Recent Quotes View Full List My Watchlist Create Watchlist Indicators DJI Nasdaq Composite SPX Gold Crude Oil Hydroworld Market Index Markets Stocks ETFs Tools Overview News Currencies International Treasuries Science 37 Reports Fourth Quarter and Full Year 2022 Financial Results By: Science 37, Inc. via GlobeNewswire March 06, 2023 at 06:00 AM EST RESEARCH TRIANGLE PARK, N.C., March 06, 2023 (GLOBE NEWSWIRE) -- Science 37 Holdings, Inc. (Nasdaq: SNCE), (“Science 37”), the industry-leading Metasite™, today reported its financial results for the quarter and full year ended December 31, 2022. “Fourth quarter results demonstrated a healthy rebound in bookings and continued efficiency and discipline with our cash resources,” stated David Coman, Chief Executive Officer of Science 37. “We remain confident that our strategy positions us well for profitable revenue growth and shareholder value creation ahead.” Quarterly Financial Highlights Revenue was $15.9 million for the quarter ended December 31, 2022, a 22% decrease compared to the same period in 2021.Net bookings were $18.6 million for the quarter ended December 31, 2022, a 57.0% decrease compared to the same period in 2021.Gross profit was $3.6 million for the quarter ended December 31, 2022, compared to $4.2 million for the same period in 2021. Adjusted gross profit(1) was $3.9 million for the quarter ended December 31, 2022, compared to $4.7 million for the same period in 2021. Gross margin was 22.9% for the quarter ended December 31, 2022, compared to 20.7% for the same period in 2021. Adjusted gross margin(1) was 24.5% for the quarter ended December 31, 2022, compared to 23.2% for the same period in the prior year.Net loss was $66.5 million for the quarter ended December 31, 2022, resulting in loss per share of $0.57, compared to a net loss of $65.1 million in the same period in 2021, or loss per share of $0.60.Long-lived asset impairment was $44.1 million for the quarter ended December 31, 2022, compared to $0.0 million for the same period in 2021. The Company remains confident in the utility of long-lived assets and there has been no change as to their intended use.Adjusted net loss(1) was $16.9 million for the quarter ended December 31, 2022, compared to an adjusted net loss of $24.4 million in the same period in 2021.Adjusted EBITDA(1) was $(11.6) million for the quarter ended December 31, 2022, compared to $(21.5) million in the same period in 2021. Annual Financial Highlights Revenue was $70.1 million for the year ended December 31, 2022, a 18% increase compared to the same period in 2021.Net bookings were $79.2 million for the year ended December 31, 2022, a 52% decrease compared to the same period in 2021.Gross profit was $15.9 million for the year ended December 31, 2022, compared to $17.2 million for the same period in 2021. Adjusted gross profit(1) was $17.6 million for the year ended December 31, 2022, compared to $18.0 million for the same period in 2021. Gross margin was 22.6% for the year ended December 31, 2022, compared to 28.9% for the same period in 2021. Adjusted gross margin(1) was 25.1% for the year ended December 31, 2022, compared to 30.3% for the same period in the prior year.Net loss was $51.0 million for the year ended December 31, 2022, resulting in loss per share of $0.44, compared to a net loss of $94.3 million in the same period in 2021, or loss per share of $2.89.Adjusted net loss(1) was $80.7 million for the year ended December 31, 2022, compared to an adjusted net loss of $52.1 million in the same period in 2021.Adjusted EBITDA(1) was $(62.5) million for the year ended December 31, 2022, compared to $(44.1) million in the same period in 2021.Cash and Cash Equivalents as of December 31, 2022 were $108.1 million. (1) Adjusted gross profit, adjusted gross margin, adjusted net income (loss) and adjusted EBITDA are non-GAAP financial measures. For a reconciliation to the most directly comparable GAAP measure, refer "Reconciliation of GAAP to non-GAAP measures" section included in this press release. Full Year 2023 Financial Outlook Science 37 is providing revenue guidance of $55.0 million to $60.0 million and adjusted EBITDA guidance of $(50.0) million to $(48.0) million for the fiscal year ending December 31, 2023. The foregoing 2023 Financial Outlook statements represent management's current estimate as of the date of this release. Actual results may differ materially depending on a number of factors. Investors are urged to read the Cautionary Note Regarding Forward-Looking Statements included in this release. Management does not assume any obligation to update these estimates. Science 37 has not provided a quantitative reconciliation of adjusted EBITDA guidance to net (income) loss on a forward-looking basis within this press release because the Company is unable, without unreasonable efforts, to provide reconciling information with respect to interest income, depreciation, amortization, stock-based compensation, restructuring costs and change in fair value of the Earn-Out liability, all of which are adjustments to adjusted EBITDA. These items, which could materially affect the computation of forward-looking GAAP net income (loss), are inherently uncertain and depend on various factors, some of which are outside of the Science 37’s control. Webcast and Conference Call Details Science 37 will host a conference call today, March 6, 2023, at 8:30 a.m. Eastern Time to discuss its quarter and year ended December 31, 2022 financial results. The call can be accessed by dialing 1-877-269-7751 (toll-free domestic) or 1-201-389-0908 (international) using the conference ID 13736111 or by utilizing the Call me™ feature using this link to request a return call for instant telephone access to the event. The live webcast may be accessed using this link to the investor relations section of the Science 37 website. A replay of the webcast will be available for approximately 90 days. About Science 37 Science 37 Holdings, Inc.’s (Nasdaq: SNCE) mission is to accelerate clinical research by enabling universal trial access for patients. As a single Metasite™, Science 37 reaches an expanded patient population beyond the traditional site and delivers the recruiting power of up to 20 sites in one with greater patient diversity. Patients gain the flexibility to participate from the comfort of their own home, at their local community provider, or at a traditional site when needed. The Science 37 Metasite is powered by a proprietary technology platform, in addition to in-house investigators, mobile nurses, and remote coordinators that drive uniform study orchestration, enabling greater compliance and high-quality data. To learn more, visit www.science37.com, or email science37@science37.com. Cautionary Note Regarding Forward-Looking Statements This press release contains certain forward-looking statements within the meaning of the federal securities laws, including statements regarding Science 37’s anticipated growth and profitability, the products offered by Science 37 and the markets in which it operates and revenue and adjusted EBITDA guidance for fiscal year 2023. These forward-looking statements generally are identified by the words “believe,” “can,” “could,” “seek,” “project,” “expect,” “anticipate,” “estimate,” “intend,” “strategy,” “future,” “opportunity,” “plan,” “may,” “might,” “should,” “will,” “would,” “will be,” “will continue,” “will likely result” and similar expressions. Forward-looking statements are predictions, projections and other statements about future events that are based on current expectations and assumptions and, as a result, are subject to risks and uncertainties. Many factors could cause actual future events to differ materially from the forward-looking statements in this press release, including but not limited to: (i) the ability to maintain the listing of Science 37’s securities on Nasdaq, (ii) volatility in the price of Science 37’s securities due to a variety of factors, including changes in the competitive and highly regulated industries in which Science 37 operates, variations in performance across competitors, changes in laws and regulations affecting Science 37’s business and changes in its capital structure, and general economic and financial market conditions, including