Filed pursuant to Rule 424(b)(3)
                                                     Registration No. 333-103114

                PROSPECTUS SUPPLEMENT NO. 1 DATED August 21, 2003
                       (To Prospectus Dated May 29, 2003,)

                               DOR BIOPHARMA, INC.

         This Prospectus Supplement No. 1 supplements information contained in
that certain Prospectus, dated May 29, 2003, (the "Prospectus"), relating to the
offer and sale by certain selling shareholders of up to 5,297,732 shares of DOR
BioPharma Inc.'s common stock. This Prospectus Supplement No. 1 is not complete
without, and may not be delivered or utilized except in connection with, the
Prospectus, including any amendments or supplements thereto. The table below
amends and supplements the information set forth in the Prospectus under the
caption "Selling Shareholders" by adding the information for Keith Price, Enrico
Torcivo, Brian Meister, Gary Kanzer, and the Amanda Ellison Living Trust and
revising the information for Ralph Ellison and Harris Kanzer.

                              SELLING STOCKHOLDERS

         Of the 5,297,732 shares of our common stock registered for resale
through this prospectus and listed under the column "Shares Available for Sale
Under This Prospectus" on the table set forth below, 5,103,432 shares were
issued or are issuable in connection with our December 2002 private placement as
follows: (1) 3,093,569 shares were sold to investors in the private placement;
(2) 1,546,789 shares are issuable upon exercise of warrants, exercisable until
December 31, 2007 at a price of $0.75 per share, sold to investors in the
private placement; (3) 310,787 shares are issuable upon exercise of warrants,
exercisable until December 31, 2007 at a price of $0.35 per share, issued as
consideration for placement services rendered in connection with the private
placement, and (4) 152,286 shares are issuable upon exercise of warrants,
exercisable until December 31, 2007 at a price of $0.75 per share, issued as
consideration for placement services rendered in connection with the private
placement. These shares of our common stock are included in this prospectus
pursuant to registration rights we granted in connection with the December 2002
private placement.

         Of the remaining 194,300 shares of our common stock registered for
resale through this prospectus and listed under the column "Shares Available for
Sale Under This Prospectus" on the table set forth below, 160,000 shares are
issuable upon exercise of warrants, exercisable until December 14, 2007 at
prices ranging from $0.35 to $0.58 per share, issued to certain of our
consultants and 34,300 shares were issued to those consultants, in each case as
payment for consulting services. These shares of our common stock are included
in this prospectus pursuant to the registration rights we granted in connection
with the engagement of these consultants.

         The following table sets forth, to our knowledge, the number of shares
beneficially owned by each of the selling stockholders as of the date of this
prospectus. We are not able to estimate the amount of shares that will be held
by each selling stockholder after the completion of this offering because (1)
the selling stockholders may sell less than all of the shares registered under
this prospectus, (2) the selling stockholders may exercise less than all of
their warrants. The following table assumes that all of the currently
outstanding warrants will be exercised into common stock and all of the shares

being registered pursuant to this prospectus will be sold. The selling
stockholders are not making any representation that any shares covered by this
prospectus will be offered for sale. Except as otherwise indicated, based on
information provided to us by each selling stockholder, the selling stockholders
have sole voting and investment power with respect to their shares of common
stock.



                                                                                                           PERCENT OF
                                                                                             NUMBER OF       COMMON
                                                                                             SHARES OF      STOCK TO
                                         NUMBER OF                           SHARES        COMMON STOCK     BE OWNED
                                         SHARES OF        PERCENT OF      AVAILABLE FOR     TO BE OWNED       AFTER
                                        COMMON STOCK     COMMON STOCK      SALE UNDER          AFTER       COMPLETION
                                        OWNED BEFORE     OWNED BEFORE         THIS         COMPLETION OF     OF THE
      NAME OF SELLING STOCKHOLDER     THE OFFERING (1)   THE OFFERING    PROSPECTUS (1)    THE OFFERING     OFFERING
      ---------------------------     ----------------   ------------    --------------    -------------   ----------
                                                                                            
