock options
granted under the plan are subject to the terms and conditions contained in the
applicable stock option agreement and the plan.

Expiration and Termination

         The term of each stock option is stated in the applicable stock option
agreement. In no event, however, may a stock option be exercised more than ten
years after the date the option is granted. In the case of an incentive stock
option granted to a 10% stockholder, the maximum term is five years from the
date the option is granted.

Option Exercise Price

         The exercise price of stock options awarded under the 2000 Equity
Incentive Plan is determined by the plan administrator at the time the stock
option is awarded. In general, incentive stock options will have an exercise
price of 100% or more of the fair market value of our common stock on the date
of grant. Nonstatutory stock options may have an exercise price as low as 85% of
fair market value on the date of grant. We have not awarded any stock options to
date with exercise prices below 100% of fair market value on the date of grant.

         The fair market value of a share of common stock on a particular date
is equal to the previous day's closing sales price (or the closing bid price, if
no sales were reported) of the common stock if the common stock is listed on any
established stock exchange or traded on the Nasdaq Stock Market. If there is no
regular public trading market for the common stock, the fair market value of the
common stock is determined by the Board of Directors.

Consideration for Exercise of Options

         The consideration to be paid for shares to be issued upon exercise of a
stock option, including the method of payment, shall be determined by the
administrator (and, in the case of an incentive stock option, shall be
determined at the time of grant) and may consist entirely of (1) cash or (2), at
the discretion of the Board of Directors, (x) by delivery of other common stock
(which must have been held at least six months), (y) according to a deferred
payment or other similar arrangement or (z) in any other form of legal
consideration acceptable to the Board.

STOCK BONUS AWARDS AND RESTRICTED STOCK AWARDS

         The terms and provisions of stock bonus awards and restricted stock
awards shall be as set forth in the grant instrument. A stock bonus may be
awarded in consideration for past services actually rendered to the company. The
purchase price for a restricted stock award shall be as the administrator shall
determine, but not less than 85% of the fair market value on the date the award
is granted or the date the purchase is consummated. Shares awarded under a stock
bonus or restricted stock award may, but need not be subject to a repurchase
right on behalf of the Company in accordance with a vesting schedule in the
event the participant's employment is terminated.

         We have not made any stock bonus awards and have made restricted stock
awards of 17,973 shares under the plan to date.

OTHER PROVISIONS

Limits on Transfer of Awards

         In general, plan participants may not sell, pledge, assign, transfer or
otherwise dispose of any stock options or other awards other than by will or the
laws of descent or distribution and the plan participant alone may exercise his
stock options or other awards during his lifetime. Awards other than incentive
stock options granted on or after April 7, 2000 may be transferred only if
permitted under the agreement that evidences the terms of the award.

                                       12


Adjustments on Changes in Capital Structure or on Change of Control

         If we effect a stock split, reverse stock split, stock dividend,
redemption, combination, reclassification or other similar change affecting our
capital stock, adjustments reflecting the change will be made in (1) the
aggregate number of shares of common stock authorized for issuance under the
plan; (2) the number of shares underlying each outstanding award; and (3) if
applicable, the price per share of each award.

         If a change in control transaction shall occur, the surviving or
acquiring corporation shall assume all awards or provide a substitute similar
award. If the surviving or acquiring corporation refuses to so provide such
assumption or substitution, then awards held by those participants whose
employment has not been terminated will be accelerated in full and the awards
will subsequently terminate if not exercised. Any other awards outstanding under
the plan will terminate if not exercised (if applicable) prior to the event.

Amendment or Termination of the Plan

         The Board may at any time amend, alter, suspend or discontinue the 2000
Equity Incentive Plan but no amendment, alteration, suspension or
discontinuation which would impair your rights under any previous grant may be
made without your consent.

Term of the Plan

         No stock options or other awards may be granted under the 2000 Equity
Incentive Plan after February 3, 2010.

UNITED STATES FEDERAL INCOME TAX CONSEQUENCES

         The following is a brief summary of certain of the federal income tax
consequences of certain transactions under the 2000 Equity Incentive Plan based
on current federal income tax laws. This summary is not intended to be
exhaustive and does not describe state or local tax consequences. Additional or
different federal tax consequences to the employee, director or consultant or to
our company may result depending on considerations other than those described
below.

Nonstatutory Stock Options

         In general, optionholders will not recognize any taxable income at the
time they are granted nonstatutory stock options. When an optionholder exercises
a nonstatutory stock option, he or she will recognize ordinary income measured
by the excess of the then fair market value of the shares over the exercise
price and we will be entitled to a deduction for a corresponding amount.
Different rules apply to options that have a "readily ascertainable fair market
value," as that phrase is defined in regulations promulgated under Section 83 of
the Internal Revenue Code of 1986.

         When an optionholder sells or otherwise disposes of shares that were
acquired by exercising nonstatutory stock options, any amount that the
optionholder receives in excess of the sum of (1) the exercise price of the
shares as of the date of exercise and (2) the amount includable in income with
respect to such option, if any, such sum being the optionholder's "basis" in the
shares, will, in general, be treated as a long-term or short-term capital gain,
depending on the holding period of the shares. We are not entitled to any tax
deduction in connection with an optionholder's sale or disposition of the
shares. If an optionholder receives less than his or her basis in the shares,
the loss will, in general, be treated as a long-term or short-term capital loss,
depending on the holding period of the shares.

Incentive Stock Options

         Optionholders will not be taxed on the grant or exercise of an
incentive stock option that qualifies under Section 422 of the Internal Revenue
Code, unless an alternative minimum tax liability is triggered. When an
optionholder sells or otherwise makes a taxable disposition of shares that he or
she acquired by exercising an incentive stock option, the optionholder will
recognize a capital gain on the excess of the amount realized on disposition
over the exercise price of the incentive stock option, provided that the
optionholder has not disposed of the shares until at least two years after the
date the option was granted and one year after the date the optionholder
exercised the option. Failure to comply with these holding requirements will
result in ordinary income treatment for the gain. Unless the optionholder
disposes of shares received on exercise of the incentive stock option before
meeting the applicable holding period requirements, we will not be entitled to a
deduction with respect to the grant or exercise of the incentive stock option.

                                       13


         In the event an optionholder makes a "disposition" of the shares
received on exercise of an incentive stock option before meeting the two-year or
one-year holding period requirements, the gain on the disposition, to the extent
of the lesser of (1) the excess of the fair market value of the shares on the
date of exercise over the exercise price or (2) the excess of the amount
realized on disposition over the exercise price, will be treated as ordinary
income to the optionholder, and we will generally be entitled to a corresponding
deduction. The balance of the gain, if any, realized on such a disposition will
be treated as long-term or short-term capital gain, depending on the holding
period of the shares. To the extent that an optionholder is entitled to capital
gains treatment, we will not be entitled to a corresponding deduction for such
gain. If the amount realized at the time of the disposition is less than the
exercise price, the optionholder will not be required to treat any amount as
ordinary income, provided the disposition is of a type that would give rise to a
recognizable loss. In such event, the loss will be treated as a long-term or
short-term capital loss depending on the holding period of the shares.

Stock Bonus Awards

         In general, if an individual receives a stock bonus award, he or she
will be taxed on the fair market value of the shares on the date the shares are
issued. We will be generally entitled to a deduction for a corresponding amount.
If, upon a taxable disposition of the shares, the stockholder receive more or
less than his or her basis in the shares, the gain or loss will be a long-term
or short-term capital gain or loss, depending on the holding period of the
shares, measured from the date that the receipt of the shares was taxable to the
stockholder.

Restricted Stock Awards

         In general, an individual will not recognize any taxable income at the
time he or she is granted an award of restricted stock, but upon the lapse of
the restrictions applicable to such award (i.e., when the shares subject to the
award are issued as either vested or transferable shares), that person will
recognize ordinary income equal to the fair market value of the shares on the
date the restrictions on the award lapsed, and we will be entitled to a
deduction for a corresponding amount. If the stockholder sells or otherwise
disposes of such shares in a taxable disposition, the sale or disposition will
be subject to the same treatment described above for a taxable disposition of
shares acquired upon an exercise of a nonstatutory stock option.

         The foregoing summary does not constitute a definitive statement of the
federal income tax effects of awards granted under the Plan.

                               PROPOSAL NUMBER 3:
                RATIFICATION AND APPROVAL OF INDEPENDENT AUDITORS

         The Board of Directors has appointed the firm of Ernst & Young LLP as
our independent auditors to make an examination of our accounts for the fiscal
year ending December 31, 2004, subject to ratification by our stockholders.
Representatives of Ernst & Young LLP, are expected to be present at the annual
meeting, will have an opportunity to make a statement if they desire to do so
and are expected to be available to respond to appropriate questions.

         THE BOARD OF DIRECTORS RECOMMENDS THAT STOCKHOLDERS VOTE "FOR"
RATIFICATION AND APPROVAL OF THE APPOINTMENT OF ERNST & YOUNG LLP AS OUR
INDEPENDENT AUDITORS FOR THE FISCAL YEAR ENDING DECEMBER 31, 2004.

COMPENSATION OF INDEPENDENT AUDITORS

         The following table presents the estimated aggregate fees billed and to
be billed by Ernst & Young LLP for services performed during our last two fiscal
years.



                                                                  YEARS ENDED DECEMBER 31,
                                                               -----------------------------
                                                                  2003                2002
                                                               -----------         ---------
                                                                             
Audit fees(1)............................................      $   194,180         $  176,000
Audit-related fees(2) ...................................           40,255             17,282
Tax fees(3)..............................................           33,800             32,309
All other fees(4)........................................               --                 --
                                                               -----------         ----------
                                                               $   268,235         $  225,591
                                                               ===========         ==========


                                       14


         (1)      "Audit fees" include professional services rendered for (i)
                  the audit of our annual financial statements for the fiscal
                  years ended December 31, 2002 and 2003, (ii) the reviews of
                  the financial statements included in our quarterly reports on
                  Form 10-Q for such years and (iii) the issuance of consents
                  and other matters relating to registration statements filed by
                  us.

         (2)      "Audit-related fees" include assurance or related services
                  reasonably related to our audit for the fiscal years ended
                  December 31, 2002 and 2003. These fees related to the audit of
                  the financial statements of our 401(k) plan and consultation
                  concerning financial accounting and reporting standards.

         (3)      "Tax fees" include professional services related to the
                  preparation of our tax returns, tax planning and other tax
                  advice for the fiscal years ended December 31, 2002 and 2003.

         (4)      "All other fees" include products and services other than
                  those disclosed as Audit fees, Audit-related fees and Tax
                  fees.

         The audit committee approved all the fees described above. As part of
its duties, the audit committee has determined that the provision by Ernst &
Young LLP of the non-audit services described above is compatible with
maintaining the auditors' independence.

Pre-Approval Policies and Procedures

         The audit committee has adopted policies and procedures requiring the
pre-approval of all audit and non-audit services rendered by our independent
auditors, either as part of the audit committee's approval of the scope of the
engagement of the independent auditors or on a case-by-case basis before the
independent auditors are engaged to provide each service. The audit committee's
pre-approval authority may be delegated to one or more of its members, but any
pre-approval decision must be reported to the full audit committee at its next
regularly scheduled meeting.

CHANGE IN INDEPENDENT PUBLIC ACCOUNTANTS

         On March 26, 2002, the Board of Directors and its audit committee
dismissed Arthur Andersen LLP as our independent public accountants and engaged
Ernst & Young LLP to serve as our independent public accountants for the fiscal
year ending December 31, 2002, subject to stockholder ratification.

         Arthur Andersen's reports on our consolidated financial statements for
each of the fiscal years ended December 31, 2001 and 2000 did not contain an
adverse opinion or disclaimer of opinion, nor were they qualified or modified as
to uncertainty, audit scope or accounting principles.

         During the fiscal years ended December 31, 2001 and 2000 and through
the date of the Board of Directors' decision, there were no disagreements with
Arthur Andersen on any matter of accounting principle or practice, financial
statement disclosure, or auditing scope or procedure which, if not resolved to
Arthur Andersen's satisfaction, would have caused them to make reference to the
subject matter in connection with their report on our consolidated financial
statements for such years; and there were no reportable events as defined in
Item 304(a)(1)(v) of Regulation S-K.

         During the fiscal years ended December 31, 2001 and 2000 and through
the date of the Board of Directors' decision, we did not consult Ernst & Young
with respect to the application of accounting principles to a specified
transaction, either completed or proposed, or the type of audit opinion that
might be rendered on our consolidated financial statements, or any other matters
or reportable events as set forth in Items 304(a)(2)(i) and (ii) of Regulation
S-K.

REPORT OF THE AUDIT COMMITTEE OF THE BOARD OF DIRECTORS

         The role of the audit committee is to assist the Board of Directors in
its oversight of our financial reporting process. The audit committee reviews
our internal accounting procedures and consults with, and reviews the services
provided by, our independent auditors. The committee operates pursuant to a
charter that was last amended and restated by the Board of Directors on February
11, 2004, a copy of which is attached to this proxy statement as Appendix C.

         The management of our company is responsible for the preparation,
presentation and integrity of our financial statements, our accounting and
financial reporting principles and internal controls and procedures designed to
assure

                                       15


compliance with the accounting standards and applicable laws and regulations.
Our independent auditors are responsible for auditing our financial statements
and expressing an opinion as to their conformity with generally accepted
accounting principles.