fluctuations in currency exchange rates, economic instability, and inflationary conditions, (iii) the ability to implement business plans, forecasts, and other expectations, and to identify and realize additional opportunities, (iv) the risk that Science 37 may never achieve or sustain profitability, (v) the risk that Science 37 will need to raise additional capital to execute its business plan, which may not be available on acceptable terms or at all, (vi) failure to realize anticipated cost savings, and (vii) risks related to the general economic and financial market conditions. The foregoing list of factors is not exhaustive. You should carefully consider the foregoing factors and the other risks and uncertainties described in the “Risk Factors” section of our Annual Report on Form 10-K for the fiscal year ended December 31, 2022 filed with the U.S. Securities and Exchange Commission (the “SEC”) on March 06, 2023 and in our other documents filed by Science 37 from time to time with the SEC. These filings identify and address other important risks and uncertainties that could cause actual events and results to differ materially from those contained in the forward-looking statements. Forward-looking statements speak only as of the date they are made. Readers are cautioned not to put undue reliance on forward-looking statements, and Science 37 assumes no obligation and does not intend to update or revise these forward-looking statements, whether as a result of new information, future events, or otherwise, except as required by law. Science 37 does not give any assurance that Science 37 will achieve its expectations. Use of Non-GAAP Financial Measures and Key Performance Measures In addition to the financial measures prepared in accordance with U.S. Generally Accepted Accounting Principles ("GAAP"), this press release contains certain non-GAAP financial measures, including adjusted gross profit, adjusted gross margin, adjusted EBITDA and adjusted net income (loss). A “non-GAAP financial measure” is generally defined as a numerical measure of a company’s financial performance that excludes or includes amounts from the most directly comparable measure calculated and presented in accordance with GAAP in the statements of operations, balance sheets, or statements of cash flows of the Company. Please refer to the reconciliations of the non-GAAP financial measures to their most directly comparable GAAP measures included in this press release and the accompanying tables contained at the end of this release. The Company defines adjusted gross profit as gross profit excluding stock-based compensation expense. The Company defines adjusted gross margin as gross margin excluding stock-based compensation expense. The Company defines adjusted net income (loss) (including adjusted diluted earnings per share) as net income (loss) (including diluted earnings per share) excluding transactions that the Company believes are not representative of its core operations, namely: restructuring and other costs; transaction and integration-related expenses; stock-based compensation expense; impairment losses; other income (expense), net; and gain or loss on extinguishment of debt. EBITDA represents earnings before interest, taxes, depreciation, and amortization. The Company defines adjusted EBITDA as EBITDA, further adjusted to exclude expenses and transactions that the Company believes are not representative of its core operations, namely: restructuring and other costs; transaction and integration-related expenses; stock-based compensation expense; impairment losses; other income (expense), net; and gain or loss on extinguishment of debt. Each of the non-GAAP measures noted above are used by management and the Board to evaluate the Company's core operating results because they exclude certain items whose fluctuations from period-to-period do not necessarily correspond to changes in the core operations of the business. Management believes that adjusted gross profit, adjusted gross margin, adjusted EBITDA and adjusted net income (loss) are helpful to investors, analysts, and other interested parties because they can assist in providing a more consistent and comparable overview of our operations across our historical periods. In addition, these measures are frequently used by analysts, investors, and other interested parties to evaluate and assess performance. Non-GAAP measures have limitations in that they do not reflect all of the amounts associated with the Company's results of operations as determined in accordance with GAAP. Also, other companies might calculate these measures differently. This press release also contains certain key performance measures which we use to evaluate our business and results, measure performance, identify trends, formulate plans and make strategic decisions. We believe that the presentation of such metrics is useful to the Company’s investors because they are used to measure and model the performance of companies such as ours. Net bookings represent new business awards, net of contract modifications, contract cancellations, and other adjustments. Net bookings represent the minimum contractual value for the initial planned duration of a contract as of the contract execution date. The minimum fixed fees, upfront implementation fees and technology and support fees are included in net bookings. Estimates of variable revenue for utilization in excess of the contracted amounts is not included in the value of net bookings. Net bookings vary from period to period depending on numerous factors, including customer authorization volume, sales performance and the overall health of the life sciences industry, among others. Contacts: INVESTOR RELATIONS:Steve HalperLifeSci AdvisorsEmail: shalper@lifesciadvisors.com MEDIA INQUIRIES:Grazia MohrenScience 37Email: pr@science37.com SCIENCE 37 HOLDINGS, INC. and SUBSIDIARIESCONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS Three Months EndedDecember 31, Year EndedDecember 31,(In thousands, except per share data) 2022 2021 2022 2021 Revenue$15,936 $20,376 $70,147 $59,597 Operating expenses: Cost of revenue (exclusive of depreciation and amortization) 12,293 16,148 54,278 42,394 Selling, general and administrative 20,432 35,646 103,254 73,122 Impairment of long-lived assets 44,079 — 44,079 — Depreciation and amortization 5,373 2,610 17,942 7,799 Restructuring costs 2,628 — 2,628 — Total operating expenses 84,805 54,404 222,181 123,315 Loss from operations (68,869) (34,028) (152,034) (63,718) Other income (expense): Interest income 948 1 1,695 3 Sublease income 102 241 820 685 Change in fair value of earn-out liability 1,130 (31,300) 98,730 (31,300)Other income (expense), net 80 (12) (289) — Total other income (expense), net 2,260 (31,070) 100,956 (30,612)Loss before income taxes (66,609) (65,098) (51,078) (94,330)Income tax (benefit) expense (88) 1 (90) 1 Net loss$(66,521) $(65,099) $(50,988) $(94,331) Net loss per share Basic and diluted$(0.57) $(0.60) $(0.44) $(2.89)Weighted average common shares outstanding: Weighted average shares used to compute basic and diluted net loss per share 116,398 109,101 115,876 32,679 Comprehensive loss Net loss$(66,521) $(65,099) $(50,988) $(94,331)Foreign currency translation 41 — 193 — Total comprehensive loss$(66,480) $(65,099) $(50,795) $(94,331) SCIENCE 37 HOLDINGS, INC. and SUBSIDIARIESCONSOLIDATED BALANCE SHEETS December 31,(In thousands, except share data) 2022 2021 Assets Current assets: Cash and cash equivalents$108,091 $214,601 Accounts receivable and unbilled services, net 10,992 10,699 Prepaid expenses and other current assets 7,121 7,403 Total current assets 126,204 232,703 Property and equipment, net — 1,393 Operating lease right-of-use assets — 2,086 Capitalized software, net — 24,290 Other assets 244 326 Total assets$126,448 $260,798 Liabilities, redeemable convertible preferred stock and stockholders’ equity Current liabilities: Accounts payable$7,206 $12,819 Accrued expenses and other liabilities 11,364 17,073 Deferred revenue 4,606 5,130 Total current liabilities 23,176 35,022 Non-current liabilities: Deferred revenue 3,654 2,478 Operating lease liabilities 716 1,322 Other long-term liabilities 1,346 1,477 Long-term earn-out liability 170 98,900 Total liabilities 29,062 139,199 