--------------------------------------------------------------------------------

                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                              Washington D.C. 20549

                                   FORM 10QSB

[ X ]    QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15 (d) OF
         THE SECURITIES EXCHANGE ACT OF 1934

For the quarterly period ended:             June 30, 2004
                                 -----------------------------------------------

                                       OR

[    ]   TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 (d) OF
         THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from                       to
                               -------------------------------------------------
Commission file number:             0-22319
                         -------------------------------------------------------

                            PATIENT INFOSYSTEMS, INC.
                            -------------------------
        (Exact name of small business issuer as specified in its charter)

          Delaware                                   16-1476509
          --------                                   ----------
(State or other jurisdiction of            (I.R.S. Employer Identification No.)
incorporation or organization)

                      46 Prince Street, Rochester, NY 14607
                    (Address of principal executive offices)

                                 (585) 242-7200
                (Issuer's telephone number, including area code)

     Check  whether  the issuer (1) filed all  reports  required  to be filed by
Section 13 or 15 (d) of the  Exchange Act during the past 12 months (or for such
shorter period that the  registrant was required to file such reports),  and (2)
has been subject to such filing  requirements for the last 90 days.
Yes [X] No [ ]

     State the number of shares  outstanding of each of the issuer's  classes of
common  equity,  as of the  latest  practicable  date:  As of August  16,  2004,
9,638,076 shares of the Company's common stock, par value $0.01 per share,  were
outstanding.

     Transitional Small Business Disclosure Format (check one) Yes [ ] No [X]


--------------------------------------------------------------------------------



PART I. FINANCIAL INFORMATION
Item 1. Consolidated Financial Statements



PATIENT INFOSYSTEMS, INC. AND SUBSIDIARIES
CONSOLIDATED BALANCE SHEETS (UNAUDITED) AS OF
ASSETS                                                                    June 30, 2004    December 31, 2003
                                                                          -------------    -----------------
CURRENT ASSETS:
                                                                                        
  Cash and cash equivalents                                                $    4,860,965     $     397,851
  Accounts receivable                                                             781,544           771,258
  Prepaid expenses and other current assets                                       125,615           156,729
                                                                          ---------------- -----------------
        Total current assets                                                    5,768,124         1,325,838

Property and equipment, net                                                       260,352           305,551

OTHER ASSETS:
  Intangible assets                                                               415,800           497,893
  Goodwill                                                                      7,004,626         6,981,876
                                                                          ---------------- -----------------

TOTAL ASSETS                                                                 $ 13,448,902       $ 9,111,158
                                                                          ================ =================

LIABILITIES AND STOCKHOLDERS' EQUITY

CURRENT LIABILITIES:
  Bank overdraft                                                              $      -        $     189,608
  Accounts payable                                                              1,173,673         1,337,862
  Accrued salaries and wages                                                      464,935           442,299
  Accrued expenses                                                                250,683         1,043,247
  Accrued dividends                                                               905,692           490,756
  Current maturities of long-term debt                                             35,148           294,117
  Deferred revenue                                                                142,809           336,598
                                                                          ---------------- -----------------
        Total current liabilities                                               2,972,940         4,134,487
                                                                          ---------------- -----------------

LINE OF CREDIT                                                                  3,000,000         3,000,000
LONG-TERM DEBT                                                                     27,741            40,295

STOCKHOLDERS' EQUITY:
  Preferred stock - $.01 par value:  shares authorized: 20,000,000
    Series C, 9% cumulative, convertible, issued and outstanding - 75,000
       as of June 30, 2004, 100,000 as of December 31, 2003                           750             1,000
    Series D, 9% cumulative, convertible, issued and outstanding - 840,118
       as of June 30, 2004, 830,100 as of December 31, 2003                         8,401             8,301
  Common stock - $.01 par value:  shares authorized:
     80,000,000; issued and outstanding - 9,638,067 as of June 30, 2004,
        4,960,354 as of December 31, 2003                                          96,381            49,604
  Additional paid-in capital                                                   53,365,081        45,596,684
  Unearned debt issuance cost                                                   (742,625)              -
  Accumulated deficit                                                        (45,279,767)      (43,719,213)
                                                                          ---------------- -----------------
        Total stockholders' equity                                              7,448,221         1,936,376
                                                                          ---------------- -----------------

TOTAL LIABILITIES AND STOCKHOLDERS' EQUITY                                   $ 13,448,902       $ 9,111,158
                                                                          ================ =================


See notes to unaudited consolidated financial statements.








PATIENT INFOSYSTEMS, INC. AND SUBSIDIARIES
CONSOLIDATED STATEMENTS OF OPERATION (UNAUDITED)
                                                Three Months Ended                  Six Months Ended
                                                     June 30,                           June 30,
                                              2004              2003             2004              2003
                                              ----              ----             ----              ----
REVENUES
                                                                                   
  Disease and demand management fees      $ 1,679,726       $ 1,580,037     $  4,024,153       $ 2,527,716
  Ancillary benefits management fees        1,393,196              -           3,069,706              -
                                         ------------- ----------------- ---------------- -----------------
       Total revenues                       3,072,922         1,580,037        7,093,859         2,527,716
                                         ------------- ----------------- ---------------- -----------------
COSTS AND EXPENSES
  Cost of sales                             2,605,933         1,184,855        5,776,638         1,946,457
  Sales and marketing                         326,511           202,458          697,633           445,061
  General and administrative                  628,970           296,842        1,645,831           572,311
  Research and development                     25,627            33,470           58,234            65,228
                                         ------------- ----------------- ---------------- -----------------
        Total costs and expenses            3,587,041         1,717,625        8,178,336         3,029,057
                                         ------------- ----------------- ---------------- -----------------
OPERATING LOSS                              (514,119)         (137,588)      (1,084,477)         (501,341)
OTHER EXPENSE
  Financing cost                            (171,375)         (713,846)        (342,750)         (713,846)
  Interest expense, net                      (25,180)         (154,764)         (55,146)         (296,217)
                                         ------------- ----------------- ---------------- -----------------
NET LOSS                                    (710,674)       (1,006,198)      (1,482,373)       (1,511,404)
CONVERTIBLE PREFERRED STOCK DIVIDENDS       (205,902)       (1,489,818)        (493,116)       (1,512,318)
                                         ------------- ----------------- ---------------- -----------------
NET LOSS ATTRIBUTABLE TO
  COMMON STOCKHOLDERS                     $ (916,576)      $(2,496,016)     $(1,975,489)      $(3,023,722)
                                         ============= ================= ================ =================
NET LOSS PER SHARE - BASIC AND DILUTED    $    (0.14)      $     (2.73)     $     (0.33)      $     (3.31)
                                         ============= ================= ================ =================
WEIGHTED AVERAGE COMMON  SHARES             6,589,015           913,009        5,972,007           913,005
                                         ============= ================= ================ =================


See notes to unaudited consolidated financial statements.







PATIENT INFOSYSTEMS, INC. AND SUBSIDIARIES
CONSOLIDATED STATEMENTS OF CASH FLOWS (UNAUDITED)
                                                                          Six Months      Six Months
                                                                             Ended           Ended
                                                                         June 30, 2004   June 30, 2003
OPERATING ACTIVITIES:
                                                                                 
  Net loss                                                              $ (1,482,373)  $ (1,511,404)
  Adjustments to reconcile net loss to net cash used in
    operating activities:
      Depreciation and amortization                                           517,683        874,205
      Compensation expense related to warrants                                234,275           -
      Increase) in accounts receivable                                       (10,286)      (113,814)
      Decrease (increase) in prepaid expenses and other current assets         31,114       (16,080)
      (Increase) decrease in accounts payable                               (164,189)        191,089
      Increase in accrued salaries and wages                                   22,636         17,169
      (Decrease) increase in accrued expenses                               (792,564)        228,815
      Decrease in deferred revenue                                          (193,789)       (24,036)
                                                                        -------------- --------------
            Net cash used in operating activities                         (1,837,493)      (354,056)
                                                                        -------------- --------------
INVESTING ACTIVITIES:
  Property and equipment additions                                           (51,849)       (25,932)
  Property and equipment disposals and retirements                              4,206          -
  Increase in notes receivable                                                   -       (2,050,000)
                                                                        -------------- --------------
          Net cash used in investing activities                              (47,643)    (2,075,932)
                                                                        -------------- --------------
FINANCING ACTIVITIES:
  Borrowing from directors, net                                                 -          1,050,000
  Borrowing from stockholders                                                   -          1,600,000
  Decrease in bank overdraft                                                (189,608)           -
  Payment of debt                                                           (271,523)           -
  Proceeds from the sale of capital stock                                   7,343,039             36
  Offering costs related to the sale of capital stock                       (533,658)           -
                                                                        -------------- --------------
            Net cash provided by financing activities                       6,348,250      2,650,036
                                                                        -------------- --------------

