SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 ________ FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of April, 2003 Serono S.A. ----------------------------------- (Registrant's Name) 15 bis, Chemin des Mines Case Postale 54 CH-1211 Geneva 20 Switzerland ----------------------------------- (Address of Principal Executive Offices) 1-15096 ----------------------------------- (Commission File No.) (Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F.) Form 20-F X Form 40-F --- --- (Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101 (b)(1).) --- (Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101 (b)(7).) --- (Indicate by check mark whether the registrant by furnishing the information contained in this form is also thereby furnishing the information to the Commission pursuant to Rule 12g3-2(b) under the Securities Exchange Act of 1934.) Yes No X --- --- (If "Yes" is marked, indicate below the file number assigned to the registrant in connection with Rule 12g3-2(b): 82-______) Serono [GRAPHIC OMITTED] Media Release FOR IMMEDIATE RELEASE ----------------------- SERONO ANNOUNCES GOOD FIRST QUARTER RESULTS WITH STRONG REVENUE GROWTH - Rebif(R) sales of $175.2m and Gonal-F(R) sales of $122.0m - - Raptiva(TM) filed for psoriasis in the EU, Switzerland and Canada - GENEVA, SWITZERLAND, APRIL 24, 2003 - Serono S.A. (virt-x: SEO and NYSE: SRA) today reported its first quarter results for the period ended March 31, 2003. HIGHLIGHTS - Total revenues of $442.4m up 29.4% in dollars and 17.3% in local currencies - Product sales up 30.1% to $407.8m - Strong Rebif(R) growth of 52.0% to $175.2m - Gonal-F(R) up 20.5% to $122.0m - Solid underlying net income growth of 16.8% excluding a $25m milestone payment related to the filing of Raptiva(TM) in the EU - Reported net income of $60.2m - On track to meet 2003 outlook of total revenue growth of 15% to 20% and net income growth of 15% to 20% on a reported basis "Our first quarter performance has been very strong with substantial top-line growth driven by sales in Neurology and Reproductive Health," said Ernesto Bertarelli, Chief Executive Officer of Serono. "Our first-quarter net income is in line with our expectations, which included a milestone payment related to the filing of Raptiva(TM) in Europe." "We are confident of our ability to meet full-year revenue growth of 15% to 20% and net income growth of 15% to 20% on a reported basis," said Allan Shaw, Chief Financial Officer. "The positive currency effect on sales was offset by a corresponding increase in total operating expenses, which resulted in a small favorable currency impact of $1.2m on the bottom line reflecting the significant natural hedge provided by our global operations." -more- FINANCIAL PERFORMANCE In the first quarter of 2003 total revenues increased by 29.4% to $442.4m (Q1 2002: $341.9m). Worldwide product sales advanced 30.1% to $407.8m (Q1 2002: $313.5m). Product sales growth in local currency was 17.6%. There was a favorable currency effect of $39.1 million on product sales due to the relative weakness of the dollar compared with the first quarter of 2002. Royalty and licensing income rose 22.1% to $34.6m (Q1 2002: $28.4m). This included a license fee from Abbott following the first regulatory approval of Humira(R) as well as the commencement of royalty payments on Humira(R) in relation to our intellectual property rights in the area of TNF antagonism. Our gross margin has increased to 84.6% of product sales (Q1 2002: 83.8%), as a result of the continued rise in the proportion of recombinant product sales, which accounted for 90.2% of total product sales in the first quarter of 2003 (Q1 2002: 85.6%). Selling, general and administrative expenses were $140.9m or 31.9% of total revenues (Q1 2002: $116.3m or 34.0% of total revenues). This increase was primarily driven by investments we made in our neurology infrastructure over the past year in the USA and selling expenses related to the promotion of Rebif(R), as well as the launch of a new presentation of Gonal-F(R) in Europe. Research and development expenses reached $127.9m or 28.9% of total revenues (Q1 2002: $75.6m or 22.1% of total revenues). As anticipated, this temporary increase reflects primarily a $25m milestone payment to Genentech as a result of the filing of Raptiva(TM) in the EU. In this quarter we also extended the Raptiva(TM) agreement, providing Serono with worldwide rights to develop and market Raptiva(TM) outside of the United States and Japan. Other operating expenses increased to $45.8m (Q1 2002: $19.4m), principally reflecting predetermined quarterly licensing fees to Amgen for the marketing rights of Novantrone(R). Novantrone(R), a commercial product