Redeemable convertible preferred stock: Redeemable convertible preferred stock, $0.0001 par value; 100,000,000 shares authorized, 0 issued and outstanding at December 31, 2022 and 2021 — — Stockholders’ equity: Common stock, $0.0001 par value; 400,000,000 shares authorized, 116,432,029 and 114,991,026 issued and outstanding at December 31, 2022 and 2021, respectively 12 11 Additional paid-in capital 350,247 323,666 Accumulated other comprehensive income 193 — Accumulated deficit (253,066) (202,078)Total stockholders’ equity 97,386 121,599 Total liabilities, preferred stock and stockholders’ equity$126,448 $260,798 SCIENCE 37 HOLDINGS, INC. and SUBSIDIARIESCONSOLIDATED STATEMENTS OF CASH FLOWS Year EndedDecember 31,(In thousands) 2022 2021 Cash flows from operating activities: Net loss$ (50,988) $ (94,331)Adjustments to reconcile net loss to net cash used in operating activities: Depreciation and amortization 17,942 7,799 Non-cash lease expense related to operating lease right-of-use assets 1,034 1,429 Stock-based compensation 24,562 8,407 (Gain) loss on change in fair value of earn-out liability (98,730) 31,300 Loss on long-lived asset impairment 44,079 — Gain on foreign currency exchange rates (372) — Provision for doubtful accounts 529 269 Loss on disposal of fixed assets — 10 Changes in operating assets and liabilities: Accounts receivable and unbilled services (821) 232 Prepaid expenses and other current assets 282 (6,026)Other assets 449 (142)Accounts payable (6,778) 5,243 Accrued expenses and other current liabilities (6,545) 7,158 Deferred revenue 652 2,044 Operating lease liabilities (606) (1,112)Other, net (132) 1,242 Net cash used in operating activities (75,443) (36,478)Cash flows from investing activities: Payments related to capitalized software development costs (31,707) (19,345)Purchases of property and equipment (167) (1,231) Net cash used in investing activities (31,874) (20,576)Cash flows from financing activities: Proceeds from warrant exercises — 10 PIPE shares issuance, net of transaction costs — 184,530 Merger shares issuance, net of transaction costs — 52,200 Proceeds from stock option exercises 610 1,432 Net cash provided by financing activities 610 238,172 Net (decrease) increase in cash and cash equivalents (106,510) 181,118 Cash and cash equivalents, beginning of period 214,601 33,483 Cash and cash equivalents, end of period$108,091 $214,601 Supplemental disclosures of non-cash activities Balance in accounts payable and accrued expenses and other current liabilities, and capitalized stock-based compensation related to capitalized software and fixed asset additions$(3,412) $(4,325)Right-of-use asset obtained in exchange for operating lease liabilities$— $(1,305)Conversion of preferred stock into common stock$— $(143,086)Earn-out shares$— $67,600 SCIENCE 37 HOLDINGS, INC. and SUBSIDIARIESReconciliation of GAAP to Non-GAAP Measures(Unaudited) The following table provides reconciliation of adjusted gross profit and adjusted gross margin to gross profit and gross margin, the most directly comparable GAAP measures, respectively: Three Months EndedDecember 31, Year EndedDecember 31,(In thousands) 2022 2021 2022 2021 Revenue$15,936 $20,376 $70,147 $59,597 Gross profit$3,643 $4,228 $15,869 $17,203 Stock-based compensation(1)$262 $499 $1,743 $846 Adjusted gross profit$3,905 $4,727 $17,612 $18,049 Gross margin 22.9% 20.7% 22.6% 28.9%Adjusted gross margin 24.5% 23.2% 25.1% 30.3% The following table provides reconciliation of adjusted EBITDA to net income (loss), the most directly comparable GAAP measure: Three Months EndedDecember 31, Year EndedDecember 31,(In thousands) 2022 2021 2022 2021 Net loss$(66,521) $(65,099) $(50,988) $(94,331)Interest income (948) (1) (1,695) (3)Depreciation and amortization 5,373 2,610 17,942 7,799 Other (income) expense(2) (1,312) 31,071 (99,261) 30,615 Stock-based compensation expense 5,138 6,494 24,562 8,407 Impairment of long-lived assets 44,079 — 44,079 — Restructuring costs 2,628 — 2,628 — Transaction related expenses — 3,185 — 3,185 Franchise taxes 54 241 284 241 Provision for income taxes (88) 1 (90) 1 Adjusted EBITDA$(11,597) $(21,498) $(62,539) $(44,086) (1) Represents the portion of total stock-based compensation recorded within cost of revenues.(2) For the three months and year ended December 31, 2022, other (income) expense includes a gain of $1.1 million and $98.7 million, respectively, associated with the change in the fair value of the earn-out liability and in each of the three months and year ended December 31, 2021, other (income) expense includes a loss of $31.3 million associated with the change in the fair value of the earn-out liability. The following table provides reconciliation of adjusted net income (loss) to net income (loss), the most directly comparable GAAP measure: Three Months EndedDecember 31, Year EndedDecember 31,(In thousands) 2022 2021 2022 2021 Net loss$(66,521) $(65,099) $(50,988) $(94,331)Interest income (948) (1) (1,695) (3)Other (income) expense(1) (1,312) 31,071 (99,261) 30,615 Stock-based compensation expense 5,138 6,494 24,562 8,407 Impairment of long-lived assets 44,079 — 44,079 — Restructuring costs 2,628 — 2,628 — Transaction related expenses — 3,185 — 3,185 Adjusted net loss$(16,936) $(24,350) $(80,675) $(52,127) (1) For the three months and year ended December 31, 2022, other (income) expense includes a gain of $1.1 million and $98.7 million, respectively, associated with the change in the fair value of the earn-out liability and in each of the three months and year ended December 31, 2021, other (income) expense includes a loss of $31.3 million associated with the change in the fair value of the earn-out liability. 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Science 37 Reports Fourth Quarter and Full Year 2022 Financial Results By: Science 37, Inc. via GlobeNewswire March 06, 2023 at 06:00 AM EST RESEARCH TRIANGLE PARK, N.C., March 06, 2023 (GLOBE NEWSWIRE) -- Science 37 Holdings, Inc. (Nasdaq: SNCE), (“Science 37”), the industry-leading Metasite™, today reported its financial results for the quarter and full year ended December 31, 2022. “Fourth quarter results demonstrated a healthy rebound in bookings and continued efficiency and discipline with our cash resources,” stated David Coman, Chief Executive Officer of Science 37. “We remain confident that our strategy positions us well for profitable revenue growth and shareholder value creation ahead.” Quarterly Financial Highlights Revenue was $15.9 million for the quarter ended December 31, 2022, a 22% decrease compared to the same period in 2021.Net bookings were $18.6 million for the quarter ended December 31, 2022, a 57.0% decrease compared to the same period in 2021.Gross profit was $3.6 million for the quarter ended December 31, 2022, compared to $4.2 million for the same period in 2021. Adjusted gross profit(1) was $3.9 million for the quarter ended December 31, 2022, compared to $4.7 million for the same period in 2021. Gross margin was 22.9% for the quarter ended December 31, 2022, compared to 20.7% for the same period in 2021. Adjusted gross margin(1) was 24.5% for the quarter ended December 31, 2022, compared to 23.2% for the same period in the prior year.Net loss was $66.5 million for the quarter ended December 31, 2022, resulting in loss per share of $0.57, compared to a net loss of $65.1 million in the same period in 2021, or loss per share of $0.60.Long-lived asset impairment was $44.1 million for the quarter ended December 31, 2022, compared to $0.0 million for the same period in 2021. The Company remains confident in the utility of long-lived assets and there has been no change as to their intended use.Adjusted net loss(1) was $16.9 million for the quarter ended December 31, 2022, compared to an adjusted net loss of $24.4 million in the same period in 2021.Adjusted EBITDA(1) was $(11.6) million for the quarter ended December 31, 2022, compared to $(21.5) million in the same period in 2021. Annual Financial Highlights Revenue was $70.1 million for the year ended December 31, 2022, a 18% increase compared to the same period in 2021.Net bookings were $79.2 million for the year ended December 31, 2022, a 52% decrease compared to the same period in 2021.Gross profit was $15.9 million for the year ended