NET INCREASE IN CASH AND CASH  EQUIVALENTS                                  4,463,114        220,048

CASH AND CASH EQUIVALENTS AT  BEGINNING OF PERIOD                             397,851          5,011
                                                                        -------------- --------------

CASH AND CASH EQUIVALENTS AT  END OF PERIOD                             $  4,860,965   $    225,059
                                                                        =============  ============

Supplemental disclosures of non-cash information
  Dividend declared on Convertible Preferred Stock                      $    414,936   $     62,126
                                                                        =============  ============
  Beneficial conversion feature of Convertible Preferred Stock          $     78,180   $  1,450,192
                                                                        =============  ============
  Portion of Finance Cost recorded as debt discount                                    $    713,846
                                                                                       ============
  Fair market value of:
    Warrants issued as an offering cost of sale of Common Stock         $    288,913
                                                                        ============
    Warrants issued as acquisition expense                              $     22,750
                                                                        ============
    Warrants issued for debt guarantee                                  $  1,085,375
                                                                        ============
    Common Stock issued for services                                    $    128,250
                                                                        ============


See notes to unaudited consolidated financial statements.






PATIENT INFOSYSTEMS, INC. AND SUBSIDIARIES


Notes to Unaudited  Consolidated  Financial Statements for the period ended June
30, 2004

1.   The consolidated  financial  statements include the accounts of the Company
     and its wholly owned subsidiaries,  Patient Infosystems Canada, Inc., which
     ceased operations in January 2001 and American  Caresource  Holdings,  Inc.
     ("ACS")  which was  created  in  December  2003.  Significant  intercompany
     transactions and balances have been eliminated in consolidation.

     Acquisition - On December 31, 2003, the Company acquired  substantially all
     the assets and liabilities of American  Caresource  Corporation for a total
     purchase price of $5,754,866.  The Company recorded this acquisition  using
     the purchase method of accounting and therefore,  the operations of ACS are
     included only since the date of the acquisition.

     The accompanying  consolidated  financial  statements for the three and six
     month  periods  ended June 30,  2004 and June 30,  2003 are  unaudited  and
     reflect all adjustments  (consisting only of normal recurring  adjustments)
     which are, in the opinion of management,  necessary for a fair presentation
     of the financial  position and operating  results for the interim  periods.
     These  unaudited  consolidated  financial  statements  should  be  read  in
     conjunction with the audited  consolidated  financial  statements and notes
     thereto,  together with  management's  discussion and analysis of financial
     condition  and results of  operations  contained  in the  Company's  Annual
     Report  on Form  10-KSB  for the year  ended  December  31,  2003.  Certain
     reclassifications  of  2003  amounts  have  been  made to  conform  to 2004
     presentations. The results of operations for the three and six months ended
     June 30, 2004 are not necessarily  indicative of the results for the entire
     year ending December 31, 2004.

     All share and per share information  contained herein gives effect to the 1
     for 12 reverse stock split which was effective as of January 9, 2004.

     The calculations for the basic and diluted loss per share for the three and
     six month periods  ended June 30, 2004 and 2003 did not include  options to
     purchase, respectively, 1,442,127 and 92,877 shares of common stock nor the
     common  equivalent  shares  issuable  upon  conversion  of the  75,000  and
     840,118,  respectively,  shares of Series C and  Series D  Preferred  Stock
     which were outstanding  because the effect would have been antidilutive due
     to the net loss in those periods.  The computation of basic and diluted net
     loss per share is as follows:



                                               Three Months Ended              Six Months Ended
                                                    June 30,                       June 30,
                                                2004         2003              2004         2003
                                                ----         ----              ----         ----

                                                                             
     Net loss                                $ (710,674)  $(1,006,198)     $(1,482,373)  $(1,511,404)

     Convertible preferred Stock dividends     (205,902)  (1,489,818)         (493,116)   (1,512,318)
                                               ---------  -----------         ---------   -----------

     Net loss attributable to
          Common Stockholders                $ (916,576)  $(2,496,016)     $(1,975,489)  $(3,023,722)
                                             -----------  ------------     ------------  ------------

     Weighted average common shares            6,589,015      913,009         5,972,007      913,005
                                               ----------     --------        ---------      -------

     Net loss per share - Basic and diluted     $ (0.14)     $ (2.73)          $ (0.33)     $ (3.31)
                                                ========     ========          ========     ========


     Stock-Based  Compensation  - In 2002,  the  Company  adopted  Statement  of
     Financial   Accounting   Standards   ("SFAS")  No.  148,   "Accounting  for
     Stock-Based  Compensation  -  Transition  and  Disclosure."  This  standard
     provides alternative methods of transition for voluntary change to the fair
     value based method of accounting  for  stock-based  employee  compensation.
     Additionally,  the standard  also  requires  prominent  disclosures  in the
     Company's  financial  statements  about the method of  accounting  used for
     stock-based employee  compensation,  and the effect of the method used when
     reporting financial statements.

     The Company  accounts for stock-based  compensation in accordance with SFAS
     No. 123,  "Accounting for Stock-Based  Compensation".  As permitted by SFAS
     No. 123, the Company continues to measure compensation for such plans using
     the intrinsic  value based method of  accounting,  prescribed by Accounting
     Principles Board ("APB"),  Opinion No. 25,  "Accounting for Stock Issued to
     Employees."   Had   compensation   cost  for  the   Company's   stock-based
     compensation  plans been determined  based on the fair value at the date of
     grant for  awards  consistent  with the  provisions  of SFAS No.  123,  the
     Company's net loss and net loss per share would have been  increased to the
     pro forma amounts indicated below:




                                           Three Months Ended                 Six Months Ended
                                                June 30,                          June 30,
                                          2004            2003              2004             2003
                                          ----            ----              ----             ----
     Net loss attributable to common
                                                                            
     shareholders - as reported        $(916,576)     $(2,496,016)      $(1,975,489)    $(3,023,722)
     Stock compensation expense          (95,843)         (30,828)       (1,257,802)        (57,162)
                                     ------------- ---------------- ----------------- ---------------
     Net loss - pro forma             (1,012,419)      (2,526,844)       (3,233,291)     (3,080,884)
     Net loss per share - basic
       and diluted - as reported        $  (0.14)        $  (2.73)        $   (0.33)       $  (3.31)
                                     ============= ================ ================= ===============
     Net loss per share - basic
       and diluted - pro forma          $  (0.15)        $  (2.77)         $  (0.54)       $  (3.37)
                                     ============= ================ ================= ===============
     Weighted average common shares     6,589,015          913,009         5,972,007         913,005


     The fair value of each option grant is estimated on the date of grant using
     the  Black-Scholes  option-pricing  model using an expected life of 7 years
     and assumed risk-free interest rates of 4.35% as of June 30, 2004 and 3.79%
     as of December 31, 2003.  The assumed  dividend yield was zero. The Company
     has used a  volatility  factor  of 113% as of June  30,  2004 and 98% as of
     December 31, 2003. For purposes of pro forma disclosure, the estimated fair
     value of each option is  amortized to expense  over that  option's  vesting
     period and only the compensation expense related to the three and six month
     periods  ended June 30, 2003 and 2004 were used to adjust the net loss on a
     pro forma basis.

