--------------------------------------------------------------------------------
                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                              Washington D.C. 20549

                                    FORM 10Q



[ X ]    QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15 (d) OF
         THE SECURITIES EXCHANGE ACT OF 1934

For the quarterly period ended:             June 30, 2001
                                --------------------------------------------

                                       OR

[    ]   TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 (d) OF
         THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from                       to

Commission file number:             0-22319
                        -----------------------------------------------------

                            PATIENT INFOSYSTEMS, INC.
             (Exact name of registrant as specified in its charter)

           Delaware                                     16-1476509
-------------------------------             ------------------------------------
(State or other jurisdiction of             (I.R.S. Employer Identification No.)
incorporation or organization)

                      46 Prince Street, Rochester, NY 14607
                    (Address of principal executive offices)
                                   (Zip Code)

                                 (716) 242-7200
              (Registrant's telephone number, including area code)


     Indicate by check mark whether the registrant (1) has filed all reports
required to be filed by Section 13 or 15 (d) of the Securities Exchange Act of
1934 during the preceding 12 months (or for such shorter period that the
registrant was required to file such reports), and (2) has been subject to such
filing requirements for the last 90 days. Yes [X] No [ ]

     As of August 7, 2001, 10,956,024 common shares were outstanding.

--------------------------------------------------------------------------------




PART I. FINANCIAL INFORMATION
Item 1. Consolidated Financial Statements



PATIENT INFOSYSTEMS, INC.
CONDENSED CONSOLIDATED BALANCE SHEETS
------------------------------------------------------------------------------------------------------------------------
                                                                                    (unaudited)
ASSETS                                                                             June 30, 2001       December 31, 2000
CURRENT ASSETS:
                                                                                                 
  Cash and cash equivalents                                                      $        4,320        $      28,231
  Accounts receivable                                                                   241,683              411,436
  Prepaid expenses and other current assets                                             114,905              166,167
                                                                               --------------------------------------
        Total current assets                                                            360,908              605,834

PROPERTY AND EQUIPMENT, net                                                             659,234              827,050

Debt issuance costs (net of accumulated amortization of $866,433 and $664,750)           26,802              192,750
Intangible assets (net of accumulated amortization of $227,899 and $156,113)            394,824              466,610
Other assets                                                                            200,000              200,000
                                                                               --------------------------------------
TOTAL ASSETS                                                                     $    1,641,768       $    2,292,244
                                                                               ======================================

LIABILITIES AND STOCKHOLDERS' DEFICIT
CURRENT LIABILITIES:
  Accounts payable                                                               $      143,632       $      233,545
  Accrued salaries and wages                                                            205,499              176,158
  Borrowings from directors                                                           2,601,000            1,171,000
  Line of credit                                                                      2,500,000                 -
  Accrued expenses                                                                      467,852              238,561
  Deferred revenue                                                                      122,809              161,961
                                                                               --------------------------------------
        Total current liabilities                                                     6,040,792            1,981,225
                                                                               --------------------------------------
LINE OF CREDIT                                                                             -               2,500,000

STOCKHOLDERS' DEFICIT:
  Common stock - $.01 par value:  shares authorized:
      20,000,000; issued and outstanding: June 30,
     2001 - 10,956,024; December 31, 2000 - 8,220,202                                   109,560               82,202
  Preferred stock - $.01 par value:  shares authorized: 5,000,000
    Series C, 9% cumulative, convertible
      issued and outstanding - 100,000                                                    1,000                1,000
  Additional paid-in capital                                                         24,377,848           24,016,798
  Accumulated other comprehensive income                                                  1,805                1,805
  Accumulated deficit                                                              (28,889,237)         (26,290,786)
                                                                               --------------------------------------
        Total stockholders' deficit                                                 (4,399,024)          (2,188,981)
                                                                               --------------------------------------
TOTAL LIABILITIES AND STOCKHOLDERS' DEFICIT                                      $    1,641,768       $    2,292,244
                                                                               ======================================

See notes to unaudited condensed consolidated financial statements.





PATIENT INFOSYSTEMS, INC.
CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS (UNAUDITED)
--------------------------------------------------------------------------------------------------------------------------
                                                              Three Months Ended                 Six Months Ended
                                                                   June 30,                          June 30,
                                                            2001             2000              2001             2000

REVENUES
                                                                                                
  Operations Fees                                       $      303,406    $      548,113   $      647,648   $    1,132,294
  Development Fees                                              27,061            17,200           56,346           21,200
  Licensing Fees                                                27,500            33,427           54,000           45,826
                                                      ---------------------------------------------------------------------
       Total revenues                                          357,967           598,740          757,994        1,199,320
                                                      ---------------------------------------------------------------------
COSTS AND EXPENSES
  Cost of sales                                                613,417         1,205,857        1,320,709        2,371,919
  Sales and marketing                                          204,271           271,550          429,190          685,661
  General and administrative                                   378,017           407,578          731,449          882,512
  Financing Costs                                              356,807           192,750          549,557          279,250
  Research and development                                      42,106            77,647           95,431          163,199
                                                      ---------------------------------------------------------------------
        Total costs and expenses                             1,594,618         2,155,382        3,126,337        4,382,541
                                                      ---------------------------------------------------------------------
OPERATING LOSS                                             (1,236,651)       (1,556,642)      (2,368,343)      (3,183,221)

