================================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                   ----------


                                    FORM 11-K

                                  ANNUAL REPORT
                        PURSUANT TO SECTION 15(d) OF THE
                         SECURITIES EXCHANGE ACT OF 1934


(MARK ONE)


|X|  ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES
     EXCHANGE ACT OF 1934

FOR THE FISCAL YEAR ENDED DECEMBER 31, 2003

                                       OR

|_|  TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES
     EXCHANGE ACT OF 1934 [NO FEE REQUIRED].

FOR THE TRANSITION PERIOD FROM                TO

                        COMMISSION FILE NUMBER 001-09974

                                   ----------

             Enzo Biochem, Inc. Salary Reduction Profit Sharing Plan

     (Full title of the plan and the address of the plan, if different from that
     of the issuer named below:)

        ENZO BIOCHEM, INC., 60 EXECUTIVE BOULEVARD, FARMINGDALE, NY 11735

     (Name of issuer of the securities held pursuant to the plan and the address
     of its principal executive office)

================================================================================



                               ENZO BIOCHEM, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN

                               TABLE OF CONTENTS



REPORT OF WATSON RICE LLP
    INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM ......................... F-1

FINANCIAL STATEMENTS FOR THE YEARS ENDED
    DECEMBER 31, 2003 AND 2002:

      Statements of Net Assets Available for Benefits ..................... F-2

      Statement of Changes in Net Assets Available for Benefits............ F-3

      Notes to Financial Statements ....................................... F-4

 SUPPLEMENTAL SCHEDULE FOR THE YEAR ENDED
    DECEMBER 31, 2003:

      Schedule H, Item 4i --
      Schedule of Assets Held at End of Year .............................. F-8

REPORT OF AUDREY WALLACH, CPA, INDEPENDENT AUDITORS ....................... F-10

FINANCIAL STATEMENTS FOR THE YEAR ENDED DECEMBER 31, 2002

STATEMENT OF NET ASSETS
  AVAILABLE FOR BENEFITS .................................................. F-11

STATEMENT OF CHANGES IN NET ASSETS
  AVAILABLE FOR BENEFITS .................................................. F-12

NOTES TO FINANCIAL STATEMENTS ............................................. F-13

SCHEDULE OF NON-EXEMPT TRANSACTIONS ....................................... F-17




             REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM


To the Trustees of
Enzo Biochem, Inc. Salary Reduction Profit Sharing Plan


We have audited the accompanying  statement of net assets available for benefits
of Enzo Biochem,  Inc. Salary  Reduction  Profit Sharing Plan (the "Plan") as of
December 31, 2003, and the related  statement of changes in net assets available
for benefits for the year ended December 31, 2003.  These  financial  statements
are the  responsibility  of the  Plan's  management.  Our  responsibility  is to
express  an  opinion  on these  financial  statements  based on our  audit.  The
financial statements of Enzo Biochem,  Inc. Salary Reduction Profit Sharing Plan
as of December  31,  2002 were  audited by other  auditors  whose  report  dated
September 20, 2003 expresses an unqualified opinion on those statements.

We conducted  our audit in accordance  with the standards of the Public  Company
Accounting Oversight Board (United States). Those standards require that we plan
and perform the audit to obtain reasonable assurance about whether the financial
statements are free of material misstatement.  An audit includes examining, on a
test basis,  evidence  supporting  the amounts and  disclosures in the financial
statements.  An audit also includes assessing the accounting principles used and
significant  estimates  made by  management,  as well as evaluating  the overall
financial  statement  presentation.   We  believe  that  our  audit  provides  a
reasonable basis for our opinion.

In our opinion,  the financial  statements  referred to above present fairly, in
all material  respects,  the net assets available for benefits of the Plan as of
December 31, 2003 and the changes in net assets  available  for benefits for the
year ended December 31, 2003 in conformity with accounting  principles generally
accepted in the United States of America.

Our audit was  conducted  for the  purpose  of  forming  an opinion on the basic
financial statements taken as a whole. The supplemental  schedule of assets held
for investment  purposes at the end of the year, is presented for the purpose of
additional analysis and is not a required part of the basic financial statements
but is supplementary information required by the Department of Labor's Rules and
Regulations for Reporting and Disclosure  under the Employee  Retirement  Income
Security Act of 1974. The  supplemental  schedule is the  responsibility  of the
Plan's management.  The supplemental schedule has been subjected to the auditing
procedures  applied in the audit of the basic  financial  statements and, in our
opinion,  is fairly  stated in all  material  respects  in relation to the basic
financial statements taken as a whole.


