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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549



                                  SCHEDULE 13G
                    UNDER THE SECURITIES EXCHANGE ACT OF 1934
                               (AMENDMENT NO. 4)*




                                  ABIOMED, Inc.
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                                (Name of Issuer)


                     Common Stock, par value $0.01 per share
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                         (Title of Class of Securities)


                                    003654100
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                                 (CUSIP Number)



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             (Date of Event Which Requires Filing of this Statement)






Check the appropriate box to designate the rule pursuant to which this Schedule
13G is filed:

[_]  Rule 13d-1 (b)
[X]  Rule 13d-1 (c)
[_]  Rule 13d-1 (d)


* The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which could alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).


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CUSIP NO. 003654100                SCHEDULE 13G                PAGE 2 OF 6 PAGES
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  1.      NAME OF REPORTING PERSONS.
          I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY).

          Dr. David M. Lederman, husband of Ms. Natalie F. Lederman
--------- ----------------------------------------------------------------------
  2.      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
          (a)  [_]
          (b)  [_]
--------- ----------------------------------------------------------------------
  3.      SEC USE ONLY


--------- ----------------------------------------------------------------------
  4.      CITIZENSHIP OR PLACE OF ORGANIZATION:

          United States
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                         5.   SOLE VOTING POWER:

                              855,000
                       ------ --------------------------------------------------
NUMBER                   6.   SHARED VOTING POWER:
OF SHARES
BENEFICIALLY                  0
OWNED BY               ------ --------------------------------------------------
EACH                     7.   SOLE DISPOSITIVE POWER:
REPORTING
PERSON WITH                   855,000
                       ------ --------------------------------------------------
                         8.   SHARED DISPOSITIVE POWER:

                              0
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   9.     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON:

          855,000
--------- ----------------------------------------------------------------------
  10.     CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
          (SEE INSTRUCTIONS)
          [_]
--------- ----------------------------------------------------------------------
  11.     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9):

          2.7%
--------- ----------------------------------------------------------------------
  12.     TYPE OF REPORTING PERSON: (SEE INSTRUCTIONS)

          IN
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                                Page 2 of 6 Pages

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CUSIP NO. 003654100                SCHEDULE 13G                PAGE 3 OF 6 PAGES
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  1.      NAME OF REPORTING PERSONS.
          I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY).

          Ms. Natalie F. Lederman, wife of Dr. David M. Lederman
--------- ----------------------------------------------------------------------
  2.      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
          (a)  [_]
          (b)  [_]
--------- ----------------------------------------------------------------------
  3.      SEC USE ONLY


--------- ----------------------------------------------------------------------
  4.      CITIZENSHIP OR PLACE OF ORGANIZATION:

          United States
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                         5.   SOLE VOTING POWER:

                              545,700
                       ------ --------------------------------------------------
NUMBER                   6.   SHARED VOTING POWER:
OF SHARES
BENEFICIALLY                  0
OWNED BY               ------ --------------------------------------------------
EACH                     7.   SOLE DISPOSITIVE POWER:
REPORTING
PERSON WITH                   545,700
                       ------ --------------------------------------------------
                         8.   SHARED DISPOSITIVE POWER:

                              0
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   9.     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON:

          545,700
--------- ----------------------------------------------------------------------
  10.     CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
          (SEE INSTRUCTIONS)
          [_]
--------- ----------------------------------------------------------------------
  11.     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9):

          1.7%
--------- ----------------------------------------------------------------------
  12.     TYPE OF REPORTING PERSON: (SEE INSTRUCTIONS)

          IN
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                                Page 3 of 6 Pages


ITEM 1(a). NAME OF ISSUER:  ABIOMED, Inc.


