H&Q HEALTHCARE INVESTORS [H&Q HEALTHCARE INVESTORS LOGO] SEMIANNUAL REPORT March 31, 2002 To our Shareholders: At quarter-end on March 31, 2002 the net asset value of your Fund was $25.61 per share. Performance data for the six months and the quarter ended March 31 compared to the indices is as follows: FISCAL YEAR TO DATE QUARTER ENDED 9/30/01 - 3/31/02 3/31/02 ----------------- ------- Net Asset Value +1.9% -14.0% Dow Jones Industrial Average +17.6% +3.8% NASDAQ Industrials +30.1% +2.1% Russell 2000 +25.1% +3.1% The Fund's second fiscal quarter ended March 31, 2002 was particularly disappointing following the Fund's strong performance during the prior quarter. During the quarter, the biotechnology sector retrenched due to both sector-specific and general factors. However, we continue to be confident in the future of healthcare in general and in emerging biotech and medtech growth companies in particular. We believe that the companies in this sector will continue to lead the advancement of knowledge and remain confident this progress will improve the human condition by providing products and services that will enhance the quality and duration of life. We have no doubt that Americans will appreciate the values of these products and will pay a premium price for them. As such we continue to believe that the investment opportunities in the future will be abundant. We also believe that as the economy generally improves over time, the healthcare sector will play a significant role in any advancement. While the stock prices of public biotechnology companies have declined during the most recent quarter, we were not aggressive buyers. Rather, we selectively reduced positions and allowed liquidity, as a percent of total assets, to rise to its highest level in recent years. We believe the Fund is well positioned to take advantage of the current situation. Valuations are becoming particularly attractive for both publicly traded and private companies. We expect that in the weeks and months ahead we will have opportunities to invest much of this liquidity at very attractive levels. Many public companies have equity market values with historically low premiums to their liquid assets creating unusual values for their technology and product opportunities. In our venture capital activity, we are now frequently seeing attractive valuations and some transactions are being done at a very significant discount to previous investment rounds completed 1-2 years ago. We believe that this also bodes well for the future. 1 Having made these assertions, it is also true that there are a number of factors that may have a mitigating impact on the Fund's performance. Certainly, the heightened scrutiny of accounting practices at a number of individual companies, as well as other corporate governance issues, is sobering to the general market. Furthermore, there are a number of issues specific to the pharmaceutical industry that are unsettling to investors. The Food and Drug Administration is still without a Commissioner, and seems to have recently become even more risk averse than usual. With several product approvals delayed, investors have concerns that product approval cycles are once again lengthening. This comes at a time when patent expirations are increasing with the threat of generic competition. These issues come amidst discussion of the control of drug pricing by government and increasing uncertainty about the ability of healthcare companies to sustain the ever-increasing cost of drug development. While these concerns are most apparent to major pharmaceutical companies, and less so for the emerging companies, sentiment does affect valuations. Some of these issues are likely to persist at least through the elections in November but we continue to believe that new products that cure or mediate the course of disease will continue to be rewarded. Two new venture investments were made in the quarter. SENOMYX discovers and develops novel flavor and fragrance molecules by combining its understanding of the biology of taste with receptor biology, combinatorial chemistry, high throughput screening and bioinformatics. AGENSYS develops fully human monoclonal antibodies to treat solid tumor cancers based on the