WATSON RICE LLP

New York, New York
July 9, 2004


                                      F-1





                               ENZO BIOCHEM, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN

                 Statements of Net Assets Available for Benefits

                                  December 31,





                                                 2003                   2002
                                              ----------            ----------
 ASSETS
 Investments at Fair Value:
    Mutual funds                              $6,213,531            $4,409,225
    Common stock                               1,685,349             1,031,265
                                              ----------            ----------
                                               7,898,880             5,440,490
                                              ----------            ----------
 Receivables:
    Employer's contributions                     282,239               257,450
    Participants' contributions                      480                     -
                                              ----------            ----------
                                                 282,719               257,450
                                              ----------            ----------

 Loans receivable -- participants                235,312               174,741
                                              ----------            ----------
 TOTAL ASSETS                                  8,416,911             5,872,681
                                              ----------            ----------
 NET ASSETS AVAILABLE FOR BENEFITS            $8,416,911            $5,872,681
                                              ==========            ==========


See notes to financial statements

                                       F-2





                               ENZO BIOCHEM, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN

            STATEMENT OF CHANGES IN NET ASSETS AVAILABLE FOR BENEFITS

                      FOR THE YEAR ENDED DECEMBER 31, 2003





Additions to Net Assets Attributed to:
 Participants' contributions                                         $   704,353
 Employer's contributions                                                284,609
 Rollovers                                                                24,698
 Interest on loans to participants                                         9,471
 Net appreciation in fair value of investments:
     Mutual funds                                      1,242,258
     Common stock                                        439,811       1,682,069
                                                       ----------     ----------
        Total Additions                                                2,705,200
                                                                      ----------
Deductions from Net Assets Attributed to:
 Benefits paid to participants                                           130,683
 Administrative expenses                                                  30,287
                                                                      ----------
        Total Deductions                                                 160,970
                                                                      ----------
Net increase in net assets                                             2,544,230
Net Assets Available for Benefits, Beginning of Year                   5,872,681
                                                                      ----------
Net Assets Available for Benefits, End of Year                        $8,416,911
                                                                      ==========


See notes to financial statements.

                                       F-3



                               ENZO BIOCHEM, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN

                         NOTES TO FINANCIAL STATEMENTS

                           DECEMBER 31, 2003 AND 2002



NOTE 1.   PLAN DESCRIPTION

          The following description of the Enzo Biochem,  Inc., Salary Reduction
          Profit-Sharing  Plan (the "Plan")  provides only general  information.
          Participants  should refer to the Plan  Agreement,  as amended,  for a
          more complete description of the Plan's provisions.

          GENERAL

          The Plan is a defined  contribution  plan  covering all eligible  full
          time employees of Enzo Biochem,  Inc., Enzo Clinical Labs,  Inc., Enzo
          Therapeutics,  Inc. and Enzo Life Sciences (the  "Companies") who have
          completed three months of service and have attained age twenty-one.

          The Plan is subject to the  provisions  of the  Employment  Retirement
          Income Security Act of 1974 (ERISA).

          CONTRIBUTIONS

          Eligible employees can elect to defer up to 17% of their compensation,
          as defined by the Plan,  limited to the maximum for each year ($12,000
          in 2003)  permitted by the Internal  Revenue  Code.  In addition,  the
          Companies  will  contribute  to  the  plan  a  discretionary  matching
          contribution equal to 50% of the employees' 401(k)  contribution,  not
          to exceed 10% of the employee's annual compensation.  Participants who
          have completed a year of service during the plan year and are actively
          employed as of the last day of the plan year shall be deemed  eligible
          to share in the matching  contribution  for the year. In 2003 and 2002
          the  total   matching   contributions   were  $282,239  and  $257,450,
          respectively, in the form of Enzo Biochem Inc. company stock.