December 31, 2022, compared to $17.2 million for the same period in 2021. Adjusted gross profit(1) was $17.6 million for the year ended December 31, 2022, compared to $18.0 million for the same period in 2021. Gross margin was 22.6% for the year ended December 31, 2022, compared to 28.9% for the same period in 2021. Adjusted gross margin(1) was 25.1% for the year ended December 31, 2022, compared to 30.3% for the same period in the prior year.Net loss was $51.0 million for the year ended December 31, 2022, resulting in loss per share of $0.44, compared to a net loss of $94.3 million in the same period in 2021, or loss per share of $2.89.Adjusted net loss(1) was $80.7 million for the year ended December 31, 2022, compared to an adjusted net loss of $52.1 million in the same period in 2021.Adjusted EBITDA(1) was $(62.5) million for the year ended December 31, 2022, compared to $(44.1) million in the same period in 2021.Cash and Cash Equivalents as of December 31, 2022 were $108.1 million. (1) Adjusted gross profit, adjusted gross margin, adjusted net income (loss) and adjusted EBITDA are non-GAAP financial measures. For a reconciliation to the most directly comparable GAAP measure, refer "Reconciliation of GAAP to non-GAAP measures" section included in this press release. Full Year 2023 Financial Outlook Science 37 is providing revenue guidance of $55.0 million to $60.0 million and adjusted EBITDA guidance of $(50.0) million to $(48.0) million for the fiscal year ending December 31, 2023. The foregoing 2023 Financial Outlook statements represent management's current estimate as of the date of this release. Actual results may differ materially depending on a number of factors. Investors are urged to read the Cautionary Note Regarding Forward-Looking Statements included in this release. Management does not assume any obligation to update these estimates. Science 37 has not provided a quantitative reconciliation of adjusted EBITDA guidance to net (income) loss on a forward-looking basis within this press release because the Company is unable, without unreasonable efforts, to provide reconciling information with respect to interest income, depreciation, amortization, stock-based compensation, restructuring costs and change in fair value of the Earn-Out liability, all of which are adjustments to adjusted EBITDA. These items, which could materially affect the computation of forward-looking GAAP net income (loss), are inherently uncertain and depend on various factors, some of which are outside of the Science 37’s control. Webcast and Conference Call Details Science 37 will host a conference call today, March 6, 2023, at 8:30 a.m. Eastern Time to discuss its quarter and year ended December 31, 2022 financial results. The call can be accessed by dialing 1-877-269-7751 (toll-free domestic) or 1-201-389-0908 (international) using the conference ID 13736111 or by utilizing the Call me™ feature using this link to request a return call for instant telephone access to the event. The live webcast may be accessed using this link to the investor relations section of the Science 37 website. A replay of the webcast will be available for approximately 90 days. About Science 37 Science 37 Holdings, Inc.’s (Nasdaq: SNCE) mission is to accelerate clinical research by enabling universal trial access for patients. As a single Metasite™, Science 37 reaches an expanded patient population beyond the traditional site and delivers the recruiting power of up to 20 sites in one with greater patient diversity. Patients gain the flexibility to participate from the comfort of their own home, at their local community provider, or at a traditional site when needed. The Science 37 Metasite is powered by a proprietary technology platform, in addition to in-house investigators, mobile nurses, and remote coordinators that drive uniform study orchestration, enabling greater compliance and high-quality data. To learn more, visit www.science37.com, or email science37@science37.com. Cautionary Note Regarding Forward-Looking Statements This press release contains certain forward-looking statements within the meaning of the federal securities laws, including statements regarding Science 37’s anticipated growth and profitability, the products offered by Science 37 and the markets in which it operates and revenue and adjusted EBITDA guidance for fiscal year 2023. These forward-looking statements generally are identified by the words “believe,” “can,” “could,” “seek,” “project,” “expect,” “anticipate,” “estimate,” “intend,” “strategy,” “future,” “opportunity,” “plan,” “may,” “might,” “should,” “will,” “would,” “will be,” “will continue,” “will likely result” and similar expressions. Forward-looking statements are predictions, projections and other statements about future events that are based on current expectations and assumptions and, as a result, are subject to risks and uncertainties. Many factors could cause actual future events to differ materially from the forward-looking statements in this press release, including but not limited to: (i) the ability to maintain the listing of Science 37’s securities on Nasdaq, (ii) volatility in the price of Science 37’s securities due to a variety of factors, including changes in the competitive and highly regulated industries in which Science 37 operates, variations in performance across competitors, changes in laws and regulations affecting Science 37’s business and changes in its capital structure, and general economic and financial market conditions, including fluctuations in currency exchange rates, economic instability, and inflationary conditions, (iii) the ability to implement business plans, forecasts, and other expectations, and to identify and realize additional opportunities, (iv) the risk that Science 37 may never achieve or sustain profitability, (v) the risk that Science 37 will need to raise additional capital to execute its business plan, which may not be available on acceptable terms or at all, (vi) failure to realize anticipated cost savings, and (vii) risks related to the general economic and financial market conditions. The foregoing list of factors is not exhaustive. You should carefully consider the foregoing factors and the other risks and uncertainties described in the “Risk Factors” section of our Annual Report on Form 10-K for the fiscal year ended December 31, 2022 filed with the U.S. Securities and Exchange Commission (the “SEC”) on March 06, 2023 and in our other documents filed by Science 37 from time to time with the SEC. These filings identify and address other important risks and uncertainties that could cause actual events and results to differ materially from those contained in the forward-looking statements. Forward-looking statements speak only as of the date they are made. Readers are cautioned not to put undue reliance on forward-looking statements, and Science 37 assumes no obligation and does not intend to update or revise these forward-looking statements, whether as a result of new information, future events, or otherwise, except as required by law. Science 37 does not give any assurance that Science 37 will achieve its expectations. Use of Non-GAAP Financial Measures and Key Performance Measures In addition to the financial measures prepared in accordance with U.S. Generally Accepted Accounting Principles ("GAAP"), this press release contains certain non-GAAP financial measures, including adjusted gross profit, adjusted gross margin, adjusted EBITDA and adjusted net income (loss). A “non-GAAP financial measure” is generally defined as a numerical measure of a company’s financial performance that excludes or includes amounts from the most directly comparable measure calculated and presented in accordance with GAAP in the statements of operations, balance sheets, or statements of cash flows of the Company. Please refer to the reconciliations of the non-GAAP financial measures to their most directly comparable GAAP measures included in this press release and the accompanying tables contained at the end of this release. The Company defines adjusted gross profit as gross profit excluding stock-based compensation expense. The Company defines adjusted gross margin as gross margin excluding stock-based compensation expense. The Company