Company's own proprietary drug targets. A follow-on investment was made in Sontra Medical in connection with its merger with ChoiceTel, a publicly traded company. This was a difficult quarter, but we believe strongly in the future growth of healthcare and in the entrepreneurial approach of the companies in which we invest. We continue to believe that attractive investment opportunities in the future will be abundant. /s/ Alan G. Carr /s/ Daniel R. Omstead Alan G. Carr Daniel R. Omstead President Emeritus President 2 H&Q HEALTHCARE INVESTORS PRIVACY NOTICE If you are a registered shareholder of the Fund, the Fund and Hambrecht & Quist Capital Management, the Funds' investment adviser, may receive nonpublic personal information about you from the information collected by the transfer agent from your transactions in Fund shares. Any nonpublic personal information is not disclosed to third parties, except as permitted or required by law. In connection with servicing your account and effecting transactions, the information received may be shared with the investment adviser and non-affiliates, including transfer agents, custodians or other service companies. Access to your nonpublic personal information is restricted to employees who need to know that information to provide products or services to you. To maintain the security of your nonpublic personal information, physical, electronic, and procedural safeguards are in place that comply with federal standards. The policies and practices described above apply to both current and former shareholders. If your Fund shares are held in "street name" at a bank or brokerage, we do not have access to your personal information and you should refer to your bank's or broker's privacy policies for a statement of the treatment of your personal information. H&Q HEALTHCARE INVESTORS PORTFOLIO AS OF MARCH 31, 2002 [CHART] TOTAL VENTURE DIFFERENCE ----- ------- ---------- AGRI/ENVIRONMENTAL 1.4% 1.3% 0.1% BIOTECHNOLOGY 45.2% 10.0% 35.3% CROs 0.5% 0.0% 0.5% DIAGNOSTICS 6.8% 2.7% 4.2% HEALTHCARE INFO SERVICES 3.5% 2.5% 0.9% MEDICAL SPECIALTY 12.2% 3.9% 8.3% MEDICAL SUPPLIES 1.4% 0.9% 0.5% PHARMACEUTICALS 6.5% 2.0% 4.5% LIQUID ASSETS 22.5% 0.0% 22.5% RESTRICTED 3 H&Q HEALTHCARE INVESTORS LARGEST HOLDINGS AS OF MARCH 31, 2002 % OF NET ASSETS --------------- Gilead Sciences 4.67% Martek Biosciences 4.23% Cubist Pharmaceuticals 3.94% Transkaryotic Therapies 3.47% CV Therapeutics 3.45% Celgene 3.09% Cytyc 2.66% Biovail 2.52% MedImmune 2.51% Endocardial Solutions 2.47% H&Q HEALTHCARE INVESTORS SIGNIFICANT PORTFOLIO TRANSACTIONS QUARTER ENDED MARCH 31, 2002 UNITS HELD UNITS HELD PURCHASES 12/31/01 3/31/02 --------- -------- ------- Agensys (Restricted) 0 952,381 Exelixis 98,000 226,500 Rigel Pharmaceuticals 0 508,500 Senomyx (Restricted) 0 1,034,519 Sontra (Restricted) Series B 536,460 933,837 WebMD 283,500 403,500 SALES Affymetrix 60,000 0 Biovail 345,924 165,924 Curis 205,311 92,500 Gilead Sciences 413,318 426,636 Scios 109,500 0 Sepracor 217,138 0 Versicor 628,165 418,165 4 H&Q HEALTHCARE INVESTORS SCHEDULE OF INVESTMENTS March 31, 2002 (UNAUDITED) CONVERTIBLE SECURITIES - 23.3% OF NET ASSETS SHARES CONVERTIBLE PREFERRED (RESTRICTED) - 21.3% VALUE ------ ----- AGRICULTURAL/ENVIRONMENTAL TECHNOLOGIES - 1.3% 375,000 Ceres Series C* $2,250,000 27,443 Ceres Series C-1*# 164,658 277,967 Ceres Series D*# 1,667,802 222,222 EPR Series A* 333,333 BIOTECHNOLOGY - 8.8% 400,000 ACADIA Pharmaceuticals Series E* 3,000,000 952,381 Agensys Series C* 3,000,000 2,380,953 Agilix Series B* 3,000,001 850,436 Avalon Pharmaceuticals Series B* 2,999,998 1,818,182 Raven biotechnologies Series B*^ 3,000,000 47,407 Therion Biologics Series A* 177,776 240,000 Therion Biologics Series B*# 900,000 407,712 Therion Biologics Series C*# 1,528,920 36,092 Therion Biologics Sinking Fund* 135,345 1,750,000 Triad Therapeutics Series A* 3,500,000 825,000 Triad Therapeutics Series B* 1,650,000 923,077 Zyomyx Series B* 3,692,308 600,000 Zyomyx Series C* 2,400,000 DIAGNOSTICS - 2.6% 1,371,429 CardioNet Series C*^ 4,800,002 484,829 CytoLogix Series A*^ 400,178 227,130 CytoLogix Series B*#^ 187,473 160,000 Masimo Series D* 1,760,000 1,724,138 Sontra Medical Series A*^ 867,759 933,837 Sontra Medical Series B*^ 470,000 HEALTHCARE INFORMATION SERVICES - 1.8% 338,983 KVM Technologies Series B*#^ 1,500,000 5,384,616 PHT Series D*^ 4,200,000 MEDICAL SPECIALTY - 3.9% 636,364 AbTox Series F* 6,364 1,632,653 OmniSonics Medical Technologies Series B*^ 2,400,000 1,034,519 Senomyx Series E* 3,000,002 639,659 Songbird Hearing Series D* 6,397 652,173 TherOx Series H* 2,999,996 820,313 VNUS Medical Technologies Series E*^ 4,200,003 MEDICAL SUPPLIES - 0.9% 343,750 LocalMed Series D* 3,438 631,580 Novacept Series G*# 3,000,005 The accompanying notes are an integral part of these financial statements. 