         In the performance of its oversight function, the audit committee has
considered and discussed the audited financial statements with management and
our independent auditors. The committee has also discussed with our independent
auditors the matters required to be discussed by Statement on Auditing Standards
No. 61, Communication with Audit Committees, as currently in effect. Finally,
the committee has received the written disclosures and the letter from the
independent auditors required by Independence Standards Board Standard No. 1,
Independence Discussions with Audit Committees, as currently in effect, and has
discussed with the independent auditors their independence.

         Based upon the reports and discussions described in this report, and
subject to the limitations on the role and responsibilities of the audit
committee referred to in the audit committee charter, the committee recommended
to the Board of Directors that the audited financial statements be included in
our annual report on Form 10-K for the year ended December 31, 2003.

                                 AUDIT COMMITTEE

                              Sam L. Barker, Ph.D.
                              Patricia M. Cloherty
                             C. Thomas Caskey, M.D.

         The foregoing report of the audit committee shall not be deemed
incorporated by reference by any general statement incorporating by reference
this proxy statement into any filing under the Securities Act of 1933 or under
the Securities Exchange Act of 1934, except to the extent that we specifically
incorporate this information by reference, and shall not otherwise be deemed
filed under such acts.

                             EXECUTIVE COMPENSATION

EXECUTIVE OFFICERS

         The executive officers of the Company and their ages and positions are
listed below.



                  NAME                             AGE                    POSITION WITH THE COMPANY
-------------------------------------------        ---     ---------------------------------------------------------
                                                     
Arthur T. Sands, M.D., Ph.D. ..............         42     President and Chief Executive Officer and Director
Julia P. Gregory ..........................         51     Executive Vice President, Corporate Development and Chief
                                                           Financial Officer
Jeffrey L. Wade, J.D. .....................         39     Executive Vice President and General Counsel
Brian P. Zambrowicz, Ph.D..................         41     Executive Vice President of Research
Walter F. Colbert .........................         54     Senior Vice President of Human Resources and Corporate
                                                           Services
Lance K. Ishimoto, Ph.D., J.D. ............         44     Senior Vice President of Intellectual Property
Alan J. Main, Ph.D. .......................         50     Senior Vice President, Lexicon Pharmaceuticals
James R. Piggott, Ph.D. ...................         49     Senior Vice President of Pharmaceutical Biology


         Information regarding the business experience of Dr. Sands is set forth
above under the heading "Election of Directors -- Nominees for Class I
Directors."

         Julia P. Gregory has been our Executive Vice President, Corporate
Development and Chief Financial Officer since August 2003 and served as our
Executive Vice President and Chief Financial Officer from February 2000 until
August 2003. From 1998 to February 2000, Ms. Gregory served as the Head of
Investment Banking for Punk, Ziegel & Company, a specialty investment banking
firm focusing on technology and healthcare and, from 1996 to February 2000, as
the Head of the firm's Life Sciences practice. From 1980 to 1996, Ms. Gregory
was an investment banker, primarily with Dillon, Read & Co., Inc., where she
represented life sciences companies beginning in 1986. Ms. Gregory is a

                                       16


member of the board of directors and the scientific advisory board of the Estee
Lauder Foundation's Institute for the Study of Aging, Inc. and a member of The
International Council for George Washington University's Elliott School of
International Affairs. She received her B.A. in International Affairs from
George Washington University and her M.B.A. from the Wharton School of the
University of Pennsylvania.

     Jeffrey L. Wade, J.D. has been our Executive Vice President and General
Counsel since February 2000 and was our Senior Vice President and Chief
Financial Officer from January 1999 to February 2000. From 1988 through December
1998, Mr. Wade was a corporate securities and finance attorney with the law firm
of Andrews & Kurth L.L.P., for the last two years as a partner, where he
represented companies in the biotechnology, information technology and energy
industries. Mr. Wade is a member of the boards of directors of the Texas
Healthcare and Bioscience Institute and the Texas Life Sciences Foundation. He
received his B.A. and J.D. from The University of Texas.

     Brian P. Zambrowicz, Ph.D. has been our Executive Vice President of
Research since August 2002. Dr. Zambrowicz served as our Senior Vice President
of Genomics from February 2000 to August 2002, Vice President of Research from
January 1998 to February 2000 and Senior Scientist from April 1996 to January
1998. From 1993 to April 1996, Dr. Zambrowicz served as a National Institutes of
Health, or NIH, postdoctoral fellow at The Fred Hutchinson Cancer Center in
Seattle, Washington, where he studied gene trapping and gene targeting
technology. Dr. Zambrowicz received his B.S. in Biochemistry from the University
of Wisconsin. He received his Ph.D. from the University of Washington, where he
studied tissue-specific gene regulation using transgenic mice.

     Walter F. Colbert has been our Senior Vice President of Human Resources and
Corporate Services since May 2002. Mr. Colbert served as our Vice President of
Human Resources from December 2000 to May 2002. From September 1997 to December
2000, Mr. Colbert was Vice President, Human Resources and Public Affairs at the
Sony Technology Center -- San Diego of Sony Electronics Inc. From September 1995
to September 1997, Mr. Colbert served as Vice President, Human Resources for The
NutraSweet Kelco Company, Monsanto Company's food ingredients business unit.
From 1976 through September 1995, Mr. Colbert served in a variety of human
resources positions in the United States and Europe with Ford Motor Company and
Monsanto Company. He received his B.A. in Political Science from Stanford
University and his M.A. in International Affairs from The Fletcher School of Law
and Diplomacy at Tufts University.

         Lance K. Ishimoto, J.D., Ph.D. has been our Senior Vice President of
Intellectual Property since February 2004. Dr. Ishimoto served as our Vice
President of Intellectual Property from July 1998 to February 2004. From 1994 to
July 1998, Dr. Ishimoto was a biotechnology patent attorney at the Palo Alto,
California office of the law firm of Pennie & Edmonds LLP. Dr. Ishimoto received
his B.A. and Ph.D. from the University of California at Los Angeles, where he
studied molecular mechanisms of virus assembly and the regulation of virus
ultrastructure. After receiving his Ph.D., Dr. Ishimoto served as an NIH
postdoctoral fellow at University of Washington School of Medicine. He received
his J.D. from Stanford University.

         Alan J. Main, Ph.D. has been our Senior Vice President, Lexicon
Pharmaceuticals since July 2001. Dr. Main was President and Chief Executive
Officer of Coelacanth Corporation, a leader in using proprietary chemistry
technologies to rapidly discover new chemical entities for drug development,
from January 2000 until our acquisition of Coelacanth in July 2001. Dr. Main was
formerly Senior Vice President, United States Research at Novartis
Pharmaceuticals Corporation, where he worked for 20 years before joining
Coelacanth. Dr. Main holds a B.Sc. from the University of Aberdeen, Scotland and
a Ph.D. in Organic Chemistry from the University of Liverpool, England and
completed postdoctoral studies at the Woodward Research Institute.

         James R. Piggott, Ph.D. has been our Senior Vice President of
Pharmaceutical Biology since January 2000. From 1990 through October 1999, Dr.
Piggott worked for ZymoGenetics, Inc., a subsidiary of Novo Nordisk, a company
focused on the discovery, development and commercialization of therapeutic
proteins for the treatment of human disease, most recently as Senior Vice
President-Research Biology from 1997 to October 1999. Dr. Piggott's
pharmaceutical research experience also includes service at the Smith Kline &
French Laboratories Ltd. unit of SmithKline Beecham plc and the G.D. Searle &
Co. unit of Monsanto Company. Dr. Piggott received his B.A. and Ph.D. from
Trinity College, Dublin.

                                       17


SUMMARY COMPENSATION TABLE

         The following table presents summary information for the years ended
December 31, 2003, 2002 and 2001 regarding the compensation of each of our five
most highly compensated executive officers.



                                                                                            LONG-TERM
                                                                                           COMPENSATION
                                                                    ANNUAL COMPENSATION       AWARDS
                                                                   ----------------------   SECURITIES
                                                                                            UNDERLYING      ALL OTHER
                  NAME AND POSITION                        YEAR      SALARY      BONUS       OPTIONS     COMPENSATION(1)
------------------------------------------------------     ----    ----------  ----------  ------------  ---------------
                                                                                          
Arthur T. Sands, M.D., Ph.D. (2)......................     2003    $  432,000  $  309,536       135,000    $    6,022
   President, Chief Executive Officer and Director         2002    $  429,333  $  243,675       170,000    $    5,600
                                                           2001    $  400,000  $  250,000       100,000    $   79,644

Julia P. Gregory......................................     2003    $  286,000  $  126,215        72,000    $    5,711
   Executive Vice President, Corporate Development         2002    $  283,833  $   86,800        90,000    $    5,600
    and Chief Financial Officer                            2001    $  260,000  $  125,000        60,000    $    5,680

Jeffrey L. Wade, J.D. ................................     2003    $  266,250  $  100,630        54,000    $    5,631
   Executive Vice President and General Counsel            2002    $  264,896  $   70,100        65,000    $    5,600
                                                           2001    $  250,000  $   85,000        50,000    $    5,730

Brian P. Zambrowicz, Ph.D.............................     2003    $  285,000  $  109,140        63,000    $    5,674
   Executive Vice President of Research                    2002    $  276,858  $   80,200        75,000    $    5,600
                                                           2001    $  250,000  $  100,000        50,000    $    5,730

Alan J. Main, Ph.D. (3) ..............................     2003    $  297,045  $   83,780        54,000    $    5,674
   Senior Vice President, Lexicon Pharmaceuticals          2002    $  296,208  $  186,700        15,000    $    5,440
                                                           2001    $  145,235  $  168,050       349,001    $      592


(1)  Other compensation during 2003, 2002 and 2001 includes the following
     amounts in respect of company matching contributions under our 401(k) plan
     and company-paid premiums for group term life insurance. In addition, other
     compensation in 2001 includes company-paid premiums paid under a
     split-dollar life insurance arrangement for Dr. Sands.



                                                                   COMPANY-PAID
                                                     COMPANY        GROUP TERM     COMPANY-PAID
                                                      401(k)           LIFE        SPLIT-DOLLAR
                                                     MATCHING        INSURANCE    LIFE INSURANCE
                                         YEAR      CONTRIBUTION      PREMIUMS        PREMIUMS
                                         ----      ------------    ------------   --------------
                                                                      
Arthur T. Sands, M.D., Ph.D. ........    2003       $     5,000      $    1,022     $     --
                                         2002       $     5,000      $      600     $     --
                                         2001       $     5,250      $      480     $ 73,914

Julia P. Gregory.....................    2003       $     5,000      $      711     $     --
                                         2002       $     5,000      $      600     $     --
                                         2001       $     5,200      $      480     $     --

Jeffrey L. Wade, J.D.................    2003       $     5,000      $      631     $     --
                                         2002       $     5,000      $      600     $     --
                                         2001       $     5,250      $      480     $     --

Brian P. Zambrowicz, Ph.D............    2003       $     5,000      $      674     $     --
                                         2002       $     5,000      $      600     $     --
                                         2001       $     5,250      $      480     $     --

Alan J. Main, Ph.D...................    2003       $     5,000      $      674     $     --
                                         2002       $     5,000      $      440     $     --
                                         2001       $       592      $       --     $     --


     The company-paid life insurance premiums in the foregoing table reflect
     payments for group term life policies maintained for the benefit of all
     employees, with the exception of the additional premiums paid in 2001 under
     a split-dollar life insurance arrangement for Dr. Sands under his
     employment agreement with us. Upon the death of Dr. Sands, we will receive
     cash under the policy in an amount equal to the aggregate premiums we paid
     for the policy, and the balance of the proceeds will be paid to the trust
     that is the beneficiary of the policy.

                                       18


(2)  The amount reflected as bonus compensation for Dr. Sands in 2003 and 2002
     includes bonus payments to Dr. Sands of $59,706 and $61,375, respectively,
     to enable him to make, for his own account, the minimum premium payments
     required for him to maintain the split-dollar life insurance arrangement
     under his employment agreement with us. Unlike the premiums we paid under
     the policy in 2001, we will not receive any cash under the policy upon Dr.
     Sands' death in respect of such bonus amount or the premiums paid by Dr.
     Sands, for his own account, under such policy.

(3)  Dr. Main joined us in July 2001 in connection with our acquisition of
     Coelacanth Corporation. His base salary for 2001 reflects compensation at
     an annualized rate of $287,000 for the portion of the year, following the
     completion of such acquisition, that he was an employee. The amount
     reflected as bonus compensation for Dr. Main in 2002 and 2001 includes
     retention bonus payments, each in the amount of $125,000, in July 2002 and
     July 2001, respectively, under an arrangement entered into in connection
     with our acquisition of Coelacanth Corporation.

OPTION GRANTS IN 2003

         The following table presents each grant of stock options in 2003 to the
individuals named in the summary compensation table.



