Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
BEAR STEARNS COMPANIES INC
  2. Issuer Name and Ticker or Trading Symbol
AFFYMAX INC [AFFY]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director __X__ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
383 MADISON AVE.
3. Date of Earliest Transaction (Month/Day/Year)
12/20/2006
(Street)

NEW YORK, NY 10179
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing(Check Applicable Line)
___ Form filed by One Reporting Person
_X_ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 12/20/2006   C   662,601 (1) A (2) 662,601 I See Footnote (3) (4)
Common Stock 12/20/2006   C   496,950 (5) A (6) 1,159,551 I See Footnote (4) (7)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Series C Convertible Preferred Stock (2) 12/20/2006   C     662,601   (8)   (8) Common Stock 662,601 $ 0 0 D  
Series D Convertible Preferred Stock (6) 12/20/2006   C     496,950   (8)   (8) Common Stock 496,950 $ 0 0 D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
BEAR STEARNS COMPANIES INC
383 MADISON AVE.
NEW YORK, NY 10179
    X    
BEAR STEARNS ASSET MANAGEMENT INC
383 MADISON AVE.
NEW YORK, NY 10179
    X    
BEAR STEARNS HEALTH INNOVENTURES MANAGEMENT LLC
383 MADISON AVE.
NEW YORK, NY 10179
    X    
BSHI Members LLC
383 MADISON AVE.
NEW YORK, NY 10179
    X    
BEAR STEARNS HEALTH INNOVENTURES LP
383 MADISON AVE.
NEW YORK, NY 10179
    X    
Bear Stearns Health Innoventures Offshore LP
383 MADISON AVE.
NEW YORK, NY 10179
    X    
BX LP
383 MADISON AVE.
NEW YORK, NY 10179
    X    
BEAR STEARNS HEALTH INNOVENTURES EMPLOYEE FUND LP
383 MADISON AVE.
NEW YORK, NY 10179
    X    
RYSER STEFAN
383 MADISON AVE.
NEW YORK, NY 10179
    X    

Signatures

 /s/ Kenneth L. Edlow, Secretary, The Bear Stearns Companies Inc.   12/20/2006
**Signature of Reporting Person Date

 /s/ Roger Baumann, Senior Managing Director, Bear Stearns Asset Management, Inc.   12/20/2006
**Signature of Reporting Person Date

 /s/ Stefan Ryser, Managing Partner, Bear Stearns Health Innoventures Management, LLC   12/20/2006
**Signature of Reporting Person Date

 /s/ Stefan Ryser, Authorized Signatory, Bear Stearns Asset Management Inc., Manager of BSHI Members, LLC   12/20/2006
**Signature of Reporting Person Date

 /s/ Stefan Ryser, Managing Partner, Bear Stearns Health Innoventures Management, LLC, General Partner of Bear Stearns Health Innoventures L.P.   12/20/2006
**Signature of Reporting Person Date

 /s/ Stefan Ryser, Managing Partner, Bear Stearns Health Innoventures Management, LLC, General Partner of Bear Stearns Health Innoventures Offshore, L.P.   12/20/2006
**Signature of Reporting Person Date

 /s/ Stefan Ryser, Managing Partner, Bear Stearns Health Innoventures Management, LLC, General Partner of BX, L.P.   12/20/2006
**Signature of Reporting Person Date

 /s/ Stefan Ryser, Managing Partner, Bear Stearns Health Innoventures Management, LLC, General Partner of Bear Stearns Health Innoventures Employee Fund, L.P.   12/20/2006
**Signature of Reporting Person Date

 /s/ Stefan Ryser, as an Individual   12/20/2006
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Automatic conversion upon the closing of the Issuer's initial public offering of Series C Preferred Stock at a rate of 1 for 1, resulting in the issuance of 662,601 shares of common stock. The shares were issued as follows: 62,203 to Bear Stearns Health Innoventures Employee Fund, L.P. ("Employee Fund"), 78,887 to Bear Stearns Health Innoventures Offshore, L.P. ("Offshore"), 95,892 to Bear Stearns Health Innoventures, L.P. ("BSHI"), 44,568 to BSHI Members, L.L.C. ("Members") and 381,051 to BX, L.P. ("BX").
(2) The Series C Preferred Stock converted into the Issuer's common stock at a rate of 1 for 1.
(3) The shares are held as follows: 62,203 by Employee Fund, 78,887 Offshore, 95,892 by BSHI, 44,568 Members and 381,051 by BX. Each Reporting Person disclaims beneficial ownership of any securities that exceed its pecuniary interest in the securities held by these entities.
(4) The Bear Stearns Companies, Inc. ("BSCI") is the parent company of Bear Stearns Asset Management, Inc. ("BSAM"). BSAM is the sole manager of Bear Stearns Health Innoventures Management, LLC ("Management") and the sole manager of Members. Dr. Ryser and Elizabeth Czerepak are managing partners of Management. Management is the sole general partner of BSHI, the sole general partner of Offshore, the sole general partner of BX, and the sole general partner of Employee Fund and Members co-invests with these funds.
(5) Automatic conversion upon the closing of the Issuer's initial public offering of Series D Preferred Stock at a rate of 1 for 1, resulting in the issuance of 496,950 shares of common stock. The shares were issued as follows: 46,652 to Employee Fund, 59,165 to Offshore, 71,919 to BSHI, 33,426 to Members and 285,788 to BX.
(6) The Series D Preferred Stock converted into the Issuer's common stock at a rate of 1 for 1.
(7) The shares are held as follows: 108,855 by Employee Fund, 138,052 Offshore, 167,811 by BSHI, 77,994 Members and 666,839 by BX. Each Reporting Person disclaims beneficial ownership of any securities that exceed its pecuniary interest in the securities held by these entities.
(8) The securities are preferred stock of the Issuer and do not have an expiration date. The securities automatically converted into common stock upon the closing of the Issuer's initial public offering.

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