SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  SCHEDULE 13D

                    UNDER THE SECURITIES EXCHANGE ACT OF 1934


                             AMARIN CORPORATION PLC
--------------------------------------------------------------------------------
                                (Name of Issuer)
--------------------------------------------------------------------------------
                           AMERICAN DEPOSITORY SHARES
       EACH REPRESENTING ONE ORDINARY SHARE, POUND STERLING1.00 PER SHARE
--------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                   023111 10 7
--------------------------------------------------------------------------------
                                 (CUSIP Number)

                                MARTIN P. SUTTER
                     10001 WOODLOCH FOREST DRIVE, SUITE 175
                           THE WOODLANDS, TEXAS 77380
                                 (281) 364-1555
--------------------------------------------------------------------------------
   (Name, Address and Telephone Number of Person Authorized to Receive Notices
                               and Communications)


                                JANUARY 27, 2003
--------------------------------------------------------------------------------
             (Date of Event which Requires Filing of this Statement)



If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  that is the subject of this  Schedule  13D, and is filing this
schedule because of Sections 240.13d-1(e),  240.13d-1(f) or 240.13d-1(g),  check
the following box. [ ]

NOTE:  Schedules  filed in paper format shall include a signed original and five
copies of the schedule,  including all exhibits. See Section 240.13d-7 for other
parties to whom copies are to be sent.

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).





                                  SCHEDULE 13D



--------------------------------------------------------------------------------------------------------------------------
CUSIP NO.          023111 10 7                                                                         PAGE 2 OF 12 PAGES
--------------------------------------------------------------------------------------------------------------------------
                                                                                                    
          NAME OF REPORTING PERSON
   1      S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                   Essex Woodlands Health Ventures Fund V, L.P.
--------------------------------------------------------------------------------------------------------------------------
          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP                                                 (a)    [   ]
   2
                                                                                                           (b)    [ X ]
--------------------------------------------------------------------------------------------------------------------------
          SEC USE ONLY
   3

--------------------------------------------------------------------------------------------------------------------------
          SOURCE OF FUNDS
   4
                   WC
--------------------------------------------------------------------------------------------------------------------------
          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR  2(e)
   5                                                                                                               [  ]

--------------------------------------------------------------------------------------------------------------------------
          CITIZENSHIP OR PLACE OF ORGANIZATION
   6
                   Delaware
-------------------------------------------------------------------------------------------------------------------------
                                         SOLE VOTING POWER
                                   7
                                              3,220,420
           NUMBER OF             -----------------------------------------------------------------------------------------
            SHARES                       SHARED VOTING POWER
         BENEFICIALLY              8
           OWNED BY                           -0-
             EACH                -----------------------------------------------------------------------------------------
           REPORTING                     SOLE DISPOSITIVE POWER
            PERSON                 9
             WITH                             3,220,420
                                 -----------------------------------------------------------------------------------------
                                         SHARED DISPOSITIVE POWER
                                   10
                                              -0-
-------------------------------------------------------------------------------------------------------------------------
          AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
   11
                   3,220,420
--------------------------------------------------------------------------------------------------------------------------
          CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES                                   
   12                                                                                                             [  ]

--------------------------------------------------------------------------------------------------------------------------
          PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
   13
                   8.6%
--------------------------------------------------------------------------------------------------------------------------
          TYPE OF REPORTING PERSON
   14
                   PN
--------------------------------------------------------------------------------------------------------------------------










--------------------------------------------------------------------------------------------------------------------------
CUSIP NO.          023111 10 7                                                                         PAGE 3 OF 12 PAGES
--------------------------------------------------------------------------------------------------------------------------
                                                                                                    
          NAME OF REPORTING PERSON
   1      S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                   Essex Woodlands Health Ventures Fund V, L.L.C.
--------------------------------------------------------------------------------------------------------------------------
          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP                                                 (a)    [   ]
   2
                                                                                                           (b)    [ X ]
--------------------------------------------------------------------------------------------------------------------------
          SEC USE ONLY
   3

--------------------------------------------------------------------------------------------------------------------------
          SOURCE OF FUNDS
   4
                   OO
--------------------------------------------------------------------------------------------------------------------------
          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR  2(e)
   5                                                                                                               [  ]

