Ownership Submission
FORM 3
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number: 3235-0104
Expires: January 31, 2005
Estimated average burden hours per response... 0.5

(Print or Type Responses)
1. Name and Address of Reporting Person *
  Lamb Peter
 2. Date of Event Requiring Statement (Month/Day/Year)
01/19/2007		 3. Issuer Name and Ticker or Trading Symbol
EXELIXIS INC [EXEL]
(Last)
(First)
(Middle)
PO BOX 511, 170 HARBOR WAY		 4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
SVP, Discovery Research & CSO
 5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

SOUTH SAN FRANCISCO, CA 94083-0511		 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)		 2. Amount of Securities Beneficially Owned
(Instr. 4)		 3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)		 4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock 2,680 (1)
I
By 401(k) plan

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)		 2. Date Exercisable and Expiration Date
(Month/Day/Year)		 3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)		 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)		 6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option (right to buy) 10/15/2000(2) 10/14/2010 Common Stock 47,250 $ 20.13 D  
Stock Option (right to buy) 01/15/2001(2) 01/14/2011 Common Stock 1,750 $ 9 D  
Stock Option (right to buy) 04/30/2001(2) 04/29/2011 Common Stock 23,625 $ 16 D  
Stock Option (right to buy) 01/01/2002(2) 12/31/2011 Common Stock 10,000 $ 16.62 D  
Stock Option (right to buy) 12/20/2002(2) 12/19/2012 Common Stock 10,000 $ 7.85 D  
Stock Option (right to buy) 04/15/2003(2) 04/14/2013 Common Stock 25,000 $ 7.47 D  
Stock Option (right to buy) 12/10/2003(2) 12/09/2013 Common Stock 40,000 $ 6.15 D  
Stock Option (right to buy) 12/13/2005(2) 12/12/2014 Common Stock 35,000 $ 8.92 D  
Stock Option (right to buy) 01/02/2007(2) 01/01/2016 Common Stock 120,000 $ 9.42 D  
Stock Option (right to buy) 01/02/2008(2) 01/01/2017 Common Stock 80,000 $ 9 D  

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
Lamb Peter
PO BOX 511
170 HARBOR WAY
SOUTH SAN FRANCISCO, CA 94083-0511		       SVP, Discovery Research & CSO  

Signatures

Peter Lamb 01/23/2007
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) The securities represent shares in the Exelixis stock fund based on a plan statement dated as of January 19, 2007.
(2) Options granted pursuant to Issuer's 2000 Equity Incentive Plan. Twenty five percent (25%) of the shares vest one year from the grant date, and the remaining shares vest in 36 equal monthly installments thereafter.

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, See Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB number.