FORM 6-K

SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549

 

FORM 6-K

 

REPORT OF FOREIGN PRIVATE ISSUER
PURSUANT TO RULE 13a - 16 OR 15d - 16 OF
THE SECURITIES EXCHANGE ACT OF 1934

 

For the month of January, 2007

 

SkyePharma PLC


(Translation of registrant's name into English)

 

SkyePharma PLC, 105 Piccadilly, London W1J 7NJ England


(Address of principal executive office)

 

Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40F.

Form 20-F X      Form 40-F

Indicate by check mark whether the registrant by furnishing the information contained in this Form is also thereby furnishing the information to the Commission pursuant to Rule 12g3-2(b) under the Securities Exchange Act of 1934.

Yes         No X

If "Yes" is marked, indicate below the file number assigned to the registrant in connection with Rule 12g3-2(b): 82- _______


 



For immediate release                                        22 January 2007


                             SkyePharma PLC ("the Company")
                           Notification of Interests of Directors

The Company was informed on 19 January 2007 by Dr David Ebsworth,  Non-Executive
Director of  SkyePharma  PLC,  that on 19 January 2007 he had  purchased  67,000
Ordinary  Shares in the Company at a price of 23.99 pence per share.  The shares
are  registered  in the name of DWP  Bank.  As a result  of the  transaction  Dr
Ebsworth now has a beneficial interest in 200,000 Ordinary Shares in the Company
which represents 0.03% of the Issued Share Capital of the Company.

                                    - ends -


SIGNATURES

     Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

                                                                  SkyePharma PLC

                                                                      By: /s/ John Murphy

                                                                       Name: John Murphy
                                                                          Title: Company Secretary

Date:   January 22, 2007