INTEREST EXPENSE                                             (101,535)          (44,604)        (185,939)         (63,499)
OTHER INCOME (EXPENSE)                                             627          (27,125)              831         (16,557)
                                                      ---------------------------------------------------------------------
NET LOSS                                                   (1,337,559)       (1,628,371)      (2,553,452)      (3,263,277)
                                                      ---------------------------------------------------------------------
CONVERTIBLE PREFERRED STOCK DIVIDENDS                         (22,500)          (22,500)         (45,000)        (572,500)
                                                      ---------------------------------------------------------------------
NET LOSS ATTRIBUTABLE TO COMMON STOCKHOLDERS            $  (1,360,059)    $  (1,650,871)   $  (2,598,452)   $  (3,835,777)
                                                      =====================================================================
NET LOSS PER SHARE - BASIC AND DILUTED                  $       (0.15)    $       (0.20)   $       (0.30)   $       (0.48)
                                                      =====================================================================
WEIGHTED AVERAGE COMMON  SHARES                              8,919,357         8,071,095        8,569,779        8,070,095
                                                      =====================================================================


See notes to unaudited condensed consolidated financial statements.





PATIENT INFOSYSTEMS, INC.
CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (UNAUDITED)
--------------------------------------------------------------------------------------------------------------------------
                                                                                    Six Months            Six Months
                                                                                       Ended                 Ended
                                                                                   June 30, 2001         June 30, 2000

OPERATING ACTIVITIES:
                                                                                                
  Net loss                                                                      $     (2,553,452)     $     (3,263,277)
  Adjustments to reconcile net loss to net cash used in
    operating activities:
      Depreciation and amortization                                                       473,383               557,880
      (Gain) loss on sale of property                                                       (305)                18,750
      Compensation expense related to issuance of stock and warrants                      352,673                 1,042
      Decrease in accounts receivable, net                                                169,753                48,181
      Decrease in prepaid expenses and other current assets                                25,500                50,144
      Decrease in other assets                                                               -                   37,723
      Decrease in accounts payable                                                       (89,913)             (310,762)
      Increase (decrease) in accrued salaries and wages                                    29,341              (29,238)
      Increase in accrued expenses                                                        184,291                16,070
      Decrease in deferred revenue                                                       (39,152)              (34,687)
                                                                                ---------------------------------------
            Net cash used in operating activities                                     (1,447,880)           (2,908,174)

INVESTING ACTIVITIES:
  Property and equipment additions                                                        (6,831)              (11,599)
  Proceeds form the sale of property                                                          800                18,240
                                                                                ---------------------------------------
          Net cash (used in) provided by investing activities                             (6,031)                 6,641

FINANCING ACTIVITIES:
  Proceeds from issuance of common and preferred stock, net                                 -                 1,012,983
  Borrowing from directors                                                              1,430,000                  -
  Line of credit borrowings                                                                 -                 2,000,000
                                                                                ---------------------------------------
            Net cash provided by financing activities                                   1,430,000             3,012,983
                                                                                ---------------------------------------
NET (DECREASE) INCREASE IN CASH AND CASH  EQUIVALENTS                                    (23,911)               111,450

CASH AND CASH EQUIVALENTS AT  BEGINNING OF PERIOD                                         28,231                489,521

CASH AND CASH EQUIVALENTS AT  END OF PERIOD                                     $          4,320      $         600,971
                                                                                =======================================
Supplemental disclosures of non-cash information
  Dividend delared on Class C Convertible Preferred Stock                       $         45,000      $          22,500
                                                                                =======================================
  Value of beneficial conversion feature on Class C Convertible Preferred Stock
    recognized as a dividend                                                    $           -         $         550,000
                                                                                =======================================

See notes to unaudited condensed consolidated financial statements.



PATIENT INFOSYSTEMS, INC.

Notes to Unaudited Condensed  Consolidated  Financial  Statements for the period
ended June 30, 2001

1.   The accompanying  condensed consolidated financial statements for the three
     and six  month  periods  ended  June 30,  2001 and 2000 are  unaudited  and
     reflect all adjustments  (consisting only of normal recurring  adjustments)
     which are, in the opinion of management,  necessary for a fair presentation
     of the financial  position and operating  results for the interim  periods.
     These unaudited condensed  consolidated financial statements should be read
     in conjunction with the audited consolidated financial statements and notes
     thereto,  together with  management's  discussion and analysis of financial
     condition  and results of  operations  contained  in the  Company's  Annual
     Report  on  Form  10-K  for the  year  ended  December  31,  2000.  Certain
     reclassifications  of  2000  amounts  have  been  made to  conform  to 2001
     presentations. The results of operations for the three and six months ended
     June 30, 2001 are not necessarily  indicative of the results for the entire
     year ending December 31, 2001.