--------------------------------------------------------------------------------------------------------------------------
          CITIZENSHIP OR PLACE OF ORGANIZATION
   6
                   Delaware
-------------------------------------------------------------------------------------------------------------------------
                                         SOLE VOTING POWER
                                   7
                                              3,220,420
           NUMBER OF             -----------------------------------------------------------------------------------------
            SHARES                       SHARED VOTING POWER
         BENEFICIALLY              8
           OWNED BY                           -0-
             EACH                -----------------------------------------------------------------------------------------
           REPORTING                     SOLE DISPOSITIVE POWER
            PERSON                 9
             WITH                             3,220,420
                                 -----------------------------------------------------------------------------------------
                                         SHARED DISPOSITIVE POWER
                                   10
                                              -0-
-------------------------------------------------------------------------------------------------------------------------
          AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
   11
                   3,220,420
--------------------------------------------------------------------------------------------------------------------------
          CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES                                   
   12                                                                                                             [  ]

--------------------------------------------------------------------------------------------------------------------------
          PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
   13
                   8.6%
--------------------------------------------------------------------------------------------------------------------------
          TYPE OF REPORTING PERSON
   14
                   OO
--------------------------------------------------------------------------------------------------------------------------








--------------------------------------------------------------------------------------------------------------------------
CUSIP NO.          023111 10 7                                                                         PAGE 4 OF 12 PAGES
--------------------------------------------------------------------------------------------------------------------------
                                                                                                    
          NAME OF REPORTING PERSON
   1      S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                   James L. Currie
--------------------------------------------------------------------------------------------------------------------------
          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP                                                 (a)    [   ]
   2
                                                                                                           (b)    [ X ]
--------------------------------------------------------------------------------------------------------------------------
          SEC USE ONLY
   3

--------------------------------------------------------------------------------------------------------------------------
          SOURCE OF FUNDS
   4
                   OO
--------------------------------------------------------------------------------------------------------------------------
          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR  2(e)
   5                                                                                                               [  ]

--------------------------------------------------------------------------------------------------------------------------
          CITIZENSHIP OR PLACE OF ORGANIZATION
   6
                   United States
-------------------------------------------------------------------------------------------------------------------------
                                         SOLE VOTING POWER
                                   7
                                              -0-
           NUMBER OF             -----------------------------------------------------------------------------------------
            SHARES                       SHARED VOTING POWER
         BENEFICIALLY              8
           OWNED BY                           3,220,420
             EACH                -----------------------------------------------------------------------------------------
           REPORTING                     SOLE DISPOSITIVE POWER
            PERSON                 9
             WITH                             -0-
                                 -----------------------------------------------------------------------------------------
                                         SHARED DISPOSITIVE POWER
                                   10
                                              3,220,420
-------------------------------------------------------------------------------------------------------------------------
          AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
   11
                   3,220,420
--------------------------------------------------------------------------------------------------------------------------
          CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES                                   
   12                                                                                                             [  ]

--------------------------------------------------------------------------------------------------------------------------
          PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
   13
                   8.6%
--------------------------------------------------------------------------------------------------------------------------
          TYPE OF REPORTING PERSON
   14
                   IN
--------------------------------------------------------------------------------------------------------------------------








--------------------------------------------------------------------------------------------------------------------------
CUSIP NO.          023111 10 7                                                                         PAGE 5 OF 12 PAGES
--------------------------------------------------------------------------------------------------------------------------
                                                                                                    
          NAME OF REPORTING PERSON
   1      S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                   Martin P. Sutter
--------------------------------------------------------------------------------------------------------------------------
          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP                                                 (a)    [   ]
   2
                                                                                                           (b)    [ X ]
--------------------------------------------------------------------------------------------------------------------------
          SEC USE ONLY
   3

--------------------------------------------------------------------------------------------------------------------------
          SOURCE OF FUNDS
   4
                   OO
--------------------------------------------------------------------------------------------------------------------------
          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR  2(e)
   5                                                                                                               [  ]

--------------------------------------------------------------------------------------------------------------------------
          CITIZENSHIP OR PLACE OF ORGANIZATION
   6
                   United States
-------------------------------------------------------------------------------------------------------------------------
                                         SOLE VOTING POWER
                                   7
                                              -0-
           NUMBER OF             -----------------------------------------------------------------------------------------
            SHARES                       SHARED VOTING POWER
         BENEFICIALLY              8
           OWNED BY                           3,220,420
             EACH                -----------------------------------------------------------------------------------------
           REPORTING                     SOLE DISPOSITIVE POWER
            PERSON                 9
             WITH                             -0-
                                 -----------------------------------------------------------------------------------------
                                         SHARED DISPOSITIVE POWER
                                   10
                                              3,220,420
-------------------------------------------------------------------------------------------------------------------------
          AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
   11
                   3,220,420
--------------------------------------------------------------------------------------------------------------------------
          CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES                                   
   12                                                                                                             [  ]