                                                  PERCENTAGE
                                                   OF TOTAL                               POTENTIAL REALIZABLE VALUE
                                     NUMBER OF     OPTIONS                                AT ASSUMED ANNUAL RATES
                                    SECURITIES     GRANTED      EXERCISE                  OF STOCK PRICE APPRECIATION
                                    UNDERLYING        TO         PRICE                           FOR OPTION TERM
                                      OPTIONS     EMPLOYEES       PER       EXPIRATION    ---------------------------
            NAME                      GRANTED      IN 2003       SHARE         DATE          5%                10%
----------------------------        ----------    ----------    --------    ----------    --------           --------
                                                                                           
Arthur T. Sands, M.D., Ph.D.          135,000         7.3%       $3.90      2/14/2013     $331,113           $839,105
Julia P. Gregory                       72,000         3.9%       $3.90      2/14/2013     $176,594           $447,523
Jeffrey L. Wade, J.D.                  54,000         2.9%       $3.90      2/14/2013     $132,445           $335,642
Brian P. Zambrowicz, Ph.D.             63,000         3.4%       $3.90      2/14/2013     $154,519           $391,583
Alan J. Main, Ph.D.                    54,000         2.9%       $3.90      2/14/2013     $132,445           $335,642


         The exercise price of each of the options in the foregoing table was
equal to the fair market value of our common stock as determined by our Board of
Directors on the date of grant. The exercise price for each option may be paid
in cash, promissory notes, in shares of our common stock valued at fair market
value on the exercise date or through a cashless exercise procedure involving a
same-day sale of the purchased shares.

         The potential realizable value of these options is calculated based on
the ten-year term of the option at the time of grant. Stock price appreciation
of 5% and 10% is assumed pursuant to rules promulgated by the Securities and
Exchange Commission and does not represent our prediction of our stock price
performance.

         Percentages shown under "Percentage of Total Options Granted to
Employees in 2003" are based on an aggregate of 1,843,400 options granted to our
employees under our 2000 Equity Incentive Plan during 2003.

AGGREGATED OPTION EXERCISES IN 2003 AND OPTION VALUES AT DECEMBER 31, 2003

         The following table presents information about:

                  -        option exercises in 2003 by each of the individuals
                           listed in the summary compensation table; and

                  -        the number and value of the shares of common stock
                           underlying unexercised options that are held by each
                           of the individuals listed in the summary compensation
                           table as of December 31, 2003.

         Amounts shown under the column "Value Realized" are based on the market
price of our common stock on the date of exercise, without taking into account
any taxes that may be payable in connection with the transaction, less the
exercise price paid for the purchased shares.

         Amounts shown under the column "Value of Unexercised In-the-Money
Options at December 31, 2003" are based on the closing price of our common stock
on The Nasdaq National Market on December 31, 2003 of $5.89 per share, without
taking into account any taxes that may be payable in connection with the
transaction, less the exercise price payable for these shares.

                                       19




                                                               NUMBER OF SECURITIES
                                                               UNDERLYING UNEXERCISED              VALUE OF UNEXERCISED
                                    SHARES                           OPTIONS AT                  IN-THE-MONEY OPTIONS AT
                                   ACQUIRED                      DECEMBER 31, 2003                 DECEMBER 31, 2003
                                      ON        VALUE      ------------------------------    -------------------------------
            NAME                   EXERCISE    REALIZED    EXERCISABLE      UNEXERCISABLE     EXERCISABLE      UNEXERCISABLE
----------------------------       --------    --------    -----------      -------------    -------------     -------------
                                                                                             
Arthur T. Sands, M.D., Ph.D.          --           --        2,568,930           273,570     $ 10,160,357      $    327,453
Julia P. Gregory                      --           --          545,629           161,371     $  1,565,722      $    221,708
Jeffrey L. Wade, J.D.                 --           --          568,499           108,001     $  1,706,116      $    121,769
Brian P. Zambrowicz, Ph.D.            --           --          938,241           124,759     $  3,235,285      $    147,619
Alan J. Main, Ph.D.                   --           --          295,711           122,290     $    188,917      $    110,627


EMPLOYMENT AGREEMENTS

         In October 1999, we entered into an employment agreement with Arthur T.
Sands, M.D., Ph.D., our President and Chief Executive Officer. Under the
agreement, Dr. Sands received an initial base salary of $200,000 a year, subject
to adjustment, with an annual discretionary bonus based upon specific objectives
to be determined by the compensation committee. Dr. Sands' current annual salary
is $473,000. The employment agreement is at-will and contains a non-competition
agreement. The agreement also provides that if we terminate Dr. Sands'
employment without cause or Dr. Sands voluntarily terminates his employment for
good reason, we will pay him his then-current salary for 12 months.

         In February 2000, we entered into an employment agreement with Julia P.
Gregory to serve as our Executive Vice President and Chief Financial Officer
starting in February 2000. In August 2003, Ms. Gregory was named Executive Vice
President, Corporate Development and Chief Financial Officer. Under the
agreement, Ms. Gregory received an initial base salary of $200,000 a year,
subject to adjustment, with an annual discretionary bonus based upon specific
objectives to be determined by the compensation committee. Ms. Gregory's current
annual salary is $329,000. The employment agreement is at-will and contains a
non-competition agreement. The agreement also provides that if we terminate Ms.
Gregory's employment without cause or Ms. Gregory voluntarily terminates her
employment for good reason, we will pay her then-current salary for six months.
If any such termination follows a change in control of our company, we will pay
Ms. Gregory her then-current salary for 12 months.

         In December 1998, we entered into an employment agreement with Jeffrey
L. Wade, J.D. to serve as our Senior Vice President and Chief Financial Officer
starting in January 1999. In February 2000, Mr. Wade was named Executive Vice
President and General Counsel. Under the agreement, Mr. Wade received an initial
base salary of $170,000 a year, subject to adjustment, with an annual
discretionary bonus based upon specific objectives to be determined by the
compensation committee. Mr. Wade's current annual salary is $292,000. The
employment agreement is at-will and contains a non-competition agreement. The
agreement also provides that if we terminate Mr. Wade's employment without cause
or Mr. Wade voluntarily terminates his employment for good reason, we will pay
him his then-current salary for six months. If any such termination follows a
change in control of our company, we will pay Mr. Wade his then-current salary
for 12 months.

         In February 2000, we entered into an employment agreement with Brian P.
Zambrowicz, Ph.D., then our Senior Vice President of Genomics. In August 2002,
Dr. Zambrowicz was named Executive Vice President of Research. Under the
agreement, Dr. Zambrowicz received an initial base salary of $200,000 a year,
subject to adjustment, with an annual discretionary bonus based upon specific
objectives to be determined by the compensation committee. Dr. Zambrowicz's
current annual salary is $312,000. The employment agreement is at-will and
contains a non-competition agreement. The agreement also provides that if we
terminate Dr. Zambrowicz's employment without cause or Dr. Zambrowicz
voluntarily terminates his employment for good reason, we will pay him his
then-current salary for six months. If any such termination follows a change in
control of our company, we will pay Dr. Zambrowicz his then-current salary for
12 months.

         In July 2001, we entered into an employment agreement with Alan J.
Main, Ph.D., our Senior Vice President, Lexicon Pharmaceuticals. Under the
agreement, Dr. Main received an initial base salary of $287,000 a year, subject
to adjustment, with an annual discretionary bonus based upon specific objectives
to be determined by the compensation committee. Dr. Main's current annual salary
is $312,000. The employment agreement is at-will and contains a non-competition
agreement. The agreement also provides that if we terminate Dr. Main's
employment without cause or Dr. Main voluntarily terminates his employment for
good reason, we will pay him his then-current salary for six months. If

                                       20


any such termination follows a change in control of our company, we will pay Dr.
Main his then-current salary for 12 months.

REPORT OF THE COMPENSATION COMMITTEE OF THE BOARD OF DIRECTORS

         The compensation committee of our Board of Directors currently consists
of Patricia M. Cloherty and Sam L. Barker, Ph.D., neither of whom is an officer
or employee of the company.

         The compensation committee is responsible for evaluating the
performance of management, determining the compensation of our executive
officers and administering our 2000 Equity Incentive Plan, under which stock
option grants and other stock awards may be made to our employees. The committee
has furnished the following report on executive compensation for 2003:

Executive Compensation Policies and Practices

         Under the supervision of the compensation committee, our company has
developed a compensation policy that is designed to attract and retain key
executives responsible for our success and motivate management to enhance
long-term stockholder value. The annual compensation package for executive
officers primarily consists of:

                  -        a cash salary, which reflects the responsibilities
                           relating to the position and individual performance;

                  -        variable performance awards payable in cash or stock
                           and tied to the achievement of specified individual
                           and corporate goals and milestones; and

                  -        long-term stock based incentive awards which
                           strengthen the mutuality of interests between our
                           executive officers and our stockholders.

         In determining the level and composition of compensation of each of our
executive officers, the compensation committee takes into account various
qualitative and quantitative indicators of corporate and individual performance.
Although no specific target has been established, the committee generally seeks
to set total compensation, including base salaries and variable performance
award targets, at or above the median of the range in comparison to peer group
companies. In setting such total compensation, the committee considers our peer
group to be similarly sized companies in the biotechnology industry. This peer
group does not necessarily coincide with the companies comprising the Nasdaq
Biotechnology Index reflected in the performance graph in this proxy statement.
Because our business and technology are continuing to develop, the use of
certain traditional performance standards, such as profitability and return on
equity, are not currently appropriate in evaluating the performance of our
executive officers. Consequently, in evaluating the performance of management,
the committee takes into consideration such factors as our achievement of
specified milestones and goals with respect to our revenues, new business
development, and our research and development programs. In addition, the
committee recognizes performance and achievements that are more difficult to
quantify, such as the successful supervision of major corporate projects and
demonstrated leadership ability.

Base Compensation

         Base compensation is established through negotiation between the
company and the executive officer at the time the executive is hired, and then
subsequently adjusted when the officer's base compensation is subject to review
or reconsideration. While we have entered into employment agreements with
certain of our executive officers, these agreements provide that base salaries
after the initial year will be reviewed and determined by the committee. When
establishing or reviewing base compensation levels for executive officers, the
committee, in accordance with its general compensation policy, considers
numerous factors, including the responsibilities relating to the position, the
qualifications of the executive and the relevant experience the individual
brings to the company, strategic goals for which the executive has
responsibility, and compensation levels of companies at a comparable stage of
development who compete with us for business, scientific and executive talents.
No pre-determined weights are given to any one of these factors. The base
salaries for the executive officers generally, and the Chief Executive Officer
specifically, for 2003 were at or above the median of the range in comparison to
our peer group companies, with most falling in a range around the 60th to 75th
percentile for such peer group companies. In establishing base compensation for
2003, the committee included in its evaluation the significant progress made by
the company in 2002, including the significant increase in our revenues as

                                       21


compared to 2001, the establishment of our drug discovery alliance with
Genentech, Inc., and the continuing advancement of our research and development
programs.

Incentive Compensation

         In addition to base compensation, the committee may award cash bonuses
and option grants or other stock-based awards under our 2000 Equity Incentive
Plan to chosen executive officers depending on the extent to which certain
defined personal and corporate performance goals are achieved. These performance
goals include those discussed generally above, as well as strategic and
operational goals for the company as a whole. In determining bonus and stock
option awards for 2003, the committee included in its evaluation the progress
made by the company in 2003, including the significant increase in our revenues
as compared to 2002, the establishment of a major new drug discovery alliance
with Bristol-Myers Squibb Company, the completion of a significant public
offering of our common stock and the continuing advancement of our research and
development programs.

         All of our employees, including our executive officers, are eligible to
receive long-term stock-based incentive awards under our 2000 Equity Incentive
Plan as a means of providing such individuals with a continuing proprietary
interest in our success. These grants align the interests of our employees and
our stockholders by providing significant incentives for our employees to
achieve and maintain high levels of performance. Our 2000 Equity Incentive Plan
enhances our ability to attract and retain the services of qualified
individuals. Factors considered in determining whether such awards are granted
to an executive officer include the executive's position, his or her performance
and responsibilities, the amount of stock options currently held by the officer,
the vesting schedules of any such options and the executive officer's other
compensation. While the committee does not adhere to any firmly established
formulas or schedules for the issuance of awards such as options or restricted
stock, the committee will generally tailor the terms of any such grant to
achieve its goal as a long-term incentive award by providing for a vesting
schedule encompassing several years.

         In February 2003, the committee approved annual stock option grants to
executive officers and other employees who satisfied eligibility requirements,
including time of service. In making such grants, the committee considered
corporate and individual performance over the year preceding the grant date and
information regarding stock option grants made by other companies in the
biotechnology industry.

Compensation of the Chief Executive Officer

         The annual base salary of Arthur T. Sands, M.D., Ph.D., our President
and Chief Executive Officer, was increased by $32,000 (or approximately eight
percent) to $432,000 in March 2002 on the basis of the company's achievements in
2001. The committee elected to leave Dr. Sands' annual base salary for 2003
unchanged from 2002 as a result of the uncertain economic environment prevailing
at the time. In light of continuing uncertainty as to whether company-paid
split-dollar life insurance premiums might be considered advances of credit, in
December 2003, the committee approved the payment to Dr. Sands of a bonus in the
amount of $59,706 to enable him to make, for his own account, the minimum
premium payment required to maintain the split-dollar life insurance arrangement
under his employment agreement with the company. In February 2004, the committee
increased Dr. Sands' base salary by $41,000 (or approximately nine percent) to
$473,000 and awarded a bonus to Dr. Sands for 2003 in the amount of $249,830, in
each case on the basis of his and the company's achievements in 2003 relative to
performance goals established at the outset of the year.