2.   In December 1999, the Company  established a credit facility for $1,500,000
     guaranteed  by Derace  Schaffer and John  Pappajohn,  two  directors of the
     Company. In consideration for their guarantees,  the Company granted to Dr.
     Schaffer  and Mr.  Pappajohn  warrants to purchase an  aggregate of 375,000
     shares of common stock for $1.5625 per share.  In March 2000,  the facility
     was  increased  by  $1,000,000  under  substantially  the same terms,  also
     guaranteed by the same Board  members.  Additional  warrants to purchase an
     aggregate  of 250,000  shares of Common  Stock for  $2.325 per share,  were
     granted to Dr.  Schaffer  and Mr.  Pappajohn  for their  guarantee  of this
     additional  line of credit.  The  estimated  fair value of the  warrants at
     March 31, 2000 was  approximately  $857,500 based on the application of the
     Black Scholes option pricing model which incorporates  current stock price,
     expected stock price volatility,  expected interest rates, and the expected
     holding period of the warrant. The Company fully amortized $857,500 of debt
     issuance costs as of March 31, 2001, the scheduled  expiration date for the
     line of credit agreement.

     On March 28, 2001, the Company  entered into an Amended and Restated Credit
     Agreement with Wells Fargo Bank Iowa,  N.A., which extended the term of the
     credit facility to March 31, 2002 under  substantially  the same terms. Dr.
     Schaffer and Mr. Pappajohn also guaranteed this extension. In consideration
     for their extended  guarantees,  the Company re-priced the 625,000 warrants
     previously  granted in connection with prior guarantees to $0.05 per share,
     effective  April 1,  2001.  The net value of these  re-priced  warrants  is
     $35,735.  The Company is amortizing this amount as debt issuance cost using
     a straight-line  method over the 12-month period ending March 31, 2002. The
     estimated fair value of the re-priced  warrants was also  determined  using
     the Black Scholes method.

3.   The Company  borrowed  $1,430,000  for working  capital from Mr.  Pappajohn
     during the six month period ended June 30, 2001. From June 30, 2001 through
     August 10,  2001,  the Company  borrowed an  additional  $330,000  from Mr.
     Pappajohn. Through August 10, 2001, a total of $2,931,000 has been borrowed
     from Mr. Pappajohn and Dr. Schaffer,  all of which is secured by the assets
     of the Company. There can be no assurances that Mr. Pappajohn will continue
     to make funds  available to the Company.  If such funds are not  available,
     the Company will cease operations.

     On June 6,  2001,  the  Company  issued  a total  of  2,319,156  shares  of
     unregistered Common Stock to Mr. Pappajohn and Dr. Schaffer as compensation
     for their  continued  financial  support of the Company.  Based upon recent
     trading of the Company's Common Stock at the time of issuance,  the Company
     assigned a fair  market  value of $0.15 per share or a total of $347,873 to
     these unregistered  shares and realized this amount as an operating expense
     in June of 2001.

4.   For the three-month  periods ended June 30, 2001 and 2000, the calculations
     for the basic and diluted loss per share were based upon loss  attributable
     to common  stockholders of $1,360,059 and $1,650,871,  respectively,  and a
     weighted  average  number  of  common  shares of  8,919,357  and  8,071,095
     respectively.

     For the six-month  periods ended June 30, 2001 and 2000,  the  calculations
     for the basic and diluted loss per share were based upon loss  attributable
     to common  stockholders of $2,598,452 and $3,835,777,  respectively,  and a
     weighted  average  number  of  common  shares of  8,569,779  and  8,070,095
     respectively.

     Options and warrants to purchase  shares of Common  Stock were  outstanding
     but not included in the computation of diluted loss per share for the three
     and six month periods ended June 30, 2001 and 2000 because the effect would
     have been antidilutive due to the net loss in those periods.

5.   The accompanying unaudited condensed consolidated financial statements have
     been prepared on a going concern basis,  which contemplates the realization
     of assets and the  satisfaction  of  liabilities  in the  normal  course of
     business.  As shown in the accompanying  unaudited  condensed  consolidated
     financial statements,  the Company incurred a net loss of for the three and
     six  month  periods  ended  June 30,  2001 of  $1,337,559  and  $2,553,452,
     respectively,  and had an  accumulated  deficit of  $28,889,237 at June 30,
     2001.  These  factors,  among others may indicate  that the Company will be
     unable to continue as a going concern for a reasonable period of time.