                                       F-4


                               ENZO BIOCHEM, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN

                   NOTES TO FINANCIAL STATEMENTS - CONTINUED


NOTE 1.   PLAN DESCRIPTION - CONTINUED

          PARTICIPANTS' ACCOUNTS

          Contributions are invested in a choice of sixteen mutual funds and the
          common  stock  of  Enzo  Biochem,  Inc.  (see  Note  7).  Contribution
          selections  are  designated by the  participants.  Each  participant's
          account  is  credited   with  the   participant's   contribution   and
          allocations of (a) the Companies  contributions and (b) Plan earnings,
          and charged with an allocation of administrative expenses. Allocations
          are based on participant compensation or account balances, as defined.
          The benefit to which a participant is entitled is the benefit that can
          be provided from the participant's vested account.

          VESTING

          Participants' contributed funds arising from salary reductions and the
          earnings  thereon,  are fully  vested  at all  times.  Vesting  in the
          Companies' matching contribution and earnings thereon, is ratable over
          four years of service.  Forfeitures are allocated  among  participants
          eligible to share for a plan year.

          LOANS TO PARTICIPANTS

          Participants may borrow from their 401(k) accounts a minimum of $1,000
          up to a maximum of 50% of their  vested  account  balance or  $50,000.
          Participants  are entitled to borrow from their  account for a maximum
          loan term of five  years  unless  the  proceeds  are used to acquire a
          principal residence in which case it may exceed 5 years. The loans are
          secured  by  the  participant's  vested  account  balance  and  bear a
          reasonable  rate of interest.  Principal  and interest is paid ratably
          through payroll deductions.

          PAYMENT OF BENEFITS

          On  termination  of service due to death,  disability  or  retirement,
          participants  may elect to receive an amount equal to the value of the
          participants'  vested  interest in their  account in either a lump sum
          amount or in various annuity  options.  For termination of service due
          to other  reasons,  a participant  may receive the value of the vested
          interest in their  account as a lump sum  distribution.  Benefits  are
          payable in the form of cash or property.


                                       F-5


                               ENZO BIOCHEM, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN

                   NOTES TO FINANCIAL STATEMENTS - CONTINUED


NOTE 1.   PLAN DESCRIPTION - CONTINUED

          OPERATING EXPENSES

          Certain  operating  expenses  of the  Plan  are  absorbed  by the Plan
          Sponsor.


NOTE 2.   SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

          The Plan's financial  statements have been prepared in conformity with
          accounting  principles  generally  accepted  in the  United  States of
          America and under the accrual basis method of accounting.

          The Plan's investments are stated at fair value except for its benefit
          responsive investment contract which is valued at contract value (Note
          4).  Investment  earnings  are  reinvested  in the  respective  funds.
          Investment   earnings  include  the  Plan's   proportionate  share  of
          interest,  dividends,  realized  gains and losses on the  disposal  of
          investments, and appreciation or depreciation in the fair value of the
          underlying  investments  comprising the respective  mutual funds.  All
          purchases and sales are recorded on a trade date basis.

          The Plan presents in the  statement of changes in net asset  available
          for benefits,  the net  appreciation in fair value of its investments,
          which  consists  of the  realized  gains or losses and the  unrealized
          appreciation (depreciation) on those investments.

          The  preparation  of  the  financial  statements  in  conformity  with
          accounting  principles  generally  accepted  in the  United  States of
          America  requires  management to make estimates and  assumptions  that
          affect reported  amounts and disclosures in the financial  statements.
          Actual results could differ from those estimates.


                                       F-6


                               ENZO BIOCHEM, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN

                   NOTES TO FINANCIAL STATEMENTS - CONTINUED


NOTE 3.   INVESTMENTS

          The  Plan's  investments  are  held  by  Counsel  Trust  Company.  The
          following  table  presents the fair values,  as  determined  by quoted
          market price,  of the  investments  except for the  Metropolitan  Life
          Insurance contract which is presented at contract value:

                                                                         2003
                                                                     -----------
          Enzo Biochem, Inc.*                                        $ 1,685,349
          American Funds American Balanced Fund CL A*                  1,115,300
          American Century Income & Growth                                33,501
          Babson Value Fund*                                             425,814
          American Funds Europacific Growth CL A*                        911,523
          Federated Kaufmann Fund Cl K                                   327,550
          Fidelity Concord Str Spartan US Eqidx                           64,696
          Fidelity Contrafund Inc. Common*                               477,631
          Aim Invesco Dynamics Fund                                       37,061
          Aim Invesco Small Company Growth Fund                           13,967
          Aim Invesco Technology Fund Investor CL                         66,829
          Janus Invt Fd Sh Ben Int*                                      571,213
          Neuberger & Berman Genesis Fund Trust                          202,482
          Putnam New Opportunities Fd Sh Ben Int A                        10,498
          American Funds Washington Mutual
             Investors Fund CL A*                                      1,401,057
          American Funds US Gov't Securities Fund CL A                   167,211
          Metropolitan Life Ins Co - Ins Prods                           387,198

          *  Denotes investments representing 5% or more of net assets available
             for benefits at December 31, 2003.


                                       F-7


                               ENZO BIOCHEM, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN

                   NOTES TO FINANCIAL STATEMENTS - CONTINUED


NOTE 4.   INVESTMENT CONTRACT WITH INSURANCE COMPANY

          The Plan has a  benefit-responsive  investment  contract  with MetLife
          Trust Company,  National Association (MetLife).  MetLife maintains the
          contributions  in separate  accounts.  The accounts are credited  with
          earnings on the  underlying  investments  and charged for  participant
          withdrawals and administrative  expenses.  The contract is included in
          the financial  statements at contract value as reported to the Plan by
          Counsel Trust Company.  Contract value represents  contributions  made
          under the contract,  plus earnings,  less participant  withdrawals and
          administrative  expenses.   Participants  may  ordinarily  direct  the
          withdrawal  or  transfer  of all or a portion of their  investment  at
          contract value.

          There are no reserves  against  contract  value for credit risk of the
          contract issuer or otherwise. The average yield and crediting interest
          rates were approximately 3.7% for 2003.


NOTE 5.   PLAN TERMINATION

          Although it has not expressed any intent to do so, the Companies  have
          the right under the Plan to  discontinue  their  contributions  at any
          time and to terminate the Plan subject to the provisions of ERISA.


NOTE 6.   TAX STATUS

          The Plan obtained its latest  determination letter in February 2002 in
          which  the  Internal  Revenue  Service  stated  that  the  Plan was in
          compliance with the applicable  requirements  of the Internal  Revenue
          Code.


NOTE 7.   RELATED PARTY TRANSACTIONS

          During 2003, the plan purchased shares of stock in Enzo Biochem, Inc.,
          the parent  company of the plan  sponsor,  at market  prices  totaling
          approximately  $353,696.  In  addition,  shares  were sold,  at market
          prices totaling approximately  $139,423. At December 31, 2003 and 2002
          the Plan held Enzo  Biochem,  Inc.  stock at  market  prices  totaling
          $1,685,349 and $1,031,265, respectively.

          Fees paid by the Plan to the Plan  administrators  amounted to $30,287
          for the year ended December 31, 2003.


                                       F-8



                               ENZO BIOCHEM, INC.
                             SALARY REDUCTIONS PLAN

                              SCHEDULE H, ITEM 4I
                     SCHEDULE OF ASSETS HELD AT END OF YEAR

                              E.I.N. # 13-2869332
                                   PLAN # 001

                          YEAR ENDED DECEMBER 31, 2003




                                                                   DESCRIPTION OF
                                                                INVESTMENT INCLUDING
                             IDENTITY OF ISSUE,                  MATURITY DATE, RATE
                            BORROWER, LESSOR OR               OF INTEREST, COLLATERAL,                   CURRENT
                               SIMILAR PARTY                    PAR OR MATURITY VALUE         COST        VALUE
  (a)                               (b)                                  (c)                  (d)          (e)
--------   ---------------------------------------------    -----------------------------    -------    ------------