2.   On December 31, 2003,  the Company  entered into the Third  Addendum to the
     Second  Amended and Restated  Credit  Agreement  with Well Fargo Bank Iowa,
     N.A., which extended the term of the $3,000,000 credit facility to July 31,
     2005. Dr. Schaffer and Mr. Pappajohn,  directors of the Company, guaranteed
     this extension. In consideration of their guarantees,  in February 2004 the
     Company granted to Dr. Schaffer and Mr.  Pappajohn  warrants to purchase an
     aggregate of 47,500 shares of Series D Convertible  Preferred Stock,  which
     are convertible into an aggregate of 475,000 shares of the Company's common
     Stock for $10.00 per preferred  share. The Company valued these warrants at
     $1,085,375 using the Black-Scholes  method. The value of these warrants was
     recorded as unearned debt issuance costs and will be amortized as financing
     costs over the  nineteen  month  period of the loan  guarantee.  During the
     three and six months ended June 30, 2004, the Company  recorded a financing
     cost of $171,375 and $342,750, respectively.

3.   On March 28, 2004, Mr.  Pappajohn and Dr.  Schaffer  signed a letter to the
     Company in which they made a commitment to obtain the operating  funds that
     the Company  believes  would be sufficient to fund its  operations  through
     January 1, 2005. There can be no assurances given that Mr. Pappajohn or Dr.
     Schaffer can raise either the required  working capital through the sale of
     the  Company's  securities  or that the Company  can borrow the  additional
     amounts needed.

4.   During  the six month  period  ended  June 30,  2004,  the  Company  issued
     4,427,713  shares of its  common  stock and  10,018  shares of its Series D
     Convertible Preferred Stock to certain investors in exchange for $7,471,289
     which  consisted  of  $7,263,200  of  working  capital,  $53,180 of accrued
     interest  payable,  $26,659 of debt and $128,250 of  services.  The Company
     incurred $533,658 of costs directly  attributable to the sale of its common
     stock.

     During the six month period ended June 30, 2004,  the Company paid $439,913
     of expenses by issuing  shares of its common stock and warrants to purchase
     shares of its common stock.  The Company issued 72,125 shares of its common
     stock as payment of $128,250 in consulting  expenses and issued warrants to
     placement agents to purchase 118,450 shares of its common stock at exercise
     prices  between  $1.68 and $2.75 per share.  The warrants  were assigned an
     aggregate  fair market value of $311,663  using a  Black-Scholes  valuation
     method.

     Of the warrants to purchase  118,450 shares of the Company's  common stock,
     the  issuance of warrants to purchase  12,500  shares,  assigned a value of
     $22,750,  resulted  in an  additional  expense  related to the  purchase of
     substantially all the assets of and assumption of liabilities from American
     Caresource Corporation on December 31, 2003. Accordingly,  goodwill related
     to this acquisition was increased by $22,750.



5.   During the three months ended June 30,  2004,  the Company  operated in two
     segments: (i) Patient Infoystems, which includes disease management, demand
     management and provider improvement services; and (ii) American Caresource,
     which includes ancillary benefits management  services.  Selected financial
     information  on the Company's  segments for the three and six month periods
     ended June 30, 2004 and 2003 and pro forma  combined as if the  acquisition
     had occurred as of January 1, 2003 are presented as follows:



                                                Three Months ended June 30,                Six Months ended June 30,
                                              2004          2003          2003         2004          2003           2003
                                          ------------- ------------- ------------- ------------ -------------- -------------
     Revenues                                                         Pro Forma                                 Pro Forma
                                                                                               
       Patient Infosystems, Inc.           $ 1,679,726   $ 1,580,037   $ 1,580,037  $ 4,024,153   $ 2,527,716    $ 2,527,716
       American Caresource Holdings, Inc.    1,393,196          -        2,198,514    3,069,706          -         4,780,131
                                          ------------- ------------- ------------- ------------ -------------- -------------
     Total revenue                           3,072,922     1,580,037     3,778,551    7,093,859      2,527,716     7,307,847
     Cost of goods
       Patient Infosystems, Inc.             1,264,083     1,184,855     1,184,855    2,790,678      1,946,457     1,946,457
       American Caresource Holdings, Inc.    1,341,850          -        2,578,961    2,985,960           -        5,578,364
     Selling, General and Administrative
       Patient Infosystems, Inc.               537,341       532,770       532,770    1,139,133      1,082,600     1,082,600
       American Caresource Holdings, Inc.      443,767          -          561,883    1,262,565           -        1,219,274
     Other
       Patient Infosystems, Inc.               190,658       868,610       868,610      387,430      1,010,063     1,010,063
       American Caresource Holdings, Inc.        5,897          -           43,269       10,466           -           48,727
                                          ------------- ------------- ------------- ------------ -------------- -------------
     Net loss
       Patient Infosystems, Inc.             (312,356)   (1,006,198)   (1,006,198)    (293,088)    (1,511,404)   (1,511,404)
       American Caresource Holdings, Inc.    (398,318)         -         (985,599)  (1,189,285)          -       (2,066,234)
                                          ------------- ------------- ------------- ------------ -------------- -------------
     Total net loss                          (710,674)   (1,006,198)   (1,991,797)  (1,482,373)    (1,511,404)   (3,577,638)
     Dividends                               (205,902)   (1,489,818)   (1,598,650)    (493,116)    (1,512,318)   (1,769,609)
                                          ------------- ------------- ------------- ------------ -------------- -------------
     Net loss attributable to
       common shareholders                   (916,576)   (2,496,016)   (3,590,447)  (1,975,489)    (3,023,722)   (5,347,247)
                                          ============= ============= ============= ============ ============== =============
     Net loss per share basic and
     diluted                                  $ (0.14)     $  (2.73)     $  (1.78)     $ (0.33)      $  (3.31)     $  (2.66)
                                          ============= ============= ============= ============ ============== =============
     Weighted average common shares          6,589,015       913,009     2,013,009    5,972,007        913,005     2,013,005



6.   The  accompanying  unaudited  consolidated  financial  statements have been
     prepared on a going concern basis,  which  contemplates  the realization of
     assets  and  the  satisfaction  of  liabilities  in the  normal  course  of
     business.  As shown in the accompanying  unaudited  consolidated  financial
     statements,  the Company incurred a net loss for the six month period ended
     June 30, 2004 of $1,482,373  and had working  capital of $2,795,184 at June
     30, 2004. These factors,  among others,  may indicate that the Company will
     be unable to continue as a going concern for a reasonable period of time.

     The  unaudited   consolidated  financial  statements  do  not  include  any
     adjustments  relating to the recoverability of assets and classification of
     liabilities  that  might be  necessary  should  the  Company  be  unable to
     continue as a going concern.  The Company's  ability to continue as a going
     concern is dependant upon its ability to generate  sufficient  cash flow to
     meet its  obligations.  Management  is currently  assessing  the  Company's
     operating   structure  for  the  purpose  of  reducing  ongoing   expenses,
     increasing  sources of revenue and is  negotiating  the terms of additional
     debt or equity financing.




Item 2.  Management's Discussion and Analysis or Plan of Operations.

     Management's  discussion  and analysis  provides a review of the  Company's
operating  results  for the three and six month  periods  ended June 30, 2004 as
compared to the three and six month  periods ended June 30, 2003 and a review of
the Company's  financial condition at June 30, 2004 as compared to June 30, 2003
and December 31, 2003. The focus of this review is on the underlying reasons for
significant  changes  and  trends  affecting  the  revenues,  net  earnings  and
financial  condition of the Company.  This review should be read in  conjunction
with the accompanying unaudited consolidated financial statements.

     In an effort to give investors a well-rounded  forward-looking  view of the
Company's current condition and future  opportunities,  this Quarterly Report on
Form 10-QSB  includes  information  from the Company's  management  about future
performance  and results.  Because they are  forward-looking,  this  information
involves  uncertainties.  These  uncertainties  include the Company's ability to
continue its operations as a result of, among other things,  continuing  losses,
working capital short falls,  uncertainties  with respect to sources of capital,
risks of market  acceptance  of or  preference  for the  Company's  systems  and
services,  competitive forces, the impact of changes in government  regulations,
general economic factors in the healthcare  industry and other factors discussed
in the Company's filings with the Securities and Exchange  Commission  including
the Company's Annual Report on Form 10-KSB for the year ended December 31, 2003.