     The unaudited condensed  consolidated  financial  statements do not include
     any adjustments relating to the recoverability of assets and classification
     of  liabilities  that might be  necessary  should the  Company be unable to
     continue as a going concern.  The Company's  ability to continue as a going
     concern is dependant upon its ability to generate  sufficient  cash flow to
     meet its  obligations.  Management  is currently  assessing  the  Company's
     operating   structure  for  the  purpose  of  reducing  ongoing   expenses,
     increasing  sources of revenue and is  negotiating  the terms of additional
     debt or equity financing.

6.   The Company holds an  investment of Common Stock in a private  company (the
     "Investment")  that is recorded at its  historical  cost of  $200,000.  The
     Company  has  been  made  aware  that the  private  company  to  which  the
     Investment  relates is seeking an  opportunity  to be sold for a  valuation
     that  would  result in the  Investment  exceeding  its  carrying  cost.  No
     assurance can be given that such sale,  if any, will be at this  valuation.
     The market value of the Investment is not readily determinable.  Management
     believes that an impairment of the Investment, if any, is temporary.

7.   On June 29, 2001,  Statement of Financial  Accounting  Standards (SFAS) No.
     141,  "Business  Combinations"  was  issued  by  the  Financial  Accounting
     Standards  Board (FASB).  SFAS No. 141 requires that the purchase method of
     accounting be used for all business  combinations  initiated after June 30,
     2001.  Goodwill  and certain  intangible  assets will remain on the balance
     sheet and not be amortized.  On an annual basis, and when there is a reason
     to suspect that their values have diminished or impaired, these assets must
     be tested for impairment,  and write-downs may be necessary. The Company is
     required  to  implement  SFAS  No.  141 on  July  1,  2001  and it has  not
     determined  the  impact,  if any,  that  this  statement  will  have on its
     consolidated financial position or the results of operations.

     On June 29, 2001, SFAS No. 142,  "Goodwill and Other Intangible Assets" was
     issued by the FASB.  SFAS No. 142 changes the  accounting for goodwill from
     an  amortization  method to an  impairment-only  approach.  Amortization of
     goodwill,  including goodwill recorded in past business combinations,  will
     cease upon adoption of this statement. The Company is required to implement
     SFAS No. 142 by January 1, 2002 and has not determined the impact,  if any,
     that this statement  will have on its  consolidated  financial  position or
     results of operations.





Item 2. Management's  Discussion and Analysis of Financial Condition and Results
     of Operations.

     Management's  discussion  and analysis  provides a review of the  Company's
operating  results for the three and six month  periods  ended June 30, 2001 and
2000 and its financial  condition at June 30, 2001.  The focus of this review is
on the underlying  business reasons for significant changes and trends affecting
the revenues,  net earnings and financial condition of the Company.  This review
should  be  read  in  conjunction  with  the  accompanying  unaudited  condensed
consolidated financial statements.

     In an effort to give investors a well-rounded view of the Company's current
condition and future opportunities,  this Quarterly Report on Form 10-Q includes
forecasts by the  Company's  management  about future  performance  and results.
Because they are forward-looking,  these forecasts involve uncertainties.  These
uncertainties  include the  Company's  ability to continue its  operations  as a
result of, among other things,  continuing losses,  working capital  shortfalls,
uncertainties with respect to sources of capital,  risks of market acceptance of
or preference for the Company's systems and services,  competitive  forces,  the
impact of, changes in government  regulations,  general  economic factors in the
healthcare  industry and other factors  discussed in the Company's  filings with
the Securities and Exchange Commission  including the Company's Annual Report on
Form 10-K for the year ended December 31, 2000.

Results of Operations

     Revenues

     Revenues  consist  of  revenues  from  operations,   development  fees  and
licensing fees. Revenues decreased from $598,740 and $1,199,320 during the three
and six month  periods  ended June 30, 2000 to $357,967 and $757,994  during the
three and six month periods ended June 30, 2001, or 40% and 37% respectively.



                                                        Three Months Ended                     Six Months Ended
                                                             June 30,                              June 30,
Revenues                                               2001             2000                 2001             2000
Operations Fees
                                                                                             
  Disease Management and Compliance                $ 116,597        $ 152,867            $ 253,774       $  328,624
  Surveys                                             36,059          131,478               86,180          261,887
  Demand Management                                  132,750          240,494              271,694          473,256
  Other                                               18,000           23,274               36,000           72,527
                                                 -----------------------------    ----------------------------------
Total Operations Fees                                303,406          548,113              647,648        1,136,294
Development Fees                                      27,061           17,200               56,346           17,200
Licensing Fees                                        27,500           33,427               54,000           45,826
                                                 -----------------------------    ----------------------------------

Total Revenues                                     $ 357,967        $ 598,740            $ 757,994       $1,199,320
                                                 -----------------------------    ----------------------------------


     Operations  revenues are generated as the Company provides  services to its
customers. Operations revenues decreased from $548,113 and $1,136,294 during the
three and six month periods ended June 30, 2000 to $303,406 and $647,648  during
the three and six month  periods ended June 30, 2001,  respectively.  Operations
revenues  continue  to be  the  primary  source  of  revenue  for  the  Company.
Operations  revenues  declined because of the termination of assignments for the
conduct of surveys as a result of the  elimination of a Medicare  product by two
of the  Company's  primary  customers and the  completion of several  compliance
programs that have not been replaced by new programs.