protected by orphan drug status, is strategic for our neurology franchise in the USA as it is complementary to Rebif(R) and allows us to leverage investments made in our neurology infrastructure. The increase in other operating expenses also includes higher amortization of goodwill. Net financial income was $8.4m in the first quarter (Q1 2002: $4.6m) reflecting the continued low interest environment. Total taxes in the first quarter were $11.5m, representing an overall tax rate of 16.0% of profit before tax (Q1 2002: $14.2m, or 17.0% of profit before tax). Reported net income was 13.4% less than last year at $60.2m (Q1 2002: $69.5m) reflecting the temporary increase in R&D expenses in the first quarter. Excluding the $25m milestone payment, our underlying net income was $81.2m representing growth of 16.8%. -more- Foreign exchange fluctuations have increased the reported US dollar value of our revenues and also raised our expenses in terms of US dollars. The net impact of translation of currency on our operating results was only $1.2m, or a 2.0% positive effect on reported net income. The company's currency exposures principally continue to be hedged by the broad geographic nature of our global operations. Basic earnings per share (EPS) for the first quarter were $3.80 per bearer share (Q1 2002: $4.32) and $0.09 per American Depositary Share (ADS) (Q1 2002: $0.11). Excluding the $25m milestone payment to Genentech in the first quarter, EPS were $5.12 per bearer share and $0.13 per ADS. For the first quarter, net cash flow from operating activities was up 156.4% to $115.2m, compared to $44.9m for Q1 2002. This includes a $55m payment received from OSI Pharmaceuticals, following the agreement by which OSI will market and promote Novantrone(R) for the approved oncology indications in the United States. As of March 31, 2003, we have bought back 281,995 of our bearer shares on the open market, representing 41.2% of the CHF500m authorized amount. The weighted average amount of equivalent bearer shares outstanding for the three months ended March 31, 2003 was 15,849,191. NEUROLOGY Rebif(R) performed very strongly with worldwide sales up 52.0% to $175.2m in the first quarter (Q1 2002: $115.3m). Rebif(R) continues its market leadership outside the US. In Europe, sales grew by 37.6% to $98.3m (Q1 2002: $71.4m). Since launch in the United States in March 2002, Rebif(R) sales have broken through the $100m mark, and at the end of March 2003, our US market share in dollar terms is estimated to be 11%. US sales were $40.3m in the first quarter of 2003 (Q1 2002: $6.2m). Underlying demand was strong with prescriptions growing at 25.4% between the fourth quarter of 2002 and the first quarter of 2003. Quarterly sales of Novantrone(R) were $12.8m in the USA for both MS and oncology. In the first quarter, we took over the marketing of Novantrone(R) in MS and we recently commenced our own promotional activities. During the quarter, we signed an agreement with OSI Pharmaceuticals by which they will market and promote Novantrone(R) in oncology allowing us to focus on the marketing of this product in MS. REPRODUCTIVE HEALTH In the first quarter, we strengthened our market leadership in reproductive health with product sales increasing by 13.7% to $160.6m (Q1 2002: $141.3m) while continuing the phase-out of our urine-derived products. In Europe, we introduced a new multidose presentation of Gonal-F(R) providing physicians with more dosing flexibility and optimal product consistency. Sales of Gonal-F(R) increased by 20.5% to $122.0m (Q1 2002: $101.2m). Recombinant product sales in this franchise grew by 22.2%, and accounted for 85.3% of Serono's gonadotropin sales. -more- GROWTH AND METABOLISM In the first quarter, sales of Serono's recombinant growth hormone products rose by 7.4% to $53.0m (Q1 2002: $49.4m). Saizen(R) sales increased by 12.3% to $33.1m (Q1 2002: $29.5m). The launch of our needle-free device, cool.click(TM), across Europe contributed to this growth. Serostim(R) sales were flat at $19.9m reflecting the rollout of the Serostim(R) Secured Distribution Program across the USA allowing us to stabilize reimbursement in the major states. REGIONAL SALES Sales in North America were very strong, growing at 56.6% to reach $149.2m (Q1 2002: $95.3m). European sales were also strong, increasing by 31.2% to $185.6m (Q1 2002: $141.5m), and sales in the Middle East, Africa and Eastern Europe were up 30.4% to $33.0m (Q1 2002: $25.3m). Sales in Japan and Oceania were stable at $11.5m (Q1 2002: $10.8m), as were sales in Asia Pacific at $13.0m (Q1 2002: $13.8m). Economic and market conditions in Latin America were reflected in first quarter sales which declined to $15.5m (Q1 2002: $26.9m); notwithstanding these conditions, we maintained our leadership position in MS and reproductive health in this region. R&D NEWS In February, we submitted a Marketing Authorization Application to the EMEA for Raptiva(TM) (efalizumab) in moderate-to-severe psoriasis and we also filed applications with Swiss and Canadian authorities. During the quarter, we announced the extension of Serono's exclusive license to develop and market Raptiva(TM) in Asia. As a result of the new agreement, Serono will now develop and market Raptiva(TM) worldwide outside of the United States and Japan. At the recent American Association of Dermatology (AAD) meeting in San Francisco, results were presented from the latest Phase 3 study of Raptiva(TM) that showed consistent, strong efficacy and safety data. The preliminary long-term data from another study demonstrated that approximately 65% of the patients who continued treatment with Raptiva(TM) through 60 weeks, achieved a 75% or greater improvement in PASI scores (PASI 75). These data also demonstrated persistent efficacy of Raptiva(TM) when administered continuously on a weekly basis. These efficacy results together with Raptiva(TM)'s rapid onset of action, its subcutaneous administration and its safety profile, mean that Raptiva(TM) has significant potential as a once-weekly continuous treatment for moderate-to-severe psoriasis. The on-going Phase 2 study of Raptiva(TM) in Rheumatoid Arthritis has completed enrollment and the Phase 2 study in Psoriatic Arthritis has recently begun enrollment. We initiated a Phase 2 trial with anastrozole for follicular development and ovulation in infertile women with ovulatory dysfunction. A phase 1 study with our B-sheet breaker peptide, a potential treatment of Alzheimer's disease, has also been initiated in healthy volunteers. -more- CONFERENCE CALL AND WEBCAST Serono will hold a conference call today, April 24, 2003, starting at 3.00 pm Central European Time (9.00 am U.S. Eastern Time) during which Serono Management will present the Company's First Quarter 2003 Results. To join the telephone conference please dial 091 610 5600 (from Switzerland), 0207 866 4111 (from the UK), +1 412 858 4600 (from the USA) and +41 91 610 5600 (from elsewhere). Telephone playback will be available one hour after the conference call and until close of business 5.00 pm CET on April 30, 2003. To access this playback please dial the following numbers: 091 612 4330 (from Switzerland), 0207 866 4300 (from the UK), +1 412 858 1440 (from the USA) and +41 91 612 4330 (from elsewhere) and enter the PIN code 519# from a touch tone telephone. The event will also be relayed by live audio webcast that interested parties may access via Serono's Corporate home page, www.serono.com. A link to the webcast will be provided immediately prior to the event, and accompanying slides will be made available for download approximately 1 hour before the beginning of the webcast. Additionally, the webcast will be available for replay until close of business on May 16, 2003. ### Some of the statements in this press release are forward looking. Such statements are inherently subject to known and unknown risks, uncertainties and other factors that may cause actual results, performance or achievements of Serono S.A. and affiliates to be materially different from those expected or anticipated in the forward-looking statements. Forward-looking statements are based on Serono's current expectations and assumptions, which may be affected by a number of factors, including those discussed in this press release and more fully described in Serono's Annual Report on Form 20-F filed with the U.S. Securities and Exchange Commission on April 17, 2003. These factors include any failure or delay in Serono's ability to develop new products, any failure to receive anticipated regulatory approvals, any problems in commercializing current products as a result of competition or other factors, our ability to obtain reimbursement coverage for our products, and government regulations limiting our ability to sell our products. Serono has no responsibility to update the forward-looking statements contained in this press release to reflect events or circumstances occurring after the date of this press release. ### ABOUT SERONO Serono is a global biotechnology leader. The Company has six recombinant products on the market, Gonal-F(R), Luveris(R), Ovidrel(R)/Ovitrelle(R), Rebif(R), Serostim(R) and Saizen(R) (Luveris(R) is not approved in the USA). In addition to being the world leader in reproductive health, Serono has strong market positions in neurology, metabolism and growth. The Company's research programs are focused on growing these businesses and on