ITEM 1(b). ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES:
           22 Cherry Hill Drive, Danvers, Massachusetts  01923


ITEM 2(a). NAME OF PERSON FILING:  Dr. David M. Lederman, husband of Ms.
           Natalie F. Lederman, and Ms. Natalie F. Lederman, wife of Dr.
           David M. Lederman


ITEM 2(b). ADDRESS OF PRINCIPAL BUSINESS OFFICE, OR, IF NONE, RESIDENCE:
           c/o Analytical LLC, P.O. Box 7015, Beverly, MA 01915


ITEM 2(c). CITIZENSHIP:  United States


ITEM 2(d). TITLE OF CLASS OF SECURITIES: Common Stock, par value $0.01 per share


ITEM 2(e). CUSIP NO.: 003654100


ITEM 3.    IF THIS STATEMENT IS FILED PURSUANT TO SS.SS. 240.13d-1(b) OR
           240.13-2(b) OR (c), CHECK WHETHER THE PERSON FILING IS A:

           (a) [_] Broker or dealer registered under section 15 of the Act
                   (15 U.S.C. 78o).
           (b) [_] Bank as defined in section 3(a)(6) of the Act (15 U.S.C.
                   78c).
           (c) [_] Insurance company as defined in section 3(a)(19) of the Act
                   (15 U.S.C. 78c).
           (d) [_] Investment company registered under section 8 of the
                   Investment Company Act of 1940 (15 U.S.C 80a-8).
           (e) [_] An investment adviser in accordance with
                   ss.240.13d-1(b)(1)(ii)(E);
           (f) [_] An employee benefit plan or endowment fund in accordance with
                   ss.240.13d-1(b)(1)(ii)(F);
           (g) [_] A parent holding company or control person in accordance with
                   ss.240.13d-1(b)(1)(ii)(G);
           (h) [_] A savings associations as defined in Section 3(b) of the
                   Federal Deposit Insurance Act (12 U.S.C. 1813);
           (i) [_] A church plan that is excluded from the definition of an
                   investment company under section 3(c)(14) of the Investment
                   Company Act of 1940 (15 U.S.C. 80a-3);
           (j) [_] Group, in accordance with ss.240.13d-1(b)(1)(ii)(J).


                                Page 4 of 6 Pages


ITEM 4.    OWNERSHIP

           (a) Amount Beneficially Owned: As of April 10, 2007, Dr. Lederman
               beneficially owns 855,000 shares of Common Stock, which amount
               includes 355,000 shares of Common Stock issuable upon the
               exercise of stock options that are currently vested, or which
               will vest within 60 days of the date of this filing. Ms. Lederman
               beneficially owns 545,700 shares of Common Stock. Each of them
               disclaims beneficial ownership of the shares held by the other.

           (b) Percent of Class: Dr. Lederman 2.7%; Ms. Lederman 1.7%; Total
               4.4%.

           (c) Number of shares as to which such person has:
               (i)   Sole power to vote or to direct the vote:
                     Dr. Lederman:  855,000 shares
                     Ms. Lederman:  545,700 shares
                     Total:       1,400,700 shares
               (ii)  Shared power to vote or direct the vote: 0
               (iii) Sole power to dispose or to direct the disposition of:
                     Dr. Lederman:  855,000 shares
                     Ms. Lederman:  545,700 shares
                     Total:       1,400,700 shares
               (iv)  shared power to dispose or to direct the disposition of: 0


ITEM 5.    OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS

           If this statement is being filed to report the fact that as of the
           date hereof the reporting person has ceased to be the beneficial
           owner of more than five percent of the class of securities, check the
           following [X].


ITEM 6.    OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON

           Not Applicable.


ITEM 7.    IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED
           THE SECURITY BEING REPORTED BY THE PARENT HOLDING COMPANY OR CONTROL
           PERSON

           Not Applicable.


ITEM 8.    IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP

           Not Applicable.


ITEM 9.    NOTICE OF DISSOLUTION OF GROUP

           Not Applicable.


                                Page 5 of 6 Pages


ITEM 10.   CERTIFICATION

           By signing below I certify that, to the best of my knowledge and
           belief, the securities referred to above were not acquired and are
           not held for the purpose of or with the effect of changing or
           influencing the control of the issuer of the securities and were not
           acquired and are not held in connection with or as a participant in
           any transaction having that purpose or effect.





                                    SIGNATURE

           After reasonable inquiry and to the best of my knowledge and belief,
I certify that the information set forth in this statement is true, complete and
correct.



                                                /s/ David M. Lederman
                                                --------------------------------
                                                David M. Lederman, Ph.D.


                                                April 10, 2007
                                                --------------------------------
                                                Date



                                                /s/ Natalie F. Lederman
                                                --------------------------------
                                                Natalie F. Lederman


                                                April 10, 2007
                                                --------------------------------
                                                Date







                                Page 6 of 6 Pages