     The Company's revenue has continued to decline. The Company has established
relationships  with several new  customers  and entered  into a joint  marketing
relationship  with one of its  strategic  partners.  While  revenues  from these
relationships  have been realized and are expected to grow, no assurances can be
given that such revenues will be material to the Company's results of operations
and  financial  condition.   The  Company  has  identified  other  possible  new
customers,  but there can be no assurance that such  prospects  will  contribute
revenue in the near term, if at all.

     Development fee revenues increased from $17,200 to $27,061 and from $17,200
to $56,346  for the three and six month  periods  ended June 30,  2000 and 2001,
respectively.  This increase was due to increased  focus on  development  of new
programs.  Development  fee  revenue  represents  the  amounts  that the Company
charges its customers for the development or customization programs for which it
anticipates  on-going  operations  revenues.  The Company  has entered  into new
development  agreements but  anticipates  that revenue from program  development
will remain constant in the future.

     License fee revenues  recognized  from the Case  Management  Support System
decreased  to $27,500 from $33,427 for the  three-month  periods  ended June 30,
2001 and 2000  respectively.  License Revenue  increased to $54,000 from $45,826
for the six month  periods  ended  June 30,  2001 and 2000  respectively.  These
changes are due to the negotiated schedule of fees in the ongoing contracts. The
Company  has  not  entered  into  any new  licensing  agreements  for  its  Case
Management  Support  System and the  revenue  for the  current  period  reflects
ongoing revenue from the existing agreements.

     Costs and Expenses

     Cost of sales include salaries and related  benefits,  services provided by
third  parties,  and  other  expenses  associated  with the  implementation  and
delivery of the  Company's  standard  and  customized  population,  demand,  and
disease  management  programs.  Cost of sales for the three and six months ended
June 30, 2001 was $613,417 and $1,320,709 respectively as compared to $1,205,857
and  $2,371,919 (a decrease of 49% and 44%  respectively)  for the three and six
month  periods  ended June 30,  2000.  The  decrease  in these  costs  primarily
reflects a response to the decreased level of population and disease  management
operational activities. The Company's gross margin continues to be negative. The
Company  anticipates  that  revenue  must  increase  before  it  will  recognize
economies of scale.  No assurance  can be given that  revenues  will increase or
that, if they do, they will exceed costs and expenses.

     Sales  and  marketing  expenses  consist  primarily  of  salaries,  related
benefits,  travel costs,  sales materials and other marketing  related expenses.
Sales and marketing  expenses for the three and six month periods ended June 30,
2001 were  $204,271 an $429,190 as  compared to $271,550  and  $685,661  for the
three and six month  periods  ended  June 30,  2000.  Spending  in this area has
decreased  due  to  the  termination  of  staff  and  renegotiation  of  certain
compensation plans. The Company anticipates expansion of the Company's sales and
marketing  staff  and  expects  it will be  required  to invest in the sales and
marketing  process,  and that such  expenses  related to sales and marketing may
increase in future periods.

     General  and  administrative   expenses  include  the  costs  of  corporate
operations,  finance and accounting, human resources and other general operating
expenses of the Company.  General and administrative  expenses for the three and
six month periods ended June 30, 2001 were $378,017 and $731,449, as compared to
$407,578 and $882,512 for the three and six month  periods  ended June 30, 2000.
These  expenditures have been incurred to maintain the corporate  infrastructure
necessary to support anticipated program operations. The decrease in these costs
is a result of reductions in staff and closing of facilities in Pennsylvania and
Canada. The Company expects that general and administrative expenses will remain
relatively constant in future periods.

     Financing costs consist of expenses incurred to obtain  sufficient  working
capital to continue  operations.  These  expense  have  primarily  consisted  of
compensation  cost for shares of the Company's  Common Stock as well as warrants
to purchase  the  Company's  Common  Stock.  Financing  costs were  $356,807 and
$549,557 for the three and six month  periods ended June 30, 2001 as compared to
$192,750 and $279,250 for the three and six month  periods  ended June 30, 2000.
The  increase  in  financing  costs  is a  result  of  the  Company's  continued
dependence on debt to obtain working  capital.  Financing  costs are expected to
remain  relatively  constant  until  such time as the  Company  can  reduce  its
dependence on debt to fund its operations.

     Research and development expenses consist primarily of salaries and related
benefits and  administrative  costs  associated  with the development of certain
components of the Company's integrated  information capture and delivery system,
as well as development of the Company's standardized disease management programs
and the Company's Internet based technology  products.  Research and development
expenses  for the three and six months  ended  June 30,  2001 were  $42,106  and
$95,431, as compared to $77,647 and $163,199 for the same periods of 2000.

