Kezar Life Sciences to Present Complete Results from the Phase 2 MISSION Trial of Zetomipzomib in Patients with Lupus Nephritis at the American College of Rheumatology Convergence 2022

Kezar Life Sciences, Inc. (Nasdaq: KZR), a clinical-stage biotechnology company discovering and developing breakthrough treatments for immune-mediated and oncologic disorders, today announced that three posters will be presented at the upcoming American College of Rheumatology (ACR) Convergence 2022, which will take place November 10 – 14, 2022 in Philadelphia, PA. Of note, the Phase 2 MISSION poster will include the full data set from the concluded study, with all 17 evaluable patients completing the 37-week trial. There will be additional MISSION data included in the poster presentation that are not available in the abstract.

Poster Presentation Details:

Abstract Title: Interim Results from the Phase 2 MISSION Study Evaluating Zetomipzomib (KZR-616), a First-in-Class Selective Immunoproteasome Inhibitor for the Treatment of Lupus Nephritis

Session: SLE – Treatment Poster II

Date/Time: November 13, 2022 from 9:00 AM - 10:30 AM ET

Presenter: Amit Saxena, MD, Assistant Professor, NYU School of Medicine

Abstract Title: Poor Health-Related Quality of Life in Patients with Lupus Nephritis

Session: Patient Outcomes, Preferences, and Attitudes Poster II

Date/Time: November 13, 2022 from 1:00 PM - 3:00 PM ET

Presenter: Cristina Arriens, MD, Clinical Associate Member, Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation

Abstract Title: Healthcare Resource Utilization and Costs of Management of Lupus Nephritis in Adult and Juvenile Patients with Systemic Lupus Erythematosus

Poster Session: Health Services Research Poster I: Lupus, RA, Spondyloarthritis and More

Date/Time: November 12, 2022 from 1:00 PM - 3:00 PM ET

Presenter: Kenneth Kalunian, MD, Professor of Medicine, University of California San Diego

The accepted ACR abstracts are currently available on the congress platform here. Following the conference, the presentation materials will be available in the “Scientific Publications” section of Kezar Life Science’s website at www.kezarlifesciences.com.

About Zetomipzomib (KZR-616)

Zetomipzomib (KZR-616) is a novel, first-in-class, selective immunoproteasome inhibitor with broad therapeutic potential across multiple autoimmune diseases. Preclinical research demonstrates that selective immunoproteasome inhibition results in a broad anti-inflammatory response in animal models of several autoimmune diseases, while avoiding immunosuppression. Data generated from Phase 1 clinical trials provide evidence that zetomipzomib exhibits a favorable safety and tolerability profile for development in severe, chronic autoimmune diseases.

About Kezar Life Sciences

Kezar Life Sciences is a clinical-stage biopharmaceutical company discovering and developing breakthrough treatments for immune-mediated and oncologic disorders. The company is pioneering first-in-class, small-molecule therapies that harness master regulators of cellular function to inhibit multiple drivers of disease via single, powerful targets. Zetomipzomib, its lead development asset, is a selective immunoproteasome inhibitor being evaluated in a Phase 2 clinical trial in lupus nephritis. This product candidate also has the potential to address multiple chronic immune-mediated diseases. KZR-261 is the first anti-cancer clinical candidate from the company’s platform targeting the Sec61 translocon and the protein secretion pathway. An open-label dose-escalation Phase 1 clinical trial of KZR-261 to assess safety, tolerability and preliminary tumor activity in solid tumors is underway. For more information, visit www.kezarlifesciences.com.

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