Recent Quotes View Full List My Watchlist Create Watchlist Indicators DJI Nasdaq Composite SPX Gold Crude Oil Hydroworld Market Index Markets Stocks ETFs Tools Overview News Currencies International Treasuries Science 37 Reports Third Quarter 2022 Financial Results By: Science 37, Inc. via GlobeNewswire November 10, 2022 at 16:01 PM EST RESEARCH TRIANGLE PARK, N.C., Nov. 10, 2022 (GLOBE NEWSWIRE) -- Science 37 Holdings, Inc. (Nasdaq: SNCE), (“Science 37”) the Agile Clinical Trial Operating System™, today reported its financial results for the quarter ended September 30, 2022. “The third quarter was challenging from a bookings perspective as we experienced delays in expected contract signings and longer sales cycles in our larger volume opportunities,” said David Coman, Chief Executive Officer of Science 37. “We made great strides in our cash management for the quarter and are confident in our growth prospects as evidenced by a strong start to fourth quarter bookings and high levels of customer engagement.” Quarterly Financial Highlights Revenue was $16.2 million for the quarter ended September 30, 2022, a 14% increase compared to $14.2 million for the same period in 2021.Net bookings were $4.7 million for the quarter ended September 30, 2022, compared to $35.9 million for the same period in 2021.Gross profit was $4.1 million for the quarter ended September 30, 2022, compared to $3.9 million for the same period in 2021. Adjusted gross profit(1) was $4.6 million for the quarter ended September 30, 2022, compared to $4.0 million for the same period in 2021. Gross margin was 25.2% for the quarter ended September 30, 2022, compared to 27.5% for the same period in 2021. Adjusted gross margin(1) was 28.3% for the quarter ended September 30, 2022, compared to 28.4% for the same period in the prior year.Net loss was $23.5 million for the quarter ended September 30, 2022, resulting in loss per share of $0.20, compared to a net loss of $14.7 million in the same period in 2021, or loss per share of $1.78.Adjusted net loss(1) was $19.5 million for the quarter ended September 30, 2022, compared to an adjusted net loss of $13.9 million in the same period in 2021.Adjusted EBITDA(1) was $(14.6) million for the quarter ended September 30, 2022, compared to $(12.0) million in the same period in 2021. Adjusted EBITDA for the quarter ended September 30, 2022 showed a 11% improvement from the second quarter of 2022 that had an Adjusted EBITDA of $(16.5) million.Cash and Cash Equivalents as of September 30, 2022 were $130.2 million. Net bookings for the quarter ended September 30, 2022 were adversely impacted by delays in expected contract signings and longer sales cycles, resulting in approximately $20 million of gross bookings recognized in the fourth quarter to date. Third quarter revenues grew 14% year-over-year to $16.2 million given our strong backlog entering the quarter, however, revenues were down quarter-over-quarter as a result of net bookings and two independent Sponsor related enrollment decisions, neither due to funding concerns. In light of these recent business conditions, we have implemented a cost reduction program that incorporates reducing our staff by approximately 16%. We expect this cost reduction program will result in approximately $21 million of gross cash savings on an annual basis. The decreases in adjusted EBITDA and adjusted net loss for the quarter ended September 30, 2022 as compared to the quarter ended September 30, 2021 were primarily due to investments to support continuing company growth and expenses related to becoming a publicly traded company in the fourth quarter of 2021. (1) Adjusted gross profit, adjusted gross margin, adjusted net loss and adjusted EBITDA are non-GAAP financial measures. For a reconciliation to the most directly comparable GAAP measure, please refer to "Reconciliation of GAAP to non-GAAP measures" section included in this press release. Full Year 2022 Financial Outlook Science 37 is providing revised revenue guidance of $68.2 million to $69.2 million and revised adjusted EBITDA guidance of $(65.4) million to $(66.4) million for the fiscal year ending December 31, 2022. The foregoing 2022 Financial Outlook statement represents management's current estimate as of the date of this release. Actual results may differ materially depending on a number of factors. Investors are urged to read the Cautionary Note Regarding Forward-Looking Statements included in this release. Management does not assume any obligation to update these estimates. Science 37 has not provided a quantitative reconciliation of adjusted EBITDA guidance to net (income) loss on a forward-looking basis within this press release because the Company is unable, without unreasonable efforts, to provide reconciling information with respect to interest income, depreciation, amortization, stock-based compensation, restructuring costs and change in fair value of the Earn-Out liability, all of which are adjustments to adjusted EBITDA. These items, which could materially affect the computation of forward-looking GAAP net income (loss), are inherently uncertain and depend on various factors, some of which are outside of the Science 37’s control. Webcast and Conference Call Details Science 37 will host a conference call on November 11, 2022, at 8:30 a.m. ET to discuss its third quarter 2022 financial results. The conference call can be accessed by registering online for dial-in information or via live audio webcast at: https://investors.science37.com/news-events/events-presentations. Participants interested in dialing in to the conference call are requested to register at a minimum 15 minutes before the start of the call to obtain a unique pin for the call. A replay of the call will be available via webcast for on-demand listening shortly after the completion of the call, at the same web link, and will remain available for approximately 90 days. About Science 37 Science 37’s mission is to enable universal access to clinical research—making it easier for patients and providers to participate from anywhere and helping to accelerate the development of treatments that impact patient lives. As a pioneer of decentralized clinical trials, the Science 37 Agile Clinical Trial Operating System (OS) supports today’s more agile clinical research designs with its full stack, end-to-end technology platform and specialized networks of patient communities, telemedicine investigators, mobile nursing, remote coordinators, community providers, and data and devices. Configurable to enable almost any study type, the Science 37 OS enables up to 15x faster enrollment, 28% better retention and 3x more diverse patient population, as compared to the traditional site-centric clinical trial model, with industry-leading workflow orchestration, evidence generation and data harmonization. For more information, visit https://www.science37.com. Cautionary Note Regarding Forward-Looking Statements This press release contains certain forward-looking statements within the meaning of the federal securities laws, including statements regarding Science 37's anticipated growth and profitability, the products offered by Science 37 and the markets in which it operates and expects to enter, expectation as to the timing and amount of cost savings related to the planned cost reduction program, projected future results, and revenue and adjusted EBITDA guidance for fiscal year 2022. These forward-looking statements generally are identified by the words “believe,” “project,” “expect,” “anticipate,” “estimate,” “intend,” “strategy,” “future,” “opportunity,” “plan,” “may,” “should,” “will,” “would,” “will be,” “will continue,” “will likely result” and similar expressions. Forward-looking statements are predictions, projections and other statements about future events that are based on current expectations and assumptions and, as a result, are subject to risks and uncertainties. Many