Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
PETERSON JEFFREY N
  2. Issuer Name and Ticker or Trading Symbol
PRESSURE BIOSCIENCES INC [PBIO]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director _____ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
110 WINCHESTER CT.
3. Date of Earliest Transaction (Month/Day/Year)
12/19/2018
(Street)

FOSTER CITY, CA 94404
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Non-Qualified Stock Option $ 3.4 12/19/2018(1)   D     334   (1) 07/18/2028 Common Stock 334 $ 0 0 (3) D  
Non-Qualified Stock Option $ 3.4 12/19/2018(1)   A   334     (2) 12/19/2028 Common Stock 334 $ 0 334 (4) D  
Non-Qualified Stock Option $ 3.4 12/19/2018(1)   D     959   (1) 07/18/2028 Common Stock 959 $ 0 0 (3) D  
Non-Qualified Stock Option $ 3.4 12/19/2018(1)   A   959     (2) 12/19/2028 Common Stock 959 $ 0 1,293 (4) D  
Non-Qualified Stock Option $ 3.4 12/19/2018(1)   D     500   (1) 07/18/2028 Common Stock 500 $ 0 0 (3) D  
Non-Qualified Stock Option $ 3.4 12/19/2018(1)   A   500     (2) 12/19/2028 Common Stock 500 $ 0 1,793 (4) D  
Non-Qualified Stock Option $ 3.4 12/19/2018(1)   D     334   (1) 07/18/2028 Common Stock 334 $ 0 0 (3) D  
Non-Qualified Stock Option $ 3.4 12/19/2018(1)   A   334     (2) 12/19/2028 Common Stock 334 $ 0 2,127 (4) D  
Non-Qualified Stock Option $ 3.4 12/19/2018(1)   D     6,467   (1) 07/18/2028 Common Stock 6,467 $ 0 0 (3) D  
Non-Qualified Stock Option $ 3.4 12/19/2018(1)   A   6,467     (2) 12/19/2028 Common Stock 6,467 $ 0 8,594 (4) D  
Non-Qualified Stock Option $ 3.4 12/19/2018(1)   D     7,500   (1) 07/18/2028 Common Stock 7,500 $ 0 0 (3) D  
Non-Qualified Stock Option $ 3.4 12/19/2018(1)   A   7,500     (2) 12/19/2028 Common Stock 7,500 $ 0 16,094 (4) D  
Non-Qualified Stock Option $ 3.4 12/19/2018(1)   D     7,500   (1) 07/18/2028 Common Stock 7,500 $ 0 0 (3) D  
Non-Qualified Stock Option $ 3.4 12/19/2018(1)   A   7,500     (2) 12/19/2028 Common Stock 7,500 $ 0 23,594 (4) D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
PETERSON JEFFREY N
110 WINCHESTER CT.
FOSTER CITY, CA 94404
  X      

Signatures

 /s/ Jeffrey N Peterson   12/21/2018
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) The reported transactions involved an amendment of an outstanding stock option, resulting in the deemed cancellation of the old stock option granted on July 18, 2018 and the grant of a replacement stock option dated December 19, 2018, which includes the same exercise price of $3.40 and a new expiration date of December 19, 2028.
(2) Stock options vest 5/12th for the first month then 1/12th per month for the remaining months for a total of 12 months.
(3) 2015 Nonqualified Stock Option Plan.
(4) 2013 Equity Incentive Plan.

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