Concordia Capital                         1,002,637               3.5%         985,714          16,923            *
Steve H. Kanzer (2)                         747,713               2.6%          80,193         666,800          2.8%
Pharmainvestors, LLC (3)                    831,666               2.1%         429,291         402,375          1.7%
Harris Kanzer (4)                           400,000               2.2%         400,000              --           --
Odisseas Myrianthopoulos (5)                225,000                 *          225,000              --           --
David M. Kent (6)                           214,286                 *          214,286              --           --
Alberto Guiterez                            214,286                 *          214,286              --           --
Ralph M. Ellison Living Trust (7)           157,143                 *          157,143              --           --
Martin Draper                               128,571                 *          128,571              --           --
William Kanzer (8)                          214,286                 *          214,286              --           --
Catherine Makary                            150,000                 *          150,000              --           --
Mitchell Littman
   and Sima Littman JTWROS                  107,143                 *          107,143              --           --
Ivy Scheinholz                               90,000                 *           90,000              --           --
Ed O'Donnell                                107,143                 *          107,143              --           --
Daniel Kessel, M.D. (9)                      64,286                 *           64,286              --           --
Lawrence and Shirley Kessel (10)            214,286                 *           64,286         161,920            *
Charles Griffith                             64,286                 *           64,286              --           --
Gilbert Goldstein                            51,429                 *           51,429              --           --
Nicholas Stergis (11)                       563,528               2.0%          80,913         439,758         1.9%
Nicholas and
   Jennifer Stergis JTWROS                   42,857                 *           42,857              --           --
Guilhem Canstagne                            42,857                 *           42,857              --           --
Ken Alberstadt                               42,857                 *           42,857              --           --
Dewey Tran                                   22,500                 *           22,500              --           --
Giuseppe Cavalieri                           42,857                 *           42,857              --           --
Eva Weinberg (12)                            15,000                 *           15,000              --           --
Peter Salomon (13)                          165,000                 *           15,000         150,000            *
John and Tiffany Ofenloch                     6,429                 *            6,429              --           --
Louis Bianco                                214,286                 *          214,286              --           --
James Bianco, M.D.                          214,286                 *          214,286              --           --
Nicole Scheinholz                            15,000                 *           15,000              --           --
Atlas Capital Services, LLC (14)            195,669                 *          195,669              --           --
Steven Pollan (15)                           35,619                 *           35,619              --           --
Dan Myers (16)                                4,505                 *            4,505              --           --
Redington, Inc. (17)                        164,300                 *          164,300              --           --
Ibis Consulting Group, Inc. (18)             30,000                 *           30,000              --           --
Evan Myrianthopoulos (19)                   215,454                 *           65,454         150,000            *
Pharmainvestors, LLC (19)                   831,666              2.1%          429,291          402,375         1.7%
Amanda Ellison Living Trust (20)             57,143                 *           57,143                -            -
Keith Price (21)                             71,428                 *           71,428                -            -
Enrico Torcivia (22)                         17,143                 *           17,143                -            -
Brian Meister (23)                           11,428                 *           11,428                -            -
Gary Kanzer (24)                            142,858                 *          142,858                -            -


*        Less than 1%.

--------------


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(1)  Includes shares of common stock issuable upon the exercise of warrants as
     follows: Concordia Capital 328,571 shares; Steve H. Kanzer 80,913 shares;
     Pharmainvestors, LLC 142,857 shares; Harris Kanzer 214,286 shares; Odisseas
     Myrianthopoulos 75,000 shares; David M. Kent 71,429 shares; Alberto
     Guiterez 71,429 shares; Ralph M. Ellison 71,429 shares; William Kanzer
     71,429 shares; Catherine Makary 50,000 shares; Martin Draper 42,857 shares;
     Mitchell Littman and Sima Littman JTWROS 35,714 shares; Ivy Scheinholz
     30,000 shares; Ed O'Donnell 35,714 shares; Daniel Kessel 21,429 shares;
     Lawrence and Shirley Kessel 171,249 shares; Charles Griffith 21,429 shares;
     Gilbert Goldstein 17,143 shares; Nicholas and Jennifer Stergis JTWROS
     80,611 shares; Guilhem Canstagne 14,286 shares; Ken Alberstadt 14,286
     shares; Dewey Tran 7,500 shares; Giuseppe Cavalieri 14,286 shares; Eva
     Weinberg 5,000 shares; Peter Salomon 5,000 shares; John and Tiffany
     Ofenloch 2,143 shares; Louis Bianco 71,429; James Bianco 71,429 shares;
     Nicole Scheinholz 5,000 shares; Atlas Capital Services, LLC 195,669 shares;
     Steven Pollan 35,619 shares; Dan Myers 4,505 shares; Reddington, Inc.
     130,000 shares; Ibis Consulting Group, Inc. 30,000 shares; and Evan
     Myrianthopoulos 65,454 shares.