         The committee granted a stock option to Dr. Sands in February 2003, at
the same time annual grants were made to other employees. The stock option
entitles Dr. Sands to purchase an aggregate of 135,000 shares of common stock at
an exercise price of $3.90 per share. In making the option grant to Dr. Sands,
the committee considered the factors described above with respect to the
February 2003 option grants generally.

Section 162(m)

         Section 162(m) of the Internal Revenue Code places a $1 million cap per
executive on the deductible compensation that can be paid to certain executives
of publicly-traded corporations. Amounts that qualify as "performance based"
compensation under Section 162(m)(4)(c) of the Code are exempt from the cap and
do not count toward the $1 million limit. Generally, stock options will qualify
as performance based compensation. The committee has discussed and considered
and will continue to evaluate the potential impact of Section 162(m) on the
company in

                                       22


making compensation determinations, but has not established a set policy with
respect to future compensation determinations.

                             COMPENSATION COMMITTEE

                              Patricia M. Cloherty
                              Sam L. Barker, Ph.D.

         The foregoing report of the compensation committee shall not be deemed
incorporated by reference by any general statement incorporating by reference
this proxy statement into any filing under the Securities Act of 1933 or under
the Securities Exchange Act of 1934, except to the extent that we specifically
incorporate this information by reference, and shall not otherwise be deemed
filed under such acts.

PERFORMANCE GRAPH

         The following performance graph compares the performance of our common
stock to the Nasdaq Composite Index and the Nasdaq Biotechnology Index for the
period beginning April 7, 2000, the date of our initial public offering, and
ending December 31, 2003. The graph assumes that the value of the investment in
our common stock and each index was $100 at April 7, 2000, and that all
dividends were reinvested.

                              [PERFORMANCE GRAPH]



                                         APRIL 7,     DECEMBER     DECEMBER     DECEMBER     DECEMBER 31,
                                         --------     --------     --------     --------     ------------
                                          2000        31, 2000     31, 2001     31, 2002         2003
                                          ----        --------     --------     --------         ----
                                                                              
Lexicon Genetics Incorporated              100            76           52          22             27
Nasdaq Composite Index                     100            56           44          30             45
Nasdaq Biotechnology Index                 100            96           81          44             64


         The foregoing stock price performance comparisons shall not be deemed
incorporated by reference by any general statement incorporating by reference
this proxy statement into any filing under the Securities Act of 1933 or under
the Securities Exchange Act of 1934, except to the extent that we specifically
incorporate such comparisons by reference, and shall not otherwise be deemed
filed under such acts.

                                       23


                            PROPOSALS OF STOCKHOLDERS

         In order for a stockholder proposal to be considered for inclusion in
our proxy statement for next year's annual meeting, we must receive the written
proposal at our principal executive offices no later than December 17, 2004. Any
such proposal must also comply with Securities and Exchange Commission
regulations regarding the inclusion of stockholder proposals in
company-sponsored proxy materials. Similarly, in order for any stockholder
proposal to be otherwise raised during next year's annual meeting, we must
receive written notice of the proposal, containing the information required by
our Bylaws, at our principal executive offices no later than December 17, 2004.
You may contact the Corporate Secretary at our principal executive offices for a
copy of the relevant Bylaw provisions for making stockholder proposals.

                              FINANCIAL INFORMATION

         Our annual report to stockholders, including financial statements,
accompanies this proxy statement but does not constitute a part of the proxy
solicitation materials. YOU MAY OBTAIN, WITHOUT CHARGE, A COPY OF OUR ANNUAL
REPORT ON FORM 10-K, INCLUDING THE FINANCIAL STATEMENTS AND EXHIBITS THERETO, BY
WRITTEN REQUEST TO CORPORATE COMMUNICATIONS, LEXICON GENETICS INCORPORATED, 8800
TECHNOLOGY FOREST PLACE, THE WOODLANDS, TEXAS 77381.

                                            By Order of the Board of Directors,

                                            /s/ Jeffrey L. Wade

                                            Jeffrey L. Wade
                                            Secretary

April 15, 2004
The Woodlands, Texas

                                       24


                                                                      APPENDIX A

                          LEXICON GENETICS INCORPORATED
                     CORPORATE GOVERNANCE COMMITTEE CHARTER

GENERAL PURPOSE

         The Corporate Governance Committee (the "Committee") of Lexicon
Genetics Incorporated (the "Company") is appointed by the Board of Directors of
the Company (the "Board") to make recommendations to the Board regarding (1) the
identification of individuals qualified to become Board members, (2) the
selection of candidates or nominees for director positions to be filled by the
Board or the stockholders of the Company and (3) the development of corporate
governance principles applicable to the Company.

COMMITTEE MEMBERSHIP

         The members of the Committee shall meet the independence requirements
of The Nasdaq Stock Market, Inc. (or any other exchange on which the Company's
securities are listed). The members of the Committee shall be appointed or
replaced by the Board on the recommendation of the Chairman of the Board.

MEETINGS

         The Committee shall meet as often as it determines is necessary to
perform the Committee's responsibilities. The Committee may request any officer
or employee of the Company or the Company's outside counsel to attend a meeting
of the Committee or to meet with any members of, or advisors to, the Committee.

COMMITTEE AUTHORITY AND RESPONSIBILITIES

         The Committee may form and delegate authority to subcommittees
consisting of one or more members when appropriate, provided that decisions of
such subcommittee shall be presented to the full Committee at its next scheduled
meeting.

         The Committee shall have the authority, to the extent it deems
necessary or appropriate, to retain independent legal experts or other advisors.
The Company shall provide for appropriate funding, as determined by the
Committee, for payment of compensation to any advisors retained by the
Committee.

         The Committee shall make regular reports to the Board and shall review
and reassess the adequacy of this Charter annually and recommend any proposed
changes to the Board for its approval. The Committee shall annually review the
Committee's own performance.

         The Committee, to the extent it deems necessary or appropriate, shall:

         Board Selection and Composition Matters

         1. Establish criteria for the identification and selection of new
members of the Board.

         2. Identify and evaluate individuals believed to be qualified as
candidates to serve on the Board and conduct all necessary and appropriate
inquiries into the backgrounds and qualifications of such possible candidates.
In identifying and evaluating candidates for membership on the Board, the
Committee shall consider all factors it deems appropriate, which may include
independence, experience, diversity, leadership qualities and strength of
character.

         3. Make recommendations to the Board regarding the selection of
director nominees to be presented for stockholder approval or necessary to fill
vacancies on the Board.

                                      A-1



                                                                      APPENDIX A

         4. Review and make recommendations regarding the size and composition
of the Board in order to ensure the Board has the requisite expertise and its
membership consists of individuals with sufficiently diverse and independent
backgrounds.

         Corporate Governance Matters

         5. Develop and recommend to the Board corporate governance principles
applicable to the Company and keep abreast of developments with regard to
corporate governance to enable the Committee to make recommendations to the
Board in light of such developments, as may be appropriate.

                                      A-2



                                                                      APPENDIX B

                          LEXICON GENETICS INCORPORATED
                           2000 EQUITY INCENTIVE PLAN

                    (RESTATED TO REFLECT SPLIT PRIOR TO IPO)

1.       PURPOSES.

         (a) AMENDMENT AND RESTATEMENT OF INITIAL PLAN. The Plan initially was
established as the 1995 Stock Option Plan, effective as of September 13, 1995
(the "Initial Plan"). The Initial Plan, as amended hereby, is amended and
restated in its entirety and renamed the 2000 Equity Incentive Plan, effective
as of its adoption. The terms of this Plan shall supersede the Initial Plan in
its entirety; provided, however, that nothing herein shall operate or be
construed as modifying the terms of an incentive stock option granted under the
Initial Plan in a manner that would treat the option as being a new grant for
purpose of Section 424(h) of the Code (as hereafter defined).

         (b) ELIGIBLE STOCK AWARD RECIPIENTS. The persons eligible to receive
Stock Awards are the Employees, Directors and Consultants of the Company and its
Affiliates.

         (c) AVAILABLE STOCK AWARDS. The purpose of the Plan is to provide a
means by which eligible recipients of Stock Awards may be given an opportunity
to benefit from increases in value of the Common Stock through the granting of
the following Stock Awards: (i) Incentive Stock Options, (ii) Nonstatutory Stock
Options, (iii) stock bonuses and (iv) rights to acquire restricted stock.

         (d) GENERAL PURPOSE. The Company, by means of the Plan, seeks to retain
the services of the group of persons eligible to receive Stock Awards, to secure
and retain the services of new members of this group and to provide incentives
for such persons to exert maximum efforts for the success of the Company and its
Affiliates.

2.       DEFINITIONS.

         (a) "AFFILIATE" means any parent corporation or subsidiary corporation
of the Company, whether now or hereafter existing, as those terms are defined in
Sections 424(e) and (f), respectively, of the Code.

         (b) "BOARD" means the Board of Directors of the Company.

         (c) "CODE" means the Internal Revenue Code of 1986, as amended.

         (d) "COMMITTEE" means a committee of one or more members of the Board
appointed by the Board in accordance with subsection 3(c).

         (e) "COMMON STOCK" means the common stock, par value $.001 per share,
of the Company.

         (f) "COMPANY" means Lexicon Genetics Incorporated, a Delaware
corporation.

         (g) "CONSULTANT" means any person, including an advisor, (i) engaged by
the Company or an Affiliate to render consulting or advisory services and who is
compensated for such services or (ii) who is a member of the Board of Directors
of an Affiliate. However, the term "Consultant" shall not include either
Directors who are not compensated by the Company for their services as Directors
or Directors who are merely paid a director's fee by the Company for their
services as Directors.

         (h) "CONTINUOUS SERVICE" means that the Participant's service with the
Company or an Affiliate, whether as an Employee, Director or Consultant, is not
interrupted or terminated. The Participant's Continuous Service

                                       B-1


                                                                      APPENDIX B

shall not be deemed to have terminated merely because of a change in the
capacity in which the Participant renders service to the Company or an Affiliate
as an Employee, Consultant or Director or a change in the entity for which the
Participant renders such service, provided that there is no interruption or
termination of the Participant's Continuous Service. For example, a change in
status from an Employee of the Company to a Consultant of an Affiliate or a
Director will not constitute an interruption of Continuous Service. The Board or
the chief executive officer of the Company, in that party's sole discretion, may
determine whether Continuous Service shall be considered interrupted in the case
of any leave of absence approved by that party, including sick leave, military
leave or any other personal leave.

         (i)      "COVERED EMPLOYEE" means the chief executive officer and the
four (4) other highest compensated officers of the Company for whom total
compensation is required to be reported to stockholders under the Exchange Act,
as determined for purposes of Section 162(m) of the Code.

         (j)      "DIRECTOR" means a member of the Board of Directors of the
Company.

         (k)      "DISABILITY" means (i) before the Listing Date, the inability
of a person, in the opinion of a qualified physician acceptable to the Company,
to perform the major duties of that person's position with the Company or an
Affiliate of the Company because of the sickness or injury of the person and
(ii) after the Listing Date, the permanent and total disability of a person
within the meaning of Section 22(e)(3) of the Code.

         (l)      "EMPLOYEE" means any person employed by the Company or an
Affiliate. Mere service as a Director or payment of a director's fee by the
Company or an Affiliate shall not be sufficient to constitute "employment" by
the Company or an Affiliate.

         (m)      "EXCHANGE ACT" means the Securities Exchange Act of 1934, as
amended.

         (n)      "FAIR MARKET VALUE" means, as of any date, the value of the
Common Stock determined as follows:

                  (i)      If the Common Stock is listed on any established
         stock exchange or traded on the Nasdaq National Market or the Nasdaq
         SmallCap Market, the Fair Market Value of a share of Common Stock shall
         be the closing sales price for such stock (or the closing bid, if no
         sales were reported) as quoted on such exchange or market (or the
         exchange or market with the greatest volume of trading in the Common
         Stock) on the last market trading day prior to the day of
         determination, as reported in The Wall Street Journal or such other
         source as the Board deems reliable.

                  (ii)     In the absence of such markets for the Common Stock,
         the Fair Market Value shall be determined in good faith by the Board.

         (o)      "INCENTIVE STOCK OPTION" means an Option intended to qualify
as an incentive stock option within the meaning of Section 422 of the Code and
the regulations promulgated thereunder.

         (p)      "LISTING DATE" means the first date upon which any security of
the Company is listed (or approved for listing) upon notice of issuance on any
securities exchange or designated (or approved for designation) upon notice of
issuance as a national market security on an interdealer quotation system.

         (q)      "NON-EMPLOYEE DIRECTOR" means a Director who either (i) is not
a current Employee or Officer of the Company or its parent or a subsidiary, does
not receive compensation (directly or indirectly) from the Company or its parent
for a subsidiary for services rendered as a consultant or in any capacity other
than as a Director (except for an amount as to which disclosure would not be
required under Item 404(a) of Regulation S-K promulgated pursuant to the
Securities Act ("Regulation S-K")), does not possess an interest in any other
transaction as to which disclosure would be required under Item 404(a) of
Regulation S-K and is not engaged in a business relationship as to which
disclosure would

                                      B-2


                                                                      APPENDIX B

be required under Item 404(b) of Regulation S-K; or (ii) is otherwise considered
a "non-employee director" for purposes of Rule 16b-3.

