Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
BOWEN R WILLIAM
  2. Issuer Name and Ticker or Trading Symbol
GEN PROBE INC [GPRO]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
Senior VP, General Counsel
(Last)
(First)
(Middle)
GEN-PROBE INCORPORATED, 10210 GENETIC CENTER DRIVE
3. Date of Earliest Transaction (Month/Day/Year)
08/01/2012
(Street)

SAN DIEGO, CA 92121
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 08/01/2012   D   15,020 D $ 82.75 0 D  

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option (Right to Buy) $ 42.5 08/01/2012   D     3,265   (1) 10/17/2015 Common Stock 3,265 $ 40.25 (1) 0 D  
Stock Option (Right to Buy) $ 60.82 08/01/2012   D     23,000   (1) 08/15/2014 Common Stock 23,000 $ 21.93 (1) 0 D  
Stock Option (Right to Buy) $ 60.15 08/01/2012   D     15,000   (1) 08/15/2015 Common Stock 15,000 $ 22.6 (1) 0 D  
Stock Option (Right to Buy) $ 38.51 08/01/2012   D     10,600   (1) 08/17/2016 Common Stock 10,600 $ 44.24 (1) 0 D  
Stock Option (Right to Buy) $ 42.66 08/01/2012   D     30,300   (1) 02/10/2017 Common Stock 30,300 $ 40.09 (1) 0 D  
Stock Option (Right to Buy) $ 63.8 08/01/2012   D     28,251   (1) 02/10/2018 Common Stock 28,251 $ 18.95 (1) 0 D  
Stock Option (Right to Buy) $ 69.22 08/01/2012   D     26,892   (2) 02/10/2019 Common Stock 26,892 (3) 0 D  
Performance Stock Rights $ 0 08/01/2012   D     3,209   (4) 02/10/2014 Common Stock 3,209 (4) 0 D  
Performance Stock Rights $ 0 08/01/2012   D     11,028   (5) 02/10/2015 Common Stock 11,028 (5) 0 D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
BOWEN R WILLIAM
GEN-PROBE INCORPORATED
10210 GENETIC CENTER DRIVE
SAN DIEGO, CA 92121
      Senior VP, General Counsel  

Signatures

 /s/ Andrew S. Greenhalgh, Attorney-in-Fact   08/02/2012
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) This stock option was canceled pursuant to the Agreement and Plan of Merger, dated as of April 29, 2012, by and among the Registrant, Hologic, Inc. ("Hologic"), and Gold Acquisition Corp. (the "Merger Agreement"), in exchange for a payment in cash, without interest and less the amount of any required tax withholding, equal to the product of: (i) the excess of $82.75 (the per share merger consideration pursuant to the Merger Agreement) over the exercise price of the stock option; and (ii) the number of shares of common stock of the Registrant underlying the stock option.
(2) 25% of the shares subject to the stock option vest on February 10, 2013, and the remaining shares vest in equal monthly installments over the following three years.
(3) Pursuant to the Merger Agreement, these options were assumed by Hologic and converted into options to acquire that number of shares of Hologic common stock which is equal to the number of shares of common stock of the Registrant subject to such options immediately prior to the merger multiplied by 4.51174963 with a per share exercise price equal to the quotient determined by dividing the per share exercise price of such options immediately prior to the merger by 4.51174963.
(4) The performance stock rights were canceled pursuant to the Merger Agreement and converted into the right to receive a payment in cash, without interest and less the amount of any required tax withholding, equal to the product of: (i) $82.75 (the per share merger consideration pursuant to the Merger Agreement); and (ii) 4,813 (which amount equals 150% of the target number of shares of common stock of the Registrant underlying the performance stock rights).
(5) The performance stock rights were canceled pursuant to the Merger Agreement and converted into the right to receive a payment in cash, without interest and less the amount of any required tax withholding, equal to the product of: (i) $82.75 (the per share merger consideration pursuant to the Merger Agreement); and (ii) 8,271 (which amount equals 150% of the target number of shares of common stock of the Registrant underlying the performance stock rights).

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