5 CONVERTIBLE SECURITIES - CONTINUED SHARES CONVERTIBLE PREFERRED (RESTRICTED) - 21.3% VALUE ------ ----- PHARMACEUTICALS/DRUG DELIVERY - 2.0% 211,765 Advanced Medicine Series C* $1,905,885 200,000 Advanced Medicine Series D-1* 1,800,000 1,398,732 Galileo Laboratories Series F* 3,000,000 ----------- $69,907,643 ----------- PRINCIPAL AMOUNT CONVERTIBLE BONDS AND NOTES - 2.0% ------ BIOTECHNOLOGY - 1.5% $6,800,000 CuraGen 6% Cvt. Deb. due 2007 ii $5,049,000 HEALTHCARE INFORMATION SERVICES - 0.4% 1,577,366 FitForAll.com (Restricted) 10% Prom. Note*#+ 158 1,350,000 KVM Technologies (Restricted) Adj. Cvt. Demand Note*#^ 1,350,000 MEDICAL SPECIALTY - 0.1% 180,000 AbTox (Restricted) 12% Prom. Note*+ 180,000 ----------- $6,579,158 ----------- TOTAL CONVERTIBLE SECURITIES (Cost $82,888,416) $76,486,801 ----------- SHARES COMMON STOCKS - 54.3% ------ AGRICULTURAL/ENVIRONMENTAL TECHNOLOGY - 0.1% 71,483 Catalytica Energy Systems* $240,898 ----------- 240,898 ----------- BIOTECHNOLOGY - 34.9% BIOPHARMACEUTICALS - 29.5% 429,898 BioTransplant* 2,256,964 2,760 BioTransplant (Restricted) Wts. (expire 8/12/04)* 2,070 6,300 BioTransplant (Restricted) Wts. (expire 10/31/04)* 4,725 1,150 BioTransplant (Restricted) Wts. (expire 8/15/05)* 3,595 410,400 Celgene* 10,157,400 54,000 Cephalon* 3,402,000 246,389 Corixa* 1,520,220 550,556 Cubist Pharmaceuticals* 10,174,275 200,001 Cubist Pharmaceuticals (Restricted) Wts. (expire 9/23/03)* 2,759,114 312,823 CV Therapeutics* 11,324,193 163,000 Genzyme* 7,118,210 426,636 Gilead Sciences* 15,354,630 The accompanying notes are an integral part of these financial statements. 6 SHARES BIOTECHNOLOGY - CONTINUED VALUE ------ ----- 210,000 MedImmune* $8,259,300 226,760 Therion Biologics (Restricted)* 850,350 264,912 Transkaryotic Therapies* 11,404,462 270,270 Tularik* 4,443,239 418,165 Versicor* 7,560,423 18,696 Versicor (Restricted) Wts. (expire 8/3/05)* 199,823 GENOMICS/DRUG DISCOVERY - 5.4% 150,000 Abgenix* 2,833,500 299,302 Dyax* 1,101,431 226,500 Exelixis* 3,123,435 78,500 Lexicon Genetics* 741,825 225,000 Lynx Therapeutics* 490,500 174,461 Molecular Devices* 3,169,956 508,500 Rigel Pharmaceuticals* 1,805,175 370,237 Telik* 4,487,272 ----------- 114,548,087 ----------- CONTRACT RESEARCH ORGANIZATIONS - 0.5% 91,400 Quintiles Transnational* 1,622,350 ----------- 1,622,350 ----------- DIAGNOSTICS - 4.2% 522,617 Biofield* 237,791 600,000 Biofield (Restricted)* 218,400 324,330 Cytyc* 8,730,963 18,500 Digene* 661,375 152,000 IDEXX Laboratories* 4,079,680 160,000 Masimo Labs (Restricted)* 1,600 900,000 Sontra Medical (Restricted)*^ 9,000 ----------- 13,938,809 ----------- HEALTHCARE INFORMATION SERVICES - 1.3% 4,366,920 Codman Group (Restricted)* 10,917 306,208 Physician WebLink (Restricted)* 1,200,473 188,096 Physician WebLink (Restricted) Wts. (expire 10/15/04)* 18,810 403,500 WebMD* 3,098,880 ----------- 4,329,080 ----------- MEDICAL SPECIALTY - 8.3% 381,818 ATS Medical* 763,636 130,900 Bioject Medical Technologies* 503,965 101,848 Biopure* 1,079,589 8,333 Biopure (Restricted) Wts. (expire 8/4/03)* 0 The accompanying notes are an integral part of these financial statements. 