(2)  Steve H. Kanzer is our Vice Chairman of the Board of Directors, and from
     June 2002 until January 2003 was our Chairman of the Board and Interim
     President. He has been a member of our Board of Directors since 1996. Mr.
     Kanzer is also Chairman, Chief Executive Officer and sole stockholder of
     Accredited Equities, Inc. and Accredited Ventures, Inc., which are merchant
     banking and venture capital firms specializing in biotechnology companies
     and, which provided placement services in connection with our December 2002
     private placement. As consideration for these placement services, we issued
     to Mr. Kanzer warrants to purchase 54,304 shares of our common stock,
     exercisable until December 31, 2007 at a price of $0.35 per share, and
     warrants to purchase 26,609 shares, exercisable until December 31, 2007 at
     a price of $0.75 per share. The shares subject to these warrants are
     registered for resale in this prospectus (see footnote (1)). The number of
     shares beneficially owned by Mr. Kanzer includes 616,800 shares immediately
     issuable upon exercise of options. The number of shares beneficially owned
     by Mr. Kanzer does not include 688,809 shares of common stock and 142,857
     shares of common stock issuable upon the exercise of warrants held by
     Pharmainvestors, LLC (see footnote (3)).

(3)  Pharmainvestors, LLC, is a limited liability company incorporated under the
     laws of Nevis, West Indies, the sole member of which is an irrevocable
     trust of which Steve H. Kanzer is a beneficiary, but over which he has no
     control. Henry Schwartz is the sole trustee of the irrevocable trust. The
     shares beneficially owned by Pharmainvestors, LLC consist of 688,809 shares
     of common stock and 142,857 shares of common stock issuable upon the
     exercise of warrants. The shares subject to these warrants are registered
     for resale in this prospectus (see footnote (1)). Mr. Kanzer disclaims
     beneficial ownership of such shares.

(4)  Harris Kanzer is the father of our Vice Chairman of the Board, Steve H.
     Kanzer. They do not reside in the same household. His shares have been
     reduced by the amount he has gifted as set forth in footnotes (21-24).

(5)  Odisseas Myrianthopoulos is the adult cousin of Evan Myrianthopoulos, one
     of the members of our board of directors. They do not reside in the same
     household.

(6)  David M. Kent was our Chief Executive Officer and President from January
     2003 to February 2003.

(7)  Ralph M. Ellison has been our Chief Executive Officer and President since
     March 2003. His shares have been reduced by the amount he has gifted as set
     forth in footnote (20).

(8)  William Kanzer is the adult brother of our Vice Chairman of the Board,
     Steve H. Kanzer. They do not reside in the same household.

(9)  Dr. Daniel Kessel is the adult brother of Dr. Larry Kessel, one of the
     members of our board of directors. They do not reside in the same
     household.

(10) Lawrence Kessel has been a member of our Board of Directors since June
     2002. The shares beneficially owned by him include 150,000 shares of common
     stock immediately issuable upon exercise of options.

