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                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                   ----------


                                    FORM 11-K

    FOR ANNUAL REPORTS OF EMPLOYEE STOCK REPURCHASE SAVINGS AND SIMILAR PLANS
                        PURSUANT TO SECTION 15(d) OF THE
                         SECURITIES EXCHANGE ACT OF 1934


(MARK ONE)


|X|  ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES
     EXCHANGE ACT OF 1934

FOR THE FISCAL YEAR ENDED DECEMBER 31, 2004

                                       OR

|_|  TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES
     EXCHANGE ACT OF 1934

FOR THE TRANSITION PERIOD FROM ______________ TO ______________

                        COMMISSION FILE NUMBER 001-09974

                                   ----------

             Enzo Biochem, Inc. Salary Reduction Profit Sharing Plan

     (Full title of the plan and the address of the plan, if different from that
     of the issuer named below:)

        ENZO BIOCHEM, INC., 60 EXECUTIVE BOULEVARD, FARMINGDALE, NY 11735

     (Name of issuer of the securities held pursuant to the plan and the address
     of its principal executive office)

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                               ENZO BIOCHEM, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN

                               TABLE OF CONTENTS



REPORT OF WATSON RICE LLP
    INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM ......................... F-1

FINANCIAL STATEMENTS FOR THE YEARS ENDED
    DECEMBER 31, 2004 AND 2003:

      Statements of Net Assets Available for Benefits ..................... F-2

      Statement of Changes in Net Assets Available for Benefits............ F-3

      Notes to Financial Statements ....................................... F-4

 SUPPLEMENTAL SCHEDULE FOR THE YEAR ENDED
    DECEMBER 31, 2004:

      Schedule H, Item 4i --
      Schedule of Assets Held at End of Year .............................. F-8




             REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM



To the Trustees of
Enzo Biochem, Inc. Salary Reduction Profit Sharing Plan


We have audited the accompanying statements of net assets available for benefits
of Enzo Biochem,  Inc. Salary  Reduction  Profit Sharing Plan (the "Plan") as of
December 31, 2004 and 2003,  and the related  statement of changes in net assets
available  for benefits for the year ended  December 31, 2004.  These  financial
statements are the responsibility of the Plan's  management.  Our responsibility
is to express an opinion on these financial statements based on our audits.

We conducted our audit in accordance with generally  accepted auditing standards
as established by the Auditing Standards Board (United States) and in accordance
with the  standards of the Public  Company  Accounting  Oversight  Board (United
States).  Those  standards  require that we plan and perform the audit to obtain
reasonable assurance about whether the financial statements are free of material
misstatement.  The Plan is not required to have, nor were we engaged to perform,
an audit of its internal  control over financial  reporting.  Our audit included
consideration  of  internal  control  over  financial  reporting  as a basis for
designing audit  procedures that are appropriate in the  circumstances,  but not
for the  purpose of  expressing  an opinion on the  effectiveness  of the Plan's
internal  control  over  financial  reporting.  Accordingly,  we express no such
opinion. An audit also includes examining,  on a test basis, evidence supporting
the amounts and disclosures in the financial statements.  An audit also includes
assessing the  accounting  principles  used and  significant  estimates  made by
management,  as well as evaluating the overall financial statement presentation.
We believe that our audits provide a reasonable basis for our opinion.

In our opinion,  the financial  statements  referred to above present fairly, in
all material  respects,  the net assets available for benefits of the Plan as of
December 31, 2004 and 2003 and the changes in net assets  available for benefits
for the year ended December 31, 2004 in conformity  with  accounting  principles
generally accepted in the United States of America.

Our audits  were  conducted  for the  purpose of forming an opinion on the basic
financial statements taken as a whole. The supplemental  schedule of assets held
for investment  purposes at the end of the year, is presented for the purpose of
additional analysis and is not a required part of the basic financial statements
but is supplementary information required by the Department of Labor's Rules and
Regulations for Reporting and Disclosure  under the Employee  Retirement  Income
Security Act of 1974. The  supplemental  schedule is the  responsibility  of the
Plan's management.  The supplemental schedule has been subjected to the auditing
procedures  applied in the audit of the basic  financial  statements and, in our
opinion,  is fairly  stated in all  material  respects  in relation to the basic
financial statements taken as a whole.