factors could cause actual future events to differ materially from the forward-looking statements in this press release, including but not limited to: (i) the ability to maintain the listing of Science 37’s securities on Nasdaq, (ii) volatility in the price of Science 37’s securities due to a variety of factors, including changes in the competitive and highly regulated industries in which Science 37 operates, variations in performance across competitors, changes in laws and regulations affecting Science 37’s business and changes in its capital structure, and general economic and financial market conditions, including fluctuations in currency exchange rates, economic instability, and inflationary conditions, (iii) the ability to implement business plans, forecasts, and other expectations, and to identify and realize additional opportunities, (iv) the risk that Science 37 may never achieve or sustain profitability, (v) the risk that Science 37 will need to raise additional capital to execute its business plan, which may not be available on acceptable terms or at all, (vi) failure to realize anticipated cost savings, and (vii) the potential adverse effects of the ongoing global COVID-19 pandemic. The foregoing list of factors is not exhaustive. You should carefully consider the foregoing factors and the other risks and uncertainties described in the “Risk Factors” section of our Annual Report on Form 10-K for the fiscal year ended December 31, 2021 filed with the U.S. Securities and Exchange Commission (the “SEC”) on March 22, 2022 and in our other documents filed by Science 37 from time to time with the SEC. These filings identify and address other important risks and uncertainties that could cause actual events and results to differ materially from those contained in the forward-looking statements. Forward-looking statements speak only as of the date they are made. Readers are cautioned not to put undue reliance on forward-looking statements, and Science 37 assumes no obligation and does not intend to update or revise these forward-looking statements, whether as a result of new information, future events, or otherwise, except as required by law. Science 37 does not give any assurance that Science 37 will achieve its expectations. Use of Non-GAAP Financial Measures and Key Performance Measures In addition to the financial measures prepared in accordance with U.S. Generally Accepted Accounting Principles ("GAAP"), this press release contains certain non-GAAP financial measures, including adjusted gross profit, adjusted gross margin, adjusted EBITDA and adjusted net income (loss). A “non-GAAP financial measure” is generally defined as a numerical measure of a company’s financial performance that excludes or includes amounts from the most directly comparable measure calculated and presented in accordance with GAAP in the statements of operations, balance sheets, or statements of cash flows of the Company. Please refer to the reconciliations of the non-GAAP financial measures to their most directly comparable GAAP measures included in this press release and the accompanying tables contained at the end of this release. The Company defines adjusted gross profit as gross profit excluding stock-based compensation expense. The Company defines adjusted gross margin as gross margin excluding stock-based compensation expense. The Company defines adjusted net income (loss) (including adjusted diluted earnings per share) as net income (loss) (including diluted earnings per share) excluding transactions that the Company believes are not representative of its core operations, namely: restructuring and other costs; transaction and integration-related expenses; stock-based compensation expense; other income (expense), net; and gain or loss on extinguishment of debt. EBITDA represents earnings before interest, taxes, depreciation, and amortization. The Company defines adjusted EBITDA as EBITDA, further adjusted to exclude expenses and transactions that the Company believes are not representative of its core operations, namely: restructuring and other costs; transaction and integration-related expenses; stock-based compensation expense; other income (expense), net; and gain or loss on extinguishment of debt. Each of the non-GAAP measures noted above are used by management and the Board to evaluate the Company's core operating results because they exclude certain items whose fluctuations from period-to-period do not necessarily correspond to changes in the core operations of the business. Management believes that adjusted gross profit, adjusted gross margin, adjusted EBITDA and adjusted net income (loss) are helpful to investors, analysts, and other interested parties because they can assist in providing a more consistent and comparable overview of our operations across our historical periods. In addition, these measures are frequently used by analysts, investors, and other interested parties to evaluate and assess performance. Non-GAAP measures have limitations in that they do not reflect all of the amounts associated with the Company's results of operations as determined in accordance with GAAP. Also, other companies might calculate these measures differently. This press release also contains certain key performance measures which we use to evaluate our business and results, measure performance, identify trends, formulate plans and make strategic decisions. We believe that the presentation of such metrics is useful to the Company’s investors because they are used to measure and model the performance of companies such as ours. Net bookings represent new business awards, net of contract modifications, contract cancellations, and other adjustments. Net bookings represent the minimum contractual value for the initial planned duration of a contract as of the contract execution date. The minimum fixed fees, upfront implementation fees and technology and support fees are included in net bookings. Estimates of variable revenue for utilization in excess of the contracted amounts is not included in the value of net bookings. Net bookings vary from period to period depending on numerous factors, including customer authorization volume, sales performance and the overall health of the life sciences industry, among others. Contacts: INVESTOR RELATIONS:Steve HalperLifeSci Advisorsinvestors@science37.com MEDIA INQUIRIES:Science 37Email: pr@science37.com SCIENCE 37 HOLDINGS, INC. and SUBSIDIARIESCONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS(unaudited) Three Months Ended September 30, Nine Months Ended September 30,(In thousands, except per share data) 2022 2021 2022 2021 Revenue$16,249 $14,236 $54,210 $39,222 Operating expenses: Cost of revenue 12,157 10,318 41,985 26,246 Selling, general and administrative 24,485 16,932 82,822 37,477 Depreciation and amortization 4,870 1,916 12,569 5,189 Total operating expenses 41,512 29,166 137,376 68,912 Loss from operations (25,263) (14,930) (83,166) (29,690) Other income (expense): Interest income 559 — 748 1 Sublease income 240 230 719 444 Change in fair value of earn-out liability 1,200 — 97,600 — Other income (expense), net (264) 8 (369) 12 Total other income (expense), net 1,735 238 98,698 457 Income (loss) before income taxes (23,528) (14,692) 15,532 (29,233)Income tax expense (benefit) — — (1) — Net income (loss)$(23,528) $(14,692) $15,533 $(29,233) Earnings (loss) per share: Basic$(0.20)$(1.78) $0.13 $(4.22)Diluted$(0.20) $(1.78) $0.12 $(4.22) Weighted average common shares outstanding: Basic 116,412 8,238 115,935 6,925 Diluted 116,412 8,238 126,717 6,925 SCIENCE 37 HOLDINGS, INC. and SUBSIDIARIESCONDENSED CONSOLIDATED BALANCE SHEETS (unaudited) (In thousands, except share data)September 30,2022December 31,2021Assets Current assets: Cash and cash equivalents$130,239 $214,601 Accounts receivable and unbilled services, net 9,018 10,699 Prepaid expenses and other current assets 6,664 7,403 Total current assets 