7 SHARES MEDICAL SPECIALTY - CONTINUED VALUE ------ ----- 92,500 Curis* $197,025 1,000,000 Endocardial Solutions* 8,110,000 441,409 Martek Biosciences* 13,895,114 1,020,000 Orthovita*^ 2,499,000 198,000 Radiance Medical Systems* 247,500 ------------ 27,295,829 ------------ MEDICAL SUPPLIES - 0.5% 645,000 EP MedSystems*^ 1,631,850 ------------ 1,631,850 ------------ PHARMACEUTICALS/DRUG DELIVERY - 4.5% 225,000 Aradigm* 1,057,500 165,924 Biovail* 8,292,881 91,500 Emisphere Technologies* 1,556,415 70,000 Teva Pharmaceutical Industries ADR 3,826,900 ------------ 14,733,696 ------------ TOTAL COMMON STOCKS (Cost $82,321,214) $178,340,599 ------------ PRINCIPAL AMOUNT TEMPORARY CASH INVESTMENTS - 22.0% ------ $7,000,000 American Express Credit, 1.45%, due 4/2/02 $6,999,718 16,500,000 American Express Credit, 1.80%, due 4/29/02 16,476,900 16,000,000 General Electric Capital Corp., 1.82%, due 5/8/02 15,970,071 8,000,000 U.S. Treasury Bill, 1.69%, due 4/11/02 7,996,244 5,900,000 U.S. Treasury Bill, 1.73%, due 4/25/02 5,893,195 19,000,000 U.S. Treasury Bill, 1.71%, due 5/2/02 18,972,023 ------------ TOTAL TEMPORARY CASH INVESTMENTS (Cost $72,308,151) $72,308,151 ------------ TOTAL INVESTMENTS (Cost $237,517,781) $327,135,551 ============ -------------- * Non income-producing security. # With warrants attached. ^ Affiliated issuers in which the Fund holds 5% or more of the voting securities (Total Market Value of $27,515,265). ii Security exempt from registration under Rule 144A of the Securities Act of 1933. These securities may be resold in transactions exempt from registration, normally to qualified institutional buyers. + Issuer filed for bankruptcy. The accompanying notes are an integral part of these financial statements. 8 H&Q HEALTHCARE INVESTORS STATEMENT OF ASSETS AND LIABILITIES March 31, 2002 (UNAUDITED) ASSETS: Investments, at value (identified cost $237,517,781; see Schedule of Investments) $327,135,551 Cash 656,175 Interest receivable 66,867 Receivable for investments sold 2,103,347 Prepaid expenses 36,391 ------------ Total assets $329,998,331 ------------ LIABILITIES: Payable for investments purchased $866,988 Accrued advisory fee 393,595 Accrued other 74,448 ------------ Total liabilities $1,335,031 ------------ NET ASSETS $328,663,300 ============ SOURCES OF NET ASSETS: Shares of beneficial interest, par value $.01 per share, unlimited number of shares authorized, amount paid in on 12,833,980 shares issued and outstanding $210,436,463 Accumulated net investment loss (1,802,602) Accumulated net realized gain on investments 30,411,669 Net unrealized gain on investments 89,617,770 ------------ Total net assets (equivalent to $25.61 per share based on 12,833,980 shares outstanding) $328,663,300 ============ The accompanying notes are an integral part of these financial statements. 9 H&Q HEALTHCARE INVESTORS STATEMENT OF OPERATIONS For the Six Months Ended March 31, 2002 (UNAUDITED) INVESTMENT INCOME: Dividend income (net of foreign tax of $1,736) $9,121 Interest income 752,373 ---------- Total investment income $761,494 EXPENSES: Advisory fees $2,339,010 Legal fees 89,182 Trustees' fees and expenses 85,716 Shareholder reporting 49,725 Accounting and auditing fees 44,348 Custodian fees 42,205 Stock exchange listing fee 30,922 Transfer agent fees 23,969 Other 13,059 ---------- Total expenses 2,718,136 ----------- Net investment loss ($1,956,642) ----------- NET REALIZED AND UNREALIZED GAIN (LOSS) ON INVESTMENTS: Net realized gain on investments $36,438,345 Decrease in net unrealized gain on investments (27,463,909) ----------- Net gain on investments $8,974,436 ----------- Net increase in net assets resulting from operations $7,017,794 =========== The accompanying notes are an integral part of these financial statements. 10 H&Q HEALTHCARE INVESTORS STATEMENTS OF CHANGES IN NET ASSETS FOR THE SIX FOR THE MONTHS ENDED YEAR ENDED MARCH 31, 2002 SEPTEMBER 30, (UNAUDITED) 2001 -------------- -------------- NET INCREASE (DECREASE) IN NET ASSETS RESULTING FROM OPERATIONS: Net investment loss ($1,956,642) ($2,222,151) Net realized gain on investments 36,438,345 63,501,379 Increase (decrease) in net unrealized gain on investments (27,463,909) (201,564,026) ------------ ------------ Net increase (decrease) in net assets resulting from operations $7,017,794 ($140,284,798) ------------ ------------ DISTRIBUTIONS TO SHAREHOLDERS FROM: Net realized capital gains ($27,561,544) ($52,289,670) ------------ ------------ CAPITAL SHARE TRANSACTIONS: Value of shares issued in reinvestment of distributions (791,916 and 1,519,574 shares, respectively) $19,833,844 $36,365,104 ------------ ------------ Net increase (decrease) in net assets ($709,906) ($156,209,364) NET ASSETS: Beginning of year 329,373,206 485,582,570 ------------ ------------ End of year $328,663,300 $329,373,206 ============ ============ The accompanying notes are an integral part of these financial statements. 