Results of Operations

     To assist the reader's understanding of the results of operations,  each of
the  Company's  segments  will  be  presented  separately  using  the  following
segmented statement of operations,  which includes pro forma results of American
Caresource  Holdings,  Inc. for the three and six month  periods  ended June 30,
2003 for comparative purposes:



                                                         Three Months ended June 30,
                                           Patient Infosystems               American Caresource
                                         2004             2003              2004              2003
                                         ----             ----              ----              ----
                                                                                            pro forma
                                                                               
Revenues                              $1,679,726       $ 1,580,037       $ 1,393,196       $ 2,198,514
Costs and expenses
      Cost of goods                    1,264,083         1,184,855         1,341,850         2,578,961
      Sales and marketing                225,508           202,458           101,003            56,359
      General and Administrative         286,206           296,842           342,764           505,524
      Research and Development            25,627            33,470              -                 -
                                     ------------ ----------------- ----------------- -----------------
       Total costs and expenses        1,801,424         1,717,625         1,785,617         3,140,844
                                     ------------ ----------------- ----------------- -----------------
Operating loss                         (121,698)         (137,588)         (392,421)         (942,330)
Other                                  (190,658)         (868,610)           (5,897)          (43,269)
                                     ------------ ----------------- ----------------- -----------------
Net loss                               (312,356)       (1,006,198)         (398,318)         (985,599)
                                     ============ ================= ================= =================







                                                          Six Months ended June 30,
                                           Patient Infosystems               American Caresource
                                         2004             2003              2004              2003
                                         ----             ----              ----              ----
                                                                                            pro forma
                                                                               
Revenues                             $ 4,024,153       $ 2,527,716       $ 3,069,706       $ 4,780,131
Costs and expenses
      Cost of goods                    2,790,678         1,946,457         2,985,960         5,578,364
      Sales and marketing                447,518           445,061           250,115           124,587
      General and Administrative         633,381           572,311         1,012,450         1,094,687
      Research and Development            58,234            65,228                 -                 -
                                     ------------ ----------------- ----------------- -----------------
       Total costs and expenses        3,929,811         3,029,057         4,248,525         6,797,638
                                     ------------ ----------------- ----------------- -----------------
Operating Profit (loss)                   94,342         (501,341)       (1,178,819)       (2,017,507)
Other                                  (387,430)       (1,010,063)          (10,466)          (48,727)
                                     ------------ ----------------- ----------------- -----------------
Net loss                               (293,088)       (1,511,404)       (1,189,285)       (2,066,234)
                                     ============ ================= ================= =================


     PATIENT INFOSYSTEMS

     Revenues

     Revenues  consist of revenues  from  operations  and other  fees.  Revenues
increased to $1,679,726 from  $1,580,037  during the three months ended June 30,
2004 and 2003,  respectively,  or 6%.  Revenues  increased  to  $4,024,153  from
$2,527,716 during the six months ended June 30, 2004 and 2003, respectively,  or
59%.



                                      Three Months Ended                 Six Months Ended
                                           June 30,                          June 30,
Revenues                            2004             2003             2004              2003
--------                            ----             ----             ----              ----
Operations Fees
                                                                        
  Provider Improvement          $ 1,165,916        $ 927,854      $ 3,024,019       $ 1,297,850
  Disease and demand management     505,425          643,074          989,063         1,192,381
                               ------------- ---------------- ---------------- -----------------
Total Operations Fees             1,671,341        1,570,928        4,013,082         2,490,231
Other Fees                            8,385            9,109           11,071            37,485
                               ------------- ---------------- ---------------- -----------------

Total Revenues                  $ 1,679,726      $ 1,580,037      $ 4,024,153       $ 2,527,716
                               ------------- ---------------- ---------------- -----------------


     Provider   innovations   and   improvement   fee  revenues  are   primarily
attributable  to  assistance  provided to  organizations  for the  management of
patients  with  chronic  disease,   including  information  technology  support,
learning  organization   services  and  data  analysis  and  reporting.   For  a
substantial  part of its innovation and improvement  work,  Patient  Infosystems
provides   services  as  a   subcontractor   to  the  Institute  for  Healthcare
Improvement.  Provider  improvement  fee  revenues  for the  three and six month
periods   ended  June  30,  2004   increased  to  $1,165,916   and   $3,024,019,
respectively,  as compared to $927,854 and  $1,297,850  for the same  respective
periods  of 2003.  The  Company  does not have a long  term  agreement  with the
Institute for Healthcare Improvement and no assurances can be given that Patient
Infosystems will continue to provide these services at the current levels, or at
all.  Revenue  recognized  during the three and six month periods ended June 30,
2004 are not necessarily indicative of the results to be expected for the entire
year ending December 31, 2004. The contracts for  substantially all the provider
improvement services are annual in nature, the largest of which ended as of June
30,  2004.  Patient  Infosystems  anticipates  renewing  this  contract  and  is
therefore  continuing to provide these services during the renewal  process.  No
assurance can be given that the contract will be renewed.

     Disease and demand  management fee revenues are primarily  attributable  to
the operation of Patient  Infosystems' call center and the delivery of Care Team
Connect for Health  directly to  patients.  Disease  and demand  management  fee
revenues for the three and six month  periods  ended June 30, 2004  decreased to
$505,425 and $989,063,  respectively, as compared to $643,074 and $1,192,381 for
the same  respective  periods of 2003.  The  decrease in these fees is primarily
attributable  to the  termination  of one  customer  on July 1,  2003 for  which
Patient  Infosystems  had $113,560 and $274,179 of revenue  during the three and
six month  periods ended June 30, 2003,  respectively.  Patient  Infosystems  is
actively  marketing its disease and demand  management  services and anticipates
continuing  to sell  its  services.  No  assurances  can be given  that  Patient
Infosystems will be able to sell its demand and disease management services, or,
to the extent there are sales,  that any such sales will have a material  effect
on the financial status of Patient Infosystems.

     Other fee revenues for the three and six month  periods ended June 30, 2004
were $8,385 and $11,071, respectively, as compared to $9,109 and $37,485 for the
same respective periods of 2003. Patient Infosystems received other revenues for
(i)  development   fees  from  a  variety  of  customers  for  creation  of,  or
modification to, specific  programs and (ii) license fees.  Patient  Infosystems
has completed substantially all services under these agreements. Development fee
revenues include clinical,  technical and operational  design or modification of
Patient Infosystems'  primary disease management  programs.  Patient Infosystems
anticipates  that revenue from  development  fees will continue to be low unless
Patient Infosystems enters into new development agreements.  Patient Infosystems
has not  entered  into any new  licensing  agreements  and the  revenue  for the
current  period  reflects  revenue  generated   exclusively  from  the  existing
agreements.

     Costs and Expenses

     Cost of sales includes salaries and related benefits,  services provided by
third  parties,  and  other  expenses  associated  with the  implementation  and
delivery of Patient  Infosystems'  provider  improvement  and demand and disease
management  programs.  Cost of sales for the three and six month  periods  ended
June 30,  2004 were  $1,264,083  and  2,790,678,  respectively,  as  compared to
$1,184,855 and $1,946,457 for the same respective  periods of 2003. The increase
in these  costs was  primarily  the result of  increased  operational  activity.
Patient  Infosystems' gross margin, being total revenues over cost of sales, was
positive  for the  three an six  month  periods  ended  June 30,  2004 and 2003.
Patient  Infosystems  anticipates that revenue must increase for it to recognize
economies of scale  adequate to improve its margins.  No assurance  can be given
that  revenues  will  increase or that, if they do, they will continue to exceed
costs and expenses.

     Sales  and  marketing  expenses  consist  primarily  of  salaries,  related
benefits,  travel costs,  sales materials and other marketing  related expenses.
Sales and  marketing  expenses  for the three and six months ended June 30, 2004
were  $225,508 and $447,518,  respectively,  as compared to $202,458 and 445,061
for the  same  respective  periods  of  2003.  Patient  Infosystems  anticipates
expansion of Patient  Infosystems' sales and marketing staff and expects it will
continue to invest in the sales and  marketing  process,  and that such expenses
related to sales and marketing may increase in future periods.