145,921 232,703 Property and equipment, net 1,074 1,393 Operating lease right-of-use assets 1,227 2,086 Capitalized software, net 41,049 24,290 Other assets 153 326 Total assets$189,424 $260,798 Liabilities, redeemable convertible preferred stock and stockholders’ equity Current liabilities: Accounts payable$6,608 $12,819 Accrued expenses and other liabilities 11,877 17,073 Deferred revenue 4,603 5,130 Total current liabilities 23,088 35,022 Non-current liabilities: Deferred revenue 4,170 2,478 Operating lease liabilities 873 1,322 Other long-term liabilities 1,390 1,477 Long-term earn-out liability 1,300 98,900 Total liabilities 30,821 139,199 Redeemable convertible preferred stock: Redeemable convertible preferred stock, $0.0001 par value; 100,000,000 shares authorized, 0 issued and outstanding at September 30, 2022 and December 31, 2021, respectively — — Stockholders’ equity: Common stock, $0.0001 par value; 400,000,000 shares authorized, 116,574,031 and 114,991,026 issued and outstanding at September 30, 2022 and December 31, 2021, respectively 12 11 Additional paid-in capital 344,984 323,666 Accumulated other comprehensive income 152 — Accumulated deficit (186,545) (202,078)Total stockholders’ equity 158,603 121,599 Total liabilities, redeemable convertible preferred stock and stockholders’ equity$189,424 $260,798 SCIENCE 37 HOLDINGS, INC. and SUBSIDIARIESCONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS(unaudited) Nine Months Ended September 30,(In thousands) 2022 2021 Cash flows from operating activities: Net income (loss)$15,533 $(29,233)Adjustments to reconcile net income (loss) to net cash used in operating activities: Depreciation and amortization 12,569 5,189 Non-cash lease expense related to operating lease right-of-use assets 859 1,153 Stock-based compensation 19,425 1,913 Gain on change in fair value of earn-out liability (97,600) — Loss on foreign currency exchange rates 282 — Provision for doubtful accounts 147 143 Changes in operating assets and liabilities: Accounts receivable and unbilled services 1,534 4,059 Prepaid expenses and other current assets 745 (2,862)Other assets (72) (142)Accounts payable (8,100) 2,110 Accrued expenses and other current liabilities (6,329) 577 Deferred revenue 1,165 2,063 Operating lease liabilities (449) (948)Other, net (86) 1,318 Net cash used in operating activities (60,377) (14,660)Cash flows from investing activities: Payments related to capitalized software development costs (24,627) (11,339)Purchases of property and equipment (162) (733)Net cash used in investing activities (24,789) (12,072)Cash flows from financing activities: Proceeds from stock option exercises 672 1,245 Net cash provided by financing activities 672 1,245 Net decrease in cash and cash equivalents (84,494) (25,487)Effect of foreign currency exchange rate changes on cash 132 — Cash and cash equivalents, beginning of period 214,601 33,483 Cash and cash equivalents, end of period$130,239 $7,996 Supplemental disclosures of non-cash activities Balance in accounts payable, accrued expenses and other current liabilities, and capitalized stock-based compensation related to capitalized software and fixed asset additions$(3,482) $(2,364)Right-of-use asset obtained in exchange for operating lease liabilities$— $(1,305)Balance in prepaid expenses and other current assets related to stock option exercises$5 $— SCIENCE 37 HOLDINGS, INC. and SUBSIDIARIESReconciliation of GAAP to Non-GAAP Measures(Unaudited) The following table provides reconciliation of adjusted gross profit and adjusted gross margin to gross profit and gross margin, the most directly comparable GAAP measures, respectively: Three Months Ended September 30, Nine Months Ended September 30,(In thousands) 2022 2021 2022 2021 Revenue$16,249 $14,236 $54,210 $39,222 Gross profit$4,092 $3,918 $12,225 $12,976 Stock-based compensation (1)$505 $129 $1,481 $346 Adjusted gross profit$4,597 $4,047 $13,706 $13,322 Gross margin 25.2% 27.5% 22.6% 33.1%Adjusted gross margin 28.3% 28.4% 25.3% 34.0% The following table provides reconciliation of adjusted EBITDA to net income (loss), the most directly comparable GAAP measure: Three Months Ended September 30, Nine Months Ended September 30,(In thousands) 2022 2021 2022 2021 Net income (loss)$(23,528) $(14,692) $15,533 $(29,233)Interest income (559) — (748) (1)Depreciation and amortization 4,870 1,916 12,569 5,189 Other income (2) (1,176) (238) (97,950) (456)Stock-based compensation 5,739 998 19,425 1,913 Franchise taxes 50 — 229 — Provision for income taxes — — (1) — Adjusted EBITDA$(14,604) $(12,016) $(50,943) $(22,588) The following table provides reconciliation of adjusted net loss to net income (loss), the most directly comparable GAAP measure: Three Months Ended September 30, Nine Months Ended September 30,(In thousands) 2022 2021 2022 2021 Net income (loss)$(23,528) $(14,692) $15,533 $(29,233)Interest income (559) — (748) (1)Other income (2) (1,176) (238) (97,950) (456)Stock-based compensation expense 5,739 998 19,425 1,913 Adjusted net loss$(19,524) $(13,932) $(63,740) $(27,777) _____________________________________(1) Represents the portion of total stock-based compensation recorded within cost of revenues.(2) Includes a gain of $1.2 million and $97.6 million recorded for the three and nine months ended September 30, 2022, respectively, associated with the change in the fair value of the earn-out liability. Data & News supplied by www.cloudquote.io Stock quotes supplied by Barchart Quotes delayed at least 20 minutes. By accessing this page, you agree to the following Privacy Policy and Terms and Conditions.
Science 37 Reports Third Quarter 2022 Financial Results By: Science 37, Inc. via GlobeNewswire November 10, 2022 at 16:01 PM EST RESEARCH TRIANGLE PARK, N.C., Nov. 10, 2022 (GLOBE NEWSWIRE) -- Science 37 Holdings, Inc. (Nasdaq: SNCE), (“Science 37”) the Agile Clinical Trial Operating System™, today reported its financial results for the quarter ended September 30, 2022. “The third quarter was challenging from a bookings perspective as we experienced delays in expected contract signings and longer sales cycles in our larger volume opportunities,” said David Coman, Chief Executive Officer of Science 37. “We made great strides in our cash management for the quarter and are confident in our growth prospects as evidenced by a strong start to fourth quarter bookings and high levels of customer engagement.” Quarterly Financial Highlights Revenue was $16.2 million for the quarter ended September 30, 2022, a 14% increase compared to $14.2 million for the same period in 2021.Net bookings were $4.7 million for the quarter ended September 30, 2022, compared to $35.9 million for the same period in 2021.Gross profit was $4.1 million for the quarter ended September 30, 2022, compared to $3.9 million for the same period in 2021. Adjusted gross profit(1) was $4.6 million for the quarter ended September 30, 2022, compared to $4.0 million for the same period in 2021. Gross margin was 25.2% for the quarter ended September 30, 2022, compared to 27.5% for the same period in 2021. Adjusted gross margin(1) was 28.3% for the quarter ended September 30, 2022, compared to 28.4% for the same period in the prior year.Net loss was $23.5 million for the quarter ended September 30, 2022, resulting in loss per share of $0.20, compared to a net loss of $14.7 million in the same period in 2021, or loss per share of $1.78.Adjusted net loss(1) was $19.5 million for the quarter ended September 30, 2022, compared to an adjusted net loss of $13.9 million in the same period in 2021.Adjusted EBITDA(1) was $(14.6) million for the quarter ended September 30, 2022, compared to $(12.0) million in the same period in 2021. Adjusted EBITDA for the quarter ended September 30, 2022 showed a 11% improvement from the second quarter of 2022 that had an Adjusted EBITDA of $(16.5) million.Cash and Cash Equivalents as of September 30, 2022 were $130.2 