establishing new therapeutic areas. Currently, there are over 30 projects in development. Serono was awarded the International James D. Watson Helix 2003 Award from the Biotechnology Industry Organization (BIO) in recognition of the Company's outstanding leadership and highest standards of scientific and product achievement. In 2002, Serono achieved worldwide revenues of US$1.546 billion, and a net income of US$321 million, making it the third largest biotech company in the world. The Company operates in 45 countries, and its products are sold in over 100 countries. Bearer shares of Serono S.A., the holding company, are traded on the virt-x (SEO) and its American Depositary Shares are traded on the New York Stock Exchange (SRA). -more- FOR MORE INFORMATION, PLEASE CONTACT: SERONO IN GENEVA, SWITZERLAND: MEDIA RELATIONS: INVESTOR RELATIONS: Tel: +41-22-739 36 00 Tel: +41-22-739 36 01 Fax: +41-22-739 30 85 Fax: +41-22-739 30 22 http://www.serono.com Reuters: SEOZ.VX / SRA.N --------------------- Bloomberg: SEO VX / SRA US SERONO, INC., ROCKLAND, MA MEDIA RELATIONS: INVESTOR RELATIONS: Tel. +1 781 681 2340 Tel. +1 781 681 2552 Fax: +1 781 681 2935 Fax: +1 781 681 2912 http://www.seronousa.com ------------------------ On the following pages, there are: - Tables detailing sales in dollars by therapeutic area, geographic region and the top 10 products for the 3 months ended March 31, 2003. - The unaudited consolidated financial statements for the 3 months ended March 31, 2003, including income statements, balance sheets and statements of cash flows, prepared in accordance with International Financial Reporting Standards (IFRS). -more- SALES BY THERAPEUTIC AREA ------------------------- THREE MONTHS ENDED THREE MONTHS ENDED MARCH 31, 2003 MARCH 31, 2002 $MILLION % OF SALES % CHANGE $ $MILLION % OF SALES ------------------------------------------------------------------------------------- Multiple Sclerosis (Rebif) 175.2 43.00% 52.00% 115.3 36.80% Reproductive Health 160.6 39.40% 13.70% 141.3 45.10% Growth 33.1 8.10% 12.30% 29.5 9.40% AIDS Wasting 19.9 4.90% 0.30% 19.9 6.30% MS/Oncology (Novantrone) 12.8 3.10% 100.00% -- -- Others 6.2 1.50% -20.00% 7.5 2.40% ------------------------------------------------------------------------------------- Total sales (US$million) $ 407.8 100% 30.10% $ 313.5 100% SALES BY GEOGRAPHIC REGION -------------------------- THREE MONTHS ENDED THREE MONTHS ENDED MARCH 31, 2003 MARCH 31, 2002 $MILLION % OF SALES % CHANGE $ $MILLION % OF SALES ----------------------------------------------------------------------------------- Europe 185.6 45.50% 31.20% 141.5 45.10% North America 149.2 36.60% 56.60% 95.3 30.40% Latin America 15.5 3.80% -42.50% 26.9 8.60% Others 57.5 14.10% 15.20% 49.8 15.90% ----------------------------------------------------------------------------------- Total sales (US$ million) $ 407.8 100% 30.10% $ 313.5 100% -more- TOP TEN PRODUCTS THREE MONTHS ENDED THREE MONTHS ENDED MARCH 31, 2003 MARCH 31, 2002 --------------------------------------------------------- * TA $MILLION % OF SALES % CHANGE $ $MILLION % OF SALES Rebif(R) MS 175.2 43.0% 52.0% 115.3 36.8% Gonal-F(R) RH 122.0 29.9% 20.5% 101.2 32.3% Saizen(R) Growth 33.1 8.1% 12.3% 29.5 9.4% Serostim(R) Wasting 19.9 4.9% 0.3% 19.9 6.3% Novantrone(R) MS/Oncology 12.8 3.1% 100.0% -- -- Pergonal(R) RH 10.3 2.5% 17.2% 8.8 2.8% Metrodin HP(R) RH 7.1 1.7% (49.2%) 14.0 4.5% Cetrotide(R) RH 5.6 1.4% 52.9% 3.7 1.2% Crinone(R) RH 4.5 1.1% 41.5% 3.2 1.0% Profasi(R) RH 3.7 0.9% (25.8%) 5.0 1.6% * THERAPEUTIC AREAS RH = Reproductive Health Wasting = AIDS Wasting MS = Multiple Sclerosis Growth = Growth Retardation Oncology = Oncology -more- CONSOLIDATED INCOME STATEMENTS THREE MONTHS ENDED MARCH 31 2003 * % OF 2002 * % of US$'000 REVENUES % change US$'000 Revenues Revenues Product sales 407,786 30.1% 313,532 Royalty and license income 34,620 22.1% 28,359 ------------------------------------------------------------------------------------------------ TOTAL REVENUES 442,406 100.0% 29.4% 341,891 100.0% ------------------------------------------------------------------------------------------------ Operating Expenses Cost of product sales 62,631 23.4% 50,760 % of Sales 15.4% 16.2% Selling, general and administrative 140,916 31.9% 21.1% 116,340 34.0% Research and development 127,937 28.9% 69.1% 75,636 22.1% Other operating expense, net 45,751 10.3% 135.5% 19,430 5.7% ------------------------------------------------------------------------------------------------ Total Operating Expenses 377,235 85.3% 43.9% 262,166 76.7% ------------------------------------------------------------------------------------------------ OPERATING INCOME 65,171 14.7% (18.3%) 79,725 