UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 6-K
REPORT OF FOREIGN PRIVATE ISSUER
PURSUANT TO RULE 13a-16 OR 15d-16
OF THE SECURITIES EXCHANGE ACT OF 1934
June 14, 2005
Commission File Number 0-21392
AMARIN CORPORATION PLC
(Translation of registrant's name into English)
7 Curzon Street
London W1J 5HG
England
(Address of principal executive offices)
Indicate by check mark whether the registrant files or will file annual
reports under cover of Form 20-F or Form 40-F:
Form 20-F [X] Form 40-F [ ]
Indicate by check mark whether by furnishing the information contained
in this Form, the registrant is also thereby furnishing the information to the
Commission pursuant to Rule 12g3-2(b) under the Securities Exchange Act of 1934.
Yes [ ] No [X]
Attachment:
Material Events
(a) Amarin Corporation announces commencement of recruitment for Miraxion
Phase III clinical trial in Huntington's disease.
This report on Form 6-K is hereby incorporated by reference
in (a) the registration statement on Form F-3 (Registration No.
333-104748) of Amarin Corporation plc and in the prospectus
contained therein, (b) the registration statement on Form F-3
(Registration No. 333-13200) of Amarin Corporation plc and in the
prospectus contained therein, (c) the registration statement on
Form F-3 (Registration No. 333-12642) of Amarin Corporation plc and
in the prospectus contained therein, (d) the registration statement
on Form F-3 (Registration No. 333-121431) of Amarin Corporation plc and
in the prospectus contained therein and (e) the registration statement
on Form F-3 (Registration No. 333-121760) of Amarin Corporation plc and
in the prospectus contained therein, and this report on Form 6-K
shall be deemed a part of each such registration statement from the
date on which this report is filed, to the extent not superseded by
documents or reports subsequently filed or furnished by Amarin
Corporation plc under the Securities Act of 1933 or the Securities
Exchange Act of 1934.
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned, thereunto duly authorized.
AMARIN CORPORATION PLC
By: /s/ Richard A.B. Stewart
Name: Richard A.B. Stewart
Title: Chief Executive Officer
Date: June 14, 2005
EXHIBIT INDEX
Index to Exhibits
Exhibit Item Sequentially Numbered Page
(a) Material event description 4
Contact:
Rick Stewart
Chief Executive Officer
Amarin Corporation plc
Phone: +44 (0) 207 907 2442
investor.relations@amarincorp.com
Alan Cooke
Chief Financial Officer
Amarin Corporation plc
Phone: +44 (0) 207 907 2442
AMARIN ANNOUNCES COMMENCEMENT OF RECRUITMENT BY HUNTINGTON STUDY
GROUP FOR MIRAXION PHASE III CLINICAL TRIAL IN HUNTINGTON'S DISEASE
LONDON, United Kingdom, June 14th, 2005 - Amarin Corporation plc
(NASDAQSC: AMRN) today announced that the Huntington Study Group ("HSG")
has commenced recruitment for the U.S. Phase III clinical trial of Miraxion(TM)
in Huntington's disease.
The HSG will be conducting a clinical study (TREND-HD) of ultra-pure ethyl-EPA
in persons 35 years of age or older who have mild to moderate Huntington's
disease. The HSG is a worldwide, not-for-profit group of physicians and other
clinical researchers who are experienced in the care of Huntington's disease
patients and dedicated to clinical research in Huntington's disease.
Huntington's disease is an inherited disease of the brain that usually begins
between the ages of 30 to 50, and includes motor, cognitive and behavioral signs
and symptoms. While there are medications to help relieve some of the disease
symptoms, there is no known treatment to slow the progression of Huntington's
disease, which affects about 30,000 people in North America.
Miraxion is thought to stabilize nerve cell membranes and improve neurological
functioning, although the exact mechanism of action is not currently known. An
earlier trial in subjects with Huntington's disease indicated that Miraxion at 2
grams daily was well tolerated over 12 months. This current trial is designed to
determine the effect of this daily dose of Miraxion on motor (movement) signs
and symptoms of Huntington's disease.
The current 12 month study includes a 6 month placebo controlled phase with
research subjects being randomly assigned to receive either Miraxion (2 grams
total daily dose) or a matching placebo. This will be followed by another 6
month observation phase in which all participants will receive Miraxion.
Researchers at 43 sites in the United States and Canada will each enroll
approximately 7-8 research subjects with early signs of Huntington's disease
who are independently ambulatory (walking) and fully self sufficient in
activities of daily living, such as eating, dressing and bathing.
There is no cost to participate in the study. Participants will be followed as
"out-patients" at regular intervals for 12 months. Individuals with mild to
moderate Huntington's disease who are interested in participating in this study
should visit the Huntington's Study Group website at: www.Huntington-Study-
Group.org or call the toll free number +1 (800) 487 7671.
Rick Stewart, chief executive officer of Amarin, commented; "commencement of
recruitment to the Phase III clinical trial for Miraxion is a major milestone
for Amarin. An immense amount of energy and dedication has been expended by all
involved to achieve this significant objective."
Contact:
Amarin Corporation plc +44 (0) 207 907 2442
Rick Stewart Chief Executive Officer
Alan Cooke Chief Financial Officer
investor.relations@amarincorp.com
Powerscourt +44 (0) 207 236 5615
Rory Godson/Victoria Brough
About Amarin Corporation
Amarin Corporation plc is a neuroscience company focused on the development and
commercialization of novel drugs for the treatment of central nervous system
disorders. Miraxion, Amarin's lead development compound, is in phase III
development for Huntington's disease and in phase II development for treatment-
unresponsive depression.
For press releases and other corporate information, visit our website at
http://www.amarincorp.com.
Statements in this press release that are not historical facts are forward-
looking statements that involve risks and uncertainties which may cause the
Company's actual results in future periods to be materially different from any
performance suggested herein. Such risks and uncertainties include, without
limitation, the inherent uncertainty of pharmaceutical research, product
development and commercialization, the impact of competitive products and
patents, as well as other risks and uncertainties detailed from time to time in
periodic reports. For more information, please refer to Amarin Corporation's
Annual Report for 2004 on Form 20-F and its Form 6-Ks as filed with the U.S.
Securities and Exchange Commission. The Company assumes no obligation to update
information on its expectations.