million. Net bookings for the quarter ended September 30, 2022 were adversely impacted by delays in expected contract signings and longer sales cycles, resulting in approximately $20 million of gross bookings recognized in the fourth quarter to date. Third quarter revenues grew 14% year-over-year to $16.2 million given our strong backlog entering the quarter, however, revenues were down quarter-over-quarter as a result of net bookings and two independent Sponsor related enrollment decisions, neither due to funding concerns. In light of these recent business conditions, we have implemented a cost reduction program that incorporates reducing our staff by approximately 16%. We expect this cost reduction program will result in approximately $21 million of gross cash savings on an annual basis. The decreases in adjusted EBITDA and adjusted net loss for the quarter ended September 30, 2022 as compared to the quarter ended September 30, 2021 were primarily due to investments to support continuing company growth and expenses related to becoming a publicly traded company in the fourth quarter of 2021. (1) Adjusted gross profit, adjusted gross margin, adjusted net loss and adjusted EBITDA are non-GAAP financial measures. For a reconciliation to the most directly comparable GAAP measure, please refer to "Reconciliation of GAAP to non-GAAP measures" section included in this press release. Full Year 2022 Financial Outlook Science 37 is providing revised revenue guidance of $68.2 million to $69.2 million and revised adjusted EBITDA guidance of $(65.4) million to $(66.4) million for the fiscal year ending December 31, 2022. The foregoing 2022 Financial Outlook statement represents management's current estimate as of the date of this release. Actual results may differ materially depending on a number of factors. Investors are urged to read the Cautionary Note Regarding Forward-Looking Statements included in this release. Management does not assume any obligation to update these estimates. Science 37 has not provided a quantitative reconciliation of adjusted EBITDA guidance to net (income) loss on a forward-looking basis within this press release because the Company is unable, without unreasonable efforts, to provide reconciling information with respect to interest income, depreciation, amortization, stock-based compensation, restructuring costs and change in fair value of the Earn-Out liability, all of which are adjustments to adjusted EBITDA. These items, which could materially affect the computation of forward-looking GAAP net income (loss), are inherently uncertain and depend on various factors, some of which are outside of the Science 37’s control. Webcast and Conference Call Details Science 37 will host a conference call on November 11, 2022, at 8:30 a.m. ET to discuss its third quarter 2022 financial results. The conference call can be accessed by registering online for dial-in information or via live audio webcast at: https://investors.science37.com/news-events/events-presentations. Participants interested in dialing in to the conference call are requested to register at a minimum 15 minutes before the start of the call to obtain a unique pin for the call. A replay of the call will be available via webcast for on-demand listening shortly after the completion of the call, at the same web link, and will remain available for approximately 90 days. About Science 37 Science 37’s mission is to enable universal access to clinical research—making it easier for patients and providers to participate from anywhere and helping to accelerate the development of treatments that impact patient lives. As a pioneer of decentralized clinical trials, the Science 37 Agile Clinical Trial Operating System (OS) supports today’s more agile clinical research designs with its full stack, end-to-end technology platform and specialized networks of patient communities, telemedicine investigators, mobile nursing, remote coordinators, community providers, and data and devices. Configurable to enable almost any study type, the Science 37 OS enables up to 15x faster enrollment, 28% better retention and 3x more diverse patient population, as compared to the traditional site-centric clinical trial model, with industry-leading workflow orchestration, evidence generation and data harmonization. For more information, visit https://www.science37.com. Cautionary Note Regarding Forward-Looking Statements This press release contains certain forward-looking statements within the meaning of the federal securities laws, including statements regarding Science 37's anticipated growth and profitability, the products offered by Science 37 and the markets in which it operates and expects to enter, expectation as to the timing and amount of cost savings related to the planned cost reduction program, projected future results, and revenue and adjusted EBITDA guidance for fiscal year 2022. These forward-looking statements generally are identified by the words “believe,” “project,” “expect,” “anticipate,” “estimate,” “intend,” “strategy,” “future,” “opportunity,” “plan,” “may,” “should,” “will,” “would,” “will be,” “will continue,” “will likely result” and similar expressions. Forward-looking statements are predictions, projections and other statements about future events that are based on current expectations and assumptions and, as a result, are subject to risks and uncertainties. Many factors could cause actual future events to differ materially from the forward-looking statements in this press release, including but not limited to: (i) the ability to maintain the listing of Science 37’s securities on Nasdaq, (ii) volatility in the price of Science 37’s securities due to a variety of factors, including changes in the competitive and highly regulated industries in which Science 37 operates, variations in performance across competitors, changes in laws and regulations affecting Science 37’s business and changes in its capital structure, and general economic and financial market conditions, including fluctuations in currency exchange rates, economic instability, and inflationary conditions, (iii) the ability to implement business plans, forecasts, and other expectations, and to identify and realize additional opportunities, (iv) the risk that Science 37 may never achieve or sustain profitability, (v) the risk that Science 37 will need to raise additional capital to execute its business plan, which may not be available on acceptable terms or at all, (vi) failure to realize anticipated cost savings, and (vii) the potential adverse effects of the ongoing global COVID-19 pandemic. The foregoing list of factors is not exhaustive. You should carefully consider the foregoing factors and the other risks and uncertainties described in the “Risk Factors” section of our Annual Report on Form 10-K for the fiscal year ended December 31, 2021 filed with the U.S. Securities and Exchange Commission (the “SEC”) on March 22, 2022 and in our other documents filed by Science 37 from time to time with the SEC. These filings identify and address other important risks and uncertainties that could cause actual events and results to differ materially from those contained in the forward-looking statements. Forward-looking statements speak only as of the date they are made. Readers are cautioned not to put undue reliance on forward-looking statements, and Science 37 assumes no obligation and does not intend to update or revise these forward-looking statements, whether as a result of new information, future events, or otherwise, except as required by law. Science 37 does not give any assurance that Science 37 will achieve its expectations. Use of Non-GAAP Financial Measures and Key Performance Measures In addition to the financial measures prepared in accordance with U.S. Generally Accepted Accounting Principles ("GAAP"), this press release contains certain non-GAAP financial measures, including adjusted gross