     General  and  administrative   expenses  include  the  costs  of  corporate
operations,  finance and accounting, human resources and other general operating
expenses of Patient  Infosystems.  General and  administrative  expenses for the
three and six month  periods  ended June 30,  2004 were  $286,206  and  633,381,
respectively,  as compared  to $296,842  and  $572,311  for the same  respective
periods of 2003. These expenditures have been incurred to maintain the corporate
infrastructure necessary to support anticipated program operations.  General and
administrative  expenses  are expected to remain  relatively  constant in future
periods.

     Research and development expenses consist primarily of salaries and related
benefits and  administrative  costs  associated  with the development of certain
components of Patient Infosystems'  integrated  information capture and delivery
system,  as well as development  of Patient  Infosystems'  standardized  disease
management programs and Patient Infosystems' Internet based technology products.
Research and development expenses for the three and six month periods ended June
30, 2004 were  $25,627  and  $58,234,  respectively,  as compared to $33,470 and
$65,228 for the same respective periods of 2003.

     Patient  Infosystems  recorded  other  expenses for the three and six month
periods ended June 30, 2004 of $190,658 and $387,430,  respectively, as compared
to $868,610  and  $1,010,063  for the same  respective  periods of,  2003.  This
increase was principally due to the interest expense and other related financing
cost on debt.

     Patient  Infosystems  had a net loss for the three  and six  month  periods
ended June 30,  2004 of  $312,356  and  $293,088,  respectively,  as compared to
$1,006,198 and $1,511,404 for the same respective periods of 2003.

     AMERICAN CARESOURCE

     Revenues

     Revenues of American  Caresource  Holdings,  Inc.  ("ACS") are comprised of
revenues from ancillary service claims and processing of patient claims.  ACS is
the  wholly-owned  subsidiary  of Patient  Infosystems,  which  holds the assets
acquired  from  American  Caresource  Corporation  following the closing of such
acquisition on December 31, 2003.  Revenues  decreased to $1.4 million from $2.2
million during the three months ended June 30, 2004 and 2003,  respectively,  or
37%. Revenues  decreased to $3.1 million from $4.8 million during the six months
ended June 30, 2004 and 2003, respectively, or 36%.



                                    Three Months Ended                         Six Months Ended
                                          June 30                                   June 30
Revenues                        2004                 2003                 2004                 2003
--------                        ----                 ----                 ----                 ----
                                                  Pro forma                                 Pro forma
                                                                               
Ancillary Health            $ 1,266,631          $ 2,100,625          $ 2,811,479          $ 4,577,569
Patient Claims                  126,565               97,889              258,227              202,562
                          --------------- -------------------- -------------------- --------------------
Total Revenues              $ 1,393,196           $2,198,514          $ 3,069,706           $4,780,131


     Ancillary  health claims  revenue for the three and six month periods ended
June 30, 2004 decreased to $1,266,631 and $2,811,479,  respectively, as compared
to $2,100,625  and  $4,577,569  for the same  respective  periods of 2003.  This
decrease is primarily  attributable  to the  cancellation  of contracts by major
clients and the  reduction of revenue from certain  providers in ACS'  ancillary
health  provider  network.  Pinnacol  Assurance  ("Pinnacol")  notified  ACS  on
December 19, 2003 of its intent to terminate  its  contract  with ACS  effective
March 18, 2004.  This  contract  was winding down through the first  quarter and
into the second  quarter of 2004.  Revenue  for  Pinnacol  decreased  97.2% from
$955,530 and 70.9% from  $1,936,799  for the three and six month  periods  ended
June 30, 2003, respectively, to $27,007 and $563,042 for the three and six month
periods  ended  June 30,  2004,  respectively.  Plan  Vista,  for  which ACS had
$129,748 and $444,169 of revenue for the three and six month  periods ended June
30, 2003,  respectively,  notified  ACS of its intent to terminate  its contract
effective  October 13, 2004 and did not  generate any revenue for ACS during the
six month period ended June 30 2004.  Terminations  of contracts  with these two
major  providers  resulted in a decrease of revenue of $169,330 and $557,513 for
the three and six month periods ended June 30, 2003,  respectively.  ACS expects
relations  with  providers  in  its  network  to  improve  as a  result  of  the
acquisition  by Patient  Infosystems.  ACS also  expects to expand its  provider
network by seeking to restore  relationships  with  providers  previously in the
network  and add new  providers  as ACS  adds new  client  payor  contracts.  No
assurances   can  be  given  that  ACS  will   expand  its   provider  or  payor
relationships, or that, to the extent such expansion occurs, that such expansion
will result in an improvement in the results of operations of ACS.

     The  processing  of  patient  claims  revenues  for the three and six month
periods ended June 30, 2004 increased  29.3% to $126,565 and increased  27.5% to
$258,227,  respectively,  as  compared  to  $97,889  and  $202,562  for the same
respective  periods of 2003.  ACS does not expect to increase its revenues  from
claims processing in future periods.



     Costs and Expenses

     Cost of revenues includes provider  payments,  direct expenses incurred for
providing  services and the related  direct labor and overhead of providing such
services.  ACS is not  liable for costs  incurred  by its  contracted  providers
unless and until these providers obtain approval from the appropriate payors and
provide the contracted services and ACS receives payment from the payors.  Costs
of revenues also include direct expenses to administer claims,  including direct
labor  associated  with  recruitment and  contracting  with providers,  database
maintenance,  data entry of claims,  claims repricing,  fulfillment and overhead
costs. Costs of revenues for the three and six month periods ended June 30, 2004
decreased to $1,341,850 and $2,985,960,  respectively, as compared to $2,578,961
and $5,578,364 for the same respective periods of 2003. This decrease was due to
a decrease in provider payments, renegotiation of management fees payable to one
client,  and to a reduction in direct expenses and overhead  associated with the
decrease in claims  volume  related to  revenue.  Provider  payments  related to
revenues  during the three and six month periods  ended June 30, 2004  decreased
$813,176 and $1,628,830, respectively as compared to the same respective periods
of 2003.  Management fees for services  rendered to ppoNEXT during the three and
six  month  periods  ended  June  30,  2004  decreased   $85,866  and  $213,039,
respectively,  as compared to the same  respective  periods of 2003, as contract
changes  negotiated  in July 2003 took effect upon the  acquisition  of American
Caresource  Corporation  by Patient  Infosystems.  Direct  expenses and overhead
associated  with ACS service  provision  during the three and six month  periods
ended June 30, 2004 decreased $353,488 and $713,897,  respectively,  as compared
to the same respective periods of 2003, as reductions were made to personnel and
other costs to align ACS' cost structure with its claims volume.

     Sales and marketing  expenses  include the salaries and related benefits of
ACS' account development employees,  travel and other costs for those employees,
and sales  materials and other  marketing or sales expenses of ACS.  Commissions
paid to  independent  outside  salespeople  are based directly on net margin per
client.  Payments to providers and all billing and processing of claims expenses
are included in cost of revenues. Sales and marketing expenses for the three and
six month  periods ended June 30, 2004  increased to $101,003 and  $250,115,  as
compared to $56,359 and $124,587 for the same  respective  periods of 2003.  The
increase in the second quarter was attributable to additional  salary expense of
$42,070 as ACS expanded its sales and marketing staff. The year-to-date increase
also  includes  a $59,480  salary  accrual  related  to the  termination  of one
employee.  ACS  anticipates  continued  investment  in the sales  and  marketing
process,  and that  expenses  related to sales and  marketing  may  continue  to
increase in future periods.

     General  and  administrative  expenses  include  the  salaries  and related
benefits  of ACS'  executive  employees,  systems  development  and  finance and
accounting  employees,  travel and other costs for those employees.  General and
administrative  expenses for the three and six month periods ended June 30, 2004
were  $342,764  and  1,012,450,   respectively,  as  compared  to  $505,524  and
$1,094,687 for the same respective periods of 2003.  Compared to the prior year,
legal fees  decreased  $77,577  and  $176,786  and  administrative  and  finance
compensation  expense decreased $58,445 and $109,557 for the three and six month
periods ended June 30, 2004,  respectively.  The personnel cost  reductions were
due to  consolidation  of these  functions  with Patient  Infosystems as well as
efficiencies and reductions in payment  processing  volume.  The cost reductions
were offset by a one time warrant  compensation  expense of $211,900  charged in
the  first  quarter  of 2004 as a result  of the  issuance  of a  warrant  to an
employee of American Caresource Corporation.