         (r)      "NONSTATUTORY STOCK OPTION" means an Option not intended to
qualify as an Incentive Stock Option.

         (s)      "OFFICER" means (i) before the Listing Date, any person
designated by the Company as an officer and (ii) on and after the Listing Date,
a person who is an officer of the Company within the meaning of Section 16 of
the Exchange Act and the rules and regulations promulgated thereunder.

         (t)      "OPTION" means an Incentive Stock Option or a Nonstatutory
Stock Option granted pursuant to the Plan.

         (u)      "OPTION AGREEMENT" means a written agreement between the
Company and an Optionholder evidencing the terms and conditions of an individual
Option grant. Each Option Agreement shall be subject to the terms and conditions
of the Plan.

         (v)      "OPTIONHOLDER" means a person to whom an Option is granted
pursuant to the Plan or, if applicable, such other person who holds an
outstanding Option.

         (w)      "OUTSIDE DIRECTOR" means a Director who either (i) is not a
current employee of the Company or an "affiliated corporation" (within the
meaning of Treasury Regulations promulgated under Section 162(m) of the Code),
is not a former employee of the Company or an "affiliated corporation" receiving
compensation for prior services (other than benefits under a tax qualified
pension plan), was not an officer of the Company or an "affiliated corporation"
at any time and is not currently receiving direct or indirect remuneration from
the Company or an "affiliated corporation" for services in any capacity other
than as a Director or (ii) is otherwise considered an "outside director" for
purposes of Section 162(m) of the Code.

         (x)      "PARTICIPANT" means a person to whom a Stock Award is granted
pursuant to the Plan or, if applicable, such other person who holds an
outstanding Stock Award.

         (y)      "PLAN" means this Lexicon Genetics Incorporated 2000 Equity
Incentive Plan.

         (z)      "RULE 16B-3" means Rule 16b-3 promulgated under the Exchange
Act or any successor to Rule 16b-3, as in effect from time to time.

         (aa)     "SECURITIES ACT" means the Securities Act of 1933, as amended.

         (bb)     "STOCK AWARD" means any right granted under the Plan,
including an Option, a stock bonus and a right to acquire restricted stock.

         (cc)     "STOCK AWARD AGREEMENT" means a written agreement between the
Company and a holder of a Stock Award evidencing the terms and conditions of an
individual Stock Award grant. Each Stock Award Agreement shall be subject to the
terms and conditions of the Plan.

         (dd)     "TEN PERCENT STOCKHOLDER" means a person who owns (or is
deemed to own pursuant to Section 424(d) of the Code) stock possessing more than
ten percent (10%) of the total combined voting power of all classes of stock of
the Company or of any of its Affiliates.

                                      B-3


                                                                      APPENDIX B

3.       ADMINISTRATION.

         (a)      ADMINISTRATION BY BOARD. The Board shall administer the Plan
unless and until the Board delegates administration to a Committee, as provided
in subsection 3(c).

         (b)      POWERS OF BOARD. The Board shall have the power, subject to,
and within the limitations of, the express provisions of the Plan:

                  (i)      To determine from time to time which of the persons
         eligible under the Plan shall be granted Stock Awards; when and how
         each Stock Award shall be granted; what type or combination of types of
         Stock Award shall be granted; the provisions of each Stock Award
         granted (which need not be identical), including the time or times when
         a person shall be permitted to receive Common Stock pursuant to a Stock
         Award; and the number of shares of Common Stock with respect to which a
         Stock Award shall be granted to each such person.

                  (ii)     To construe and interpret the Plan and Stock Awards
         granted under it, and to establish, amend and revoke rules and
         regulations for its administration. The Board, in the exercise of this
         power, may correct any defect, omission or inconsistency in the Plan or
         in any Stock Award Agreement, in a manner and to the extent it shall
         deem necessary or expedient to make the Plan fully effective.

                  (iii)    To amend the Plan or a Stock Award as provided in
         Section 12.

                  (iv)     Generally, to exercise such powers and to perform
         such acts as the Board deems necessary or expedient to promote the best
         interests of the Company that are not in conflict with the provisions
         of the Plan.

         (c)      DELEGATION TO COMMITTEE.

                  (i)      GENERAL. The Board may delegate administration of the
         Plan to a Committee or Committees of one (1) or more members of the
         Board, and the term "Committee" shall apply to any person or persons to
         whom such authority has been delegated. If administration is delegated
         to a Committee, the Committee shall have, in connection with the
         administration of the Plan, the powers theretofore possessed by the
         Board, including the power to delegate to a subcommittee any of the
         administrative powers the Committee is authorized to exercise (and
         references in this Plan to the Board shall thereafter be to the
         Committee or subcommittee), subject, however, to such resolutions, not
         inconsistent with the provisions of the Plan, as may be adopted from
         time to time by the Board. The Board may abolish the Committee at any
         time and revest in the Board the administration of the Plan.

                  (ii)     COMMITTEE COMPOSITION WHEN COMMON STOCK IS PUBLICLY
         TRADED. At such time as the Common Stock is publicly traded, in the
         discretion of the Board, a Committee may consist solely of two or more
         Outside Directors, in accordance with Section 162(m) of the Code,
         and/or solely of two or more Non-Employee Directors, in accordance with
         Rule 16b-3. Within the scope of such authority, the Board or the
         Committee may (1) delegate to a committee of one or more members of the
         Board who are not Outside Directors the authority to grant Stock Awards
         to eligible persons who are either (a) not then Covered Employees and
         are not expected to be Covered Employees at the time of recognition of
         income resulting from such Stock Award or (b) not persons with respect
         to whom the Company wishes to comply with Section 162(m) of the Code,
         and/or (2) delegate to a committee of one or more members of the Board
         who are not Non-Employee Directors the authority to grant Stock Awards
         to eligible persons who are not then subject to Section 16 of the
         Exchange Act.

         (d)      EFFECT OF BOARD'S DECISION. All determinations,
interpretations and constructions made by the Board in good faith shall not be
subject to review by any person and shall be final, binding and conclusive on
all persons.

                                      B-4


                                                                      APPENDIX B

4.       SHARES SUBJECT TO THE PLAN.

         (a)      SHARE RESERVE. Subject to the provisions of Section 11
relating to adjustments upon changes in Common Stock, the Common Stock that may
be issued pursuant to Stock Awards shall not exceed in the aggregate Eleven
Million, Two Hundred Fifty Thousand (11,250,000) shares.

         (b)      EVERGREEN SHARE RESERVE INCREASE.

                  (i)      Notwithstanding subsection 4(a) hereof on each
         January 1 (the "Calculation Date") for a period of ten (10) years,
         commencing on January 1, 2001, the aggregate number of shares of Common
         Stock that is available for issuance under the Plan shall automatically
         be increased by that number of shares equal to the greater of (1) five
         percent (5%) of the Diluted Shares Outstanding or (2) the number of
         shares of Common Stock subject to Stock Awards granted during the prior
         12-month period; provided, however, that the Board, from time to time,
         may provide for a lesser increase in the aggregate number of shares of
         Common Stock that is available for issuance under the Plan.

                  (ii)     Subject to the provisions of Section 11 hereof
         relating to adjustments upon changes in securities, the increase in the
         maximum aggregate number of shares of Common Stock that is available
         for issuance pursuant to Stock Awards granted under the Plan shall not
         exceed Thirty Million (30,000,000) shares.

                  (iii)    "Diluted Shares Outstanding" shall mean, as of any
         date, (1) the number of outstanding shares of Common Stock of the
         Company on such Calculation Date, plus (2) the number of shares of
         Common Stock issuable upon such Calculation Date assuming the
         conversion of all outstanding Preferred Stock and convertible notes,
         plus (3) the additional number of dilutive Common Stock equivalent
         shares outstanding as the result of any options or warrants outstanding
         during the fiscal year, calculated using the treasury stock method.

         (c)      REVERSION OF SHARES TO THE SHARE RESERVE. If any Stock Award
shall for any reason expire or otherwise terminate, in whole or in part, without
having been exercised in full, the shares of Common Stock not acquired under
such Stock Award shall revert to and again become available for issuance under
the Plan.

         (d)      SOURCE OF SHARES. The shares of Common Stock subject to the
Plan may be unissued shares or reacquired shares, bought on the market or
otherwise.

5.       ELIGIBILITY.

         (a)      ELIGIBILITY FOR SPECIFIC STOCK AWARDS. Incentive Stock Options
may be granted only to Employees. Stock Awards other than Incentive Stock
Options may be granted to Employees, Directors and Consultants.

         (b)      TEN PERCENT STOCKHOLDERS. A Ten Percent Stockholder shall not
be granted an Incentive Stock Option unless the exercise price of such Option is
at least one hundred ten percent (110%) of the Fair Market Value of the Common
Stock at the date of grant and the Option is not exercisable after the
expiration of five (5) years from the date of grant.

         (c)      SECTION 162(m) LIMITATION. Subject to the provisions of
Section 11 relating to adjustments upon changes in the shares of Common Stock,
no Employee shall be eligible to be granted Options covering more than Three
Million (3,000,000) shares during any calendar year. This subsection 5(c) shall
not apply prior to the Listing Date and, following the Listing Date, this
subsection 5(c) shall not apply until (i) the earliest of: (1) the first
material modification of the Plan (including any increase in the number of
shares of Common Stock reserved for issuance under the Plan in accordance with
Section 4); (2) the issuance of all of the shares of Common Stock reserved for
issuance under the Plan; (3) the expiration of the Plan; or (4) the first
meeting of stockholders at which Directors are to be elected that occurs after
the close of the third calendar year following the calendar year in which
occurred the first registration of an equity

                                      B-5


                                                                      APPENDIX B

security under Section 12 of the Exchange Act; or (ii) such other date required
by Section 162(m) of the Code and the rules and regulations promulgated
thereunder.

         (d)      CONSULTANTS.

                  (i)      Prior to the Listing Date, a Consultant shall not be
         eligible for the grant of a Stock Award if, at the time of grant,
         either the offer or the sale of the Company's securities to such
         Consultant is not exempt under Rule 701 of the Securities Act ("Rule
         701") because of the nature of the services that the Consultant is
         providing to the Company, or because the Consultant is not a natural
         person, or as otherwise provided by Rule 701, unless the Company
         determines that such grant need not comply with the requirements of
         Rule 701 and will satisfy another exemption under the Securities Act as
         well as comply with the securities laws of all other relevant
         jurisdictions.

                  (ii)     From and after the Listing Date, a Consultant shall
         not be eligible for the grant of a Stock Award if, at the time of
         grant, a Form S-8 Registration Statement under the Securities Act
         ("Form S-8") is not available to register either the offer or the sale
         of the Company's securities to such Consultant because of the nature of
         the services that the Consultant is providing to the Company, or
         because the Consultant is not a natural person, or as otherwise
         provided by the rules governing the use of Form S-8, unless the Company
         determines both (i) that such grant (A) shall be registered in another
         manner under the Securities Act (e.g., on a Form S-3 Registration
         Statement) or (B) does not require registration under the Securities
         Act in order to comply with the requirements of the Securities Act, if
         applicable, and (ii) that such grant complies with the securities laws
         of all other relevant jurisdictions.

                  (iii)    Rule 701 and Form S-8 generally are available to
         consultants and advisors only if (i) they are natural persons; (ii)
         they provide bona fide services to the issuer, its parents, its
         majority-owned subsidiaries or majority-owned subsidiaries of the
         issuer's parent; and (iii) the services are not in connection with the
         offer or sale of securities in a capital-raising transaction, and do
         not directly or indirectly promote or maintain a market for the
         issuer's securities.

6.       OPTION PROVISIONS.

         Each Option shall be in such form and shall contain such terms and
conditions as the Board shall deem appropriate. All Options shall be separately
designated Incentive Stock Options or Nonstatutory Stock Options at the time of
grant, and, if certificates are issued, a separate certificate or certificates
will be issued for shares of Common Stock purchased on exercise of each type of
Option. The provisions of separate Options need not be identical, but each
Option shall include (through incorporation of provisions hereof by reference in
the Option or otherwise) the substance of each of the following provisions:

         (a)      TERM. Subject to the provisions of subsection 5(b) regarding
Ten Percent Stockholders, no Option granted prior to the Listing Date shall be
exercisable after the expiration of ten (10) years from the date it was granted,
and no Incentive Stock Option granted on or after the Listing Date shall be
exercisable after the expiration of ten (10) years from the date it was granted.

         (b)      EXERCISE PRICE OF AN INCENTIVE STOCK OPTION. Subject to the
provisions of subsection 5(b) regarding Ten Percent Stockholders, the exercise
price of each Incentive Stock Option shall be not less than one hundred percent
(100%) of the Fair Market Value of the Common Stock subject to the Option on the
date the Option is granted. Notwithstanding the foregoing, an Incentive Stock
Option may be granted with an exercise price lower than that set forth in the
preceding sentence if such Option is granted pursuant to an assumption or
substitution for another option in a manner satisfying the provisions of Section
424(a) of the Code.