                                                                                             
   *       Enzo Biochem, Inc.                                       Common Stock               **        $1,685,349
           American Funds American Balanced Fund CL A               Mutual Fund                **         1,115,300
           American Century Income & Growth                         Mutual Fund                **            33,501
           Babson Value Fund                                        Mutual Fund                **           425,814
           American Funds Europacific Growth CL A                   Mutual Fund                **           911,523
           Federated Kaufmann Fund Cl K                             Mutual Fund                **           327,550
           Fidelity Concord Str Spartan US Eqidx                    Mutual Fund                **            64,696
           Fidelity Contrafund Inc. Common                          Mutual Fund                **           477,631
           Aim Invesco Dynamics Fund                                Mutual Fund                **            37,061
           Aim Invesco Small Company Growth Fund                    Mutual Fund                **            13,967
           Aim Invesco Technology Fund Investor CL                  Mutual Fund                **            66,829
           Janus Invt Fd Sh Ben Int                                 Mutual Fund                **           571,213
           Neuberger & Berman Genesis Fund Trust                    Mutual Fund                **           202,482
           Putnam New Opportunities Fd Sh Ben Int A                 Mutual Fund                **            10,498
           American Funds Washington Mutual
              Investors Fund CL A                                   Mutual Fund                **         1,401,057
           American Fund US Gov't Securities Fund CL A              Mutual Fund                **           167,211
           Metropolitan Life Ins Co - Ins Prods                     Mutual Fund                **           387,198

           Participant Loans                                       5.00% - 9.50%               **           235,312


   *   Party-in-interest.
  **   Cost information is not required.


See Independent Auditors' Report.


                                       F-9


                               AUDREY WALLACH, CPA
                           Certified Public Accountant

                                780 CYNTHIA DRIVE
                              EAST MEADOW, NY 11554
                            Telephone: (516) 565-6441
                             E-mail: EMHAWK@aol.com



                         REPORT OF INDEPENDENT AUDITORS


To the Sponsor of the
Enzo Biochem, Inc.
Salary Reduction Profit Sharing Plan


We have audited the accompanying statements of net assets available for benefits
of the Enzo Biochem,  Inc. Salary  Reduction Profit Sharing Plan (the "Plan") as
of December  31, 2002 and 2001,  and the  related  statements  of changes in net
assets  available  for  benefits for the year ended  December  31,  2002.  These
financial  statements  are the  responsibility  of the  Plan's  management.  Our
responsibility  is to express an opinion on these financial  statements based on
our audits.

We conducted our audits in accordance with auditing standards generally accepted
in the  United  States of  America.  Those  standards  require  that we plan and
perform the audit to obtain  reasonable  assurance  about  whether the financial
statements are free of material misstatement.  An audit includes examining, on a
test basis,  evidence  supporting  the amounts and  disclosures in the financial
statements.  An audit also includes assessing the accounting principles used and
significant  estimates  made by  management,  as well as evaluating  the overall
financial  statement  presentation.   We  believe  that  our  audits  provide  a
reasonable basis for our opinion.

In our opinion,  the financial  statements  referred to above present fairly, in
all material  respects,  the net assets available for benefits of the Plan as of
December 31, 2002 and 2001, and the changes in net assets available for benefits
for the year ended December 31, 2002, in conformity with  accounting  principles
generally accepted in the United States of America.

Our audits  were  performed  for the  purpose of forming an opinion on the basic
financial statements taken as a whole. The supplemental  schedules of (1) assets
held  for  investment  purposes  as of  December  31,  2002  and (2)  reportable
transaction  for the year ended December 31, 2002, are presented for the purpose
of  additional  analysis  and are not a  required  part of the  basic  financial
statements  but are  supplementary  information  required by the  Department  of
Labor's Rules and  Regulations  for Reporting and Disclosure  under the Employee
Retirement  Income Security Act of 1974.  These  supplemental  schedules are the
responsibility of the Plan's  management.  The supplemental  schedules have been
subjected to the auditing procedures applied in the audit of the basic financial
statements and, in our opinion,  are fairly stated in all material respects when
in relation to the basic financial statements taken as a whole.

Audrey Wallach, CPA

East Meadow, New York
September 30, 2003


                                      F-10



Audrey Wallach, CPA


                               ENZO BIOCHEM, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN
                 STATEMENT OF NET ASSETS AVAILABLE FOR BENEFITS
                           DECEMBER 31, 2002 AND 2001



                                                        2002             2001
                                                    -----------      -----------
Assets:

     Investments: (Note 8)                          $ 5,615,231      $ 6,385,787

     Receivables:
          Employer contributions                        257,450          246,923
                                                    -----------      -----------
               Total receivables                        257,450          246,923
                                                    -----------      -----------

               Total assets                           5,872,681        6,632,710
                                                    ===========      ===========

Liabilities:

               Total liabilities                             --               --
                                                    -----------      -----------
Net assets available for benefits                   $ 5,872,681      $ 6,632,710
                                                    ===========      ===========


                 See accompanying notes to financial statements

                                      F-11



Audrey Wallach, CPA


                               ENZO BIOCHEM, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN
            STATEMENT OF CHANGES IN NET ASSETS AVAILABLE FOR BENEFITS
                          YEAR ENDED DECEMBER 31, 2002



Additions to net assets attributed to:
     Investment income:
          Interest                                                 $      7,319
          Net appreciation (depreciation) in
            fair value of investments                                (1,282,647)
                                                                   ------------
                                                                     (1,275,328

     Contributions:
          Participant                                                   634,148
          Employer                                                      257,450
                                                                   ------------
                                                                        891,598
                                                                   ------------

               Total additions                                         (383,730)
                                                                   ------------

Deductions from net assets attributed to:
          Benefits paid to participants                                 337,032
          Administration expenses                                        39,267
                                                                   ------------
               Total deductions                                         376,299
                                                                   ------------

               Net (decrease)                                          (760,029)

Net assets available for benefits:
          Beginning of the year                                       6,632,710
                                                                   ------------

               End of the year                                     $  5,872,681
                                                                   ============


                 See accompanying notes to financial statements

                                      F-12



Audrey Wallach, CPA


                               ENZO BIOCHEM, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN
                         NOTES TO FINANCIAL STATEMENTS
                                DECEMBER 31, 2002


1.   Description of the Plan

The following description of the Enzo Biochem, Inc. ("Company") Salary Reduction
Profit Sharing Plan ("Plan") provides only general information. Participants
should refer to the Plan agreement for a more complete description of the Plan's
provisions.

Effective January 1, 1997, Enzo Labs, Inc. amended the Enzo Biochem, Inc. Salary
Reduction Profit Sharing Plan. The Plan was further amended, effective January
1, 2002, to comply with recent legislation and to ensure continued tax-favored
treatment. The Plan operates under the favorable determination letter issued by
the Internal Revenue Service dated February 14, 2002. Additional employers which
have adopted the provisions of the Plan are Enzo clinical Labs, Inc. (formerly
Enzo Labs, Inc.), Enzo Therapeutics, Inc. and Enzo Diagnostics, Inc.

The Plan is a defined contribution plan covering substantially all full-time
employees who have completed three months of service and attained age 21, who
are not covered under a collective bargaining agreement. It is subject to the
provisions of the Employee Retirement Income Security Act (ERISA).

2.   Summary of Significant Accounting Policies

a.   The Plan's financial statements are prepared on the accrual basis of
     accounting, except for cash basis of recording of benefits paid.

b.   The Plan's investments are stated at fair value. Quoted market prices are
     used to value investments. Shares of mutual funds are valued at the net
     asset value of shares held by the Plan at year end.

c.   The preparation of the financial statements in conformity with generally
     accepted accounting principles requires management to make estimates and
     assumptions that affect certain reported amounts and disclosures.
     Accordingly actual results may differ from those estimates.

3.   Contributions

Each year, participants may contribute up to 17% of the participant's annual
compensation, as defined in the Plan. Employee contributions vest immediately.
Participants direct the investment of their contributions into various
investment options offered by the Plan.

                                      F-13



Audrey Wallach, CPA



In addition the Company makes discretionary matching contributions equal to 50%
of participant contributions to the extent of amounts not exceeding 10% of
participants' annual compensation. In 2002 and 2001 the totals of the matching
contributions were $257,450 and $246,923 respectively, in the form of Enzo
Biochem, Inc. Company stock.

Employer contributions vest ratably over four years of service.

Forfeitures attributable to Company contribution accounts are allocated among
participants eligible to share for a Plan year.

4.   PAYMENT OF BENEFITS

Participants' benefits under the Plan are payable to participants, their
beneficiaries or their estates upon the termination of employment, normal
retirement, late retirement, disability, death or hardship. Benefits are payable
in the form of lump-sum distributions of cash or property.

5.   LOANS TO PARTICIPANTS

The Plan provides for loans to participants, which may be repaid through payroll
deductions. Loans (i) bear a reasonable rate of interest, (ii) are secured by
the participant's account, (iii) are available to all participants on a uniform
and non-discriminatory basis, (iv) are limited to 50% of the participant's
vested account balance or $50,000 less the highest outstanding loan balance in
the previous twelve months, (v) provide for repayment over a period not to
exceed five years unless such loan is used to purchase a primary residence.

