Filed Pursuant to Rule 424(b)(3)
Registration Nos. 333-208439
333-208439-01

PROSPECTUS SUPPLEMENT NO. 4

(to Prospectus dated March 27, 2018)

INVESCO DB MULTI-SECTOR COMMODITY TRUST

INVESCO DB AGRICULTURE FUND

101,372,875 Common Units of Beneficial Interest

This Prospectus Supplement No. 4 (“Supplement No. 4”) supplements and amends the Prospectus dated March 27, 2018 (the “Prospectus”). This Supplement No. 4 is being filed to reflect a change in the Principal Financial and Accounting Officer – Investment Pools of Invesco Capital Management LLC (the “Managing Owner”). Effective after the close of business on September 4, 2018 (the “Effective Date”), Kelli Gallegos has replaced Steven Hill as Principal Financial and Accounting Officer – Investment Pools of the Managing Owner. Accordingly, as of the Effective Date, all references to Steven Hill as Principal Financial and Accounting Officer – Investment Pools are deleted and replaced by Kelli Gallegos. In addition, the following biography for Kelli Gallegos replaces Steven Hill’s biography beginning on page 66 of the Prospectus:

Kelli Gallegos (48) has been Principal Financial and Accounting Officer – Investment Pools for the Managing Owner since September 2018. Additionally, since September 2018, Ms. Gallegos has been Principal Financial and Accounting Officer – Investment Pools of Invesco Specialized Products, LLC (sponsor to a suite of currency exchange-traded funds, “ISP”), Head of North America Fund Reporting of Invesco, Ltd. (“Invesco”, a global investment management company), and Vice President and Treasurer of Invesco Exchange Traded Fund Trust, Invesco Exchange-Traded Fund Trust II, Invesco India Exchange-Traded Fund Trust, Invesco Actively Managed Exchange-Traded Fund Trust, Invesco Actively Managed Exchange-Traded Commodity Fund Trust, and Invesco Exchange-Traded Self-Indexed Fund Trusts (each a registered investment company offering series of exchange-traded funds, the “Invesco ETFs”). She has also served as Vice President (since March 2016), Principal Financial Officer (since March 2016) and Assistant Treasurer (since December 2008) for a suite of mutual funds advised by Invesco Advisers, Inc., a registered investment adviser (the “Invesco Funds”). In her roles with the Managing Owner, ISP, Invesco, the Invesco ETFs and the Invesco Funds, Ms. Gallegos has financial and administrative oversight responsibilities for, and serves as Principal Financial Officer of the Invesco ETFs, the Trust, the Fund and the exchange-traded funds for which ISP serves as sponsor (the “CurrencyShares Trusts”). Previously, she was Director of Fund Financial Services from December 2008 to September 2018, Assistant Treasurer for the Managing Owner from January 2013 to September 2018, Assistant Treasurer of ISP from April 2018 to September 2018, Assistant Treasurer for the Invesco ETFs from September 2014 to September 2018 and Assistant Vice President for the Invesco Funds from December 2008 to March 2016. In such roles, Ms. Gallegos managed the group of personnel responsible for the preparation of fund financial statements and other information necessary for shareholder reports, fund prospectuses, regulatory filings, and for the coordination and oversight of third-party service providers of the Fund, the Invesco ETFs, the Invesco Funds, and the

CurrencyShares Trusts. Ms. Gallegos earned a BBA in accounting from Harding University in Searcy, AR. Ms. Gallegos was listed as a pending principal of the Managing Owner on September 4, 2018.

Supplement No. 4 should be read together with the Prospectus.

Shares of the Invesco DB Agriculture Fund are listed on NYSE Arca, Inc. under the symbol “DBA”.

Investing in the Shares involves significant risks. See “RISK FACTORS” starting on page 13 of the Prospectus.

These securities have not been approved or disapproved by the Securities and Exchange Commission or any state securities commission nor has the Securities and Exchange Commission passed upon the adequacy or accuracy of the Prospectus or this Prospectus Supplement No. 4. Any representation to the contrary is a criminal offense.

The Fund is not a mutual fund or any other type of investment company within the meaning of the Investment Company Act of 1940, as amended, and is not subject to regulation thereunder.

THE COMMODITY FUTURES TRADING COMMISSION HAS NOT PASSED UPON THE MERITS OF PARTICIPATING IN THESE POOLS NOR HAS THE COMMISSION PASSED ON THE ADEQUACY OR ACCURACY OF THIS DISCLOSURE DOCUMENT.

The date of this Prospectus Supplement No. 4 is September 4, 2018.

PLEASE RETAIN THIS SUPPLEMENT FOR FUTURE REFERENCE

P-DBA-PRO-1-SUP-4