defines adjusted net income (loss) (including adjusted diluted earnings per share) as net income (loss) (including diluted earnings per share) excluding transactions that the Company believes are not representative of its core operations, namely: restructuring and other costs; transaction and integration-related expenses; stock-based compensation expense; impairment losses; other income (expense), net; and gain or loss on extinguishment of debt. EBITDA represents earnings before interest, taxes, depreciation, and amortization. The Company defines adjusted EBITDA as EBITDA, further adjusted to exclude expenses and transactions that the Company believes are not representative of its core operations, namely: restructuring and other costs; transaction and integration-related expenses; stock-based compensation expense; impairment losses; other income (expense), net; and gain or loss on extinguishment of debt. Each of the non-GAAP measures noted above are used by management and the Board to evaluate the Company's core operating results because they exclude certain items whose fluctuations from period-to-period do not necessarily correspond to changes in the core operations of the business. Management believes that adjusted gross profit, adjusted gross margin, adjusted EBITDA and adjusted net income (loss) are helpful to investors, analysts, and other interested parties because they can assist in providing a more consistent and comparable overview of our operations across our historical periods. In addition, these measures are frequently used by analysts, investors, and other interested parties to evaluate and assess performance. Non-GAAP measures have limitations in that they do not reflect all of the amounts associated with the Company's results of operations as determined in accordance with GAAP. Also, other companies might calculate these measures differently. This press release also contains certain key performance measures which we use to evaluate our business and results, measure performance, identify trends, formulate plans and make strategic decisions. We believe that the presentation of such metrics is useful to the Company’s investors because they are used to measure and model the performance of companies such as ours. Net bookings represent new business awards, net of contract modifications, contract cancellations, and other adjustments. Net bookings represent the minimum contractual value for the initial planned duration of a contract as of the contract execution date. The minimum fixed fees, upfront implementation fees and technology and support fees are included in net bookings. Estimates of variable revenue for utilization in excess of the contracted amounts is not included in the value of net bookings. Net bookings vary from period to period depending on numerous factors, including customer authorization volume, sales performance and the overall health of the life sciences industry, among others. Contacts: INVESTOR RELATIONS:Steve HalperLifeSci AdvisorsEmail: shalper@lifesciadvisors.com MEDIA INQUIRIES:Grazia MohrenScience 37Email: pr@science37.com SCIENCE 37 HOLDINGS, INC. and SUBSIDIARIESCONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS Three Months EndedDecember 31, Year EndedDecember 31,(In thousands, except per share data) 2022 2021 2022 2021 Revenue$15,936 $20,376 $70,147 $59,597 Operating expenses: Cost of revenue (exclusive of depreciation and amortization) 12,293 16,148 54,278 42,394 Selling, general and administrative 20,432 35,646 103,254 73,122 Impairment of long-lived assets 44,079 — 44,079 — Depreciation and amortization 5,373 2,610 17,942 7,799 Restructuring costs 2,628 — 2,628 — Total operating expenses 84,805 54,404 222,181 123,315 Loss from operations (68,869) (34,028) (152,034) (63,718) Other income (expense): Interest income 948 1 1,695 3 Sublease income 102 241 820 685 Change in fair value of earn-out liability 1,130 (31,300) 98,730 (31,300)Other income (expense), net 80 (12) (289) — Total other income (expense), net 2,260 (31,070) 100,956 (30,612)Loss before income taxes (66,609) (65,098) (51,078) (94,330)Income tax (benefit) expense (88) 1 (90) 1 Net loss$(66,521) $(65,099) $(50,988) $(94,331) Net loss per share Basic and diluted$(0.57) $(0.60) $(0.44) $(2.89)Weighted average common shares outstanding: Weighted average shares used to compute basic and diluted net loss per share 116,398 109,101 115,876 32,679 Comprehensive loss Net loss$(66,521) $(65,099) $(50,988) $(94,331)Foreign currency translation 41 — 193 — Total comprehensive loss$(66,480) $(65,099) $(50,795) $(94,331) SCIENCE 37 HOLDINGS, INC. and SUBSIDIARIESCONSOLIDATED BALANCE SHEETS December 31,(In thousands, except share data) 2022 2021 Assets Current assets: Cash and cash equivalents$108,091 $214,601 Accounts receivable and unbilled services, net 10,992 10,699 Prepaid expenses and other current assets 7,121 7,403 Total current assets 126,204 232,703 Property and equipment, net — 1,393 Operating lease right-of-use assets — 2,086 Capitalized software, net — 24,290 Other assets 244 326 Total assets$126,448 $260,798 Liabilities, redeemable convertible preferred stock and stockholders’ equity Current liabilities: Accounts payable$7,206 $12,819 Accrued expenses and other liabilities 11,364 17,073 Deferred revenue 4,606 5,130 Total current liabilities 23,176 35,022 Non-current liabilities: Deferred revenue 3,654 2,478 Operating lease liabilities 716 1,322 Other long-term liabilities 1,346 1,477 Long-term earn-out liability 170 98,900 Total liabilities 29,062 139,199 Redeemable convertible preferred stock: Redeemable convertible preferred stock, $0.0001 par value; 100,000,000 shares authorized, 0 issued and outstanding at December 31, 2022 and 2021 — — Stockholders’ equity: Common stock, $0.0001 par value; 400,000,000 shares authorized, 116,432,029 and 114,991,026 issued and outstanding at December 31, 2022 and 2021, respectively 12 11 Additional paid-in capital 350,247 323,666 Accumulated other comprehensive income 193 — Accumulated deficit (253,066) (202,078)Total stockholders’ equity 97,386 121,599 Total liabilities, preferred stock and stockholders’ equity$126,448 $260,798 SCIENCE 37 HOLDINGS, INC. and SUBSIDIARIESCONSOLIDATED STATEMENTS OF CASH FLOWS Year EndedDecember 31,(In thousands) 2022 2021 Cash flows from operating activities: Net loss$ (50,988) $ (94,331)Adjustments to reconcile net loss to net cash used in operating activities: Depreciation and amortization 17,942 7,799 Non-cash lease expense related to operating lease right-of-use assets 1,034 1,429 Stock-based compensation 24,562 8,407 (Gain) loss on change in fair value of earn-out liability (98,730) 31,300 Loss on long-lived asset impairment 44,079 — Gain on foreign currency exchange rates (372) — Provision for doubtful accounts 529 269 Loss on disposal of fixed assets — 10 Changes in operating assets and liabilities: Accounts receivable and unbilled services (821) 232 Prepaid expenses and other current assets 282 (6,026)Other assets 449 (142)Accounts payable (6,778) 5,243 Accrued expenses and other current liabilities (6,545) 7,158 Deferred revenue 652 2,044 Operating lease liabilities (606) (1,112)Other, net (132) 1,242 Net cash used in operating activities (75,443) (36,478)Cash flows from investing activities: Payments related to capitalized software development costs (31,707) (19,345)Purchases of property and equipment (167) (1,231) Net cash used in investing activities (31,874) (20,576)Cash flows from financing activities: Proceeds from warrant exercises — 10 PIPE shares issuance, net of transaction costs — 184,530 Merger shares issuance, net of transaction costs — 52,200 Proceeds from stock option exercises 610 1,432 Net cash provided by financing activities 610 238,172 Net (decrease) increase in cash and cash equivalents (106,510) 181,118 Cash and cash equivalents, beginning of period 214,601 33,483 Cash and cash equivalents, end of period$108,091 $214,601 Supplemental disclosures of non-cash activities Balance in accounts payable and accrued expenses and other current liabilities, and capitalized stock-based compensation related to capitalized software and fixed asset additions$(3,412) $(4,325)Right-of-use asset obtained in exchange for operating lease liabilities$— $(1,305)Conversion of preferred