11 H&Q HEALTHCARE INVESTORS STATEMENT OF CASH FLOWS For the Six Months Ended March 31, 2002 (UNAUDITED) CASH FLOWS USED FOR OPERATING ACTIVITIES: Interest income received $696,153 Dividends received 9,121 Operating expenses paid (2,788,312) ----------- Net cash used for operating activities ($2,083,038) ----------- CASH FLOWS PROVIDED FROM INVESTING ACTIVITIES Purchases of portfolio securities ($19,127,650) Net purchases of temporary cash investments (22,821,310) Sales and maturities of portfolio securities 51,859,628 ----------- Net cash provided from investing activities $9,910,668 ----------- CASH FLOWS USED FOR FINANCING ACTIVITIES: Cash distributions paid, net ($7,727,700) ----------- Net cash used for financing activities ($7,727,700) ----------- NET INCREASE IN CASH $99,930 CASH AT BEGINNING OF PERIOD 556,245 ----------- CASH AT END OF PERIOD $656,175 =========== RECONCILIATION OF NET INCREASE IN NET ASSETS RESULTING FROM OPERATIONS TO NET CASH USED FOR OPERATING ACTIVITIES: Net decrease in net assets resulting from operations $7,017,794 Accretion of discount (56,220) Net realized gain on investments (36,438,345) Net decrease in unrealized gain on investments 27,463,909 Increase in prepaid expenses (19,741) Decrease in accrued expenses (50,435) ----------- Net cash used for operating activities ($2,083,038) =========== Noncash financing activities not included herein consist of stock distributions of $19,833,844. The accompanying notes are an integral part of these financial statements. 12 H&Q HEALTHCARE INVESTORS FINANCIAL HIGHLIGHTS (SELECTED DATA FOR EACH SHARE OF BENEFICIAL INTEREST OUTSTANDING THROUGHOUT THE PERIOD INDICATED) FOR THE SIX MONTHS ENDED FOR THE YEARS ENDED SEPTEMBER 30, MARCH 31, 2002 -------------------------------------------------------------------- (UNAUDITED)(1) 2001 2000 1999 1998 1997 -------------- ------------ ------------ ------------ ------------ ------------ Net asset value per share: Beginning of period $27.350 $46.147 $21.771 $16.711 $23.106 $25.754 ------------ ------------ ------------ ------------ ------------ ------------ Net investment income (loss) ($0.158)* ($0.195)* ($0.290) ($0.176) ($0.217) ($0.224) Net realized and unrealized gain (loss) on investments 0.678 (13.822) 28.131 5.596 (5.108) 4.524 ------------ ------------ ------------ ------------ ------------ ------------ Total increase (decrease) from investment operations $0.520 ($14.017) $27.841 $5.420 ($5.325) $4.300 ------------ ------------ ------------ ------------ ------------ ------------ Dilutive effect of sale of common stock and related expenses from rights offering -- -- -- -- -- (2.458) Capital gains distributions to shareholders ($2.260) ($4.780) ($3.465) ($0.360) ($1.070) ($4.490) ------------ ------------ ------------ ------------ ------------ ------------ Net asset value per share: End of period $25.610 $27.350 $46.147 $21.771 $16.711 $23.106 ============ ============ ============ ============ ============ ============ Per share market value: End of period $22.200 $21.740 $36.188 $16.313 $13.125 $19.000 Total investment return at market value 11.50% (27.23%) 151.66% 27.39% (26.05%) 14.01% RATIOS AND SUPPLEMENTAL DATA: Net assets at end of period $328,663,300 $329,373,206 $485,582,570 $209,519,627 $157,976,073 $207,728,666 Ratio of operating expenses to average net assets** 1.55% 1.42% 1.45% 1.46% 1.46% 1.57% Ratio of net investment loss to average net assets** (1.12%) (0.62%) (0.86%) (0.91%) (1.11%) (1.13%) Portfolio turnover rate 6.54% 16.17% 12.90% 24.88% 17.15% 17.47% Number of shares outstanding at end of period 12,833,980 12,042,064 10,522,490 9,623,524 9,453,317 8,990,179 (1) The Fund adopted the provisions of the AICPA Audit and Accounting Guide for Investment Companies and began accreting discounts and amortizing premiums on all debt securities. The effect of this change for the six months ended March 31, 2002 was a decrease in net investment loss per share of $.004, a decrease in net realized and unrealized gain (loss) per share of $.004, and a decrease in the ratio of net investment loss to average net assets from (1.15%) to (1.12%). Per share data and ratios for the periods prior to October 1, 2001 have not been restated to reflect this change in presentation. * Net investment loss per share has been computed using average shares outstanding. ** Annualized. The accompanying notes are an integral part of these financial statements. 