23.3% ------------------------------------------------------------------------------------------------ Financial income, net 8,382 81.7% 4,613 Other expense, net 1,499 543 ------------------------------------------------------------------------------------------------ Total Non Operating Income, Net 6,883 4,070 ------------------------------------------------------------------------------------------------ Income Before Taxes and Minority Interests 72,054 16.3% (14.0%) 83,795 24.5% Taxes 11,529 14,245 ------------------------------------------------------------------------------------------------ Income Before Minority Interests 60,525 69,550 Minority interests 367 73 ------------------------------------------------------------------------------------------------ NET INCOME 60,158 13.6% (13.4%) 69,477 20.3% ------------------------------------------------------------------------------------------------ Milestone payment for Raptiva 1) 25,000 0 Tax impact (4,000) 0 ------------------------------------------------------------------------------------------------ NET INCOME W/O RAPTIVA MILESTONE PAYMENT 81,158 18.3% 16.8% 69,477 20.3% ------------------------------------------------------------------------------------------------ * Unaudited 1) Payment made to Genentech for filing of Raptiva in Europe 2003 2002 % CHANGE 2003 2002 % CHANGE W/O RAPTIVA MILESTONE Basic Earnings per Share (in U.S. dollars) PAYMENT 1) -------------------------------------------------------------------------------------------------- - Bearer shares 3.80 4.32 (12.2%) 5.12 4.32 18.5% -------------------------------------------------------------------------------------------------- - Registered shares 1.52 1.73 (12.2%) 2.05 1.73 18.5% -------------------------------------------------------------------------------------------------- - American depositary shares 0.09 0.11 (12.2%) 0.13 0.11 18.5% -------------------------------------------------------------------------------------------------- Diluted Earnings per Share (in U.S. dollars) - Bearer shares 3.79 4.32 (12.1%) 5.12 4.32 18.6% -------------------------------------------------------------------------------------------------- - Registered shares 1.52 1.73 (12.1%) 2.05 1.73 18.6% -------------------------------------------------------------------------------------------------- - American depositary shares 0.09 0.11 (12.1%) 0.13 0.11 18.6% --------------------------------------------------------------------------------------------------Basic earnings per share are calculated in accordance with IAS 33 (Earnings per Share) by dividing the net income of the group, US$60.2 million (2002 US$69.5 million), by an appropriate number of shares. This is 11,443,975 bearer shares (2002 11,670,858) and 11,013,040 registered shares (2002 11,013,040). The total weighted average equivalent number of bearer shares is 15,849,191 (2002 16,076,074) for the three months ended March 31, 2003. As each American depositary share represents ownership interest in one fortieth of a bearer share, basic and diluted earnings per American depositary share is calculated as one fortieth of the earnings per bearer share. For diluted earnings per share, the total number of bearer shares is adjusted to assume conversion of all share options granted to employees and directors. The number of bearer shares used to calculate diluted earnings per share is 11,451,180 (2002 11,695,125). -more- CONSOLIDATED BALANCE SHEETS As of MARCH 31, 2003 * December 31, 2002 US$ 000 US$ 000 ASSETS Current Assets Cash and cash equivalents 603,323 686,033 Short-term financial assets 436,256 378,865 Trade accounts receivable 273,943 257,313 Inventories 277,865 259,477 Prepaid expenses 43,460 26,609 Other current assets 192,435 208,100 ----------------------------------------------------------------------------------------------------- Total Current Assets 1,827,282 1,816,397 ----------------------------------------------------------------------------------------------------- Long-Term Assets Property, plant and equipment 604,715 554,509 Long-term financial assets 780,597 711,201 Intangible assets 229,089 230,117 Deferred tax assets 137,345 136,687 Other long-term assets 44,420 45,763 ----------------------------------------------------------------------------------------------------- Total Long-Term Assets 1,796,166 1,678,277 ----------------------------------------------------------------------------------------------------- TOTAL ASSETS 3,623,448 3,494,674 ----------------------------------------------------------------------------------------------------- LIABILITIES Current Liabilities Bank advances 61,065 70,093 Trade accounts payable 66,127 60,591 Current portion of long-term debt 24,101 23,505 Income taxes 33,397 