A loan will not be issued for an amount less than $1,000.00.

6.   TERMINATION

Although it has not expressed any intent to do so, the Company reserves the
right to terminate the Plan at any time. Termination of the Plan shall result in
immediate vesting of the entire amount credited to each participant. Upon
termination of the Plan, the trustees shall retain sufficient assets to complete
all scheduled payments due to former participants or their beneficiaries and
estates.

7.   TAX STATUS

The trust established under the plan to hold the Plan's assets is qualified
pursuant to the appropriate section of the Internal Revenue Code, and
accordingly, the Plan's net investment income is exempt from income taxes. The
Plan has a favorable determination letter from the Internal Revenue Service. The
Plan sponsor believes that the Plan qualifies and operates as designed.

                                      F-14



Audrey Wallach, CPA



8    INVESTMENTS

     The Company has adopted and implemented a daily valuation multi-fund family
     program for eligible employees. Under the daily valuation program
     participants are able to invest their accounts under a menu of mutual
     funds. A participant may (i) access his or her account value at any time
     and (ii) direct the investment of his or her existing account and future
     contributions by a toll-free number or via the internet at any time among
     the mutual funds offered under the Plan. Under the program the automated
     voice response system is electronically linked to IBG to effect fund
     transfers. IBG provides trade confirmations for any and all buys, sells and
     exchanges (i.e., deposits, transfers, distributions) of funds under the
     daily valuation program.

     FORM 5500 SCHEDULE H PART IV LINE 4i

     Schedule of Assets (Held at End of Year)

                    Description                           Current Value
                    -----------                           -------------

     Spartan US Equity Index Fund                                32,836
     American Century Income & Growth Fund                       16,252
     American Balanced Fund Class A                             784,501*
     American US Government Securities Fund                     143,439
     Invesco Dynamics Fund                                       24,794
     Invesco Small Company Growth Fund                            7,858
     Invesco Technology Class II Fund                            40,098
     Babson Value Fund                                          304,432*
     American EuroPacific Growth Fund                           625,071*
     Janus Fund                                                 412,893*
     Federal Kaufmann Fund Class K                              209,195
     Neuberger Berman Genesis Trust                             135,767
     Putnam New Opportunities Fund                                7,086
     American Washington Mutual Investors Fund Class A        1,059,846*
     Fidelity FMMT Retirement Money Market Fund                 272,559
     Fidelity Contrafund                                        331,444*
     Enzo Biochem, Inc. Common Stock                          1,031,265*
     Participant Loans                                          174,741
     Cash                                                         1,154
                                                          -------------

                                                              5,615,231
                                                          =============

     * Represents more than 5% of total assets.

                                      F-15



Audrey Wallach, CPA



9.   NON-EXEMPT TRANSACTIONS

It was noted that there were unintentional delays by the Company in remitting
employee deferrals to the trust in amounts totaling $88,234. Accordingly, the
Plan should be reimbursed for the $137 in lost earnings.




                                      F-16



Audrey Wallach, CPA


                               ENZO BIOCHEM, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN

                         SCHEDULE G, PART III FORM 5500
                             NONEXEMPT TRANSACTIONS
                      FOR THE YEAR ENDED DECEMBER 31, 2002


(a)  Identity of party involved

     Enzo Biochem, Inc.

(b)  Relationship to plan

     Plan Sponsor

(c)  Description of transactions including maturity date, rate of interest

     Employee deferral and loan payments not deposited with the Plan in a timely
     manner. Interest at 6%.

(h)  Cost of asset

     $137


                 See accompanying notes to financial statements

                                      F-17







                                   SIGNATURES

     THE PLAN. Pursuant to the requirements of the Securities Exchange Act of
1934, a trustee of the below named employee benefit plan has duly caused this
annual report to be signed on its behalf by the undersigned hereunto duly
authorized.

                                            Enzo Biochem, Inc.
                                            Salary Reduction Profit Sharing Plan

Date: June 25, 2004

                                            /s/ Herbert Bass
                                            -----------------------------
                                            By: Herbert Bass
                                                Trustee


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