stock into common stock$— $(143,086)Earn-out shares$— $67,600 SCIENCE 37 HOLDINGS, INC. and SUBSIDIARIESReconciliation of GAAP to Non-GAAP Measures(Unaudited) The following table provides reconciliation of adjusted gross profit and adjusted gross margin to gross profit and gross margin, the most directly comparable GAAP measures, respectively: Three Months EndedDecember 31, Year EndedDecember 31,(In thousands) 2022 2021 2022 2021 Revenue$15,936 $20,376 $70,147 $59,597 Gross profit$3,643 $4,228 $15,869 $17,203 Stock-based compensation(1)$262 $499 $1,743 $846 Adjusted gross profit$3,905 $4,727 $17,612 $18,049 Gross margin 22.9% 20.7% 22.6% 28.9%Adjusted gross margin 24.5% 23.2% 25.1% 30.3% The following table provides reconciliation of adjusted EBITDA to net income (loss), the most directly comparable GAAP measure: Three Months EndedDecember 31, Year EndedDecember 31,(In thousands) 2022 2021 2022 2021 Net loss$(66,521) $(65,099) $(50,988) $(94,331)Interest income (948) (1) (1,695) (3)Depreciation and amortization 5,373 2,610 17,942 7,799 Other (income) expense(2) (1,312) 31,071 (99,261) 30,615 Stock-based compensation expense 5,138 6,494 24,562 8,407 Impairment of long-lived assets 44,079 — 44,079 — Restructuring costs 2,628 — 2,628 — Transaction related expenses — 3,185 — 3,185 Franchise taxes 54 241 284 241 Provision for income taxes (88) 1 (90) 1 Adjusted EBITDA$(11,597) $(21,498) $(62,539) $(44,086) (1) Represents the portion of total stock-based compensation recorded within cost of revenues.(2) For the three months and year ended December 31, 2022, other (income) expense includes a gain of $1.1 million and $98.7 million, respectively, associated with the change in the fair value of the earn-out liability and in each of the three months and year ended December 31, 2021, other (income) expense includes a loss of $31.3 million associated with the change in the fair value of the earn-out liability. The following table provides reconciliation of adjusted net income (loss) to net income (loss), the most directly comparable GAAP measure: Three Months EndedDecember 31, Year EndedDecember 31,(In thousands) 2022 2021 2022 2021 Net loss$(66,521) $(65,099) $(50,988) $(94,331)Interest income (948) (1) (1,695) (3)Other (income) expense(1) (1,312) 31,071 (99,261) 30,615 Stock-based compensation expense 5,138 6,494 24,562 8,407 Impairment of long-lived assets 44,079 — 44,079 — Restructuring costs 2,628 — 2,628 — Transaction related expenses — 3,185 — 3,185 Adjusted net loss$(16,936) $(24,350) $(80,675) $(52,127) (1) For the three months and year ended December 31, 2022, other (income) expense includes a gain of $1.1 million and $98.7 million, respectively, associated with the change in the fair value of the earn-out liability and in each of the three months and year ended December 31, 2021, other (income) expense includes a loss of $31.3 million associated with the change in the fair value of the earn-out liability.
RESEARCH TRIANGLE PARK, N.C., March 06, 2023 (GLOBE NEWSWIRE) -- Science 37 Holdings, Inc. (Nasdaq: SNCE), (“Science 37”), the industry-leading Metasite™, today reported its financial results for the quarter and full year ended December 31, 2022. “Fourth quarter results demonstrated a healthy rebound in bookings and continued efficiency and discipline with our cash resources,” stated David Coman, Chief Executive Officer of Science 37. “We remain confident that our strategy positions us well for profitable revenue growth and shareholder value creation ahead.” Quarterly Financial Highlights Revenue was $15.9 million for the quarter ended December 31, 2022, a 22% decrease compared to the same period in 2021.Net bookings were $18.6 million for the quarter ended December 31, 2022, a 57.0% decrease compared to the same period in 2021.Gross profit was $3.6 million for the quarter ended December 31, 2022, compared to $4.2 million for the same period in 2021. Adjusted gross profit(1) was $3.9 million for the quarter ended December 31, 2022, compared to $4.7 million for the same period in 2021. Gross margin was 22.9% for the quarter ended December 31, 2022, compared to 20.7% for the same period in 2021. Adjusted gross margin(1) was 24.5% for the quarter ended December 31, 2022, compared to 23.2% for the same period in the prior year.Net loss was $66.5 million for the quarter ended December 31, 2022, resulting in loss per share of $0.57, compared to a net loss of $65.1 million in the same period in 2021, or loss per share of $0.60.Long-lived asset impairment was $44.1 million for the quarter ended December 31, 2022, compared to $0.0 million for the same period in 2021. The Company remains confident in the utility of long-lived assets and there has been no change as to their intended use.Adjusted net loss(1) was $16.9 million for the quarter ended December 31, 2022, compared to an adjusted net loss of $24.4 million in the same period in 2021.Adjusted EBITDA(1) was $(11.6) million for the quarter ended December 31, 2022, compared to $(21.5) million in the same period in 2021. Annual Financial Highlights Revenue was $70.1 million for the year ended December 31, 2022, a 18% increase compared to the same period in 2021.Net bookings were $79.2 million for the year ended December 31, 2022, a 52% decrease compared to the same period in 2021.Gross profit was $15.9 million for the year ended December 31, 2022, compared to $17.2 million for the same period in 2021. Adjusted gross profit(1) was $17.6 million for the year ended December 31, 2022, compared to $18.0 million for the same period in 2021. Gross margin was 22.6% for the year ended December 31, 2022, compared to 28.9% for the same period in 2021. Adjusted gross margin(1) was 25.1% for the year ended December 31, 2022, compared to 30.3% for the same period in the prior year.Net loss was $51.0 million for the year ended December 31, 2022, resulting in loss per share of $0.44, compared to a net loss of $94.3 million in the same period in 2021, or loss per share of $2.89.Adjusted net loss(1) was $80.7 million for the year ended December 31, 2022, compared to an adjusted net loss of $52.1 million in the same period in 2021.Adjusted EBITDA(1) was $(62.5) million for the year ended December 31, 2022, compared to $(44.1) million in the same period in 2021.Cash and Cash Equivalents as of December 31, 2022 were $108.1 million. (1) Adjusted gross profit, adjusted gross margin, adjusted net income (loss) and adjusted EBITDA are non-GAAP financial measures. For a reconciliation to the most directly comparable GAAP measure, refer "Reconciliation of GAAP to non-GAAP measures" section included in this press release. Full Year 2023 Financial Outlook Science 37 is providing revenue guidance of $55.0 million to $60.0 million and adjusted EBITDA guidance of $(50.0) million to $(48.0) million for the fiscal year ending December 31, 2023. The foregoing 2023 Financial Outlook statements represent management's current estimate as of the date of this release. Actual results may differ materially depending on a number of factors. Investors are urged to read the Cautionary Note Regarding Forward-Looking Statements included in this release. Management does not assume any obligation to update these estimates. Science 37 has not provided a quantitative reconciliation of adjusted EBITDA guidance to net (income) loss on a forward-looking basis within this press release because the Company is unable, without unreasonable efforts, to provide reconciling information with respect to interest income, depreciation, amortization, stock-based compensation, restructuring costs and change in fair value of the Earn-Out liability, all of which are adjustments to adjusted EBITDA. These items, which could materially affect the computation of forward-looking GAAP net income (loss), are inherently uncertain and depend on various factors, some of which are outside of the Science 37’s control. Webcast and Conference Call Details Science 37 will host a conference call today, March 6, 2023, at 8:30 a.m. Eastern Time to discuss its quarter and year ended December 31, 2022 financial results. The call can be accessed by dialing 1-877-269-7751 (toll-free domestic) or 1-201-389-0908 (international) using the conference ID 13736111 or by utilizing the Call me™ feature using this link to