UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549

                                    FORM 8-K

                             CURRENT REPORT PURSUANT
                          TO SECTION 13 OR 15(d) OF THE
                         SECURITIES EXCHANGE ACT OF 1934

     Date of report (Date of earliest event reported):  NOVEMBER 8, 2006
                                                      --------------------------

                               ENZO BIOCHEM, INC.
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             (Exact Name of Registrant as Specified in Its Charter)

                                    NEW YORK
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                 (State or Other Jurisdiction of Incorporation)

      001-09974                                           13-2866202
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(Commission File Number)                       (IRS Employer Identification No.)

     527 MADISON AVENUE
      NEW YORK, NEW YORK                                     10022
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(Address of Principal Executive Offices)                    (Zip Code)

                                 (212) 583-0100
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              (Registrant's Telephone Number, Including Area Code)


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          (Former Name or Former Address, if Changed Since Last Report)

Check  the  appropriate  box  below  if the  Form  8-K  filing  is  intended  to
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     CFR 230.425)

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     Exchange Act (17 CFR 240.13e-4(c))






ITEM 5.03.   AMENDMENTS TO ARTICLES OF INCORPORATION OR BYLAWS; CHANGE IN
             FISCAL YEAR.
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         (a) On November 8, 2006,  the Board of Directors of Enzo Biochem,  Inc.
voted by  unanimous  written  consent  to add a new  Section 17 to Article II of
Enzo's  Bylaws,  effective  immediately,  to provide  that the total  cumulative
length of time that any  Outside  Director  (a member of the Board who is not an
officer  or  employee  of Enzo)  may serve on the Board  shall be  limited  to a
maximum of three three-year terms,  whether  consecutively or in total, plus any
portion of an earlier  three-year term that such Outside  Director may have been
appointed to serve.

         A copy of Enzo's  Bylaws,  as  amended,  is  attached to this Report as
Exhibit 3.1 and is incorporated herein by reference.

ITEM 9.01.    FINANCIAL STATEMENTS AND EXHIBITS.
              ----------------------------------

(c) EXHIBITS.

EXHIBIT NO.                DESCRIPTION
-----------                ------------
3.1                        Amended and Restated Bylaws of Enzo Biochem, Inc.





                                   SIGNATURES

         Pursuant to the requirements of the Securities Exchange Act of 1934, as
amended,  the  registrant has duly caused this report to be signed on its behalf
by the undersigned hereunto duly authorized.

                                         ENZO BIOCHEM, INC.


Date:  November 13, 2006                 By: /s/ ELAZAR RABBANI
                                             -----------------------------------
                                             Dr. Elazar Rabbani, Ph.D.
                                             Chairman of the Board and Chief
                                             Executive Officer





                                  EXHIBIT INDEX


EXHIBIT NO.               DESCRIPTION
------------              ------------
3.1                       Amended and Restated Bylaws of Enzo Biochem, Inc.