Watson Rice LLP

May 23, 2005
New York, New York




                                                                          Page 2


                               ENZO BIOCHEM, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN

                 STATEMENTS OF NET ASSETS AVAILABLE FOR BENEFITS

                                  DECEMBER 31,





                                                      2004              2003
                                                   -----------       -----------

ASSETS

Cash                                               $    13,334       $        --
Investments at Fair Value:
    Mutual funds                                     7,765,886         6,213,531
    Common stock                                     2,289,847         1,685,349
                                                   -----------       -----------
                                                    10,055,733         7,898,880
                                                   -----------       -----------

Receivables:
    Employer's contributions                           351,579           282,239
    Participants' contributions                         19,258               480
                                                   -----------       -----------
                                                       370,837           282,719
                                                   -----------       -----------

Loans receivable - participants                        218,831           235,312
                                                   -----------       -----------

TOTAL ASSETS                                        10,658,735         8,416,911
                                                   -----------       -----------


LIABILITIES

  Benefit claims payable                                 6,333                --
                                                   -----------       -----------

TOTAL LIABILITIES                                        6,333                --
                                                   -----------       -----------

NET ASSETS AVAILABLE FOR BENEFITS                  $10,652,402       $ 8,416,911
                                                   ===========       ===========





See notes to financial statements.




                                                                          Page 3


                               ENZO BIOCHEM, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN

            STATEMENT OF CHANGES IN NET ASSETS AVAILABLE FOR BENEFITS

                      FOR THE YEAR ENDED DECEMBER 31, 2004






Additions to Net Assets Attributed to:
  Participants' contributions                                        $   885,264
  Employer's contributions                                               351,579
  Rollovers                                                               24,149
  Interest on loans to participants                                       11,413
  Investment income                                                      102,623

  Net appreciation in fair value of investments:
      Mutual funds                                         752,772
      Common stock                                         190,241       943,013
                                                        ----------   -----------

         Total Additions                                               2,318,041
                                                                     -----------

Deductions from Net Assets Attributed to:
  Benefits paid to participants                                           57,715
  Administrative expenses                                                 24,835
                                                                     -----------

         Total Deductions                                                 82,550
                                                                     -----------

Net increase in net assets                                             2,235,491

Net Assets Available for Benefits, Beginning of Year                   8,416,911
                                                                     -----------

Net Assets Available for Benefits, End of Year                       $10,652,402
                                                                     ===========





See notes to financial statements.




                                                                          Page 4

                               ENZO BIOCHEM, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN

                          NOTES TO FINANCIAL STATEMENTS



NOTE 1:       PLAN DESCRIPTION

              The  following  description  of  the  Enzo  Biochem,  Inc.  Salary
              Reduction  Profit-Sharing  Plan ("the Plan") provides only general
              information.  Participants should refer to the Plan Agreement,  as
              amended, for a more complete description of the Plan's provisions.

              GENERAL

              The Plan is a defined contribution plan covering all eligible full
              time employees of Enzo Biochem,  Inc.,  Enzo Clinical Labs,  Inc.,
              Enzo  Therapeutics,  Inc. and Enzo Life Sciences (the "Companies")
              who have  completed  three months of service and have attained age
              twenty-one.

              The Plan is subject to the  provisions of the Employee  Retirement
              Income Security Act of 1974 (ERISA).