request a return call for instant telephone access to the event. The live webcast may be accessed using this link to the investor relations section of the Science 37 website. A replay of the webcast will be available for approximately 90 days. About Science 37 Science 37 Holdings, Inc.’s (Nasdaq: SNCE) mission is to accelerate clinical research by enabling universal trial access for patients. As a single Metasite™, Science 37 reaches an expanded patient population beyond the traditional site and delivers the recruiting power of up to 20 sites in one with greater patient diversity. Patients gain the flexibility to participate from the comfort of their own home, at their local community provider, or at a traditional site when needed. The Science 37 Metasite is powered by a proprietary technology platform, in addition to in-house investigators, mobile nurses, and remote coordinators that drive uniform study orchestration, enabling greater compliance and high-quality data. To learn more, visit www.science37.com, or email science37@science37.com. Cautionary Note Regarding Forward-Looking Statements This press release contains certain forward-looking statements within the meaning of the federal securities laws, including statements regarding Science 37’s anticipated growth and profitability, the products offered by Science 37 and the markets in which it operates and revenue and adjusted EBITDA guidance for fiscal year 2023. These forward-looking statements generally are identified by the words “believe,” “can,” “could,” “seek,” “project,” “expect,” “anticipate,” “estimate,” “intend,” “strategy,” “future,” “opportunity,” “plan,” “may,” “might,” “should,” “will,” “would,” “will be,” “will continue,” “will likely result” and similar expressions. Forward-looking statements are predictions, projections and other statements about future events that are based on current expectations and assumptions and, as a result, are subject to risks and uncertainties. Many factors could cause actual future events to differ materially from the forward-looking statements in this press release, including but not limited to: (i) the ability to maintain the listing of Science 37’s securities on Nasdaq, (ii) volatility in the price of Science 37’s securities due to a variety of factors, including changes in the competitive and highly regulated industries in which Science 37 operates, variations in performance across competitors, changes in laws and regulations affecting Science 37’s business and changes in its capital structure, and general economic and financial market conditions, including fluctuations in currency exchange rates, economic instability, and inflationary conditions, (iii) the ability to implement business plans, forecasts, and other expectations, and to identify and realize additional opportunities, (iv) the risk that Science 37 may never achieve or sustain profitability, (v) the risk that Science 37 will need to raise additional capital to execute its business plan, which may not be available on acceptable terms or at all, (vi) failure to realize anticipated cost savings, and (vii) risks related to the general economic and financial market conditions. The foregoing list of factors is not exhaustive. You should carefully consider the foregoing factors and the other risks and uncertainties described in the “Risk Factors” section of our Annual Report on Form 10-K for the fiscal year ended December 31, 2022 filed with the U.S. Securities and Exchange Commission (the “SEC”) on March 06, 2023 and in our other documents filed by Science 37 from time to time with the SEC. These filings identify and address other important risks and uncertainties that could cause actual events and results to differ materially from those contained in the forward-looking statements. Forward-looking statements speak only as of the date they are made. Readers are cautioned not to put undue reliance on forward-looking statements, and Science 37 assumes no obligation and does not intend to update or revise these forward-looking statements, whether as a result of new information, future events, or otherwise, except as required by law. Science 37 does not give any assurance that Science 37 will achieve its expectations. Use of Non-GAAP Financial Measures and Key Performance Measures In addition to the financial measures prepared in accordance with U.S. Generally Accepted Accounting Principles ("GAAP"), this press release contains certain non-GAAP financial measures, including adjusted gross profit, adjusted gross margin, adjusted EBITDA and adjusted net income (loss). A “non-GAAP financial measure” is generally defined as a numerical measure of a company’s financial performance that excludes or includes amounts from the most directly comparable measure calculated and presented in accordance with GAAP in the statements of operations, balance sheets, or statements of cash flows of the Company. Please refer to the reconciliations of the non-GAAP financial measures to their most directly comparable GAAP measures included in this press release and the accompanying tables contained at the end of this release. The Company defines adjusted gross profit as gross profit excluding stock-based compensation expense. The Company defines adjusted gross margin as gross margin excluding stock-based compensation expense. The Company defines adjusted net income (loss) (including adjusted diluted earnings per share) as net income (loss) (including diluted earnings per share) excluding transactions that the Company believes are not representative of its core operations, namely: restructuring and other costs; transaction and integration-related expenses; stock-based compensation expense; impairment losses; other income (expense), net; and gain or loss on extinguishment of debt. EBITDA represents earnings before interest, taxes, depreciation, and amortization. The Company defines adjusted EBITDA as EBITDA, further adjusted to exclude expenses and transactions that the Company believes are not representative of its core operations, namely: restructuring and other costs; transaction and integration-related expenses; stock-based compensation expense; impairment losses; other income (expense), net; and gain or loss on extinguishment of debt. Each of the non-GAAP measures noted above are used by management and the Board to evaluate the Company's core operating results because they exclude certain items whose fluctuations from period-to-period do not necessarily correspond to changes in the core operations of the business. Management believes that adjusted gross profit, adjusted gross margin, adjusted EBITDA and adjusted net income (loss) are helpful to investors, analysts, and other interested parties because they can assist in providing a more consistent and comparable overview of our operations across our historical periods. In addition, these measures are frequently used by analysts, investors, and other interested parties to evaluate and assess performance. Non-GAAP measures have limitations in that they do not reflect all of the amounts associated with the Company's results of operations as determined in accordance with GAAP. Also, other companies might calculate these measures differently. This press release also contains certain key performance measures which we use to evaluate our business and results, measure performance, identify trends, formulate plans and make strategic decisions. We believe that the presentation of such metrics is useful to the Company’s investors because they are used to measure and model the performance of companies such as ours. Net bookings represent new business awards, net of contract modifications, contract cancellations, and other adjustments. Net bookings represent the minimum contractual value for the initial planned duration of a contract as of the contract execution date. The minimum fixed fees, upfront implementation fees and technology and support fees are included in net bookings. Estimates of variable revenue for utilization in excess of the contracted amounts is not included in the value of net bookings. Net bookings vary from period to period depending on numerous factors, including customer authorization volume, sales performance and the overall health of the life sciences industry, among