On January 6, 2015, Alfred E. Mann notified our Board of Directors of his decision to resign as our Chief Executive Officer, which resignation became effective on January 9, 2015. Mr. Mann continues to serve as the Chairman of our Board of Directors.

On January 9, 2015, our Board of Directors appointed Hakan S. Edstrom to the position of Chief Executive Officer. Mr. Edstrom concurrently resigned as our Chief Operating Officer but continues to serve as our President. Concurrently with Mr. Edstrom's resignation from the position, our Board of Directors appointed Juergen A. Martens, Ph.D. as our Chief Operating Officer.

Mr. Edstrom, age 64, has been our President and, until his resignation from the position on January 9, 2015, our Chief Operating Officer since April 2001, and has served as one of our directors since December 2001. Mr. Edstrom was with Bausch & Lomb, Inc., a health care product company, from January 1998 to April 2001, advancing to the position of Senior Corporate Vice President and President of Bausch & Lomb, Inc. Americas Region. From 1981 to 1997, Mr. Edstrom was with Pharmacia Corporation, where he held various executive positions, including President and Chief Executive Officer of Pharmacia Ophthalmics Inc. Mr. Edstrom was educated in Sweden and holds a master's degree in Business Administration from the Stockholm School of Economics.

Dr. Martens, age 59, has been our Chief Technology Officer since September 2005. From September 2005 until June 2011, Dr. Martens served as our Corporate Vice President of Technical Operations, and from June 2011 until his appointment as our Chief Operating Officer on January 9, 2015, Dr. Martens served as our Corporate Vice President of Pharmaceutical Development and Technical Operations. From 2000 to August 2005, he was employed by Nektar Therapeutics, most recently as Vice President of Pharmaceutical Technology Development. Previously, he held technical management positions at Aerojet Fine Chemicals from 1998 to 2000 and at FMC Corporation from 1996 to 1998. From 1987 to 1996, Dr. Martens held a variety of management positions with increased responsibility in research and development, plant management, and business process development at Lonza, a global biological product manufacturing company, in Switzerland and in the United States. Dr. Martens holds a bachelor's degree in chemical engineering from the Technical College Mannheim/Germany, a bachelor's and master's degree in Chemistry and a doctorate in Physical Chemistry from the University of Marburg/Germany.

The information called for by Item 5.02(c)(3) of Form 8-K has not been determined as of the date of filing this report.

On January 12, 2015, we issued a press release announcing certain of the management transitions described above, which is attached hereto as Exhibit 99.1.