         (c)      EXERCISE PRICE OF A NONSTATUTORY STOCK OPTION. Subject to the
provisions of subsection 5(b) regarding Ten Percent Stockholders, the exercise
price of each Nonstatutory Stock Option granted prior

                                      B-6


                                                                      APPENDIX B

to the Listing Date shall be not less than eighty-five percent (85%) of the Fair
Market Value of the Common Stock subject to the Option on the date the Option is
granted. The exercise price of each Nonstatutory Stock Option granted on or
after the Listing Date shall be not less than eighty-five percent (85%) of the
Fair Market Value of the Common Stock subject to the Option on the date the
Option is granted. Notwithstanding the foregoing, a Nonstatutory Stock Option
may be granted with an exercise price lower than that set forth in the preceding
sentence if such Option is granted pursuant to an assumption or substitution for
another option in a manner satisfying the provisions of Section 424(a) of the
Code.

         (d)      CONSIDERATION. The purchase price of Common Stock acquired
pursuant to an Option shall be paid, to the extent permitted by applicable
statutes and regulations, either (i) in cash at the time the Option is exercised
or (ii) at the discretion of the Board at the time of the grant of the Option
(or subsequently in the case of a Nonstatutory Stock Option) (1) by delivery to
the Company of other Common Stock, (2) according to a deferred payment or other
similar arrangement with the Optionholder or (3) in any other form of legal
consideration that may be acceptable to the Board. Unless otherwise specifically
provided in the Option, the purchase price of Common Stock acquired pursuant to
an Option that is paid by delivery to the Company of other Common Stock
acquired, directly or indirectly from the Company, shall be paid only by shares
of the Common Stock of the Company that have been held for more than six (6)
months (or such longer or shorter period of time required to avoid a charge to
earnings for financial accounting purposes). At any time that the Company is
incorporated in Delaware, payment of the Common Stock's "par value," as defined
in the Delaware General Corporation Law, shall not be made by deferred payment.

         In the case of any deferred payment arrangement, interest shall be
compounded at least annually and shall be charged at the minimum rate of
interest necessary to avoid the treatment as interest, under any applicable
provisions of the Code, of any amounts other than amounts stated to be interest
under the deferred payment arrangement.

         (e)      TRANSFERABILITY OF AN INCENTIVE STOCK OPTION. An Incentive
Stock Option shall not be transferable except by will or by the laws of descent
and distribution and shall be exercisable during the lifetime of the
Optionholder only by the Optionholder. Notwithstanding the foregoing, the
Optionholder may, by delivering written notice to the Company, in a form
satisfactory to the Company, designate a third party who, in the event of the
death of the Optionholder, shall thereafter be entitled to exercise the Option.

         (f)      TRANSFERABILITY OF A NONSTATUTORY STOCK OPTION. A Nonstatutory
Stock Option granted prior to the Listing Date shall not be transferable except
by will or by the laws of descent and distribution, and to the extent provided
in the Option Agreement and shall be exercisable during the lifetime of the
Optionholder only by the Optionholder. A Nonstatutory Stock Option granted on or
after the Listing Date shall be transferable to the extent provided in the
Option Agreement. If the Nonstatutory Stock Option does not provide for
transferability, then the Nonstatutory Stock Option shall not be transferable
except by will or by the laws of descent and distribution and shall be
exercisable during the lifetime of the Optionholder only by the Optionholder.
Notwithstanding the foregoing, the Optionholder may, by delivering written
notice to the Company, in a form satisfactory to the Company, designate a third
party who, in the event of the death of the Optionholder, shall thereafter be
entitled to exercise the Option.

         (g)      VESTING GENERALLY. The total number of shares of Common Stock
subject to an Option may, but need not, vest and therefore become exercisable in
periodic installments that may, but need not, be equal. The Option may be
subject to such other terms and conditions on the time or times when it may be
exercised (which may be based on performance or other criteria) as the Board may
deem appropriate. The vesting provisions of individual Options may vary. The
provisions of this subsection 6(g) are subject to any Option provisions
governing the minimum number of shares of Common Stock as to which an Option may
be exercised.

         (h)      TERMINATION OF CONTINUOUS SERVICE. In the event an
Optionholder's Continuous Service terminates (other than upon the Optionholder's
death or Disability), the Optionholder may exercise his or her Option (to the
extent that the Optionholder was entitled to exercise such Option as of the date
of termination) but only within such period of time ending on the earlier of (i)
the date three (3) months following the termination of the Optionholder's
Continuous Service (or such longer or shorter period specified in the Option
Agreement, which period shall not be less than thirty (30) days for Options
granted prior to the Listing Date unless such termination is for cause), or (ii)
the

                                      B-7


                                                                      APPENDIX B

expiration of the term of the Option as set forth in the Option Agreement.
If, after termination, the Optionholder does not exercise his or her Option
within the time specified in the Option Agreement, the Option shall terminate.

         (i)      EXTENSION OF TERMINATION DATE. An Optionholder's Option
Agreement may also provide that if the exercise of the Option following the
termination of the Optionholder's Continuous Service (other than upon the
Optionholder's death or Disability) would be prohibited at any time solely
because the issuance of shares of Common Stock would violate the registration
requirements under the Securities Act, then the Option shall terminate on the
earlier of (i) the expiration of the term of the Option set forth in subsection
6(a) or (ii) the expiration of a period of three (3) months after the
termination of the Optionholder's Continuous Service during which the exercise
of the Option would not be in violation of such registration requirements.

         (j)      DISABILITY OF OPTIONHOLDER. In the event that an
Optionholder's Continuous Service terminates as a result of the Optionholder's
Disability, the Optionholder may exercise his or her Option (to the extent that
the Optionholder was entitled to exercise such Option as of the date of
termination), but only within such period of time ending on the earlier of (i)
the date twelve (12) months following such termination (or such longer or
shorter period specified in the Option Agreement, which period shall not be less
than six (6) months for Options granted prior to the Listing Date) or (ii) the
expiration of the term of the Option as set forth in the Option Agreement. If,
after termination, the Optionholder does not exercise his or her Option within
the time specified herein, the Option shall terminate.

         (k)      DEATH OF OPTIONHOLDER. In the event (i) an Optionholder's
Continuous Service terminates as a result of the Optionholder's death or (ii)
the Optionholder dies within the period (if any) specified in the Option
Agreement after the termination of the Optionholder's Continuous Service for a
reason other than death, then the Option may be exercised (to the extent the
Optionholder was entitled to exercise such Option as of the date of death) by
the Optionholder's estate, by a person who acquired the right to exercise the
Option by bequest or inheritance by a person designated to exercise the option
upon the Optionholder's death pursuant to subsection 6(e) or 6(f), but only
within the period ending on the earlier of (1) the date eighteen (18) months
following the date of death (or such longer or shorter period specified in the
Option Agreement, which period shall not be less than six (6) months for Options
granted prior to the Listing Date) or (2) the expiration of the term of such
Option as set forth in the Option Agreement. If, after death, the Option is not
exercised within the time specified herein, the Option shall terminate.

         (l)      EARLY EXERCISE. The Option may, but need not, include a
provision whereby the Optionholder may elect at any time before the
Optionholder's Continuous Service terminates to exercise the Option as to any
part or all of the shares of Common Stock subject to the Option prior to the
full vesting of the Option. Subject to the "Repurchase Limitation" in subsection
10(g), any unvested shares of Common Stock so purchased may be subject to a
repurchase option in favor of the Company or to any other restriction the Board
determines to be appropriate. Provided that the "Repurchase Limitation" in
subsection 10(g) is not violated, the Company will not exercise its repurchase
option until at least six (6) months (or such longer or shorter period of time
required to avoid a charge to earnings for financial accounting purposes) have
elapsed following exercise of the Option unless the Board otherwise specifically
provides in the Option.

         (m)      RIGHT OF REPURCHASE. Subject to the "Repurchase Limitation" in
subsection 10(g), the Option may, but need not, include a provision whereby the
Company may elect, prior to the Listing Date, to repurchase all or any part of
the vested shares of Common Stock acquired by the Optionholder pursuant to the
exercise of the Option. Provided that the "Repurchase Limitation" in subsection
10(g) is not violated, the Company will not exercise its repurchase option until
at least six (6) months (or such longer or shorter period of time required to
avoid a charge to earnings for financial accounting purposes) have elapsed
following exercise of the Option unless the Board otherwise specifically
provides in the Option.

         (n)      RIGHT OF FIRST REFUSAL. The Option may, but need not, include
a provision whereby the Company may elect, prior to the Listing Date, to
exercise a right of first refusal following receipt of notice from the
Optionholder of the intent to transfer all or any part of the shares of Common
Stock received upon the exercise of the

                                      B-8


                                                                      APPENDIX B

Option. Except as expressly provided in this subsection 6(n), such right of
first refusal shall otherwise comply with any applicable provisions of the
Bylaws of the Company.

         (o)      RE-LOAD OPTIONS.

                  (i)      Without in any way limiting the authority of the
         Board to make or not to make grants of Options hereunder, the Board
         shall have the authority (but not an obligation) to include as part of
         any Option Agreement a provision entitling the Optionholder to a
         further Option (a "Re-Load Option") in the event the Optionholder
         exercises the Option evidenced by the Option Agreement, in whole or in
         part, by surrendering other shares of Common Stock in accordance with
         this Plan and the terms and conditions of the Option Agreement. Unless
         otherwise specifically provided in the Option, the Optionholder shall
         not surrender shares of Common Stock acquired, directly or indirectly
         from the Company, unless such shares have been held for more than six
         (6) months (or such longer or shorter period of time required to avoid
         a charge to earnings for financial accounting purposes).

                  (ii)     Any such Re-Load Option shall (1) provide for a
         number of shares of Common Stock equal to the number of shares of
         Common Stock surrendered as part or all of the exercise price of such
         Option; (2) have an expiration date which is the same as the expiration
         date of the Option the exercise of which gave rise to such Re-Load
         Option; and (3) have an exercise price which is equal to one hundred
         percent (100%) of the Fair Market Value of the Common Stock subject to
         the Re-Load Option on the date of exercise of the original Option.
         Notwithstanding the foregoing, a Re-Load Option shall be subject to the
         same exercise price and term provisions heretofore described for
         Options under the Plan.

                  (iii)    Any such Re-Load Option may be an Incentive Stock
         Option or a Nonstatutory Stock Option, as the Board may designate at
         the time of the grant of the original Option; provided, however, that
         the designation of any Re-Load Option as an Incentive Stock Option
         shall be subject to the one hundred thousand dollar ($100,000) annual
         limitation on the exercisability of Incentive Stock Options described
         in subsection 10(d) and in Section 422(d) of the Code. There shall be
         no Re-Load Options on a Re-Load Option. Any such Re-Load Option shall
         be subject to the availability of sufficient shares of Common Stock
         under subsection 4(a) and the "Section 162(m) Limitation" on the grants
         of Options under subsection 5(c) and shall be subject to such other
         terms and conditions as the Board may determine which are not
         inconsistent with the express provisions of the Plan regarding the
         terms of Options.

7.       PROVISIONS OF STOCK AWARDS OTHER THAN OPTIONS.

         (a)      STOCK BONUS AWARDS. Each stock bonus agreement shall be in
such form and shall contain such terms and conditions as the Board shall deem
appropriate. The terms and conditions of stock bonus agreements may change from
time to time, and the terms and conditions of separate stock bonus agreements
need not be identical, but each stock bonus agreement shall include (through
incorporation of provisions hereof by reference in the agreement or otherwise)
the substance of each of the following provisions:

                  (i)      CONSIDERATION. A stock bonus may be awarded in
         consideration for past services actually rendered to the Company or an
         Affiliate for its benefit.

                  (ii)     VESTING. Subject to the "Repurchase Limitation" in
         subsection 10(h), shares of Common Stock awarded under the stock bonus
         agreement may, but need not, be subject to a share repurchase option in
         favor of the Company in accordance with a vesting schedule to be
         determined by the Board.

                  (iii)    TERMINATION OF PARTICIPANT'S CONTINUOUS SERVICE.
         Subject to the "Repurchase Limitation" in subsection 10(g), in the
         event a Participant's Continuous Service terminates, the Company may
         reacquire any or all of the shares of Common Stock held by the
         Participant which have not vested as of the date of termination under
         the terms of the stock bonus agreement.

                                      B-9


                                                                      APPENDIX B

                  (iv)     TRANSFERABILITY. For a stock bonus award made before
         the Listing Date, rights to acquire shares of Common Stock under the
         stock bonus agreement shall not be transferable except by will or by
         the laws of descent and distribution and shall be exercisable during
         the lifetime of the Participant only by the Participant. For a stock
         bonus award made on or after the Listing Date, rights to acquire shares
         of Common Stock under the stock bonus agreement shall be transferable
         by the Participant only upon such terms and conditions as are set forth
         in the stock bonus agreement, as the Board shall determine in its
         discretion, so long as Common Stock awarded under the stock bonus
         agreement remains subject to the terms of the stock bonus agreement.