(11) Nicholas Stergis is employed by Accredited Equities, Inc., which served as
     a selected dealer to our placement agent for the December 2002 private
     placement. As consideration for these placement services, we issued to Mr.
     Stergis warrants to purchase 54,304 shares of our common stock, exercisable
     until December 31, 2007 at a price of $0.35 per share, and warrants to
     purchase 26,609 shares, exercisable until December 31, 2007 at a price of
     $0.75 per share. The shares subject to these




                                       3

     warrants are registered for resale in this prospectus (see footnote (1)).
     The number of shares beneficially owned by Mr. Stergis includes 129,552
     shares of common stock issuable upon exercise of options. The number of
     shares beneficially owned by Mr. Stergis does not include 42,857 shares of
     common stock owned by Nicholas and Jennifer Stergis as joint tenants with
     right of survivorship.

(12) Eva Weinberg is the adult sister of Dr. Peter Salomon, one of the members
     of our board of directors. They do not reside in the same household.

(13) Dr. Peter Salomon has been a member of our Board of Directors since June
     2002. The shares beneficially owned by him include 150,000 shares of common
     stock immediately issuable upon exercise of options.

(14) Atlas Capital Services, LLC provided placement services in connection with
     our December 2002 private placement. As consideration for the placement
     services provided by Atlas, we issued to Atlas warrants to purchase 131,321
     shares, exercisable until December 31, 2007 at a price of $0.35 per share,
     and warrants to purchase 64,348 shares, exercisable until December 31, 2007
     at a price of $0.75 per share. The shares subject to these warrants are
     registered for resale in this prospectus (see footnote (1)).

(15) Steve Pollan is an employee of Atlas Capital Services, LLC. As
     consideration for the placement services provided by Atlas, we issued to
     Mr. Pollan warrants to purchase 23,905 shares, exercisable until December
     31, 2007 at a price of $0.35 per share, and warrants to purchase 11,714
     shares, exercisable until December 31, 2007 at a price of $0.75 per share.
     The shares subject to these warrants are registered for resale in this
     prospectus (see footnote (1)).

(16) Dan Myers is an employee of Atlas Capital Services, LLC. As consideration
     for the placement services provided by Atlas, we issued to Mr. Myers
     warrants to purchase 3,024 shares, exercisable until December 31, 2007 at a
     price of $0.35 per share, and warrants to purchase 1,481 shares,
     exercisable until December 31, 2007 at a price of $0.75 per share. The
     shares subject to these warrants are registered for resale in this
     prospectus (see footnote (1)).

(17) Redington, Inc. serves as a consultant to the Company. We issued to
     Redington warrants to purchase 130,000 shares, exercisable until December
     14, 2007 at prices ranging from $0.35 to $0.58 per share, as payment for
     consulting services. These warrants vest upon the Company's common stock
     attaining certain price levels, and the shares subject to these warrants
     are registered for resale in this prospectus. (see footnote (1)).

(18) Ibis Consulting Group, Inc. serves as a consultant to the Company. We
     issued to Ibis warrants to purchase 30,000 shares, exercisable until
     December 14, 2004 at prices ranging from $0.35 to $0.58 per share, as
     payment for consulting services. The shares subject to these warrants are
     registered for resale in this prospectus (see footnote (1)).

(19) Evan Myrianthopoulos has been a member of our Board of Directors since
     November 2002. Mr. Myrianthopoulos provided placement services in
     connection with our December 2002 private placement. As consideration for
     these services, we issued to Mr. Myrianthopoulos warrants to purchase
     43,929 shares, exercisable until December 31, 2007 at a price of $0.35 per
     share, and warrants to purchase 21,525 shares, exercisable until December
     31, 2007 at a price of $0.75 per share. The shares subject to these
     warrants are registered for resale in this prospectus (see footnote (1)).
     The number of shares beneficially owned by Mr. Myrianthopoulos includes
     150,000 shares immediately issuable upon exercise of options.

(20) Amanda Ellison is the wife of our Chief Executive Officer and President
     Ralph Ellison. The shares were gifted to the Amanda Ellison living trust
     from the Ralph Ellison living trust.

(21) Keith Price acquired his shares in a gift from Harris Kanzer.

(22) Enrico Torcivia acquired his shares in a gift from Harris Kanzer.

(23) Brian Meister acquired his shares in a gift form Harris Kanzer.

(24) Gary Kanzer, the brother of our Vice Chairman Steve Kanzer, acquired his
     shares in a gift from Harris Kanzer.

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