Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
VAGELOS P ROY
   2. Issuer Name and Ticker or Trading Symbol
REGENERON PHARMACEUTICALS INC [REGN] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
Chairman of the Board
(Last)
(First)
(Middle)
777 OLD SAW MILL RIVER ROAD		 3. Date of Earliest Transaction (Month/Day/Year)
07/09/2018
(Street)

TARRYTOWN, NY 10591		 4. If Amendment, Date Original Filed(Month/Day/Year)
 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		 7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 07/09/2018   M(1)   153,274 A $ 16.8 553,121 D  
Common Stock 07/09/2018   F(1)   78,604 D $ 370.52 474,517 D  
Common Stock 07/10/2018   S(1)   900 D $ 364.75 (2) 473,617 D  
Common Stock 07/10/2018   S(1)   17,221 D $ 365.56 (3) 456,396 D  
Common Stock 07/10/2018   S(1)   24,339 D $ 366.49 (4) 432,057 D  
Common Stock 07/10/2018   S(1)   6,405 D $ 367.4 (5) 425,652 D  
Common Stock 07/10/2018   S(1)   12,211 D $ 368.61 (6) 413,441 D  
Common Stock 07/10/2018   S(1)   13,194 D $ 369.41 (7) 400,247 D  
Common Stock 07/10/2018   S(1)   100 D $ 370.17 400,147 D  
Common Stock 07/10/2018   S(1)   300 D $ 371.29 (8) 399,847 D  
Common Stock 07/06/2018   G V 610 D $ 0 147,934 I by CLAT
Common Stock               2,310 I By 401(k) Plan
Common Stock               83,652 I by Spouse as Trustee
Common Stock               1,203 I by trust for grandch (9)

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		 6. Date Exercisable and Expiration Date
(Month/Day/Year)		 7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)		 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		 11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Non-Qualified Stock Option (right to buy) $ 16.8 07/09/2018   M(1)     153,274   (10) 12/17/2018 Common Stock 153,274 $ 0 0 D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
VAGELOS P ROY
777 OLD SAW MILL RIVER ROAD
TARRYTOWN, NY 10591		   X     Chairman of the Board  

Signatures

 /s/**P. Roy Vagelos   07/10/2018
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).
(2) Represents volume-weighted average price of sales of 900 shares of Company stock on July 10, 2018 at prices ranging from $364.73 to $364.83. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on July 10, 2018 at each separate price.
(3) Represents volume-weighted average price of sales of 17,221 shares of Company stock on July 10, 2018 at prices ranging from $365.05 to $365.99. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on July 10, 2018 at each separate price.
(4) Represents volume-weighted average price of sales of 24,339 shares of Company stock on July 10, 2018 at prices ranging from $366.00 to $366.99. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on July 10, 2018 at each separate price.
(5) Represents volume-weighted average price of sales of 6,405 shares of Company stock on July 10, 2018 at prices ranging from $367.02 to $367.98. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on July 10, 2018 at each separate price.
(6) Represents volume-weighted average price of sales of 12,211 shares of Company stock on July 10, 2018 at prices ranging from $368.01 to $368.99. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on July 10, 2018 at each separate price.
(7) Represents volume-weighted average price of sales of 13,194 shares of Company stock on July 10, 2018 at prices ranging from $369.00 to $369.87. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on July 10, 2018 at each separate price.
(8) Represents volume-weighted average price of sales of 300 shares of Company stock on July 10, 2018 at prices ranging from $371.28 to $371.32. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on July 10, 2018 at each separate price.
(9) By a trust for the benefit of certain grandchildren of the reporting person, of which the reporting person and/or the spouse of the reporting person is trustee.
(10) The stock option award (combined incentive stock option and non-qualified stock option) vests in four equal annual installments, commencing one year after the date of grant.

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