Biotech Stock (ATNM)

DelveInsight's analysts estimate that relapsed/refractory acute myeloid leukemia market is poised to show significant growth, mainly attributed to recent drug approvals, increasing incidence, and anticipated launch of novel therapies during the forecast period (2023–2032).

Time to pull up Actinium Pharmaceuticals, Inc. (NYSE AMERICAN: ATNM), on your screens now. Actinium Pharmaceuticals is dedicated to advancing targeted radiotherapies to significantly enhance survival outcomes for patients who have exhausted conventional cancer treatments. Among its leading candidates, Iomab-B is set to revolutionize the bone marrow transplant process for blood cancer treatment, while Actimab-A continues to show potential in pivotal trials for r/r AML. With over 230 patents in its portfolio, Actinium is also at the forefront of developing next-generation conditioning agents like Iomab-ACT to augment outcomes in cell and gene therapies, marking it as a leader in the oncology space.

Actinium Pharmaceuticals, Inc. (NYSE AMERICAN: ATNM), a pioneer in the development of Antibody Radiation Conjugates (ARCs) and other targeted radiotherapies, recently shared significant findings from its Phase 3 SIERRA trial at the 2024 European Hematology Association (EHA) Hybrid Congress in Madrid, Spain. This key trial focused on Iomab-B, a promising therapeutic agent for patients with relapsed or refractory acute myeloid leukemia (r/r AML).

The SIERRA trial, which targeted an older patient demographic (55 years and older) suffering from active r/r AML, enrolled 153 participants and provided critical insights into the efficacy of Iomab-B led bone marrow transplants (BMT). Notably, the trial's primary endpoint of durable complete remission was achieved exclusively by patients receiving Iomab-B led BMT, showcasing impressive survival rates: 92% at one year and 69% at two years, with significantly higher event-free survival.

Key Outcomes for Patients with TP53 Mutation

During the congress, Dr. Hannah Choe from Ohio State University, who is also a SIERRA trial investigator, presented compelling data regarding patients with the TP53 mutation, a genetic alteration associated with poor prognosis and limited treatment options. The data highlighted:

- A stark contrast in median Overall Survival (OS) between patients with TP53 mutations receiving Iomab-B (5.49 months) and those who did not (1.66 months), emphasizing Iomab-B's efficacy (hazard ratio=0.23, p=0.0002).

- Iomab-B's ability to improve outcomes even in TP53 negative patients, showcasing its potential to overcome detrimental genetic profiles.

Long-Term Efficacy Results

Further data presented revealed that 75% of patients on the Iomab-B arm achieved complete remission, compared to just 6.3% in the control arm. The durability of these remissions was underscored by a 22% durable complete remission rate in the Iomab-B arm, a significant statistic given the zero percent in the control group. Patients achieving durable complete remission also demonstrated remarkable survival rates, not reaching median overall survival yet.

Iomab-B was noted for its favorable safety profile, significantly reducing the risks of sepsis and mucositis compared to traditional care, further advocating its role as a safer and more effective treatment modality.

ATNM has a 52 week high of $10.24. According to TipRanks.com, ATNM has average price target of $29.40 suggesting a significant upside potential from the current levels. 

Other biotech stocks to keep on top of radar include Biomarin Pharmaceuticals Inc. (NASDAQ: BMRN), Halozyme Therapeutics, Inc. (NASDAQ: HALO), Incyte Corporation (NASDAQ: INCY), Exelixis, Inc. (NASDAQ: EXEL), Mimedx Group, Inc. (NASDAQ: MDXG), Genmab AS (NASDAQ: GMAB), Vertex Pharmaceuticals Inc. (NASDAQ: VRTX), Bio-Techne Corp (NASDAQ: TECH), Jazz Pharmaceuticals PLC (NASDAQ: JAZZ).

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Sources:

https://www.tipranks.com/stocks/atnm

https://finance.yahoo.com/news/actinium-highlights-oral-presentation-eha-123000963.html

https://www.prnewswire.com/news-releases/relapsedrefractory-acute-myeloid-leukemia-market-growing-rapidly-estimates-delveinsight--key-companies-active-in-the-domain---pfizer-merck-novartis-astellas-amgen-janssen-kartos-cullinan-oncology-meryx-301833050.html

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