     The Company  recorded  interest  expenses of $101,535  and $185,939 for the
three and six month  periods  ended June 30,  2001 as  compared  to $44,604  and
$63,499 for the three and six month periods ended June 30, 2000.  These expenses
are related the Company's  debt and are expected to increase  steadily until the
Company becomes less dependant on debt to fund its operations.

     The Company  recorded  other  income of $627and  $831 for the three and six
month  periods  ended June 30, 2001 as compared to expenses  $27,125 and $16,557
for the same periods of 2000, principally due to the sale of certain assets.

     The Company had a net loss  attributable to the common  shareholders  after
preferred  stock  dividends,  of $1,360,059 and $2,598,452 for the three and six
months  ended June 30, 2001 as compared to  $1,650,871  and  $3,835,777  for the
three and six month periods ended June 30, 2000 respectively.  This represents a
net loss per common  share of $.30 for the first half of 2001,  as compared to a
net loss of $.48 per common share in the first half of 2000. The preferred stock
dividends in 2000 include a beneficial conversion feature for the 100,000 shares
of Series C Stock of $550,000.

     Liquidity and Capital Resources

     At June 30, 2001 the Company had a working capital deficit of $5,679,884 as
compared to $1,375,391 at December 31, 2000.  The June 30, 2001 amounts  reflect
the effects of the Company's continuing losses as well as increased  borrowings,
$2,500,000 of which was  considered to be a long-term  liability at December 31,
2000 but is  classified  as a  current  liability  at June 30,  2001.  Since its
inception,  the Company has primarily  funded its  operations,  working  capital
needs and capital  expenditures from the sale of equity securities and borrowing
from directors.

     On March 31,  2000,  the Company  completed a private  placement of 100,000
shares  of newly  issued  Series C 9%  Cumulative  Convertible  Preferred  Stock
("Series  C"),  raising  $1,000,000  in  total  proceeds.  These  shares  can be
converted  into Common Stock at a rate of 8 shares of Common Stock to 1 share of
Series C Preferred Stock.  Each Series C share has voting rights equivalent to 8
shares of Common Stock  (800,000  shares).  The proceeds from this issuance were
used to support the Company's operations. The fair market value of the Company's
Common  Stock at the time of  issuance  of Series C Stock was $1.9375 per share.
The Series C Preferred  Stock is convertible as a price equal to $1.25 per share
of Common Stock resulting in a discount,  or beneficial  conversion  feature, of
$0.6875  per  share.  The total  amount of this  beneficial  conversion  feature
($550,000) is deemed to be the  equivalent of a preferred  stock  dividend.  The
Company  recorded  the deemed  dividend at the date of  issuance  by  increasing
accumulated  deficit and increasing  additional  paid-in  capital.  Accordingly,
there was no net effect on total stockholders' equity.

     In December 1999, the Company  established a credit facility for $1,500,000
guaranteed by Derace Schaffer and John Pappajohn,  two directors of the Company.
In consideration for their  guarantees,  the Company granted to Dr. Schaffer and
Mr.  Pappajohn  warrants to purchase an  aggregate  of 375,000  shares of common
stock for $1.5625 per share.  In March  2000,  the  facility  was  increased  by
$1,000,000 under substantially the same terms, also guaranteed by the same Board
members.  Additional  warrants  to purchase an  aggregate  of 250,000  shares of
Common  Stock for  $2.325  per  share,  were  granted  to Dr.  Schaffer  and Mr.
Pappajohn for their guarantee of this  additional line of credit.  The estimated
fair value of the warrants at March 31, 2000 was approximately $857,500 based on
the  application of the Black Scholes  option  pricing model which  incorporates
current stock price,  expected stock price volatility,  expected interest rates,
and the  expected  holding  period of the  warrant.  The Company  completed  the
amortization of $857,500 as debt issuance expense as of March 31, 2001.

     On March 28, 2001, the Company  entered into an Amended and Restated Credit
Agreement  with Wells  Fargo Bank Iowa,  N.A.,  which  extended  the term of the
credit  facility  to March 31,  2002 under  substantially  the same  terms.  Dr.
Schaffer and Mr. Pappajohn also guaranteed this extension.  In consideration for
their extended guarantees, the Company re-priced the 625,000 warrants previously
granted in connection with prior guarantees to $0.05 per share,  effective April
1, 2001.  The  Company  assigned a fair  value of  $35,735 to the  warrants  and
intends to fully amortize this deferred  financing cost using the  straight-line
method over the 12-month  period ending March 31, 2002. The estimated fair value
of the re-priced  warrants was determined as the difference between (i) the fair
market  value of the  original  warrants  as of April 1,  2001  using  the Black
Scholes  method and (ii) the fair market value of the  re-priced  warrants as of
April 1, 2001.