     ACS recorded  other  expense for the three and six month periods ended June
30, 2004 of $5,897 and $10,466, respectively, as compared to $43,269 and $48,727
for the same respective periods of 2003. Any new financing  arrangements will be
made by Patient Infosystems.  Consequently, ACS' interest expense is expected to
be minimal in future periods.

     ACS had a net loss for the three and six month  periods ended June 30, 2004
of $398,318 and $1,189,285, respectively, as compared to $985,599 and $2,066,234
for the same respective periods of 2003.

     INCOME (LOSS)

     The Company reported a net loss attributable to common shareholders for the
three  month   periods   ended  June  30,  2004  of  $916,576  and   $1,975,489,
respectively,  as compared to $2,496,016 and $3,023,722 for the same  respective
periods  of 2003.  This  represents  a loss per share of $0.14 and $0.33 for the
same  respective  periods  or 2004 as  compared  to $2.73 and $3.31 for the same
respective  periods of 2003.  The Company's loss per share for the three and six
month  periods  ended June 30,  2003,  on a pro forma basis,  assuming  that the
acquisition  of  substantially  all  the  assets  and  liabilities  of  American
Caresource  Corporation  had  occurred  on  January 1, 2003 was $1.78 and $2.66,
respectively,  as  compared  to $0.14  and  $0.33  loss per  share  for the same
respective  period of 2004.  During the six  months  ended  June 30,  2004,  the
Company  recorded a  beneficial  conversion  feature  of $78,180  related to the
issuance of 10,018 shares of the Company's Series D Preferred  Stock,  which was
recorded as a dividend,  and declared  $414,936 of dividends on the  outstanding
preferred stock.

     LIQUIDITY AND CAPITAL RESOURCES

     At June 30, 2004, the Company had working capital of $2,795,184 as compared
to a deficit of  $2,808,649 at December 31, 2003.  Through June 30, 2004,  these
amounts  reflect the effects of the  Company's  continuing  losses,  borrowings,
offset by its recent sale of capital stock. Since its inception, the Company has
primarily funded its operations,  working capital needs and capital expenditures
from the sale of equity securities or the incurrence of debt.

     On March 28, 2003, the Company  entered into an Amended and Restated Credit
Agreement  with Wells  Fargo Bank Iowa,  N.A.,  which  extended  the term of the
Company's $3,000,000 credit facility to January 2, 2004, under substantially the
same terms. Mr. Pappajohn and Dr. Schaffer, directors of the Company, guaranteed
this extension.

     On December 31, 2003,  the Company  entered into the Third  Addendum to the
Second Amended and Restated  Credit  Agreement with Well Fargo Bank Iowa,  N.A.,
which extended the term of the $3,000,000  credit facility to July 31, 2005. Mr.
Pappajohn and Dr. Schaffer guaranteed this extension.  In consideration of their
guarantees,  In  February  2004 the  Company  granted  to Dr.  Schaffer  and Mr.
Pappajohn  warrants  to  purchase  an  aggregate  of  47,500  shares of Series D
Convertible  Preferred  Stock,  convertible into 475,000 shares of the Company's
common stock for $10.00 per preferred  share.  The Company valued these warrants
at $1,085,375 using the  Black-Scholes  method.  The value of these warrants was
recorded as unearned debt issuance cost and will be amortized as financing costs
over the  nineteen  month  period of the loan  guarantee.  During the six months
ended June 30, 2004, the Company recorded a financing cost of $342,750.

     In January 2004, the Company borrowed $200,000 for working capital from Mr.
Pappajohn  which was repaid in March 2004 using the  proceeds of the sale of the
Company's  common stock.  During the three month period ended June 30, 2004, the
Company borrowed $570,000 of working capital from Mr. Pappajohn which was repaid
in June 2004 using the proceeds of the sale of the Company's common stock.

     On March 28, 2004, Mr.  Pappajohn and Dr.  Schaffer  signed a letter to the
Company in which they made a commitment to obtain the  operating  funds that the
Company  believes would be sufficient to fund its operations  through January 1,
2005.  There can be no assurances  given that Mr.  Pappajohn or Dr. Schaffer can
raise  either the required  working  capital  through the sale of the  Company's
securities or that the Company can borrow the additional amounts needed.

     During  the six month  period  ended  June 30,  2004,  the  Company  issued
4,427,713  shares  of its  common  stock  and  10,018  shares  of its  Series  D
Convertible Preferred Stock to certain investors in exchange for an aggregate of
$7,471,289 which consisted of $7,263,200 of working capital,  $53,180 of accrued
interest payable, $26,659 of debt and $128,250 of services. The Company incurred
$533,658 of costs directly attributable to the sale of its common stock.

     During the six month period ended June 30, 2004,  the Company paid $439,913
of  expenses  by issuing  shares of its common  stock and  warrants  to purchase
shares of its common stock. The Company issued 72,125 shares of its common stock
as payment of $128,250 in consulting  expenses and issued  warrants to placement
agents to purchase 118,450 shares of its common stock at exercise prices between
$1.68 and $2.75 per share.  The warrants were assigned an aggregate  fair market
value of $311,663 using a Black-Scholes valuation method.

     Of the warrants to purchase  118,450 shares of the Company's  common stock,
the issuance of warrants to purchase 12,500 shares, assigned a value of $22,750,
resulted in an additional  expense related to the purchase of substantially  all
the assets of and assumption of liabilities from American Caresource Corporation
on December 31, 2003.  Accordingly,  goodwill  related to this  acquisition  was
increased by $22,750.

     The  Company has  expended  significant  amounts to expand its  operational
capabilities, including increasing its administrative and technical costs. While
Patient  Infosystems  has both  curtailed its spending  levels and increased its
revenue,  to the extent that ACS.  revenues do not increase  substantially,  the
Company's' losses will continue and its available capital will diminish further.
The  Company's'  operations  are  currently  being  funded by the sale of equity
securities.  There can be no assurances  given that the Company can raise either
the required  working capital through the sale of its securities or that Patient
Infosystems  can borrow the additional  amounts  needed.  In such  instance,  if
Patient Infosystems is unable to identify additional sources of capital, it will
likely be forced to curtail or cease  operations.  As a result of the above, the
Independent  Auditors'  Report on Patient  Infosystems'  consolidated  financial
statements for the year ended  December 31, 2003 includes an emphasis  paragraph
indicating that Patient  Infosystems'  recurring  losses from  operations  raise
substantial  doubt  about  Patient  Infosystems'  ability to continue as a going
concern. The accompanying  consolidated  financial statements do not include any
adjustments that might result from the outcome of this uncertainty.

     INFLATION

     Inflation did not have a significant  impact on the Company's  costs during
the three and six month  periods  ended  June 30,  2004 and June 30,  2003.  The
Company  continues  to monitor the impact of  inflation in order to minimize its
effects  through  pricing   strategies,   productivity   improvements  and  cost
reductions.

