UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549

                                    FORM 8-K




                                 CURRENT REPORT



                     Pursuant to Section 13 or 15(d) of the
                         Securities Exchange Act of 1934


      Date of Report (Date of Earliest Event Reported): September 23, 2004


                                    XOMA LTD.
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             (Exact name of registrant as specified in its charter)


                                     BERMUDA
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                 (State or other jurisdiction of incorporation)


              0-14710                                      52-2154066
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     (Commission File Number)                 (IRS Employer Identification No.)

2910 Seventh Street, Berkeley, California                                  94710
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(Address of principal executive offices)                              (Zip code)

Registrant's telephone number, including area code                (510) 204-7200
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          (Former name or former address, if changed since last report)










Item 8.01. Other Events

     As announced on September 23, 2004, XOMA Ltd. and Aphton Corporation have
entered into a collaborative agreement.

     A copy of the press release is attached hereto as Exhibit 1 and is
incorporated herein by reference.

Item 9.01. Exhibits

1. Press Release dated September 23, 2004.







                                      -2-

                                    SIGNATURE

     Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.

Dated:  September 23, 2004                XOMA LTD.




                                          By:  /s/  Christopher J. Margolin
                                               -------------------------------
                                               Christopher J. Margolin
                                               Vice President, General
                                               Counsel and Secretary









                                  EXHIBIT INDEX


Number   Description

1. Press Release dated September 23, 2004.