13 H&Q HEALTHCARE INVESTORS NOTES TO FINANCIAL STATEMENTS March 31, 2002 (UNAUDITED) (1) ORGANIZATION H&Q Healthcare Investors (the Fund) is a Massachusetts business trust registered under the Investment Company Act of 1940 as a diversified closed-end management investment company. The Fund's investment objective is long-term capital appreciation through investment in securities of companies in the healthcare industries. The Fund invests primarily in securities of public and private companies that are believed to have significant potential for above-average growth. The Fund was organized on October 31, 1986 and commenced operations on April 22, 1987. The preparation of these financial statements requires the use of certain estimates by management in determining the entity's assets, liabilities, revenues and expenses. Actual results could differ from these estimates. The following is a summary of significant accounting policies consistently followed by the Fund, which are in conformity with those generally accepted in the United States of America. INVESTMENT SECURITIES Investments traded on national securities exchanges or in the over-the-counter market that are National Market System securities are valued at the last sale price or, lacking any sales, at the mean between the last bid and asked prices. Other over-the-counter securities are valued at the most recent bid prices as obtained from one or more dealers that make markets in the securities. As indicated in Note 4, investments for which market quotations are not readily available are valued at fair value as determined in good faith by the Trustees of the Fund. Temporary cash investments with maturity of 60 days or less are valued at amortized cost. Investment transactions are recorded on a trade date basis. Gains and losses from sales of investments are recorded using the "identified cost" method. Interest income is recorded on the accrual basis. Dividend income is recorded on the ex-dividend date. The Fund adopted the provisions of the AICPA Audit and Accounting Guide for Investment Companies, as revised, effective October 1, 2001 and began accreting discounts and amortizing premiums on all debt securities. Prior to this date, the Fund did not accrete discounts or amortize premiums on long-term debt securities. The cumulative effect of this accounting change had no impact on the total net assets of the Fund, but resulted in an increase in cost of securities and a corresponding decrease in net unrealized appreciation of $154,000 based on securities held at September 30, 2001. The effect of this change for the six months ended March 31, 2002 was to decrease net investment loss by $56,220 with a corresponding decrease in the change in net unrealized appreciation of $56,220. FEDERAL INCOME TAXES It is the Fund's policy to comply with the requirements of the Internal Revenue Code applicable to regulated investment companies and to distribute to its shareholders substantially all of its taxable income and its net realized capital gains, if any. Therefore, no Federal income or excise tax provision is required. DISTRIBUTIONS The Fund records all distributions to shareholders from net investment income, if any, and realized gains on the ex-dividend date. Such distributions are determined in conformity with income tax regulations. Due to permanent book/tax differences in accounting for certain transactions, certain distributions may be treated as distributions from capital as opposed to distributions of net investment income or realized capital gains. 