         (b)      RESTRICTED STOCK AWARDS. Each restricted stock purchase
agreement shall be in such form and shall contain such terms and conditions as
the Board shall deem appropriate. The terms and conditions of the restricted
stock purchase agreements may change from time to time, and the terms and
conditions of separate restricted stock purchase agreements need not be
identical, but each restricted stock purchase agreement shall include (through
incorporation of provisions hereof by reference in the agreement or otherwise)
the substance of each of the following provisions:

                  (i)      PURCHASE PRICE. Subject to the provisions of
         subsection 5(b) regarding Ten Percent Stockholders, the purchase price
         under each restricted stock purchase agreement shall be such amount as
         the Board shall determine and designate in such restricted stock
         purchase agreement. Such purchase price shall not be less than
         eighty-five percent (85%) of the Common Stock's Fair Market Value on
         the date such award is made or at the time the purchase is consummated.

                  (ii)     CONSIDERATION. The purchase price of Common Stock
         acquired pursuant to the restricted stock purchase agreement shall be
         paid either: (i) in cash at the time of purchase; (ii) at the
         discretion of the Board, according to a deferred payment or other
         similar arrangement with the Participant; or (iii) in any other form of
         legal consideration that may be acceptable to the Board in its
         discretion; provided, however, that at any time that the Company is
         incorporated in Delaware, then payment of the Common Stock's "par
         value," as defined in the Delaware General Corporation Law, shall not
         be made by deferred payment.

                  (iii)    VESTING. Subject to the "Repurchase Limitation" in
         subsection 10(g), shares of Common Stock acquired under the restricted
         stock purchase agreement may, but need not, be subject to a share
         repurchase option in favor of the Company in accordance with a vesting
         schedule to be determined by the Board.

                  (iv)     TERMINATION OF PARTICIPANT'S CONTINUOUS SERVICE.
         Subject to the "Repurchase Limitation" in subsection 10(g), in the
         event a Participant's Continuous Service terminates, the Company may
         repurchase or otherwise reacquire any or all of the shares of Common
         Stock held by the Participant which have not vested as of the date of
         termination under the terms of the restricted stock purchase agreement.

                  (v)      TRANSFERABILITY. For a restricted stock award made
         before the Listing Date, rights to acquire shares of Common Stock under
         the restricted stock purchase agreement shall not be transferable
         except by will or by the laws of descent and distribution and shall be
         exercisable during the lifetime of the Participant only by the
         Participant. For a restricted stock award made on or after the Listing
         Date, rights to acquire shares of Common Stock under the restricted
         stock purchase agreement shall be transferable by the Participant only
         upon such terms and conditions as are set forth in the restricted stock
         purchase agreement, as the Board shall determine in its discretion, so
         long as Common Stock awarded under the restricted stock purchase
         agreement remains subject to the terms of the restricted stock purchase
         agreement.

                                      B-10


                                                                      APPENDIX B

8.       COVENANTS OF THE COMPANY.

         (a)      AVAILABILITY OF SHARES. During the terms of the Stock Awards,
the Company shall keep available at all times the number of shares of Common
Stock required to satisfy such Stock Awards.

         (b)      SECURITIES LAW COMPLIANCE. The Company shall seek to obtain
from each regulatory commission or agency having jurisdiction over the Plan such
authority as may be required to grant Stock Awards and to issue and sell shares
of Common Stock upon exercise of the Stock Awards; provided, however, that this
undertaking shall not require the Company to register under the Securities Act
the Plan, any Stock Award or any Common Stock issued or issuable pursuant to any
such Stock Award. If, after reasonable efforts, the Company is unable to obtain
from any such regulatory commission or agency the authority which counsel for
the Company deems necessary for the lawful issuance and sale of Common Stock
under the Plan, the Company shall be relieved from any liability for failure to
issue and sell Common Stock upon exercise of such Stock Awards unless and until
such authority is obtained.

9.       USE OF PROCEEDS FROM STOCK.

         Proceeds from the sale of Common Stock pursuant to Stock Awards shall
constitute general funds of the Company.

10.      MISCELLANEOUS.

         (a)      ACCELERATION OF EXERCISABILITY AND VESTING. The Board shall
have the power to accelerate the time at which a Stock Award may first be
exercised or the time during which a Stock Award or any part thereof will vest
in accordance with the Plan, notwithstanding the provisions in the Stock Award
stating the time at which it may first be exercised or the time during which it
will vest.

         (b)      STOCKHOLDER RIGHTS. No Participant shall be deemed to be the
holder of, or to have any of the rights of a holder with respect to, any shares
of Common Stock subject to such Stock Award unless and until such Participant
has satisfied all requirements for exercise of the Stock Award pursuant to its
terms.

         (c)      NO EMPLOYMENT OR OTHER SERVICE RIGHTS. Nothing in the Plan or
any instrument executed or Stock Award granted pursuant thereto shall confer
upon any Participant any right to continue to serve the Company or an Affiliate
in the capacity in effect at the time the Stock Award was granted or shall
affect the right of the Company or an Affiliate to terminate (i) the employment
of an Employee with or without notice and with or without cause, (ii) the
service of a Consultant pursuant to the terms of such Consultant's agreement
with the Company or an Affiliate or (iii) the service of a Director pursuant to
the Bylaws of the Company or an Affiliate, and any applicable provisions of the
corporate law of the state in which the Company or the Affiliate is
incorporated, as the case may be.

         (d)      INCENTIVE STOCK OPTION $100,000 LIMITATION. To the extent that
the aggregate Fair Market Value (determined at the time of grant) of Common
Stock with respect to which Incentive Stock Options are exercisable for the
first time by any Optionholder during any calendar year (under all plans of the
Company and its Affiliates) exceeds one hundred thousand dollars ($100,000), the
Options or portions thereof which exceed such limit (according to the order in
which they were granted) shall be treated as Nonstatutory Stock Options.

         (e)      INVESTMENT ASSURANCES. The Company may require a Participant,
as a condition of exercising or acquiring Common Stock under any Stock Award,
(i) to give written assurances satisfactory to the Company as to the
Participant's knowledge and experience in financial and business matters and/or
to employ a purchaser representative reasonably satisfactory to the Company who
is knowledgeable and experienced in financial and business matters and that he
or she is capable of evaluating, alone or together with the purchaser
representative, the merits and risks of exercising the Stock Award; and (ii) to
give written assurances satisfactory to the Company stating that the Participant
is acquiring Common Stock subject to the Stock Award for the Participant's own
account and not with any present intention of selling or otherwise distributing
the Common Stock. The foregoing requirements, and any assurances given pursuant
to such

                                      B-11


                                                                      APPENDIX B

requirements, shall be inoperative if (1) the issuance of the shares of Common
Stock upon the exercise or acquisition of Common Stock under the Stock Award has
been registered under a then currently effective registration statement under
the Securities Act or (2) as to any particular requirement, a determination is
made by counsel for the Company that such requirement need not be met in the
circumstances under the then applicable securities laws. The Company may, upon
advice of counsel to the Company, place legends on stock certificates issued
under the Plan as such counsel deems necessary or appropriate in order to comply
with applicable securities laws, including, but not limited to, legends
restricting the transfer of the Common Stock.

         (f)      WITHHOLDING OBLIGATIONS. To the extent provided by the terms
of a Stock Award Agreement, the Participant may satisfy any federal, state or
local tax withholding obligation relating to the exercise or acquisition of
Common Stock under a Stock Award by any of the following means (in addition to
the Company's right to withhold from any compensation paid to the Participant by
the Company) or by a combination of such means: (i) tendering a cash payment;
(ii) authorizing the Company to withhold shares of Common Stock from the shares
of Common Stock otherwise issuable to the Participant as a result of the
exercise or acquisition of Common Stock under the Stock Award, provided,
however, that no shares of Common Stock are withheld with a value exceeding the
minimum amount of tax required to be withheld by law; or (iii) delivering to the
Company owned and unencumbered shares of Common Stock.

         (g)      REPURCHASE LIMITATION. The terms of any repurchase option
shall be specified in the Stock Award and may be either at Fair Market Value at
the time of repurchase or at not less than the original purchase price.

11.      ADJUSTMENTS UPON CHANGES IN STOCK.

         (a)      CAPITALIZATION ADJUSTMENTS. If any change is made in the
Common Stock subject to the Plan, or subject to any Stock Award, without the
receipt of consideration by the Company (through merger, consolidation,
reorganization, recapitalization, reincorporation, stock dividend, dividend in
property other than cash, stock split, liquidating dividend, combination of
shares, exchange of shares, change in corporate structure or other transaction
not involving the receipt of consideration by the Company), the Plan will be
appropriately adjusted in the class(es) and maximum number of securities subject
to the Plan pursuant to subsection 4(a) and the maximum number of securities
subject to award to any person pursuant to subsection 5(c), and the outstanding
Stock Awards will be appropriately adjusted in the class(es) and number of
securities and price per share of Common Stock subject to such outstanding Stock
Awards. The Board shall make such adjustments, and its determination shall be
final, binding and conclusive. (The conversion of any convertible securities of
the Company shall not be treated as a transaction "without receipt of
consideration" by the Company.)

         (b)      CHANGE IN CONTROL -- DISSOLUTION OR LIQUIDATION. In the event
of a dissolution or liquidation of the Company, then all outstanding Stock
Awards shall terminate immediately prior to such event.

         (c)      CHANGE IN CONTROL -- ASSET SALE, MERGER, CONSOLIDATION OR
REVERSE MERGER. In the event of (i) a sale, lease or other disposition of all or
substantially all of the assets of the Company, (ii) a merger or consolidation
in which the Company is not the surviving corporation or (iii) a reverse merger
in which the Company is the surviving corporation but the shares of Common Stock
outstanding immediately preceding the merger are converted by virtue of the
merger into other property, whether in the form of securities, cash or
otherwise, then any surviving corporation or acquiring corporation shall assume
any Stock Awards outstanding under the Plan or shall substitute similar stock
awards (including an award to acquire the same consideration paid to the
stockholders in the transaction described in this subsection 11(c) for those
outstanding under the Plan). In the event any surviving corporation or acquiring
corporation refuses to assume such Stock Awards or to substitute similar stock
awards for those outstanding under the Plan, then with respect to Stock Awards
held by Participants whose Continuous Service has not terminated, the vesting of
such Stock Awards (and, if applicable, the time during which such Stock Awards
may be exercised) shall be accelerated in full, and the Stock Awards shall
terminate if not exercised (if applicable) at or prior to such event. With
respect to any other Stock Awards outstanding under the Plan, such Stock Awards
shall terminate if not exercised (if applicable) prior to such event.

                                      B-12


                                                                      APPENDIX B

12.      AMENDMENT OF THE PLAN AND STOCK AWARDS.

         (a)      AMENDMENT OF PLAN. The Board at any time, and from time to
time, may amend the Plan. However, except as provided in Section 11 relating to
adjustments upon changes in Common Stock, no amendment shall be effective unless
approved by the stockholders of the Company to the extent stockholder approval
is necessary to satisfy the requirements of Section 422 of the Code, Rule 16b-3
or any Nasdaq or securities exchange listing requirements.

         (b)      STOCKHOLDER APPROVAL. The Board may, in its sole discretion,
submit any other amendment to the Plan for stockholder approval, including, but
not limited to, amendments to the Plan intended to satisfy the requirements of
Section 162(m) of the Code and the regulations thereunder regarding the
exclusion of performance-based compensation from the limit on corporate
deductibility of compensation paid to certain executive officers.

         (c)      CONTEMPLATED AMENDMENTS. It is expressly contemplated that the
Board may amend the Plan in any respect the Board deems necessary or advisable
to provide eligible Employees with the maximum benefits provided or to be
provided under the provisions of the Code and the regulations promulgated
thereunder relating to Incentive Stock Options and/or to bring the Plan and/or
Incentive Stock Options granted under it into compliance therewith.

         (d)      NO IMPAIRMENT OF RIGHTS. Rights under any Stock Award granted
before amendment of the Plan shall not be impaired by any amendment of the Plan
unless (i) the Company requests the consent of the Participant and (ii) the
Participant consents in writing.

         (e)      AMENDMENT OF STOCK AWARDS. The Board at any time, and from
time to time, may amend the terms of any one or more Stock Awards; provided,
however, that the rights under any Stock Award shall not be impaired by any such
amendment unless (i) the Company requests the consent of the Participant and
(ii) the Participant consents in writing.

13. TERMINATION OR SUSPENSION OF THE PLAN.

         (a)      PLAN TERM. The Board may suspend or terminate the Plan at any
time. Unless sooner terminated, the Plan shall terminate on the day before the
tenth (10th) anniversary of the date the Plan is adopted by the Board or
approved by the stockholders of the Company, whichever is earlier. No Stock
Awards may be granted under the Plan while the Plan is suspended or after it is
terminated.

         (b)      NO IMPAIRMENT OF RIGHTS. Suspension or termination of the Plan
shall not impair rights and obligations under any Stock Award granted while the
Plan is in effect except with the written consent of the Participant.

14.      EFFECTIVE DATE OF PLAN.

         The Plan shall become effective as determined by the Board, but no
Stock Award shall be exercised (or, in the case of a stock bonus, shall be
granted) unless and until the Plan has been approved by the stockholders of the
Company, which approval shall be within twelve (12) months before or after the
date the Plan is adopted by the Board.