     FORWARD LOOKING STATEMENTS

     When used in this and in future  filings of the Company with the Securities
and Exchange  Commission  ("SEC"),  in the Company's  press releases and in oral
statements  made with the  approval of an  authorized  executive  officer of the
Company,  the words or phrases "will likely result,"  "expects,"  "plans," "will
continue,"  "is  anticipated,"  "estimated,"  "project," or "outlook" or similar
expressions  (including  confirmations by an authorized executive officer of the
Company  of any such  expressions  made by a third  party  with  respect  to the
Company)  are  intended  to  identify  "forward-looking  statements"  within the
meaning of the Private  Securities  Litigation  Reform Act of 1995.  The Company
wishes  to  caution   readers   not  to  place   undue   reliance  on  any  such
forward-looking  statements,  each of which speak only as of the date made. Such
statements,  including those made with respect to future sources of revenue, new
customers  and control of costs and  expenses,  are subject to certain risks and
uncertainties  that  could  cause  actual  results  to  differ  materially  from
historical  earnings  and  those  presently  anticipated  or  projected.   These
uncertainties  include the  Company's  ability to continue its  operations  as a
result of, among other things,  continuing losses,  working capital short falls,
uncertainties with respect to sources of capital,  risks of market acceptance of
or preference for the Company's systems and services,  competitive  forces,  the
impact of changes in government  regulations,  general  economic  factors in the
healthcare  industry and other factors  discussed in the Company's  filings with
the SEC including the Company's  Annual Report on Form 10-KSB for the year ended
December 31, 2003. The Company has no obligation to publicly  release the result
of any revisions, which may be made to any forward-looking statements to reflect
anticipated or unanticipated events or circumstances occurring after the date of
such statements.






Item 3. Controls and Procedures.

     Our management,  with the  participation of our Chief Executive Officer and
Vice  President,  Financial  Planning,  has evaluated the  effectiveness  of our
disclosure  controls  and  procedure  as of  June  30,  2004.  Based  upon  this
evaluation,  our Chief Executive Officer and Vice President,  Financial Planning
concluded  that  our  disclosure  controls  and  procedures  are  effective  for
recording, processing, summarizing and reporting the information we are required
to disclose in the reports we file under the  Securities  Exchange  Act of 1934,
within the time periods  specified in the SEC's rules and forms. Such evaluation
did not  identify any change in our internal  control over  financial  reporting
that  occurred  during  the  quarter  ended  June 30,  2004 that has  materially
affected, or is reasonably likely to affect, our internal control over financial
reporting.

PART II - OTHER INFORMATION

Item 1.  Legal Proceedings

     A former  employee of American  Caresource  Corporation  filed a lawsuit on
June 16,  2004  entitled  Schrier  v.  American  Caresource  Corporation,  (Ind.
Superior  Ct.),  alleging  that  she  was  terminated  on  February  5,  2003 in
retaliation for refusing to engage in illegal conduct. She alleges that American
Caresource Corporation engaged in various activities that would have constituted
violations of agreements with customers, various laws, rules and regulations and
would have resulted in inaccurate  financial  information  being provided to the
Company in  connection  with the  acquisition  transaction.  The  plaintiff  has
demanded damages of $123,000. We have conducted a preliminary investigation into
the  allegations  and  ACS and we  intend  to  contest  the  plaintiff's  claims
vigorously.


Item 2. Changes in Securities and Use of Proceeds

     Recent Sales of Unregistered Securities

     On June 17, 2004, the Company sold 3,365,000  shares of its common stock to
institutional and other accredited  investors for an aggregate purchase price of
$5,653,200.  C.E. Unterberg, Towbin acted as placement agent in the transaction.
C.E.  Unterberg,  Towbin was paid  $360,158 in fees and  expenses and received a
warrant to purchase  93,450 shares of the Company's  common stock at an exercise
price of $1.68 per share.  In addition,  Lipman  Capital Group  received  50,000
shares of the Company's  common stock in  connection  with  consulting  services
relating to the  transaction.  Derace  Shaffer,  the  Company's  Chairman of the
Board, purchased 100,000 shares of common stock in the private placement.

     As a result of the June 17, 2004  transaction,  the  Company was  obligated
pursuant  to the  anti-dilution  provisions  in the  Company's  agreements  with
certain  stockholders  who purchased the Company's  securities  during the first
quarter of 2004, to issue an additional  155,161  shares of common stock to such
stockholders  such that the effective price per share for the shares  originally
purchased by those  stockholders  would be $1.68,  being the price per share for
the stock sold on June 17, 2004.

     The  securities  issued by the  Company  on June 17,  2004  were  issued in
reliance upon the exemption from the registration requirements of the Securities
Act of 1933  ("Securities  Act"), as set forth in section 4(2) of the Securities
Act and Rule  506 of  Regulation  D  promulgated  thereunder.  All  persons  and
entities who received the Company's  securities  represented to the Company that
they were accredited  investors and were acquiring the securities for investment
and not distribution  and that they could bear the risks of the investment.  The
Company provided written  disclosure that the securities had not been registered
under  the  Securities  Act and  that  any  resale  must be made  pursuant  to a
registration or an available exemption from registration.


Item 6. Exhibits and Reports on Form 8-K


Exhibit #     Description of Exhibits


3.1--   Certificate of Amendment to the Certificate of Incorporation

3.2 *   By-Laws

4.1--   Patient Infosystems, Inc. Amended and Restated Stock Option Plan

4.2 *** Certificate of Designations, Powers, Preferences and Relative,
        Participating, Optional or Other Special Rights, and the Qualifications,
        Limitations Thereof of the Series C Preferred Stock of Patient
        InfoSystems, Inc.

4.3     Certificate of Designations, Powers, Preferences and Relative,
        Participating, Optional or Other Special Rights, and the Qualifications,
        Limitations Thereof of the Series D Preferred Stock of Patient
        InfoSystems, Inc.

10.20 + Lease Agreement dated as of February 22, 1995 between Patient
        Infosystems and Conifer Prince Street Associates.

10.21 + First Addendum to Lease Agreement dated as of August 22, 1995 between
        Patient Infosystems and Conifer Prince Street Associates.

10.22 + Second Addendum to Lease Agreement dated as of November 17, 1995 between
        Patient Infosystems and Conifer Prince Street Associates.

10.23 + Third Addendum to Lease Agreement dated as of March 28, 1996 between
        Patient Infosystems and Conifer Prince Street Associates.

10.24 + Fourth Addendum to Lease Agreement dated as of October 29, 1996 between
        Patient Infosystems and Conifer Prince Street Associates.

10.25 + Fifth Addendum to Lease Agreement dated as of November 30, 1996 between
        Patient Infosystems and Conifer Prince Street Associates.

10.26 + Sixth Addendum to Lease Agreement dated as of November 24, 1997 between
        Patient Infosystems and Conifer Prince Street Associates.

10.30 ++ Seventh Addendum to Lease Agreement dated as of June 16, 1999 between
        Patient Infosystems and Conifer Prince Street Associates.

10.33 ++ Revolving Note dated as of December 23, 1999 between Patient
        Infosystems and Norwest Bank Iowa, National Association.

10.34 ++ Credit Agreement dated as of December 23, 1999 between Patient
        Infosystems and Norwest Bank Iowa, National Association.

10.35 ++ Security Agreement dated as of December 23, 1999 between Patient
        Infosystems and Norwest Bank Iowa, National Association.

10.36 ++ Arbitration Agreement dated as of December 23, 1999 between Patient
        Infosystems and Norwest Bank Iowa, National Association.

10.37 ++ Financing Statement executed by Patient Infosystems and Norwest Bank
        Iowa, National Association.

10.38 ++ First Amendment to Credit Agreement dated as of March 21, 2000 between
        Patient Infosystems and Norwest Bank Iowa, National Association.

10.39 ++ Note Modification Agreement dated as of March 21, 2000 between Patient
        Infosystems and Norwest Bank Iowa, National Association.

10.41 *** Form of Subscription Agreement dated on or about March 31, 2000
        between Patient Infosystems and John Pappajohn, Derace Schaffer, Gerald
        Kirke and Michael Richards for Series C 9% Cumulative Convertible
        Preferred Stock.

10.42 *** Form of Registration Rights Agreement dated on or about March 31, 2000
        between Patient Infosystems and John Pappajohn, Derace Schaffer, Gerald
        Kirke and Michael Richards for Series C 9% Cumulative Convertible
        Preferred Stock.

10.43 *** Eighth Addendum to Lease Agreement dated as of December 8, 2000
        between Patient Infosystems and Conifer Prince Street Associates.

10.45 *** Amended and Restated Credit Agreement dated as of March 28, 2001
        between Patient Infosystems and Wells Fargo Bank Iowa, National
        Association.

10.46 *** Revolving Note dated as of March 28, 2001 between Patient Infosystems
        and Wells Fargo Bank Iowa, National Association.