14 DISTRIBUTION POLICY The current distribution policy is to declare distributions in stock. Stock distributions will automatically be paid in newly issued shares of the Fund unless otherwise instructed by the shareholder. Pursuant to an SEC exemptive order, the Fund has implemented a fixed distribution policy that permits the Fund to make quarterly distributions at a rate of 2% of the Fund's net assets to shareholders of record. The Fund intends to use net realized capital gains when making quarterly distributions. This could result in a return of capital to shareholders if the amount of the distribution exceeds the Fund's net investment income and realized capital gains. It is anticipated that net realized capital gains in excess of the total distributed under this policy would be included in the December distribution. STATEMENT OF CASH FLOWS The cash amount shown in the Statement of Cash Flows is the amount included in the Fund's Statement of Assets and Liabilities and represents cash on hand at its custodian and does not include temporary cash investments at March 31, 2002. (2) SECURITIES TRANSACTIONS The aggregate cost of purchases and proceeds from sales of investment securities (other than temporary cash investments) for the six months ended March 31, 2002 totaled $19,472,411 and $51,623,922, respectively. At March 31, 2002, the total cost of securities for Federal income tax purposes was $237,492,781. The net unrealized gain on securities held by the Fund was $89,617,770, including gross unrealized gain of $126,920,790 and gross unrealized loss of $37,303,020. (3) INVESTMENT ADVISORY FEES AND OTHER TRANSACTIONS WITH AFFILIATES The Fund has entered into an Investment Advisory Agreement (the Advisory Agreement) with Hambrecht & Quist Capital Management Incorporated (the Adviser). Pursuant to the terms of the Advisory Agreement, the Fund pays the Adviser a monthly fee at the rate when annualized of (i) 2.5% of the average net assets for the month of its venture capital and other restricted securities up to 25% of net assets and (ii) for the month, for all other assets, 1.0% of the average net assets up to $250 million, 0.9% of the average net assets for the next $250 million, 0.8% of the average net assets for the next $500 million and 0.7% of the average net assets thereafter. The aggregate fee may not exceed a rate when annualized of 1.375%. Certain officers and Trustees of the Fund are also officers of the Adviser. The Adviser is an indirect wholly owned subsidiary of J.P. Morgan Chase & Co. On March 22, 2002, the Trustees of the Fund approved a new investment advisory agreement with Hambrecht & Quist Capital Management LLC, subject to certain conditions, including approval by the Fund's shareholders. The terms of the new agreement are substantially identical to those in the current Advisory Agreement. Trustees who are not affiliates of the Adviser receive an annual fee of $15,000 plus $1,500 for each meeting attended. (4) VENTURE CAPITAL AND OTHER RESTRICTED SECURITIES The Fund may invest in venture capital and other restricted securities if these securities would currently comprise 40% or less of net assets. The value of these securities represents 23% of the Fund's net assets at March 31, 2002. The value of the venture capital and other restricted securities is determined in good faith by the Trustees. However, because of the inherent uncertainty of valuations, these estimated 15 values may differ significantly from the values that would have been used had a ready market for the securities existed, and the differences could be material. In fiscal 2001, the Fund sold a restricted security subject to future contingent payments whose estimated value of $1,647,054 has also been determined by the Trustees and which is included in the Receivable for Investments Sold in the Statement of Assets and Liabilities. The following table details the acquisition date, cost, carrying value per unit, and value of the Fund's venture capital and other restricted securities at March 31, 2002, as determined by the Trustees of the Fund. ACQUISITION CARRYING VALUE SECURITY DATE COST PER UNIT VALUE ------------------------------------ --------------- ---------- -------------- ---------- AbTox Series F Cvt. Pfd. 3/7/97 $1,415,569 $0.010 $6,364 12% Promissory Note 2/26/98-3/26/98 180,000 1.000 180,000 ACADIA Pharmaceuticals Series E Cvt. Pfd. 5/2/00 3,000,273 7.500 3,000,000 Advanced Medicine Series C Cvt. Pfd. 2/5/99 1,800,123 9.000 1,905,885 Series D-1 Cvt. Pfd. 8/28/00 1,800,900 9.000 1,800,000 Agensys Series C Cvt. Pfd. 2/14/02 3,000,000 3.150 3,000,000 Agilix Series B Cvt. Pfd. 11/18/01 3,000,001 1.260 3,000,001 Avalon Pharmaceuticals Series B Cvt. Pfd. 10/22/01 2,999,998 3.528 2,999,998 Biofield Common 12/15/00 302,984 0.364 218,400 Biopure Common Warrants (expire 8/4/03) 5/13/99 0 0.000 0 BioTransplant Common Warrants (expire 8/12/04) 8/12/94 0 0.750 2,070 Common Warrants (expire 10/31/04) 10/31/94 0 0.750 4,725 Common Warrants (expire 8/15/05) 8/18/95 0 3.126 3,595 CardioNet^ Series C Cvt. Pfd. 5/3/01 4,823,275 3.500 4,800,002 Ceres Series C Cvt. Pfd. 12/23/98 1,502,620 6.000 2,250,000 Series C-1 Cvt. Pfd.