U.S. SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 3
INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES
Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934,
Section 17(a) of the Public Utility Holding Company Act of 1935 or
Section 30(f) of the Investment Company Act of 1940
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1. Name and Address of Reporting Person*
ORBIMED ADVISORS LLC
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(Last) (First) (Middle)
767 Third Avenue, 6th Floor
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(Street)
New York NY 10017
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(City) (State) (Zip)
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2. Date of Event Requiring Statement (Month/Day/Year)
February 22, 2000
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3. IRS Identification Number of Reporting Person, if an Entity (Voluntary)
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4. Issuer Name and Ticker or Trading Symbol
Orphan Medical Inc. (Orph)
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5. Relationship of Reporting Person to Issuer
(Check all applicable)
[_] Director [X] 10% Owner
[_] Officer (give title below) [_] Other (specify below)
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1. Name and Address of Reporting Person*
ORBIMED ADVISORS INC.
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(Last) (First) (Middle)
767 Third Avenue, 6th Floor
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(Street)
New York NY 10017
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(City) (State) (Zip)
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2. Date of Event Requiring Statement (Month/Day/Year)
February 22, 2000
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3. IRS Identification Number of Reporting Person, if an Entity (Voluntary)
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4. Issuer Name and Ticker or Trading Symbol
Orphan Medical Inc. (Orph)
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5. Relationship of Reporting Person to Issuer
(Check all applicable)
[_] Director [X] 10% Owner
[_] Officer (give title below) [_] Other (specify below)
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1. Name and Address of Reporting Person*
ISALY SAMUEL D.
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(Last) (First) (Middle)
767 Third Avenue, 6th Floor
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(Street)
New York NY 10017
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(City) (State) (Zip)
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2. Date of Event Requiring Statement (Month/Day/Year)
February 22, 2000
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3. IRS Identification Number of Reporting Person, if an Entity (Voluntary)
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4. Issuer Name and Ticker or Trading Symbol
Orphan Medical Inc. (Orph)
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5. Relationship of Reporting Person to Issuer
(Check all applicable)
[_] Director [X] 10% Owner
[_] Officer (give title below) [_] Other (specify below)
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6. If Amendment, Date of Original (Month/Day/Year)
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7. Individual or Joint/Group Filing (Check applicable line)
[_] Form Filed by One Reporting Person
[X] Form Filed by More than One Reporting Person
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Table I -- Non-Derivative Securities Beneficially Owned
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3. Ownership Form: 4. Nature of
2. Amount of Securities Direct (D) or Indirect
1. Title of Security Beneficially Owned Indirect (I) Beneficial Ownership
(Instr. 4) (Instr. 4) (Instr. 5) (Instr.4)
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Common Stock N/A no beneficial ownership pursuant to Rule 16a-1(a)(2) (See note 1)
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* If the Form is filed by more than one Reporting Person, see Instruction
5(b)(v).
Reminder: Report on a separate line for each class of securities beneficially
owned directly or indirectly.
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Table II -- Derivative Securities Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
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5. Owner-
3. Title and Amount of Securities ship
Underlying Derivative Security Form of
2. Date Exercisable (Instr. 4) Derivative
and Expiration Date --------------------------------- 4. Conver- Security:
(Month/Day/Year) Amount sion or Direct 6. Nature of
---------------------- or Exercise (D) or Indirect
Date Expira- Number Price of Indirect Beneficial
1. Title of Derivative Exer- tion of Derivative (I) Ownership
Security (Instr. 4) cisable Date Title Shares Security (Instr. 5) (Instr. 5)
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Explanation of Responses:
1. Orbimed Advisors LLC and Orbimed Advisors Inc. have investment management
discretion over a number of collective investment funds investing in Orphan
Medical Inc. stock. OrbiMed Advisors Inc. is 100% owned by Samuel D. Isaly and
OrbiMed Advisors LLC is 57% owned by Samuel D. Isaly.
/s/Samuel D. Isaly
Managing Member of OrbiMed Advisors LLC
OrbiMed Advisors Inc.
August 15, 2001
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**Signature of Reporting Person Date
** Intentional misstatements or omissions of facts constitute Federal Criminal
Violations.
See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Signature Page for Other Reporting Persons:
SAMUEL D. ISALY
By: /s/Samuel D. Isaly August 15, 2001
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Name: Samuel D. Isaly Date
Designated Filer
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OrbiMed Advisors LLC
Date of Event Requiring Statement--2/22/00
Issuer Name - ORPHAN MEDICAL INC.
Trading Symbol-"ORPH"
Other Reporting Persons:
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Samuel D. Isaly
767 Third Avenue, 6th Floor
New York, NY 10010