others. Contacts: INVESTOR RELATIONS:Steve HalperLifeSci AdvisorsEmail: shalper@lifesciadvisors.com MEDIA INQUIRIES:Grazia MohrenScience 37Email: pr@science37.com SCIENCE 37 HOLDINGS, INC. and SUBSIDIARIESCONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS Three Months EndedDecember 31, Year EndedDecember 31,(In thousands, except per share data) 2022 2021 2022 2021 Revenue$15,936 $20,376 $70,147 $59,597 Operating expenses: Cost of revenue (exclusive of depreciation and amortization) 12,293 16,148 54,278 42,394 Selling, general and administrative 20,432 35,646 103,254 73,122 Impairment of long-lived assets 44,079 — 44,079 — Depreciation and amortization 5,373 2,610 17,942 7,799 Restructuring costs 2,628 — 2,628 — Total operating expenses 84,805 54,404 222,181 123,315 Loss from operations (68,869) (34,028) (152,034) (63,718) Other income (expense): Interest income 948 1 1,695 3 Sublease income 102 241 820 685 Change in fair value of earn-out liability 1,130 (31,300) 98,730 (31,300)Other income (expense), net 80 (12) (289) — Total other income (expense), net 2,260 (31,070) 100,956 (30,612)Loss before income taxes (66,609) (65,098) (51,078) (94,330)Income tax (benefit) expense (88) 1 (90) 1 Net loss$(66,521) $(65,099) $(50,988) $(94,331) Net loss per share Basic and diluted$(0.57) $(0.60) $(0.44) $(2.89)Weighted average common shares outstanding: Weighted average shares used to compute basic and diluted net loss per share 116,398 109,101 115,876 32,679 Comprehensive loss Net loss$(66,521) $(65,099) $(50,988) $(94,331)Foreign currency translation 41 — 193 — Total comprehensive loss$(66,480) $(65,099) $(50,795) $(94,331) SCIENCE 37 HOLDINGS, INC. and SUBSIDIARIESCONSOLIDATED BALANCE SHEETS December 31,(In thousands, except share data) 2022 2021 Assets Current assets: Cash and cash equivalents$108,091 $214,601 Accounts receivable and unbilled services, net 10,992 10,699 Prepaid expenses and other current assets 7,121 7,403 Total current assets 126,204 232,703 Property and equipment, net — 1,393 Operating lease right-of-use assets — 2,086 Capitalized software, net — 24,290 Other assets 244 326 Total assets$126,448 $260,798 Liabilities, redeemable convertible preferred stock and stockholders’ equity Current liabilities: Accounts payable$7,206 $12,819 Accrued expenses and other liabilities 11,364 17,073 Deferred revenue 4,606 5,130 Total current liabilities 23,176 35,022 Non-current liabilities: Deferred revenue 3,654 2,478 Operating lease liabilities 716 1,322 Other long-term liabilities 1,346 1,477 Long-term earn-out liability 170 98,900 Total liabilities 29,062 139,199 Redeemable convertible preferred stock: Redeemable convertible preferred stock, $0.0001 par value; 100,000,000 shares authorized, 0 issued and outstanding at December 31, 2022 and 2021 — — Stockholders’ equity: Common stock, $0.0001 par value; 400,000,000 shares authorized, 116,432,029 and 114,991,026 issued and outstanding at December 31, 2022 and 2021, respectively 12 11 Additional paid-in capital 350,247 323,666 Accumulated other comprehensive income 193 — Accumulated deficit (253,066) (202,078)Total stockholders’ equity 97,386 121,599 Total liabilities, preferred stock and stockholders’ equity$126,448 $260,798 SCIENCE 37 HOLDINGS, INC. and SUBSIDIARIESCONSOLIDATED STATEMENTS OF CASH FLOWS Year EndedDecember 31,(In thousands) 2022 2021 Cash flows from operating activities: Net loss$ (50,988) $ (94,331)Adjustments to reconcile net loss to net cash used in operating activities: Depreciation and amortization 17,942 7,799 Non-cash lease expense related to operating lease right-of-use assets 1,034 1,429 Stock-based compensation 24,562 8,407 (Gain) loss on change in fair value of earn-out liability (98,730) 31,300 Loss on long-lived asset impairment 44,079 — Gain on foreign currency exchange rates (372) — Provision for doubtful accounts 529 269 Loss on disposal of fixed assets — 10 Changes in operating assets and liabilities: Accounts receivable and unbilled services (821) 232 Prepaid expenses and other current assets 282 (6,026)Other assets 449 (142)Accounts payable (6,778) 5,243 Accrued expenses and other current liabilities (6,545) 7,158 Deferred revenue 652 2,044 Operating lease liabilities (606) (1,112)Other, net (132) 1,242 Net cash used in operating activities (75,443) (36,478)Cash flows from investing activities: Payments related to capitalized software development costs (31,707) (19,345)Purchases of property and equipment (167) (1,231) Net cash used in investing activities (31,874) (20,576)Cash flows from financing activities: Proceeds from warrant exercises — 10 PIPE shares issuance, net of transaction costs — 184,530 Merger shares issuance, net of transaction costs — 52,200 Proceeds from stock option exercises 610 1,432 Net cash provided by financing activities 610 238,172 Net (decrease) increase in cash and cash equivalents (106,510) 181,118 Cash and cash equivalents, beginning of period 214,601 33,483 Cash and cash equivalents, end of period$108,091 $214,601 Supplemental disclosures of non-cash activities Balance in accounts payable and accrued expenses and other current liabilities, and capitalized stock-based compensation related to capitalized software and fixed asset additions$(3,412) $(4,325)Right-of-use asset obtained in exchange for operating lease liabilities$— $(1,305)Conversion of preferred stock into common stock$— $(143,086)Earn-out shares$— $67,600 SCIENCE 37 HOLDINGS, INC. and SUBSIDIARIESReconciliation of GAAP to Non-GAAP Measures(Unaudited) The following table provides reconciliation of adjusted gross profit and adjusted gross margin to gross profit and gross margin, the most directly comparable GAAP measures, respectively: Three Months EndedDecember 31, Year EndedDecember 31,(In thousands) 2022 2021 2022 2021 Revenue$15,936 $20,376 $70,147 $59,597 Gross profit$3,643 $4,228 $15,869 $17,203 Stock-based compensation(1)$262 $499 $1,743 $846 Adjusted gross profit$3,905 $4,727 $17,612 $18,049 Gross margin 22.9% 20.7% 22.6% 28.9%Adjusted gross margin 24.5% 23.2% 25.1% 30.3% The following table provides reconciliation of adjusted EBITDA to net income (loss), the most directly comparable GAAP measure: Three Months EndedDecember 31, Year EndedDecember 31,(In thousands) 2022 2021 2022 2021 Net loss$(66,521) $(65,099) $(50,988) $(94,331)Interest income (948) (1) (1,695) (3)Depreciation and amortization 5,373 2,610 17,942 7,799 Other (income) expense(2) (1,312) 31,071 (99,261) 30,615 Stock-based compensation expense 5,138 6,494 24,562 8,407 Impairment of long-lived assets 44,079 — 44,079 — Restructuring costs 2,628 — 2,628 — Transaction related expenses — 3,185 — 3,185 Franchise taxes 54 241 284 241 Provision for income taxes (88) 1 (90) 1 Adjusted EBITDA$(11,597) $(21,498) $(62,539) $(44,086) (1) Represents the portion of total stock-based compensation recorded within cost of revenues.(2) For the three months and year ended December 31, 2022, other (income) expense includes a gain of $1.1 million and $98.7 million, respectively, associated with the change in the fair value of the earn-out liability and in each of the three months and year ended December 31, 2021, other (income) expense includes a loss of $31.3 million associated with the change in the fair value of the earn-out liability. The following table provides reconciliation of adjusted net income (loss) to net income (loss), the most directly comparable GAAP measure: Three Months EndedDecember 31, Year EndedDecember 31,(In thousands) 2022 2021 2022 2021 Net loss$(66,521) $(65,099) $(50,988) $(94,331)Interest income (948) (1) (1,695) (3)Other (income) expense(1) (1,312) 31,071 (99,261) 30,615 Stock-based compensation expense 5,138 6,494 24,562 8,407 Impairment of long-lived assets 44,079 — 44,079 — Restructuring costs 2,628 — 2,628 — Transaction related expenses — 3,185 — 3,185 Adjusted net loss$(16,936) $(24,350) $(80,675) $(52,127) (1) For the three months and year ended December 31, 2022, other (income) expense includes a gain of $1.1 million and $98.7 million, respectively, associated with the change in the fair value of the earn-out liability and in each of the three months and year ended December 31, 2021, other (income) expense includes a loss of $31.3 million associated with the change in the fair value of the earn-out liability.