              CONTRIBUTIONS

              Eligible  employees  can  elect  to  defer  up  to  17%  of  their
              compensation,  as defined by the Plan,  limited to the maximum for
              each year  ($13,000 in 2004 and $12,000 in 2003)  permitted by the
              Internal  Revenue  Code.   Effective  January  1,  2002,  catch-up
              contributions   are  also  permitted  for  participants  who  have
              attained  age 50 by December  31st,  in  accordance  with  Section
              414(v)  of the Code,  in an  amount  up to a maximum  of $3,000 in
              2004, and $2,000 in 2003, without regard to the Plan limitation of
              17%  of  compensation,   bringing  those  participants'  statutory
              limitation to $16,000 for 2004 and $14,000 for 2003.

              In  addition,   the  Companies  will  contribute  to  the  Plan  a
              discretionary matching contribution equal to 50% of the employees'
              401(k)  contribution,  not to exceed 50% of 10% of the  employee's
              annual  compensation.  Participants  who have  completed a year of
              service  during the plan year and are actively  employed as of the
              last day of the plan year shall be deemed eligible to share in the
              matching  contribution  for the  year.  In 2004 and 2003 the total
              matching  contributions were $351,579 and $282,239,  respectively,
              in the form of Enzo Biochem Inc. company stock.

              PARTICIPANTS' ACCOUNTS

              Contributions  are  invested in a choice of fourteen  mutual funds
              and  the  common  stock  of  Enzo  Biochem,  Inc.  (see  Note  7).
              Contribution  selections are designated by the participants.  Each
              participant's   account  is   credited   with  the   participant's
              contribution  and  allocations of (a) the Companies  contributions
              and,  (b)  Plan  earnings,  and  charged  with  an  allocation  of
              administrative  expenses.  Allocations  are  based on  participant
              compensation or account balances, as defined. The benefit to which
              a participant is entitled is the benefit that can be provided from
              the participant's vested account.

              VESTING

              Participants' contributed funds arising from salary reductions and
              the earnings  thereon,  are fully vested at all times.  Vesting in
              the Companies'  matching  contribution  and earnings  thereon,  is
              ratable over four years of service. Any forfeited amounts shall be
              applied to reduce future employers'  contributions.  For the years
              ended  December  31, 2004 and 2003,  employer  contributions  were
              reduced   by   forfeitures   of   approximately   $7,000  and  $0,
              respectively.



                                                                          Page 5


                               ENZO BIOCHEM, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN

                          NOTES TO FINANCIAL STATEMENTS



NOTE 1:       PLAN DESCRIPTION (CONTINUED)

              LOANS TO PARTICIPANTS

              Participants  may borrow from their  401(k)  accounts a minimum of
              $1,000 up to a maximum of 50% of their vested  account  balance or
              $50,000.  Participants  are entitled to borrow from their  account
              for a maximum loan term of five years unless the proceeds are used
              to  acquire a  principal  residence  in which case it may exceed 5
              years. The loans are secured by the  participant's  vested account
              balance and bear a  reasonable  rate of  interest.  Principal  and
              interest is paid ratably through payroll deductions.

              PAYMENT OF BENEFITS

              On termination of service due to death,  disability or retirement,
              participants  may elect to receive an amount equal to the value of
              the  participants'  vested  interest in their  account in either a
              lump sum amount or in various annuity options.  For termination of
              service due to other reasons,  a participant may receive the value
              of  the  vested   interest   in  their   account  as  a  lump  sum
              distribution.  Benefits  are  payable  in  the  form  of  cash  or
              property.

              OPERATING EXPENSES

              Certain  operating  expenses of the Plan are  absorbed by the Plan
              Sponsor.


NOTE 2:       SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

              The Plan's  financial  statements have been prepared in conformity
              with accounting principles generally accepted in the United States
              of America and under the accrual basis method of accounting.

              The Plan's  investments  are  stated at fair value  except for its
              benefit responsive investment contract which is valued at contract
              value  (Note  4).  Investment   earnings  are  reinvested  in  the
              respective   funds.   Investment   earnings   include  the  Plan's
              proportionate  share of realized  gains and losses on the disposal
              of investments, and appreciation or depreciation in the fair value
              of the underlying  investments  comprising  the respective  mutual
              funds. All purchases and sales are recorded on a trade date basis.