10.47 *** Form of Promissory Notes payable to Dr. Schaffer and Mr. Pappajohn.

10.48 *** Form of Security Agreements with Dr. Schaffer and Mr. Pappajohn.

10.49 *** Ninth Addendum to Lease Agreement dated as of January 7, 2002 between
        Patient Infosystems and Conifer Prince Street Associates.

10.50 # Letter of Agreement dated as of March 25, 2002 between Patient
        Infosystems, John Pappajohn and Derace Schaffer.

10.51 # Second Amended and Restated Credit Agreement dated as of March 28, 2002
between Patient Infosystems and Wells Fargo Bank Iowa, National Association.

10.52 # Revolving Note dated as of March 28, 2002 between Patient Infosystems
        and Wells Fargo Bank Iowa, National Association.

10.53 # Security Agreement dated as of March 28, 2002 between Patient
        Infosystems and Wells Fargo Bank Iowa, National Association.

10.54 ## Addendum to Amended and Restated Credit Agreement dated as of June 28,
        2002 between Patient Infosystems and Wells Fargo Bank Iowa, National
        Association.

10.55 ## Agreement for Purchase and Sale of Assets dated as of September 23,
        2002 between Patient Infosystems and American CareSource Corporation.

10.56 ### Tenth Addendum to Lease Agreement dated as of June 24, 2002 between
        Patient Infosystems and Conifer Prince Street Associates.

10.57 ### Eleventh Addendum to Lease Agreement dated as of December 30, 2002
        between Patient Infosystems and Conifer Prince Street Associates.

10.58 ### Letter of Agreement dated as of March 28, 2003 between Patient
        Infosystems, John Pappajohn and Derace Schaffer.

10.59 ### Second Addendum to Second Amended and Restated Credit Agreement dated
        as of March 28, 2003 between Patient Infosystems and Wells Fargo Bank,
        National Association.

10.60 ### Modification Agreement dated as of March 28, 2003 between Patient
        Infosystems and Wells Fargo Bank, National Association.

10.61 ^ Amended and Restated Agreement for the Purchase and Sale of Assets among
        Patient Infosystems, Inc., American Caresource Corporation, formerly
        known as Health Data Solutions, and the Stockholders Signatory hereto,
        dated April 10, 2003.

10.62 ^ Note and Stock Purchase Agreement between Patient Infosystems, Inc. and
        a group of investors, dated April 10, 2003.

10.63 ^ Patient Infosystems, Inc. Series D Convertible Preferred Stock
        Registration Right Agreement dated April 10, 2003.

10.64 ^ Credit Agreement between American Caresource Corporation and Patient
        Infosystems, Inc. dated April 10, 2003.

10.65 ^^ Twelfth Addendum to Lease Agreement dated as of April 28, 2003 between
        Patient Infosystems and Conifer Prince Street Associates.

10.66 ^^ Thirteenth Addendum to Lease Agreement dated as of June 27, 2003
        between Patient Infosystems and Conifer Prince Street Associates.

10.67 ^^^ Amendment No. 1 to the Amended and Restated Agreement for the Purchase
        and Sale of Assets dated as of July 30, 2003 between Patient Infosystems
        and American Caresource Corporation.

10.68 ^^^ Amendment No. 1 to the Note and Stock Purchase Agreement dated as of
        September 11, 2003 between Patient Infosystems and a group of investors.

10.69 ^^^ Amendment No. 1 to the Credit Agreement dated as of July 30, 2003
        between Patient Infosystems and American Caresource Corporation.

10.70 ^^^ Amendment No. 2 to the Amended and Restated Agreement for the Purchase
        and Sale of Assets dated as of October 8, 2003 between Patient
        Infosystems and American Caresource Corporation.

10.71 -- Third Addendum to Second Amended and Restated Credit Agreement dated as
        of December 31, 2003 between Patient Infosystems and Wells Fargo Bank,
        National Association.

10.72-- Form of Securities Purchase Agreement.

10.73   Fourteenth  Addendum to Lease  Agreement  dated as of May 18, 2004
        between Patient Infosystems and Conifer Prince Street Associates.

10.74   Form of Securities Purchase Agreement.

31.1    Certification of the Chief Executive Officer pursuant to Section 302 of
        the Sarbanes-Oxley Act of 2002.

31.2    Certification of the Principal Accounting Officer pursuant to Section
        302 of the Sarbanes-Oxley Act of 2002.

32.1    Certification pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.


--   Previously filed with the Securities and Exchange  Commission as an Exhibit
     to the Annual Report on Form 10-K filed on March 30, 2004 and  incorporated
     herein by reference.

*    Previously filed with the Securities and Exchange  Commission as an Exhibit
     to the  Registration  Statement  on Form  S-1  filed  on July 3,  1996  and
     incorporated herein by reference.

**   Previously filed with the Securities and Exchange  Commission as an Exhibit
     to the  Registration  Statement  on  Form  S-8  filed  on May 3,  2000  and
     incorporated herein by reference.

***  Previously filed with the Securities and Exchange  Commission as an Exhibit
     to the Annual  Report on Form 10-K filed on April 2, 2001 and  incorporated
     herein by reference.

+    Previously filed with the Securities and Exchange  Commission as an Exhibit
     to the Annual Report on Form 10-K filed on April 13, 1999 and  incorporated
     herein by reference.

++   Previously filed with the Securities and Exchange  Commission as an Exhibit
     to the Annual Report on Form 10-K filed on March 30, 2000 and  incorporated
     herein by reference.

#    Previously filed with the Securities and Exchange  Commission as an Exhibit
     to the Annual Report on Form 10-K filed on April 10, 2002 and  incorporated
     herein by reference.

##   Previously filed with the Securities and Exchange  Commission as an Exhibit
     to the  Quarterly  Report  on Form  10-Q  filed on  November  14,  2002 and
     incorporated herein by reference.

###  Previously filed with the Securities and Exchange  Commission as an Exhibit
     to the Annual Report on Form 10-K filed on March 31, 2003 and  incorporated
     herein by reference.

^    Previously filed with the Securities and Exchange  Commission as an Exhibit
     to the  Quarterly  Report  on  Form  10-QSB  filed  on  May  15,  2003  and
     incorporated herein by reference.

^^   Previously filed with the Securities and Exchange  Commission as an Exhibit
     to the  Quarterly  Report  on Form  10-QSB  filed on  August  15,  2003 and
     incorporated herein by reference.

^^^  Previously filed with the Securities and Exchange  Commission as an Exhibit
     to the  Quarterly  Report on Form  10-QSB  filed on  November  14, 2003 and
     incorporated herein by reference.

(b)  The following  current reports on Form 8-K have been filed as of August 16,
     2004:

          On April 8,  2004,  the  Company  filed a  current  report on Form 8-K
     reporting  that  the  Company  issued  a  press  release  announcing  a new
     customer.

          On April 28,  2004,  the  Company  filed a current  report on Form 8-K
     reporting a change in the Company's  independent  accountants from Deloitte
     and Touche LLP to McGladrey and Pullen LLP.

          On May 18,  2004,  the  Company  filed a  current  report  on Form 8-K
     reporting that the Company  issued a press release  regarding the Company's
     earnings for the quarter ended March 31, 2004.

          On June 18,  2004,  the  Company  filed a  current  report on Form 8-K
     reporting that the Company issued a press release  regarding the closing of
     a private placement of shares of its common stock.




SIGNATURES

In accordance with the requirements of the Securities Exchange Act of 1934, the
registrant caused this report to be signed on its behalf by the undersigned,
thereunto duly authorized.


                                                  PATIENT INFOSYSTEMS, INC.


Date: August 16, 2004           By:            /s/Kent A. Tapper
      ---------------------              -----------------------------------
                                         Name:    Kent A. Tapper
                                         Title:   Senior Vice President
                                                  (Principal Financial Officer)


Date: August 16, 2004                          /s/Roger L. Chaufournier
      ---------------------     --------------------------------------------
                                                  Roger L. Chaufournier
                                                  Director, President and
                                                  Chief Executive Officer
                                                  (Authorized Officer and
                                                  Principal Executive Officer)