As filed with the Securities and Exchange Commission on May 15, 2006.

                                                Registration No. 33-65024

                                  UNITED STATES
                      SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                     POST-EFFECTIVE AMENDMENT TO FORM S-8
                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933

                     NOVARTIS VACCINES AND DIAGNOSTICS, INC.
             (Exact name of registrant as specified in its charter)

                                    Delaware
  (State or other jurisdiction of incorporation or organization)

                                   94-2754624
                    (I.R.S. Employer Identification No.)

                               4560 Horton Street
                              Emeryville, CA 94608
                                 (510) 655-8730
          (Address, including zip code, and telephone number, including
              area code, of registrant's principal executive offices)

                          CHIRON 1991 STOCK OPTION PLAN
                              (Full Title of Plan)

                              Thomas Kendris, Esq.
                  Vice President, General Counsel and Secretary
                     Novartis Vaccines and Diagnostics, Inc.
                               4560 Horton Street
                              Emeryville, CA 94608
                                 (510) 655-8730
         (Name, address, including zip code, and telephone number,
                  including area code, of agent for service)




                           TERMINATION OF REGISTRATION

           This Post-Effective Amendment No. 2 relates to the Registration
Statement on Form S-8 (File No. 33-65024) filed on June 25, 1993, pertaining to
the Common Stock of the Registrant, formerly known as Chiron Corporation, to be
offered under the 1991 Stock Option Plan of Chiron Corporation.

           The undersigned Registrant hereby removes and withdraws from
registration all securities registered pursuant to this Registration Statement
that remain unissued.







                                   SIGNATURES

                  Pursuant to the requirements of the Securities Act of 1933,
the registrant certifies that it has reasonable grounds to believe that it meets
all of the requirements for filing on Form S-8 and has duly caused this
Post-Effective Amendment to the registration statement to be signed on its
behalf by the undersigned, thereunto duly authorized, in the City of Emeryville,
County of Alameda, State of California on May 15, 2006.


                                   NOVARTIS VACCINES AND DIAGNOSTICS,
                                   INC.


                               By: /s/ Thomas Kendris
                                  ----------------------------------------------
                                   Name:  Thomas Kendris
                                   Title: Vice President and Secretary


           Pursuant to the requirements of the Securities Act of 1933, this
Post-Effective Amendment to the registration statement has been signed by the
following persons in the capacities and on the dates indicated:


                               By: /s/ Joerg Reinhardt
                                  ----------------------------------------------
                                   Name:  Joerg Reinhardt
                                   Title: Director, President and Chief
                                          Executive Officer (Principal
                                          Executive Officer)
                                   Date:  May 15, 2006


                               By: /s/ Reto Braendli
                                  ----------------------------------------------
                                   Name:  Reto Braendli
                                   Title: Vice President and Chief Financial
                                          Officer (Principal Financial and
                                          Accounting Officer)
                                   Date:  May 15, 2006


                               By: /s/ Raymund Breu
                                  ----------------------------------------------
                                   Name:  Raymund Breu
                                   Title: Director
                                   Date:  May 15, 2006


                               By: /s/ Paulo Costa
                                  ----------------------------------------------
                                   Name:  Paulo Costa
                                   Title: Director
                                   Date:  May 15, 2006