     The Company  borrowed  $1,430,000  for working  capital from Mr.  Pappajohn
during the six month  period  ended June 30,  2001.  From June 30, 2001  through
August 10, 2001, the Company borrowed an additional $330,000 from Mr. Pappajohn.
Through  August 10,  2001,  a total of  $2,931,000  has been  borrowed  from Mr.
Pappajohn  and Dr.  Schaffer,  all of  which is  secured  by the  assets  of the
Company.  There can be no assurances  that Mr.  Pappajohn  will continue to make
funds  available to the Company.  If such funds are not  available,  the Company
will cease operations.

     The Company holds an  investment of Common Stock in a private  company (the
"Investment")  that is recorded at its historical cost of $200,000.  The Company
has been made aware that the private company to which the Investment  relates is
seeking an  opportunity  to be sold for a  valuation  that  would  result in the
Investment  exceeding  its carrying  cost.  No assurance  can be given that such
sale, if any, will be at this  valuation.  The market value of the Investment is
not  readily  determinable.  Management  believes  that  an  impairment  of  the
Investment, if any, is temporary.

     The  Company has  expended  substantial  amounts to expand its  operational
capabilities  and  strengthen  its  infrastructure,  which at the same  time has
increased its  administrative  and technical  costs. In addition,  the Company's
cash has been  steadily  depleted as a result of operating  losses.  The Company
anticipates  that its losses will  continue  and,  except for the loans from Mr.
Pappajohn,  the Company has no available capital.  Accordingly,  the Company has
been  required  to seek  capital to  maintain  its  operations.  The  Company is
continuing its efforts to raise additional capital privately through the sale of
convertible  preferred  stock in a private  placement  to  accredited  investors
through the efforts of its officers  and  directors.  No assurance  can be given
that the Company will  successfully  raise the necessary  funds.  Any additional
financing,  which includes the issuance of additional securities of the Company,
may be dilutive to the Company's existing stockholders. If the Company is unable
to identify additional capital, it will be required to cease operations.

     Inflation

     Inflation did not have a significant  impact on the Company's  costs during
the  three and six month  periods  ended  June 30,  2001 and 2000.  The  Company
continues  to monitor the impact of  inflation  in order to minimize its effects
through pricing strategies, productivity improvements and cost reductions.

     Forward Looking Statements

     When used in this and in future  filings by the Company with the Securities
and Exchange Commission,  in the Company's press releases and in oral statements
made with the approval of an authorized  executive  officer of the Company,  the
words or phrases "will likely result,"  "expects," "plans," "will continue," "is
anticipated,"  "estimated,"  "project,"  or  "outlook"  or  similar  expressions
(including  confirmations by an authorized  executive  officer of the Company of
any such  expressions  made by a third party with  respect to the  Company)  are
intended  to  identify  "forward-looking  statements"  within the meaning of the
Private Securities  Litigation Reform Act of 1995. The Company wishes to caution
readers not to place undue reliance on any such forward-looking statements, each
of which speak only as of the date made.  Such statements are subject to certain
risks and  uncertainties  that could cause actual  results to differ  materially
from  historical  earnings and those presently  anticipated or projected.  These
uncertainties  include the  Company's  ability to continue its  operations  as a
result of, among other things,  continuing losses,  working capital short falls,
uncertainties with respect to sources of capital,  risks of market acceptance of
or preference for the Company's systems and services,  competitive  forces,  the
impact of, changes in government  regulations,  general  economic factors in the
healthcare  industry and other factors  discussed in the Company's  filings with
the Securities and Exchange Commission  including the Company's Annual Report on
Form 10-K for the year ended December 31, 2000. The Company has no obligation to
publicly  release  the  result  of  any  revisions,  which  may be  made  to any
forward-looking  statements to reflect  anticipated or  unanticipated  events or
circumstances occurring after the date of such statements.

     New Accounting Pronouncements

     During  the  first  quarter  of 2001,  the  Company  adopted  Statement  of
Financial  Accounting  Standards  ("SFAS") No. 133,  Accounting  for  Derivative
Instruments  and  Hedging  Activities.   The  Company  has  not  identified  any
derivatives  that  meet  criteria  for a  derivative  instrument  and  does  not
participate in any hedging  activities.  As a result,  management of the Company
concluded  that  there  was no  material  effect on the  Company's  consolidated
financial  position,  results of  operations  or cash flows  resulting  from the
adoption of SFAS No. 133 at March 31, 2001.

     In September 2000, the Financial Accounting Standards Board issued SFAS No.
140,   "Accounting   for  Transfers  and  Servicing  of  Financial   Assets  and
Extinguishment of Liabilities,"  which supercedes SFAS No. 125,  "Accounting for
Transfers and Servicing of Financial Assets and Extinguishments of Liabilities."
This standard is effective for transfers  occurring  after March 31, 2001,  with
certain disclosure requirements effective for the year ending December 31, 2000.
Management of the Company has concluded that there was no material effect on the
Company's consolidated  financial position,  results of operations or cash flows
resulting from the adoption of SFAS No. 140 at June 30, 2001.