profit, adjusted gross margin, adjusted EBITDA and adjusted net income (loss). A “non-GAAP financial measure” is generally defined as a numerical measure of a company’s financial performance that excludes or includes amounts from the most directly comparable measure calculated and presented in accordance with GAAP in the statements of operations, balance sheets, or statements of cash flows of the Company. Please refer to the reconciliations of the non-GAAP financial measures to their most directly comparable GAAP measures included in this press release and the accompanying tables contained at the end of this release. The Company defines adjusted gross profit as gross profit excluding stock-based compensation expense. The Company defines adjusted gross margin as gross margin excluding stock-based compensation expense. The Company defines adjusted net income (loss) (including adjusted diluted earnings per share) as net income (loss) (including diluted earnings per share) excluding transactions that the Company believes are not representative of its core operations, namely: restructuring and other costs; transaction and integration-related expenses; stock-based compensation expense; other income (expense), net; and gain or loss on extinguishment of debt. EBITDA represents earnings before interest, taxes, depreciation, and amortization. The Company defines adjusted EBITDA as EBITDA, further adjusted to exclude expenses and transactions that the Company believes are not representative of its core operations, namely: restructuring and other costs; transaction and integration-related expenses; stock-based compensation expense; other income (expense), net; and gain or loss on extinguishment of debt. Each of the non-GAAP measures noted above are used by management and the Board to evaluate the Company's core operating results because they exclude certain items whose fluctuations from period-to-period do not necessarily correspond to changes in the core operations of the business. Management believes that adjusted gross profit, adjusted gross margin, adjusted EBITDA and adjusted net income (loss) are helpful to investors, analysts, and other interested parties because they can assist in providing a more consistent and comparable overview of our operations across our historical periods. In addition, these measures are frequently used by analysts, investors, and other interested parties to evaluate and assess performance. Non-GAAP measures have limitations in that they do not reflect all of the amounts associated with the Company's results of operations as determined in accordance with GAAP. Also, other companies might calculate these measures differently. This press release also contains certain key performance measures which we use to evaluate our business and results, measure performance, identify trends, formulate plans and make strategic decisions. We believe that the presentation of such metrics is useful to the Company’s investors because they are used to measure and model the performance of companies such as ours. Net bookings represent new business awards, net of contract modifications, contract cancellations, and other adjustments. Net bookings represent the minimum contractual value for the initial planned duration of a contract as of the contract execution date. The minimum fixed fees, upfront implementation fees and technology and support fees are included in net bookings. Estimates of variable revenue for utilization in excess of the contracted amounts is not included in the value of net bookings. Net bookings vary from period to period depending on numerous factors, including customer authorization volume, sales performance and the overall health of the life sciences industry, among others. Contacts: INVESTOR RELATIONS:Steve HalperLifeSci Advisorsinvestors@science37.com MEDIA INQUIRIES:Science 37Email: pr@science37.com SCIENCE 37 HOLDINGS, INC. and SUBSIDIARIESCONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS(unaudited) Three Months Ended September 30, Nine Months Ended September 30,(In thousands, except per share data) 2022 2021 2022 2021 Revenue$16,249 $14,236 $54,210 $39,222 Operating expenses: Cost of revenue 12,157 10,318 41,985 26,246 Selling, general and administrative 24,485 16,932 82,822 37,477 Depreciation and amortization 4,870 1,916 12,569 5,189 Total operating expenses 41,512 29,166 137,376 68,912 Loss from operations (25,263) (14,930) (83,166) (29,690) Other income (expense): Interest income 559 — 748 1 Sublease income 240 230 719 444 Change in fair value of earn-out liability 1,200 — 97,600 — Other income (expense), net (264) 8 (369) 12 Total other income (expense), net 1,735 238 98,698 457 Income (loss) before income taxes (23,528) (14,692) 15,532 (29,233)Income tax expense (benefit) — — (1) — Net income (loss)$(23,528) $(14,692) $15,533 $(29,233) Earnings (loss) per share: Basic$(0.20)$(1.78) $0.13 $(4.22)Diluted$(0.20) $(1.78) $0.12 $(4.22) Weighted average common shares outstanding: Basic 116,412 8,238 115,935 6,925 Diluted 116,412 8,238 126,717 6,925 SCIENCE 37 HOLDINGS, INC. and SUBSIDIARIESCONDENSED CONSOLIDATED BALANCE SHEETS (unaudited) (In thousands, except share data)September 30,2022December 31,2021Assets Current assets: Cash and cash equivalents$130,239 $214,601 Accounts receivable and unbilled services, net 9,018 10,699 Prepaid expenses and other current assets 6,664 7,403 Total current assets 145,921 232,703 Property and equipment, net 1,074 1,393 Operating lease right-of-use assets 1,227 2,086 Capitalized software, net 41,049 24,290 Other assets 153 326 Total assets$189,424 $260,798 Liabilities, redeemable convertible preferred stock and stockholders’ equity Current liabilities: Accounts payable$6,608 $12,819 Accrued expenses and other liabilities 11,877 17,073 Deferred revenue 4,603 5,130 Total current liabilities 23,088 35,022 Non-current liabilities: Deferred revenue 4,170 2,478 Operating lease liabilities 873 1,322 Other long-term liabilities 1,390 1,477 Long-term earn-out liability 1,300 98,900 Total liabilities 30,821 139,199 Redeemable convertible preferred stock: Redeemable convertible preferred stock, $0.0001 par value; 100,000,000 shares authorized, 0 issued and outstanding at September 30, 2022 and December 31, 2021, respectively — — Stockholders’ equity: Common stock, $0.0001 par value; 400,000,000 shares authorized, 116,574,031 and 114,991,026 issued and outstanding at September 30, 2022 and December 31, 2021, respectively 12 11 Additional paid-in capital 344,984 323,666 Accumulated other comprehensive income 152 — Accumulated deficit (186,545) (202,078)Total stockholders’ equity 158,603 121,599 Total liabilities, redeemable convertible preferred stock and stockholders’ equity$189,424 $260,798 SCIENCE 37 HOLDINGS, INC. and SUBSIDIARIESCONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS(unaudited) Nine Months Ended September 30,(In thousands) 2022 2021 Cash flows from operating activities: Net income (loss)$15,533 $(29,233)Adjustments to reconcile net income (loss) to net cash used in operating activities: Depreciation and amortization 12,569 5,189 Non-cash lease expense related to operating lease right-of-use assets 859 1,153 Stock-based compensation 19,425 1,913 Gain on change in fair value of earn-out liability (97,600) — Loss on foreign currency exchange rates 282 — Provision for doubtful accounts 147 143 Changes in operating assets and liabilities: Accounts receivable and unbilled services 1,534 4,059 Prepaid expenses and other current assets 745 (2,862)Other assets (72) (142)Accounts payable (8,100) 2,110 Accrued expenses and other current liabilities (6,329) 577 Deferred revenue 1,165 2,063 Operating lease liabilities (449) (948)Other, net (86) 1,318 Net cash used in operating activities (60,377) (14,660)Cash flows from investing activities: Payments related to capitalized software development costs (24,627) (11,339)Purchases of property and equipment (162) (733)Net