55,152 Other current liabilities 418,437 348,704 ----------------------------------------------------------------------------------------------------- Total Current Liabilities 603,127 558,045 ----------------------------------------------------------------------------------------------------- Long-Term Liabilities Long-term debt 24,893 25,857 Deferred tax liabilities 12,343 12,080 Other long-term liabilities 461,648 436,329 ----------------------------------------------------------------------------------------------------- Total Long-Term Liabilities 498,884 474,266 ----------------------------------------------------------------------------------------------------- Total Liabilities 1,102,011 1,032,311 ----------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------- Minority Interests 1,554 1,165 ----------------------------------------------------------------------------------------------------- SHAREHOLDERS' EQUITY Share capital 253,851 253,416 Share premium 1,001,621 989,141 Treasury shares (147,526) (126,460) Retained earnings 1,424,786 1,364,626 Fair value reserves (51,512) (44,807) Cumulative foreign currency translation adjustments 38,663 25,282 ----------------------------------------------------------------------------------------------------- Total Shareholders' Equity 2,519,883 2,461,198 ----------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------- Total Liabilities, Minority Interests and Shareholders' Equity 3,623,448 3,494,674 ----------------------------------------------------------------------------------------------------- * Unaudited -more- CONSOLIDATED STATEMENTS OF CASH FLOWS Three months ended March 31 2003 * 2002 * US$ 000 US$ 000 Cash Flows From Operating Activities Income before taxes and minority interests 72,054 83,795 Depreciation and amortization 34,498 22,846 Financial income (12,087) (16,526) Financial expense 2,161 2,608 Other non-cash items 13,686 (8) -------------------------------------------------------------------------------------------- Cash Flows From Operating Activities Before Working Capital Changes 110,312 92,715 -------------------------------------------------------------------------------------------- Working Capital Changes Trade accounts payable, other current liabilities and deferred income 74,800 (12,879) Trade accounts receivable (9,982) (11,381) Inventories (22,638) (5,514) Prepaid expenses and other current assets (6,200) 4,421 Taxes paid (31,081) (22,424) -------------------------------------------------------------------------------------------- NET CASH FLOWS FROM OPERATING ACTIVITIES 115,211 44,938 -------------------------------------------------------------------------------------------- Cash Flows From Investing Activities Purchase of property, plant and equipment (57,468) (28,805) Purchase of intangible and other long-term assets (7,257) (2,616) Purchase of financial assets (130,926) (777,970) Other non-current liabilities (4,308) (6,903) Proceeds from sale of property, plant and equipment 2,220 24 Interest received 21,330 (260) -------------------------------------------------------------------------------------------- Net Cash Flows From Investing Activities (176,409) (816,530) -------------------------------------------------------------------------------------------- Cash Flows From Financing Activities Proceeds from issuance of share capital 13,090 11,602 Proceeds from exercises of stock options 159 349 Premiums received on written calls 384 -- Purchase of treasury shares (24,637) -- Repayment of bank advances (9,260) (34,645) Repayment of long-term debt (1,517) (605) Interest paid (1,102) (2,054) -------------------------------------------------------------------------------------------- Net Cash Flows From Financing Activities (22,883) (25,353) -------------------------------------------------------------------------------------------- Effect of Exchange Rate Changes on Cash and Cash Equivalents 1,371 (672) -------------------------------------------------------------------------------------------- Net Increase in Cash and Cash Equivalents (82,710) (797,617) -------------------------------------------------------------------------------------------- Cash and Cash Equivalents - Beginning of period 686,033 1,131,091 -------------------------------------------------------------------------------------------- - End of period 603,323 333,474 -------------------------------------------------------------------------------------------- * Unaudited -end- SIGNATURES Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized. SERONO S.A. a Swiss corporation (Registrant) April 24, 2003 By: /s/ Allan Shaw ----------------------------- Name: Allan Shaw Title: Chief Financial Officer