              The  Plan  presents  in the  statement  of  changes  in net  asset
              available for benefits,  the net appreciation in fair value of its
              investments,  which  consists of the realized  gains or losses and
              the unrealized appreciation (depreciation) on those investments.

              The  preparation  of the financial  statements in conformity  with
              accounting  principles  generally accepted in the United States of
              America requires management to make estimates and assumptions that
              affect   reported   amounts  and   disclosures  in  the  financial
              statements. Actual results could differ from those estimates.




                                                                          Page 6

                               ENZO BIOCHEM, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN

                          NOTES TO FINANCIAL STATEMENTS



NOTE 3:       INVESTMENTS

              The  following  table  presents the fair values,  as determined by
              quoted  market   price,   of  the   investments   except  for  the
              Metropolitan  Life  Insurance   contract  which  is  presented  at
              contract value:



                                                                                  2004                   2003
                                                                             -------------          --------------
                                                                                              
              Enzo Biochem, Inc.*                                            $   2,289,847          $    1,685,349
              American Century Government Bond                               $     188,121          $       33,501
              American Funds AMCAP Fund CL A                                 $      26,459          $      167,211
              American Funds American Balanced Fund CL A*                    $   1,318,378          $    1,115,300
              American Funds Europacific Growth CL A*                        $   1,174,844          $      911,523
              American Funds Washington Mutual
                Investors Fund CL A*                                         $   2,117,271          $    1,401,057
              Baron Growth Fund                                              $      46,874          $            -
              Federated Kaufmann Fund K                                      $     471,276          $      327,550
              Fidelity Contrafund*                                           $     673,476          $      477,631
              Fidelity Spartan US Equity Index Fund                          $     178,479          $       64,696
              Freemont Bond Fund                                             $       6,481          $            -
              Hotchkis & Wiley Mid Cap Value CL 1                            $      26,381          $            -
              Janus Fund*                                                    $     696,237          $      571,213
              Neuberger & Berman Genesis Fund Trust                          $     319,346          $      202,482
              Metropolitan Life Ins Co - GIC                                 $     522,263          $      387,198
              Babson Value Fund                                              $           -          $      425,814
              Aim Invesco Dynamics Fund                                      $           -          $       37,061
              Aim Invesco Small Company Growth Fund                          $           -          $       13,967
              Aim Invesco Technology Fund Investor CL                        $           -          $       66,829
              Putnam New Opportunities Fd Sh Ben Int A                       $           -          $       10,498


              *  Denotes  investments  representing  5% or more of net
                 assets available for benefits at December 31, 2004.


NOTE 4:       INVESTMENT CONTRACT WITH INSURANCE COMPANY

              The Plan has a benefit-responsive investment contract with MetLife
              Trust Company,  National Association (MetLife).  MetLife maintains
              the contributions in separate accounts.  The accounts are credited
              with  earnings  on the  underlying  investments  and  charged  for
              participant withdrawals and administrative  expenses. The contract
              is  included in the  financial  statements  at  contract  value as
              reported  to the Plan by Counsel  Trust  Company.  Contract  value
              represents  contributions made under the contract,  plus earnings,
              less   participant   withdrawals  and   administrative   expenses.
              Participants  may ordinarily  direct the withdrawal or transfer of
              all or a portion of their investment at contract value.

              There are no reserves  against  contract  value for credit risk of
              the contract issuer or otherwise.  The average yield and crediting
              interest rates were approximately 3.7% for both 2004 and 2003.



                                                                          Page 7


                               ENZO BIOCHEM, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN

                          NOTES TO FINANCIAL STATEMENTS



NOTE 5:       PLAN TERMINATION

              Although it has not  expressed  any intent to do so, the Companies
              have the right under the Plan to discontinue  their  contributions
              at any time and to terminate the Plan subject to the provisions of
              ERISA.


NOTE 6:       TAX STATUS

              The Plan obtained its latest determination letter in February 2002
              in which the Internal  Revenue Service stated that the Plan was in
              compliance  with  the  applicable  requirements  of  the  Internal
              Revenue Code.