cash used in investing activities (24,789) (12,072)Cash flows from financing activities: Proceeds from stock option exercises 672 1,245 Net cash provided by financing activities 672 1,245 Net decrease in cash and cash equivalents (84,494) (25,487)Effect of foreign currency exchange rate changes on cash 132 — Cash and cash equivalents, beginning of period 214,601 33,483 Cash and cash equivalents, end of period$130,239 $7,996 Supplemental disclosures of non-cash activities Balance in accounts payable, accrued expenses and other current liabilities, and capitalized stock-based compensation related to capitalized software and fixed asset additions$(3,482) $(2,364)Right-of-use asset obtained in exchange for operating lease liabilities$— $(1,305)Balance in prepaid expenses and other current assets related to stock option exercises$5 $— SCIENCE 37 HOLDINGS, INC. and SUBSIDIARIESReconciliation of GAAP to Non-GAAP Measures(Unaudited) The following table provides reconciliation of adjusted gross profit and adjusted gross margin to gross profit and gross margin, the most directly comparable GAAP measures, respectively: Three Months Ended September 30, Nine Months Ended September 30,(In thousands) 2022 2021 2022 2021 Revenue$16,249 $14,236 $54,210 $39,222 Gross profit$4,092 $3,918 $12,225 $12,976 Stock-based compensation (1)$505 $129 $1,481 $346 Adjusted gross profit$4,597 $4,047 $13,706 $13,322 Gross margin 25.2% 27.5% 22.6% 33.1%Adjusted gross margin 28.3% 28.4% 25.3% 34.0% The following table provides reconciliation of adjusted EBITDA to net income (loss), the most directly comparable GAAP measure: Three Months Ended September 30, Nine Months Ended September 30,(In thousands) 2022 2021 2022 2021 Net income (loss)$(23,528) $(14,692) $15,533 $(29,233)Interest income (559) — (748) (1)Depreciation and amortization 4,870 1,916 12,569 5,189 Other income (2) (1,176) (238) (97,950) (456)Stock-based compensation 5,739 998 19,425 1,913 Franchise taxes 50 — 229 — Provision for income taxes — — (1) — Adjusted EBITDA$(14,604) $(12,016) $(50,943) $(22,588) The following table provides reconciliation of adjusted net loss to net income (loss), the most directly comparable GAAP measure: Three Months Ended September 30, Nine Months Ended September 30,(In thousands) 2022 2021 2022 2021 Net income (loss)$(23,528) $(14,692) $15,533 $(29,233)Interest income (559) — (748) (1)Other income (2) (1,176) (238) (97,950) (456)Stock-based compensation expense 5,739 998 19,425 1,913 Adjusted net loss$(19,524) $(13,932) $(63,740) $(27,777) _____________________________________(1) Represents the portion of total stock-based compensation recorded within cost of revenues.(2) Includes a gain of $1.2 million and $97.6 million recorded for the three and nine months ended September 30, 2022, respectively, associated with the change in the fair value of the earn-out liability.
RESEARCH TRIANGLE PARK, N.C., Nov. 10, 2022 (GLOBE NEWSWIRE) -- Science 37 Holdings, Inc. (Nasdaq: SNCE), (“Science 37”) the Agile Clinical Trial Operating System™, today reported its financial results for the quarter ended September 30, 2022. “The third quarter was challenging from a bookings perspective as we experienced delays in expected contract signings and longer sales cycles in our larger volume opportunities,” said David Coman, Chief Executive Officer of Science 37. “We made great strides in our cash management for the quarter and are confident in our growth prospects as evidenced by a strong start to fourth quarter bookings and high levels of customer engagement.” Quarterly Financial Highlights Revenue was $16.2 million for the quarter ended September 30, 2022, a 14% increase compared to $14.2 million for the same period in 2021.Net bookings were $4.7 million for the quarter ended September 30, 2022, compared to $35.9 million for the same period in 2021.Gross profit was $4.1 million for the quarter ended September 30, 2022, compared to $3.9 million for the same period in 2021. Adjusted gross profit(1) was $4.6 million for the quarter ended September 30, 2022, compared to $4.0 million for the same period in 2021. Gross margin was 25.2% for the quarter ended September 30, 2022, compared to 27.5% for the same period in 2021. Adjusted gross margin(1) was 28.3% for the quarter ended September 30, 2022, compared to 28.4% for the same period in the prior year.Net loss was $23.5 million for the quarter ended September 30, 2022, resulting in loss per share of $0.20, compared to a net loss of $14.7 million in the same period in 2021, or loss per share of $1.78.Adjusted net loss(1) was $19.5 million for the quarter ended September 30, 2022, compared to an adjusted net loss of $13.9 million in the same period in 2021.Adjusted EBITDA(1) was $(14.6) million for the quarter ended September 30, 2022, compared to $(12.0) million in the same period in 2021. Adjusted EBITDA for the quarter ended September 30, 2022 showed a 11% improvement from the second quarter of 2022 that had an Adjusted EBITDA of $(16.5) million.Cash and Cash Equivalents as of September 30, 2022 were $130.2 million. Net bookings for the quarter ended September 30, 2022 were adversely impacted by delays in expected contract signings and longer sales cycles, resulting in approximately $20 million of gross bookings recognized in the fourth quarter to date. Third quarter revenues grew 14% year-over-year to $16.2 million given our strong backlog entering the quarter, however, revenues were down quarter-over-quarter as a result of net bookings and two independent Sponsor related enrollment decisions, neither due to funding concerns. In light of these recent business conditions, we have implemented a cost reduction program that incorporates reducing our staff by approximately 16%. We expect this cost reduction program will result in approximately $21 million of gross cash savings on an annual basis. The decreases in adjusted EBITDA and adjusted net loss for the quarter ended September 30, 2022 as compared to the quarter ended September 30, 2021 were primarily due to investments to support continuing company growth and expenses related to becoming a publicly traded company in the fourth quarter of 2021. (1) Adjusted gross profit, adjusted gross margin, adjusted net loss and adjusted EBITDA are non-GAAP financial measures. For a reconciliation to the most directly comparable GAAP measure, please refer to "Reconciliation of GAAP to non-GAAP measures" section included in this press release. Full Year 2022 Financial Outlook Science 37 is providing revised revenue guidance of $68.2 million to $69.2 million and revised adjusted EBITDA guidance of $(65.4) million to $(66.4) million for the fiscal year ending December 31, 2022. The foregoing 2022 Financial Outlook statement represents management's current estimate as of the date of this release. Actual results may differ materially depending on a number of factors. Investors are urged to read the Cautionary Note Regarding Forward-Looking Statements included in this release. Management does not assume any obligation to update these estimates. Science 37 has not provided a quantitative reconciliation of adjusted EBITDA guidance to net (income) loss on a forward-looking basis within this press release because the Company is unable, without unreasonable efforts, to provide reconciling information with respect to interest income, depreciation, amortization, stock-based compensation, restructuring costs and change in fair value of the Earn-Out liability, all of which are adjustments to adjusted EBITDA. These items, which could materially affect the computation of forward-looking GAAP net income (loss), are inherently uncertain and depend on various factors, some of which are outside of the Science 37’s control. Webcast and Conference Call Details Science 37 will host a conference call on November 11, 2022, at 8:30 a.m. ET to discuss its third quarter 2022 financial results. The conference call can be accessed