Former President Trump lashed out at actor George Clooney on Wednesday night, calling the Democratic Party ally a "rat" for calling on the president to cease reelection efforts.

Clooney published an op-ed in The New York Times earlier in the day, expressing his belief that President Biden "saved our democracy" by beating Trump in 2020 but acknowledging that Democrats "are not going to win in November with this president."

Trump responded to the op-ed later that night via Truth Social, his proprietary social media platform, saying, "So now fake movie actor George Clooney, who never came close to making a great movie, is getting into the act. He’s turned on Crooked Joe like the rats they both are."

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"What does Clooney know about anything? He uses the Democrat ‘talking point’ that Biden, the WORST President in the history of the United States, has ‘saved our Democracy,'" Trump stated.

Clooney did take an apologetic tone in his op-ed — outright stating "I love Joe Biden" and that he believes in his "character" and "morals" — but claimed to have witnessed his decline firsthand at a fundraiser last month.

"It’s devastating to say it, but the Joe Biden I was with three weeks ago at the fund-raiser was not the Joe ‘big F-ing deal’ Biden of 2010. He wasn’t even the Joe Biden of 2020. He was the same man we all witnessed at the debate," Clooney wrote. 

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The actor joined a growing list of Hollywood elites and megadonors who've turned on Biden following the debate, where his halting, frail and at-times confused performance alarmed supporters. 

"Crooked Joe Biden didn’t save our Democracy, he brought our Democracy to its knees. Clooney should get out of politics and go back to television. Movies never really worked for him!!!" Trump concluded.

Dave Portnoy, the founder of Barstool Sports, mocked Clooney for waiting until three weeks after his star-studded fundraiser for Biden in which he raised millions of dollars to acknowledge the president is "a vegetable."

"George Clooney, what a f------ hero this guy is, huh? Comes forward today — now, this guy threw a fundraiser, raised tens of millions, co-chair for Biden, three weeks ago. Today comes out, he’s like, ‘Guess what? The guy you saw in the debate, that vegetable, that’s f------ Biden, he’s a vegetable. He was a vegetable three weeks ago.’ Acting like he’s doing some heroic thing," Portnoy said in a video posted on X.

Besides Clooney, members of Biden's party, political allies and liberal media figures have also pressured the president to drop out of the race, warning he cannot beat former President Trump.

Despite mounting pressure to step aside, Biden has insisted to supporters and media outlets this week that he will stay in the race and remains the best candidate to beat his GOP rival. 

Fox News Digital's Kristine Parks and Brie Stimson contributed to this report.