--------------------------------------------------------------------------------------------------------------------------
          PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
   13
                   8.6%
--------------------------------------------------------------------------------------------------------------------------
          TYPE OF REPORTING PERSON
   14
                   IN
--------------------------------------------------------------------------------------------------------------------------








--------------------------------------------------------------------------------------------------------------------------
CUSIP NO.          023111 10 7                                                                         PAGE 6 OF 12 PAGES
--------------------------------------------------------------------------------------------------------------------------
                                                                                                    
          NAME OF REPORTING PERSON
   1      S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                   Immanuel Thangaraj
--------------------------------------------------------------------------------------------------------------------------
          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP                                                 (a)    [   ]
   2
                                                                                                           (b)    [ X ]
--------------------------------------------------------------------------------------------------------------------------
          SEC USE ONLY
   3

--------------------------------------------------------------------------------------------------------------------------
          SOURCE OF FUNDS
   4
                   OO
--------------------------------------------------------------------------------------------------------------------------
          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR  2(e)
   5                                                                                                               [  ]

--------------------------------------------------------------------------------------------------------------------------
          CITIZENSHIP OR PLACE OF ORGANIZATION
   6
                   United States
-------------------------------------------------------------------------------------------------------------------------
                                         SOLE VOTING POWER
                                   7
                                              -0-
           NUMBER OF             -----------------------------------------------------------------------------------------
            SHARES                       SHARED VOTING POWER
         BENEFICIALLY              8
           OWNED BY                           3,220,420
             EACH                -----------------------------------------------------------------------------------------
           REPORTING                     SOLE DISPOSITIVE POWER
            PERSON                 9
             WITH                             -0-
                                 -----------------------------------------------------------------------------------------
                                         SHARED DISPOSITIVE POWER
                                   10
                                              3,220,420
-------------------------------------------------------------------------------------------------------------------------
          AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
   11
                   3,220,420
--------------------------------------------------------------------------------------------------------------------------
          CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES                                   
   12                                                                                                             [  ]

--------------------------------------------------------------------------------------------------------------------------
          PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
   13
                   8.6%
--------------------------------------------------------------------------------------------------------------------------
          TYPE OF REPORTING PERSON
   14
                   IN
--------------------------------------------------------------------------------------------------------------------------








--------------------------------------------------------------------------------------------------------------------------
CUSIP NO.          023111 10 7                                                                         PAGE 7 OF 12 PAGES
--------------------------------------------------------------------------------------------------------------------------
                                                                                                    
          NAME OF REPORTING PERSON
   1      S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                   J. Douglas Eplett
--------------------------------------------------------------------------------------------------------------------------
          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP                                                 (a)    [   ]
   2
                                                                                                           (b)    [ X ]
--------------------------------------------------------------------------------------------------------------------------
          SEC USE ONLY
   3

--------------------------------------------------------------------------------------------------------------------------
          SOURCE OF FUNDS
   4
                   OO
--------------------------------------------------------------------------------------------------------------------------
          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR  2(e)
   5                                                                                                               [  ]

--------------------------------------------------------------------------------------------------------------------------
          CITIZENSHIP OR PLACE OF ORGANIZATION
   6
                   United States
-------------------------------------------------------------------------------------------------------------------------
                                         SOLE VOTING POWER
                                   7
                                              -0-
           NUMBER OF             -----------------------------------------------------------------------------------------
            SHARES                       SHARED VOTING POWER
         BENEFICIALLY              8
           OWNED BY                           3,220,420
             EACH                -----------------------------------------------------------------------------------------
           REPORTING                     SOLE DISPOSITIVE POWER
            PERSON                 9
             WITH                             -0-
                                 -----------------------------------------------------------------------------------------
                                         SHARED DISPOSITIVE POWER
                                   10
                                              3,220,420
-------------------------------------------------------------------------------------------------------------------------
          AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
   11
                   3,220,420
--------------------------------------------------------------------------------------------------------------------------
          CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES                                   
   12                                                                                                             [  ]

--------------------------------------------------------------------------------------------------------------------------
          PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
   13
                   8.6%
--------------------------------------------------------------------------------------------------------------------------
          TYPE OF REPORTING PERSON
   14
                   IN
--------------------------------------------------------------------------------------------------------------------------






                         ORIGINAL REPORT ON SCHEDULE 13D

Item 1.  Security and Issuer

         This statement on Schedule 13D relates to the American Depository
Shares of Amarin Corporation PLC (the "Company"), each of which represents one
ordinary share, Pound Sterling1.00 per share (the "Ordinary Shares"), of the
Company. The Company's principal executive offices are located at 7 Curzon
Street, London W1J5HG, England.