by registering online for dial-in information or via live audio webcast at: https://investors.science37.com/news-events/events-presentations. Participants interested in dialing in to the conference call are requested to register at a minimum 15 minutes before the start of the call to obtain a unique pin for the call. A replay of the call will be available via webcast for on-demand listening shortly after the completion of the call, at the same web link, and will remain available for approximately 90 days. About Science 37 Science 37’s mission is to enable universal access to clinical research—making it easier for patients and providers to participate from anywhere and helping to accelerate the development of treatments that impact patient lives. As a pioneer of decentralized clinical trials, the Science 37 Agile Clinical Trial Operating System (OS) supports today’s more agile clinical research designs with its full stack, end-to-end technology platform and specialized networks of patient communities, telemedicine investigators, mobile nursing, remote coordinators, community providers, and data and devices. Configurable to enable almost any study type, the Science 37 OS enables up to 15x faster enrollment, 28% better retention and 3x more diverse patient population, as compared to the traditional site-centric clinical trial model, with industry-leading workflow orchestration, evidence generation and data harmonization. For more information, visit https://www.science37.com. Cautionary Note Regarding Forward-Looking Statements This press release contains certain forward-looking statements within the meaning of the federal securities laws, including statements regarding Science 37's anticipated growth and profitability, the products offered by Science 37 and the markets in which it operates and expects to enter, expectation as to the timing and amount of cost savings related to the planned cost reduction program, projected future results, and revenue and adjusted EBITDA guidance for fiscal year 2022. These forward-looking statements generally are identified by the words “believe,” “project,” “expect,” “anticipate,” “estimate,” “intend,” “strategy,” “future,” “opportunity,” “plan,” “may,” “should,” “will,” “would,” “will be,” “will continue,” “will likely result” and similar expressions. Forward-looking statements are predictions, projections and other statements about future events that are based on current expectations and assumptions and, as a result, are subject to risks and uncertainties. Many factors could cause actual future events to differ materially from the forward-looking statements in this press release, including but not limited to: (i) the ability to maintain the listing of Science 37’s securities on Nasdaq, (ii) volatility in the price of Science 37’s securities due to a variety of factors, including changes in the competitive and highly regulated industries in which Science 37 operates, variations in performance across competitors, changes in laws and regulations affecting Science 37’s business and changes in its capital structure, and general economic and financial market conditions, including fluctuations in currency exchange rates, economic instability, and inflationary conditions, (iii) the ability to implement business plans, forecasts, and other expectations, and to identify and realize additional opportunities, (iv) the risk that Science 37 may never achieve or sustain profitability, (v) the risk that Science 37 will need to raise additional capital to execute its business plan, which may not be available on acceptable terms or at all, (vi) failure to realize anticipated cost savings, and (vii) the potential adverse effects of the ongoing global COVID-19 pandemic. The foregoing list of factors is not exhaustive. You should carefully consider the foregoing factors and the other risks and uncertainties described in the “Risk Factors” section of our Annual Report on Form 10-K for the fiscal year ended December 31, 2021 filed with the U.S. Securities and Exchange Commission (the “SEC”) on March 22, 2022 and in our other documents filed by Science 37 from time to time with the SEC. These filings identify and address other important risks and uncertainties that could cause actual events and results to differ materially from those contained in the forward-looking statements. Forward-looking statements speak only as of the date they are made. Readers are cautioned not to put undue reliance on forward-looking statements, and Science 37 assumes no obligation and does not intend to update or revise these forward-looking statements, whether as a result of new information, future events, or otherwise, except as required by law. Science 37 does not give any assurance that Science 37 will achieve its expectations. Use of Non-GAAP Financial Measures and Key Performance Measures In addition to the financial measures prepared in accordance with U.S. Generally Accepted Accounting Principles ("GAAP"), this press release contains certain non-GAAP financial measures, including adjusted gross profit, adjusted gross margin, adjusted EBITDA and adjusted net income (loss). A “non-GAAP financial measure” is generally defined as a numerical measure of a company’s financial performance that excludes or includes amounts from the most directly comparable measure calculated and presented in accordance with GAAP in the statements of operations, balance sheets, or statements of cash flows of the Company. Please refer to the reconciliations of the non-GAAP financial measures to their most directly comparable GAAP measures included in this press release and the accompanying tables contained at the end of this release. The Company defines adjusted gross profit as gross profit excluding stock-based compensation expense. The Company defines adjusted gross margin as gross margin excluding stock-based compensation expense. The Company defines adjusted net income (loss) (including adjusted diluted earnings per share) as net income (loss) (including diluted earnings per share) excluding transactions that the Company believes are not representative of its core operations, namely: restructuring and other costs; transaction and integration-related expenses; stock-based compensation expense; other income (expense), net; and gain or loss on extinguishment of debt. EBITDA represents earnings before interest, taxes, depreciation, and amortization. The Company defines adjusted EBITDA as EBITDA, further adjusted to exclude expenses and transactions that the Company believes are not representative of its core operations, namely: restructuring and other costs; transaction and integration-related expenses; stock-based compensation expense; other income (expense), net; and gain or loss on extinguishment of debt. Each of the non-GAAP measures noted above are used by management and the Board to evaluate the Company's core operating results because they exclude certain items whose fluctuations from period-to-period do not necessarily correspond to changes in the core operations of the business. Management believes that adjusted gross profit, adjusted gross margin, adjusted EBITDA and adjusted net income (loss) are helpful to investors, analysts, and other interested parties because they can assist in providing a more consistent and comparable overview of our operations across our historical periods. In addition, these measures are frequently used by analysts, investors, and other interested parties to evaluate and assess performance. Non-GAAP measures have limitations in that they do not reflect all of the amounts associated with the Company's results of operations as determined in accordance with GAAP. Also, other companies might calculate these measures differently. This press release also contains certain key performance measures which we use to evaluate our business and results, measure performance, identify trends, formulate plans and make strategic