15.      CHOICE OF LAW.

         The law of the State of Delaware shall govern all questions concerning
the construction, validity and interpretation of this Plan, without regard to
such state's conflict of laws rules.

                                      B-13


                                                                      APPENDIX C

                          LEXICON GENETICS INCORPORATED
                             AUDIT COMMITTEE CHARTER

GENERAL PURPOSE

         The Audit Committee of Lexicon Genetics Incorporated (the "Company") is
appointed by the Board of Directors of the Company (the "Board") to assist the
Board in monitoring (1) the integrity of the financial statements of the
Company, (2) the independent auditor's qualifications and independence, (3) the
performance of the Company's independent auditors and (4) the compliance by the
Company with legal and regulatory requirements.

COMMITTEE MEMBERSHIP

         The Audit Committee shall consist of no fewer than three members. The
members of the Audit Committee shall meet the independence and experience
requirements of The Nasdaq Stock Market, Inc. (or any other exchange on which
the Company's securities are listed) and the Securities Exchange Act of 1934,
including all rules and regulations promulgated thereunder (the "Exchange Act").
At least one member of the Audit Committee shall be an "audit committee
financial expert" as defined by the rules of the Securities and Exchange
Commission (the "Commission"). The members of the Audit Committee shall be
appointed or replaced by the Board on the recommendation of the Chairman of the
Board.

MEETINGS

         The Audit Committee shall meet as often as it determines, but not less
frequently than quarterly. The Audit Committee shall meet periodically with
management and the independent auditor in separate executive sessions. The Audit
Committee may request any officer or employee of the Company or the Company's
outside counsel or independent auditor to attend a meeting of the Committee or
to meet with any members of, or advisors to, the Committee.

COMMITTEE AUTHORITY AND RESPONSIBILITIES

         The Audit Committee shall have the sole authority to appoint or replace
the independent auditor (subject, if applicable, to shareholder ratification).
The Audit Committee shall be directly responsible for the determination of
appropriate compensation and oversight of the work of the independent auditor
(including resolution of disagreements between management and the independent
auditor regarding financial reporting) for the purpose of preparing or issuing
an audit report or related work. The independent auditor shall report directly
to the Audit Committee.

         The Audit Committee shall preapprove all auditing services and
permitted non-audit services (including the fees and terms thereof) to be
performed for the Company by its independent auditor, subject to the de minimis
exceptions for non-audit services described in Section 10A(i)(1)(B) of the
Exchange Act which are approved by the Audit Committee prior to the completion
of the audit. The Audit Committee may form and delegate authority to
subcommittees consisting of one or more members when appropriate, including the
authority to grant preapprovals of audit and permitted non-audit services,
provided that decisions of such subcommittee to grant preapprovals shall be
presented to the full Audit Committee at its next scheduled meeting.

         The Audit Committee shall have the authority, to the extent it deems
necessary or appropriate, to retain independent legal, accounting or other
advisors.

         The Company shall provide for appropriate funding, as determined by the
Audit Committee, for payment of compensation to the independent auditor for the
purpose of rendering or issuing an audit report or related work and to any
advisors retained by the Audit Committee.

         The Audit Committee shall make regular reports to the Board and shall
prepare the report required by the Exchange Act to be included in the Company's
annual proxy statement. The Audit Committee shall review and reassess the
adequacy of this Charter annually and recommend any proposed changes to the
Board for its approval. The Audit Committee shall annually review the Audit
Committee's own performance.

                                      C-1


                                                                      APPENDIX C

         The Audit Committee, to the extent it deems necessary or appropriate,
         shall:

         Financial Statement and Disclosure Matters

                  1.       Review and discuss with management and the
         independent auditor the annual audited financial statements, including
         disclosures made in management's discussion and analysis, and recommend
         to the Board whether the audited financial statements should be
         included in the Company's Form 10 K.

                  2.       Review and discuss with management and the
         independent auditor the Company's quarterly financial statements prior
         to the filing of its Form 10 Q, including the results of the
         independent auditor's review of the quarterly financial statements.

                  3.       Discuss with management and the independent auditor
         significant financial reporting issues and judgments made in connection
         with the preparation of the Company's financial statements, including
         any significant changes in the Company's selection or application of
         accounting principles, any major issues as to the adequacy of the
         Company's internal controls and any special steps adopted in light of
         material control deficiencies.

                  4.       Review and discuss quarterly reports from the
         independent auditors on:

                           (a)      All critical accounting policies and
                  practices to be used.

                           (b)      All alternative treatments of financial
                  information within generally accepted accounting principles
                  that have been discussed with management, ramifications of the
                  use of such alternative disclosures and treatments, and the
                  treatment preferred by the independent auditor.

                           (c)      Other material written communications
                  between the independent auditor and management, such as any
                  management letter or schedule of unadjusted differences.

                  5.       Discuss with management the Company's earnings press
         releases, including the use of "pro forma" or "adjusted" non-GAAP
         information, as well as financial information and earnings guidance
         provided to analysts and rating agencies. Such discussion may be done
         generally (consisting of discussing the types of information to be
         disclosed and the types of presentations to be made).

                  6.       Discuss with management and the independent auditor
         the selection and application of accounting principles for the
         Company's significant transactions.

                  7.       Discuss with management and the independent auditor
         the effect of financial, regulatory and accounting initiatives as well
         as off-balance sheet structures on the Company's financial statements.

                  8.       Discuss with management the Company's major financial
         risk exposures and the steps management has taken to monitor and
         control such exposures, including the Company's risk assessment and
         risk management policies.

                  9.       Discuss with the independent auditor the matters
         required to be discussed by Statement on Auditing Standards No. 61
         relating to the conduct of the audit, including any difficulties
         encountered in the course of the audit work, any restrictions on the
         scope of activities or access to requested information, and any
         significant disagreements with management.

                  10.      Review disclosures made to the Audit Committee by the
         Company's CEO and CFO during their certification process for the Form
         10-K and Form 10-Q about any significant deficiencies in the design or
         operation of internal controls or material weaknesses therein and any
         fraud involving management or other employees who have a significant
         role in the Company's internal controls.

                                      C-2


                                                                      APPENDIX C

         Oversight of the Company's Relationship with the Independent Auditor

                  11.      Review and evaluate the lead partner of the
         independent auditor team.

                  12.      Obtain and review a report from the independent
         auditor at least annually regarding (a) the independent auditor's
         internal quality-control procedures, (b) any material issues raised by
         the most recent internal quality-control review, or peer review, of the
         firm, or by any inquiry or investigation by governmental or
         professional authorities within the preceding five years respecting one
         or more independent audits carried out by the firm, (c) any steps taken
         to deal with any such issues, and (d) all relationships between the
         independent auditor and the Company. Evaluate the qualifications,
         performance and independence of the independent auditor, including
         considering whether the auditor's quality controls are adequate and the
         provision of permitted non-audit services is compatible with
         maintaining the auditor's independence, taking into account the
         opinions of management. The Audit Committee shall present its
         conclusions with respect to the independent auditor to the Board.

                  13.      Ensure the rotation of the audit partners as required
         by law. Consider whether, in order to assure continuing auditor
         independence, it is appropriate to adopt a policy of rotating the
         independent auditing firm on a regular basis.

                  14.      Recommend to the Board policies for the Company's
         hiring of employees or former employees of the independent auditor who
         participated in any capacity in the audit of the Company.

                  15.      Discuss with the national office of the independent
         auditor issues on which they were consulted by the Company's audit team
         and matters of audit quality and consistency.

                  16.      Meet with the independent auditor prior to the audit
         to discuss the planning and staffing of the audit.

         Compliance Oversight Responsibilities

                  17.      Obtain from the independent auditor assurance that
         Section 10A(b) of the Exchange Act has not been implicated.

                  18.      Obtain reports from management and the independent
         auditor that the Company and its subsidiary/foreign affiliated entities
         are in conformity with applicable legal requirements and the Company's
         internal policies. Review reports and disclosures of insider and
         affiliated party transactions. Advise the Board with respect to the
         Company's policies and procedures regarding compliance with applicable
         laws and regulations and with the Company's internal policies.

                  19.      Establish procedures for the receipt, retention and
         treatment of complaints received by the Company regarding accounting,
         internal accounting controls or auditing matters, and the confidential,
         anonymous submission by employees of concerns regarding questionable
         accounting or auditing matters.

                  20.      Discuss with management and the independent auditor
         any correspondence with regulators or governmental agencies and any
         published reports which raise material issues regarding the Company's
         financial statements or accounting policies.

                  21.      Discuss with the Company's General Counsel legal
         matters that may have a material impact on the financial statements or
         the Company's compliance policies.

         The Audit Committee shall also have such other authority and
responsibilities as may be determined from time to time by the Board.

                                      C-3


                                                                      APPENDIX C

LIMITATION OF AUDIT COMMITTEE'S ROLE

         While the Audit Committee has the authority and responsibilities set
forth in this Charter, it is not the duty of the Audit Committee to (1) plan or
conduct audits, (2) determine that the Company's financial statements and
disclosures are complete, accurate and fairly presented and are in accordance
with generally accepted accounting principles and applicable rules and
regulations or (3) assure compliance with the Company's internal controls and
policies. These are the responsibilities of management or the independent
auditor.

                                      C-4


PROXY
                          LEXICON GENETICS INCORPORATED
                         ANNUAL MEETING OF STOCKHOLDERS
                                  MAY 19, 2004

         THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS OF
                          LEXICON GENETICS INCORPORATED


         The undersigned hereby appoints Arthur T. Sands and Jeffrey L. Wade,
and each of them, as proxies and attorneys-in-fact, with the power to act
without the other and with power of substitution, to represent the undersigned
at the Annual Meeting of Stockholders of Lexicon Genetics Incorporated (the
"Company") to be held at The Marriott Woodlands Waterway Hotel and Convention
Center, 1601 Lake Robbins Drive, The Woodlands, Texas, on May 19, 2004, at 1:30
p.m., local time, and any adjournments or postponements thereof, and to vote all
of the shares of stock the undersigned would be entitled to vote if personally
present at such meeting (1) as provided on the other side of this proxy and (2),
in their discretion, on such other business as may properly come before such
meeting or any adjournment or postponement thereof.

          (CONTINUED AND TO BE MARKED, DATED AND SIGNED ON OTHER SIDE)
--------------------------------------------------------------------------------
    ADDRESS CHANGE/COMMENTS (MARK THE CORRESPONDING BOX ON THE REVERSE SIDE)







--------------------------------------------------------------------------------
                            --FOLD AND DETACH HERE--




                                                                                                            

THE BOARD OF DIRECTORS RECOMMENDS A VOTE FOR PROPOSALS 1, 2 AND 3.                        Please
                                                                                          Mark Here
                                                                                          for Address           [ ]
                                                                                          Change or
                                                                                          Comments
                                                                                          SEE REVERSE SIDE

THIS PROXY WILL BE VOTED AS DIRECTED OR, IF NO
DIRECTION IS INDICATED, WILL BE VOTED:

"FOR" the election of the nominees for Class I
Director;

"FOR" the proposal to ratify and approve the                                                              FOR    AGAINST   ABSTAIN
Company's existing 2000 Equity Incentive Plan so
that grants under the plan will remain exempt from                     2. Ratification and approval of
a cap on deductible compensation imposed by                            the Company's existing 2000
Section 162(m) of the Internal Revenue Code; and                       Equity Incentive Plan so that
                                                                       grants under the plan will remain   [ ]     [ ]      [ ]
                                                                       exempt from a cap on
                                                                       deductible compensation imposed
                                                                       by section 162(m)
                                                                       of the Internal Revenue Code.

"FOR" the proposal to ratify and approve the
appointment of Ernst & Young LLP as the Company's                                                         FOR    AGAINST   ABSTAIN
independent public accountants for the fiscal year                     3. Ratification and approval
ending December 31, 2004.                                              of the appointment of
                                                                       Ernst & Young LLP as the
                                                                       Company's independent               [ ]     [ ]      [ ]
                                                                       auditors for the fiscal year
1. ELECTION OF CLASS I DIRECTORS:          FOR           WITHHOLD      ending December 31,2004.
                                           all          AUTHORITY
                                         nominees        to vote
                                          listed          for
                                         except as        all
                                         indicated      nominees

Nominees: 01 Robert J. Lefkowitz, M.D.
          02 Alan S. Nies, M.D.           [ ]            [ ]

INSTRUCTION: To withhold authority to vote for any                               IF YOU PLAN TO ATTEND THE MEETING IN PERSON,
individual nominee, write that nominee's name on                                           PLEASE MARK THE FOLLOWING BOX. [ ]
the following line.


-------------------------------------------------------                          Dated:                              , 2004
                                                                                       -----------------------------

                                                                                 ------------------------------------------
                                                                                                 (Signature)


                                                                                 ------------------------------------------
                                                                                         (Signature if held jointly)

                                                                                 Please date, sign as name appears at the
                                                                                 left, and return promptly. If the shares are
                                                                                 registered in the names of two or more
                                                                                 persons, each should sign. When signing as
                                                                                 Corporate Officer, President, Executor,
                                                                                 Administrator, Trustee or Guardian, please
                                                                                 give full title. Please note any changes in
                                                                                 your address alongside the address as it
                                                                                 appears in the proxy.
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                                                    --FOLD AND DETACH HERE--