NOTE 7:       RELATED PARTY TRANSACTIONS

              During 2004, the Plan  purchased  shares of stock in Enzo Biochem,
              Inc.,  the parent  company of the Plan  sponsor,  at market prices
              totaling approximately $133,000. In addition, shares were sold, at
              market prices  totaling  approximately  $103,000.  At December 31,
              2004 and 2003 the Plan held  Enzo  Biochem,  Inc.  stock at market
              prices totaling $2,289,847 and $1,685,349, respectively.

              Fees  paid by the  Plan to the  Plan  administrators  amounted  to
              $24,835 for the year ended December 31, 2004.


NOTE 8:       RISKS AND UNCERTAINTIES

              The Plan  invests in  various  investment  securities.  Investment
              securities  are  exposed to various  risk such as  interest  rate,
              market, and credit risks. Due to the level of risk associated with
              certain investment securities,  it is at least reasonably possible
              that changes in the values of investment  securities will occur in
              the near  term and  that  such  changes  could  materially  affect
              participants'  account  balances  and the amounts  reported in the
              statement of net assets available for benefits.



                                                                          Page 8


                               ENZO BIOCHEM, INC.
                      SALARY REDUCTIONS PROFIT SHARING PLAN

                               SCHEDULE H, ITEM 4i
                     SCHEDULE OF ASSETS HELD AT END OF YEAR

                               E.I.N. # 13-2869332
                                   PLAN # 001

                          YEAR ENDED DECEMBER 31, 2004






                                                                     DESCRIPTION OF
                                                                  INVESTMENT INCLUDING
                     IDENTITY OF ISSUE,                           MATURITY DATE, RATE
                    BORROWER, LESSOR OR                         OF INTEREST, COLLATERAL,
                       SIMILAR PARTY                             PAR OR MATURITY VALUE         COST         CURRENT VALUE
 (a)                       (b)                                            (c)                  (d)               (e)
 ---    ----------------------------------------------------    ------------------------     -----------    -------------
                                                                                                      
 *      Enzo Biochem, Inc.                                            Common Stock                          $   2,289,847
        American Century Government Bond                              Mutual Fund                           $     188,121
        American Funds AMCAP Fund CL A                                Mutual Fund                           $      26,459
        American Funds American Balanced Fund CL A                    Mutual Fund                           $   1,318,378
        American Funds Europacific Growth CL A                        Mutual Fund                           $   1,174,844
        American Funds Washington Mutual                              Mutual Fund                           $   2,117,271
          Investors Fund CL A
        Baron Growth Fund                                             Mutual Fund                           $      46,874
        Federated Kaufmann Fund K                                     Mutual Fund                           $     471,276
        Fidelity Contrafund                                           Mutual Fund                           $     673,476
        Fidelity Spartan US Equity Index Fund                         Mutual Fund                           $     178,479
        Freemont Bond Fund                                            Mutual Fund                           $       6,481
        Hotchkis & Wiley Mid Cap Value CL 1                           Mutual Fund                           $      26,381
        Janus Fund                                                    Mutual Fund                           $     696,237
        Neuberger & Berman Genesis Fund Trust                         Mutual Fund                           $     319,346
        Metropolitan Life Ins Co.                                Guaranteed Investment                      $     522,263
                                                                      Contract

        Participant Loans                                             5.00% - 9.50%           $     -0-    $     218,831



        * Party-in-interest.





See Independent Auditors' Report.







                                   SIGNATURES

     THE PLAN. Pursuant to the requirements of the Securities Exchange Act of
1934, a trustee of the below named employee benefit plan has duly caused this
annual report to be signed on its behalf by the undersigned hereunto duly
authorized.

                                            Enzo Biochem, Inc.
                                            Salary Reduction Profit Sharing Plan

Date: June 29, 2005

                                            /s/ Herbert Bass
                                            -----------------------------
                                            By: Herbert Bass
                                                Trustee


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