decisions. We believe that the presentation of such metrics is useful to the Company’s investors because they are used to measure and model the performance of companies such as ours. Net bookings represent new business awards, net of contract modifications, contract cancellations, and other adjustments. Net bookings represent the minimum contractual value for the initial planned duration of a contract as of the contract execution date. The minimum fixed fees, upfront implementation fees and technology and support fees are included in net bookings. Estimates of variable revenue for utilization in excess of the contracted amounts is not included in the value of net bookings. Net bookings vary from period to period depending on numerous factors, including customer authorization volume, sales performance and the overall health of the life sciences industry, among others. Contacts: INVESTOR RELATIONS:Steve HalperLifeSci Advisorsinvestors@science37.com MEDIA INQUIRIES:Science 37Email: pr@science37.com SCIENCE 37 HOLDINGS, INC. and SUBSIDIARIESCONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS(unaudited) Three Months Ended September 30, Nine Months Ended September 30,(In thousands, except per share data) 2022 2021 2022 2021 Revenue$16,249 $14,236 $54,210 $39,222 Operating expenses: Cost of revenue 12,157 10,318 41,985 26,246 Selling, general and administrative 24,485 16,932 82,822 37,477 Depreciation and amortization 4,870 1,916 12,569 5,189 Total operating expenses 41,512 29,166 137,376 68,912 Loss from operations (25,263) (14,930) (83,166) (29,690) Other income (expense): Interest income 559 — 748 1 Sublease income 240 230 719 444 Change in fair value of earn-out liability 1,200 — 97,600 — Other income (expense), net (264) 8 (369) 12 Total other income (expense), net 1,735 238 98,698 457 Income (loss) before income taxes (23,528) (14,692) 15,532 (29,233)Income tax expense (benefit) — — (1) — Net income (loss)$(23,528) $(14,692) $15,533 $(29,233) Earnings (loss) per share: Basic$(0.20)$(1.78) $0.13 $(4.22)Diluted$(0.20) $(1.78) $0.12 $(4.22) Weighted average common shares outstanding: Basic 116,412 8,238 115,935 6,925 Diluted 116,412 8,238 126,717 6,925 SCIENCE 37 HOLDINGS, INC. and SUBSIDIARIESCONDENSED CONSOLIDATED BALANCE SHEETS (unaudited) (In thousands, except share data)September 30,2022December 31,2021Assets Current assets: Cash and cash equivalents$130,239 $214,601 Accounts receivable and unbilled services, net 9,018 10,699 Prepaid expenses and other current assets 6,664 7,403 Total current assets 145,921 232,703 Property and equipment, net 1,074 1,393 Operating lease right-of-use assets 1,227 2,086 Capitalized software, net 41,049 24,290 Other assets 153 326 Total assets$189,424 $260,798 Liabilities, redeemable convertible preferred stock and stockholders’ equity Current liabilities: Accounts payable$6,608 $12,819 Accrued expenses and other liabilities 11,877 17,073 Deferred revenue 4,603 5,130 Total current liabilities 23,088 35,022 Non-current liabilities: Deferred revenue 4,170 2,478 Operating lease liabilities 873 1,322 Other long-term liabilities 1,390 1,477 Long-term earn-out liability 1,300 98,900 Total liabilities 30,821 139,199 Redeemable convertible preferred stock: Redeemable convertible preferred stock, $0.0001 par value; 100,000,000 shares authorized, 0 issued and outstanding at September 30, 2022 and December 31, 2021, respectively — — Stockholders’ equity: Common stock, $0.0001 par value; 400,000,000 shares authorized, 116,574,031 and 114,991,026 issued and outstanding at September 30, 2022 and December 31, 2021, respectively 12 11 Additional paid-in capital 344,984 323,666 Accumulated other comprehensive income 152 — Accumulated deficit (186,545) (202,078)Total stockholders’ equity 158,603 121,599 Total liabilities, redeemable convertible preferred stock and stockholders’ equity$189,424 $260,798 SCIENCE 37 HOLDINGS, INC. and SUBSIDIARIESCONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS(unaudited) Nine Months Ended September 30,(In thousands) 2022 2021 Cash flows from operating activities: Net income (loss)$15,533 $(29,233)Adjustments to reconcile net income (loss) to net cash used in operating activities: Depreciation and amortization 12,569 5,189 Non-cash lease expense related to operating lease right-of-use assets 859 1,153 Stock-based compensation 19,425 1,913 Gain on change in fair value of earn-out liability (97,600) — Loss on foreign currency exchange rates 282 — Provision for doubtful accounts 147 143 Changes in operating assets and liabilities: Accounts receivable and unbilled services 1,534 4,059 Prepaid expenses and other current assets 745 (2,862)Other assets (72) (142)Accounts payable (8,100) 2,110 Accrued expenses and other current liabilities (6,329) 577 Deferred revenue 1,165 2,063 Operating lease liabilities (449) (948)Other, net (86) 1,318 Net cash used in operating activities (60,377) (14,660)Cash flows from investing activities: Payments related to capitalized software development costs (24,627) (11,339)Purchases of property and equipment (162) (733)Net cash used in investing activities (24,789) (12,072)Cash flows from financing activities: Proceeds from stock option exercises 672 1,245 Net cash provided by financing activities 672 1,245 Net decrease in cash and cash equivalents (84,494) (25,487)Effect of foreign currency exchange rate changes on cash 132 — Cash and cash equivalents, beginning of period 214,601 33,483 Cash and cash equivalents, end of period$130,239 $7,996 Supplemental disclosures of non-cash activities Balance in accounts payable, accrued expenses and other current liabilities, and capitalized stock-based compensation related to capitalized software and fixed asset additions$(3,482) $(2,364)Right-of-use asset obtained in exchange for operating lease liabilities$— $(1,305)Balance in prepaid expenses and other current assets related to stock option exercises$5 $— SCIENCE 37 HOLDINGS, INC. and SUBSIDIARIESReconciliation of GAAP to Non-GAAP Measures(Unaudited) The following table provides reconciliation of adjusted gross profit and adjusted gross margin to gross profit and gross margin, the most directly comparable GAAP measures, respectively: Three Months Ended September 30, Nine Months Ended September 30,(In thousands) 2022 2021 2022 2021 Revenue$16,249 $14,236 $54,210 $39,222 Gross profit$4,092 $3,918 $12,225 $12,976 Stock-based compensation (1)$505 $129 $1,481 $346 Adjusted gross profit$4,597 $4,047 $13,706 $13,322 Gross margin 25.2% 27.5% 22.6% 33.1%Adjusted gross margin 28.3% 28.4% 25.3% 34.0% The following table provides reconciliation of adjusted EBITDA to net income (loss), the most directly comparable GAAP measure: Three Months Ended September 30, Nine Months Ended September 30,(In thousands) 2022 2021 2022 2021 Net income (loss)$(23,528) $(14,692) $15,533 $(29,233)Interest income (559) — (748) (1)Depreciation and amortization 4,870 1,916 12,569 5,189 Other income (2) (1,176) (238) (97,950) (456)Stock-based compensation 5,739 998 19,425 1,913 Franchise taxes 50 — 229 — Provision for income taxes — — (1) — Adjusted EBITDA$(14,604) $(12,016) $(50,943) $(22,588) The following table provides reconciliation of adjusted net loss to net income (loss), the most directly comparable GAAP measure: Three Months Ended September 30, Nine Months Ended September 30,(In thousands) 2022 2021 2022 2021 Net income (loss)$(23,528) $(14,692) $15,533 $(29,233)Interest income (559) — (748) (1)Other income (2) (1,176) (238) (97,950) (456)Stock-based compensation expense 5,739 998 19,425 1,913 Adjusted net loss$(19,524) $(13,932) $(63,740) $(27,777) _____________________________________(1) Represents the portion of total stock-based compensation recorded within cost of revenues.(2) Includes a gain of $1.2 million and $97.6 million recorded for the three and nine months ended September 30, 2022, respectively, associated with the change in the fair value of the earn-out liability.