     On June 29, 2001,  Statement of Financial  Accounting  Standards (SFAS) No.
141, "Business  Combinations" was issued by the Financial  Accounting  Standards
Board (FASB).  SFAS No. 141 requires  that the purchase  method of accounting be
used for all business  combinations  initiated after June 30, 2001. Goodwill and
certain intangible assets will remain on the balance sheet and not be amortized.
On an annual basis, and when there is a reason to suspect that their values have
diminished  or  impaired,  these  assets  must be  tested  for  impairment,  and
write-downs may be necessary.  The Company is required to implement SFAS No. 141
on  July 1,  2001  and it has not  determined  the  impact,  if any,  that  this
statement  will have on its  consolidated  financial  position or the results of
operations.

     On June 29, 2001, SFAS No. 142,  "Goodwill and Other Intangible Assets" was
issued by the FASB.  SFAS No. 142 changes the  accounting  for goodwill  from an
amortization  method to an impairment-only  approach.  Amortization of goodwill,
including  goodwill  recorded  in past  business  combinations,  will cease upon
adoption of this statement. The Company is required to implement SFAS No. 142 by
January 1, 2002 and has not determined  the impact,  if any, that this statement
will have on its consolidated financial position or results of operations.

Item 3.  Quantitative and Qualitative Disclosures About Market Risk

     The Company is exposed to changes in interest  rates  primarily in its cash
transactions.  The interest paid on the Company's  outstanding line of credit is
based upon the prime rate.  The Company has the option of reducing  its interest
expenses by rolling the outstanding line of credit balance into notes that carry
a rate equal to LIBOR plus 1.75%.

     In relation to the operations of Patient Infosystems  Canada,  fluctuations
of foreign  currency can impact the Company's net  operating  results.  However,
management  believes that due to the relative size of its  operations in Canada,
such  impact  would  be  considered  immaterial  to the  consolidated  financial
statements.  The Company  currently has no  significant  investments  in foreign
currency instruments.

     The  balances  the Company has in cash or cash  equivalents  are  generally
available without legal restrictions to fund ordinary business  operations.  The
Company  regularly  invests excess operating cash in certificates of deposit and
U.S.  government bonds and other bonds that are subject to changes in short-term
interest rates.  Accordingly,  the Company believes that the market risk arising
from its holding of these financial  instruments is minimal. The Company did not
make any purchases of  available-for-sale  securities in the three and six month
periods ended June 30, 2000 and 2001.

PART II - OTHER INFORMATION

Item 2.  Changes in Securities and Use of Proceeds

     Borrowing from directors

     The Company  borrowed  $1,430,000  for working  capital from Mr.  Pappajohn
during the six month  period  ended June 30,  2001.  From June 30, 2001  through
August 10, 2001, the Company borrowed an additional $330,000 from Mr. Pappajohn.
Through  August  10,  2001 a total  of  $2,931,000  has been  borrowed  from Mr.
Pappajohn  and Dr.  Schaffer,  all of  which is  secured  by the  assets  of the
Company.  There can be no assurances  that Mr.  Pappajohn  will continue to make
funds  available to the Company.  If such funds are not  available,  the Company
will cease operations.

Item 6.  Exhibits and Reports on Form 8-K

     On June  7,  2001,  the  Company  issued  a press  release  concerning  the
execution of a definitive  agreement to acquire  substantially all the assets of
Health Data  Solutions of  Brownsburg,  Indiana and its affiliate  American Care
Source of Dallas, Texas.

Exhibits:

(a)  (11)  Statements of Computation of Per Share Earnings



SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned thereunto duly authorized.

Dated:  August 10, 2001



                                              PATIENT INFOSYSTEMS, INC.
                                                           (Registrant)


Date: August 10, 2001                         /s/ Roger L. Chaufournier
                                              ----------------------------------
                                              Roger L. Chaufournier
                                              Director, President and
                                              Chief Executive Officer

Date: August 10, 2001                         /s/ Kent A. Tapper
                                              ----------------------------------
                                              Kent A. Tapper
                                              Principal Accounting Officer



Exhibit 11.       Statement of Computation of Per Share Earnings



PATIENT INFOSYSTEMS, INC.
                                                       Three Months Ended                        Six Months Ended
                                                            June 30,                                 June 30,
                                                      2001             2000                  2001                2000

                                                                                              
Net loss                                       $ (1,337,559)    $ (1,628,371)         $ (2,553,452)       $ (3,263,277)

Convertible preferred Stock dividends               (22,500)         (22,500)              (45,000)           (572,500)

Net loss attributable to Common Stockholders   $ (1,360,059)    $ (1,650,871)         $ (2,598,452)       $ (3,835,777)

Weighted average common shares                     8,919,357        8,071,095             8,569,779           8,070,095

Net loss per share - Basic and diluted         $      (0.15)    $      (0.20)         $      (0.30)       $      (0.48)