Item 2.  Identity and Background

         (a) This Schedule 13D is being filed jointly by Essex Woodlands Health
Ventures Fund V, L.P., a Delaware limited partnership (the "Partnership"), Essex
Woodlands Health Ventures V, L.L.C., a Delaware limited liability company, the
general partner of the Partnership (the "General Partner"), James L. Currie, an
individual, Martin P. Sutter, an individual, Immanuel Thangaraj, an individual,
and J. Douglas Eplett, an individual (collectively, the "Reporting Persons").

         (b) The address of the principal business of each of the Reporting
Persons is 10001 Woodloch Forest Drive, Suite 175, The Woodlands, Texas 77380.

         (c) The principal business of the Partnership is venture capital
investments. The principal business of the General Partner is to act as the
general partner of the Partnership. Messrs. Currie, Sutter, Thangaraj and Eplett
are Managing Directors of the General Partner.

         (d) None of the Reporting Persons have during the last five years been
convicted in a criminal proceeding (excluding traffic violations or similar
misdemeanors).

         (e) None of the Reporting Persons have during the last five years been
a party to a civil proceeding of a judicial or administrative body of competent
jurisdiction as a result of which such person was or is subject to a judgment,
decree or final order enjoining future violations of, or prohibiting or
mandating activities subject to, federal or state securities laws or finding any
violation with respect to such laws.

         (f) Messrs. Currie, Sutter, Thangaraj and Eplett are citizens of the
United States.

Item 3.  Source and Amount of Funds or Other Consideration

         On January 27, 2003, the Partnership entered into a Subscription
Agreement (the "Subscription Agreement") with the Company, pursuant to which the
Partnership agreed to purchase 2,012,361 Ordinary Shares of the Company for a
purchase price of $3.4785 per share, which was based upon the average closing
price of the Company's American Depository Shares for the five trading days
ended January 14, 2003. The funds to purchase the Ordinary Shares were obtained
from working capital contributed by the partners in the Partnership.

         The Ordinary Shares purchased under the Subscription Agreement have
certain registration rights under a certain Registration Rights Agreement
executed in connection with the Subscription Agreement whereby the Company would
effect a Registration Statement on Form F-3 as soon as possible, but in any
event prior to 90 days, after the transaction. The forms of the Subscription
Agreement and the Registration Rights Agreement are filed as Exhibit 2.11 and
Exhibit 2.12, respectively, to the Company's Form 20-F on April 24, 2003. The
Company filed a Registration Statement on Form F-3 with the Commission on April
25, 2003.

         On October 6, 2004, the Partnership purchased an additional 1,267,159
Ordinary Shares in a private placement at a price of $0.947 per share, which was
based on the average closing price of the Company's American Depositary Shares
for the ten trading days ended October 6, 2004. The Company 


                                  Page 8 of 12





intends to file a registration statement for such shares with the Commission
within 60 days of the transaction. The funds to purchase the additional Ordinary
Shares were obtained from working capital contributed by the partners in the
Partnership.

Item 4.  Purpose of Transaction

         The Reporting Persons acquired the Ordinary Shares of the Company
reported herein solely for the purpose of investment. The Reporting Persons may
make additional purchases of Ordinary Shares or their equivalents either in the
open market or in private transactions depending on the Company's business,
prospects and financial condition, the market for the Ordinary Shares, general
economic conditions, money and stock market conditions and other future
developments.

         Except as described in this Schedule 13D, none of the Reporting Persons
have any present plan or proposal which relates to, or could result in, any of
the events referred to in paragraphs (a) through (j), inclusive, of Item 4 of
Schedule 13D. However, the Reporting Persons will continue to review the
business of the Company and, depending upon one or more of the factors referred
to above, may in the future propose that the Company take one or more such
actions.

         The information contained in Item 3 of this Schedule 13D is hereby
incorporated by reference.

Item 5.  Interest in Securities of the Partnership

         TOTAL OUTSTANDING SHARES. According to information provided to the
Reporting Persons by the Company, the number of the Company's Ordinary Shares
outstanding on November 11, 2004 (which includes Ordinary Shares represented by
outstanding American Depository Shares) was 37,632,123.

         THE PARTNERSHIP. As of the date of filing this Schedule 13D, the
Partnership is the holder of record of 3,220,420 American Depository Shares of
the Company, representing approximately 8.6% of the Ordinary Shares outstanding,
and has sole voting and investment power with respect to such securities.

         THE GENERAL PARTNER. The General Partner of the Partnership may also be
deemed to have sole voting and investment power with respect to such securities.
The General Partner disclaims beneficial ownership of such securities except to
the extent of its pecuniary interest therein.