* 1/4/01 111,488 6.000 164,658 Series D Cvt. Pfd.* 3/14/01 1,667,802 6.000 1,667,802 Codman Group Common 1/26/96-8/24/97 2,552,759 0.002 10,917 Cubist Pharmaceuticals Common Warrants (expire 9/23/03) 9/23/98 235 13.796 2,759,114 CytoLogix^ Series A Cvt. Pfd. 1/13/98-7/21/99 2,331,986 0.825 400,178 Series B Cvt. Pfd.* 1/11/01 1,150,335 0.825 187,473 EPR Series A Cvt. Pfd. 3/9/94 1,000,409 1.500 333,333 FitForAll.com 10% Promissory Note* 2/22/00-9/18/00 1,613,493 0.000 158 Galileo Laboratories Series F Cvt. Pfd. 8/18/00 3,001,764 2.145 3,000,000 16 ACQUISITION CARRYING VALUE SECURITY DATE COST PER UNIT VALUE ------------------------------------ --------------- ---------- -------------- ---------- KVM Technologies^ Series B Cvt. Pfd.* 2/19/98 $1,501,320 $4.425 $1,500,000 Adj. Cvt. Demand Note* 6/21/99-7/31/01 1,350,625 1.000 1,350,000 LocalMed Series D Cvt. Pfd. 2/9/96 1,376,970 0.010 3,438 Masimo Series D Cvt. Pfd. 8/14/96 1,120,040 11.000 1,760,000 Masimo Labs Common 8/14/96 0 0.010 1,600 Novacept Series G Cvt. Pfd.* 3/27/01 3,000,005 4.750 3,000,005 OmniSonics Medical Technologies^ Series B Cvt. Pfd. 5/24/01 2,404,472 1.470 2,400,000 PHT^ Series D Cvt. Pfd. 7/23/01 4,200,000 0.780 4,200,000 Physician WebLink Common 2/5/97 1,200,325 3.920 1,200,473 Warrants (expire 10/15/04) 10/15/98 0 0.100 18,810 Raven biotechnologies^ Series B Cvt. Pfd. 12/12/00 3,000,833 1.650 3,000,000 Senomyx Series E Cvt. Pfd. 2/19/02 3,000,002 2.900 3,000,002 Songbird Hearing Series D Cvt. Pfd. 12/14/00 3,002,086 0.010 6,397 Sontra Medical^ Common 3/26/01 0 0.010 9,000 Series A Cvt. Pfd. 9/9/98 1,205,089 0.503 867,759 Series B Cvt. Pfd. 3/26/01-2/28/02 470,000 0.503 470,000 Therion Biologics Common 7/12/90-10/16/96 511,365 3.750 850,350 Series A Cvt. Pfd. 8/20/96-10/16/96 444,850 3.750 177,776 Series B Cvt. Pfd.* 2/24/99-6/22/99 900,914 3.750 900,000 Series C Cvt. Pfd.* 9/26/01 1,528,920 3.750 1,528,920 Sinking Fund Cvt. Pfd. 10/17/94-4/3/96 721,291 3.750 135,345 TherOx Series H Cvt. Pfd. 9/11/00 3,001,873 4.600 2,999,996 Triad Therapeutics Series A Cvt. Pfd. 6/8/99 1,750,860 2.000 3,500,000 Series B Cvt. Pfd. 12/20/00 1,653,135 2.000 1,650,000 Versicor Warrants (expire 8/3/05) 6/28/99 905 10.688 199,823 VNUS Medical Technologies^ Series E Cvt. Pfd. 8/20/01 4,200,003 5.120 4,200,003 Zyomyx Series B Cvt. Pfd. 2/19/99 1,200,550 4.000 3,692,308 Series C Cvt. Pfd. 3/2/00 1,200,690 4.000 2,400,000 ----------- ----------- $81,203,137 $76,716,678 =========== =========== * With warrants attached. ^ Affiliated issuers. 17 H&Q HEALTHCARE INVESTORS 30 Rowes Wharf, 4th Floor Boston, Massachusetts 02110-3328 (617) 310-0567 OFFICERS Daniel R. Omstead, ENGSCD, President Alan G. Carr, President Emeritus Kimberley L. Carroll, Treasurer Jennifer L. Morris, Secretary TRUSTEES Alan G. Carr Lawrence S. Lewin Robert P. Mack, M.D. Eric Oddleifson Oleg M. Pohotsky Uwe E. Reinhardt, Ph.D. Henri A. Termeer INVESTMENT ADVISER Hambrecht & Quist Capital Management Incorporated CUSTODIAN AND TRANSFER AGENT State Street Bank and Trust Company LEGAL COUNSEL Dechert Price & Rhoads ---------------------- Shareholders with questions regarding share transfers may call 1-800-426-5523 Interim daily net asset value may be obtained by calling 1-800-451-2597 For copies of the Fund's DIVIDEND REINVESTMENT PLAN, please contact the Plan Agent, State Street Bank & Trust Co. P.O. Box 8200, Boston, MA 02266-8200 Telephone: 1-800-426-5523 H&Q HEALTHCARE INVESTORS New York Stock Exchange Symbol: HQH www.hqcm.com Out of concern for the environment and in an effort to reduce Fund expenses, this report is printed on recycled paper. HQHCM-SAR-02