         MESSRS. CURRIE, SUTTER, THANGARAJ AND EPLETT. Under the operating
agreement of the General Partner, Messrs. Currie, Sutter, Thangaraj and Eplett
have the power by unanimous consent (i) to cause the Partnership to buy and sell
marketable securities of portfolio companies and (ii) to direct the voting of
such securities. As a result, Messrs. Currie, Sutter, Thangaraj and Eplett may
also be deemed to have shared dispositive power and shared voting power with
respect to the securities held by the Partnership. Messrs. Currie, Sutter,
Thangaraj and Eplett disclaim beneficial ownership of such securities except to
the extent of their respective pecuniary interests therein.

         On October 6, 2004, the Partnership purchased an additional 1,267,159
Ordinary Shares as described in Item 3 herein.

         On November 9, 2004, the Partnership disposed of 50,000 Ordinary Shares
of the Company for $3.7752 per share and 9,100 Ordinary Shares of the Company
for $4.00 per share in the open market.

Item 6.  Contracts, Arrangements, Understandings or Relationships with respect
         to Securities of the Company

         The information contained in Item 3 of this Schedule 13D is hereby
incorporated by reference.


                                  Page 9 of 12





Item 7.  Material to be filed as Exhibits

         Exhibit A: Joint Filing Agreement, dated December 7, 2004.















                                  Page 10 of 12





                                   SIGNATURES

         After reasonable inquiry and to the best of our knowledge and belief,
the undersigned certify that the information set forth in this statement is
true, complete and correct.

Date: December 7, 2004                 ESSEX WOODLANDS HEALTH VENTURES
                                       FUND V, L.P.

                                           By: Essex Woodlands Health Ventures 
                                               V, L.L.C.

                                                   /s/ Martin P. Sutter
                                           -------------------------------------
                                           Name:   Martin P. Sutter
                                           Title:  Managing Director


                                       ESSEX WOODLANDS HEALTH VENTURES
                                       V, L.L.C.


                                          /s/ Martin P. Sutter
                                       -----------------------------------------
                                       Name:  Martin P. Sutter
                                       Title: Managing Director



                                          /s/ James L. Currie
                                       -----------------------------------------
                                       Name:  James L. Currie


                                          /s/ Martin P. Sutter
                                       -----------------------------------------
                                       Name:  Martin P. Sutter



                                          /s/ Immanuel Thangaraj
                                       -----------------------------------------
                                       Name:  Immanuel Thangaraj



                                          /s/ J. Douglas Eplett
                                       -----------------------------------------
                                       Name:  J. Douglas Eplett



                                  Page 11 of 12






                                    EXHIBIT A

                             JOINT FILING AGREEMENT

         Each of the undersigned agrees that (i) the statement on Schedule 13D
relating to the American Depository Shares representing Ordinary Shares of
Amarin Corporation PLC, has been adopted and filed on behalf of each of them,
(ii) all future amendments to such statement on Schedule 13D will, unless
written notice to the contrary is delivered as described below, be jointly filed
on behalf of each of them, and (iii) the provisions of Rule 13d-1(k)(1) under
the Securities Exchange Act of 1934 apply to each of them. This agreement may be
terminated with respect to the obligations to jointly file future amendments to
such statement on Schedule 13D as to any of the undersigned upon such person
giving written notice thereof to each of the other persons signature hereto, at
the principal office thereof.

         This Agreement may be executed in any number of counterparts, each of
which shall be deemed an original, but all of which together shall constitute
one and the same instrument.


Date: December 7, 2004                 ESSEX WOODLANDS HEALTH VENTURES
                                       FUND V, L.P.

                                           By: Essex Woodlands Health Ventures
                                               V, L.L.C.

                                            /s/ Martin P. Sutter
                                           -------------------------------------
                                           Name:   Martin P. Sutter
                                           Title:     Managing Director


                                       ESSEX WOODLANDS HEALTH VENTURES
                                       V, L.L.C.


                                          /s/ Martin P. Sutter
                                       -----------------------------------------
                                       Name:  Martin P. Sutter
                                       Title: Managing Director

                                          /s/ James L. Currie
                                       -----------------------------------------
                                       Name:  James L. Currie


                                          /s/ Martin P. Sutter
                                       -----------------------------------------
                                       Name:  Martin P. Sutter



                                          /s/ Immanuel Thangaraj
                                       -----------------------------------------
                                       Name:  Immanuel Thangaraj



                                          /s/ J. Douglas Eplett
                                       -----------------------------------------
                                       Name:  J. Douglas Eplett