FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person * Boxer Capital, LLC   2. Issuer Name and Ticker or Trading Symbol Mirati Therapeutics, Inc. [MRTX] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director __X__ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) 11682 EL CAMINO REAL, SUITE 320,  3. Date of Earliest Transaction (Month/Day/Year) 10/03/2017 (Street) SAN DIEGO, CA 92130 4. If Amendment, Date Original Filed(Month/Day/Year) 6. Individual or Joint/Group Filing(Check Applicable Line) ___ Form filed by One Reporting Person _X_ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 10/03/2017   X   189,780 A $ 7.86 1,227,774 D (1)   Common Stock 10/03/2017   X   78,186 A $ 7.86 513,630 D (2)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code (Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date (Month/Day/Year)

7. Title and Amount of Underlying Securities (Instr. 3 and 4)

8. Price of Derivative Security (Instr. 5)

9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)

11. Nature of Indirect Beneficial Ownership (Instr. 4)

Code

V

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

Warrant (right to purchase)

$ 7.86

10/03/2017

X

189,780

11/21/2012

11/21/2017

Common Stock

189,780

$ 0

0

D

Warrant (right to purchase)

$ 7.86

10/03/2017

X

78,186

11/21/2012

11/21/2017

Common Stock

78,186

$ 0

0

D

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
Boxer Capital, LLC 11682 EL CAMINO REAL, SUITE 320 SAN DIEGO, CA 92130		X
Braslyn Ltd. CAY HOUSE, EP TAYLOR DRIVE LYFORD CAY, NEW PROVIDENCE, C5 N7776		X
LEWIS JOSEPH C/O CAY HOUSE P.O. BOX N-7776 E.P. TAYLOR DRIVE LYFORD CAY NEW PROVIDENCE, C5		X
Fuglesang Christopher 11682 EL CAMINO REAL, SUITE 320 SAN DIEGO, CA 92130		X
LAPPE RODNEY W 4660 LA JOLLA VILLAGE DRIVE, SUITE 500 SAN DIEGO, CA 92121	X	X
LIEBERBURG IVAN M 11682 EL CAMINO REAL, SUITE 320 SAN DIEGO, CA 92130		X
Reisman Neil 11682 EL CAMINO REAL, SUITE 320 SAN DIEGO, CA 92130	X	X
Dissanayake Shehan Bharatha 11682 EL CAMINO REAL, SUITE 320 SAN DIEGO, CA 92130		X
Davis Aaron I. 11682 EL CAMINO REAL, SUITE 320 SAN DIEGO, CA 92130		X
MVA Investors, LLC 11682 EL CAMINO REAL, SUITE 320 SAN DIEGO, CA 92130		X

Signatures

Boxer Capital, LLC, By: /s/ Aaron I Davis, Aaron I. Davis		10/03/2017
**Signature of Reporting Person		Date
MVA Investors, LLC, By: /s/ Aaron I. Davis, Aaron I. Davis		10/03/2017
**Signature of Reporting Person		Date
Braslyn Ltd., By: /s/ Jason Callender, Jason Callender		10/03/2017
**Signature of Reporting Person		Date
Joseph C. Lewis, By: /s/ Joseph C. Lewis, Joseph C. Lewis		10/03/2017
**Signature of Reporting Person		Date
Christopher Fuglesang, By: /s/ Christopher Fuglesang, Christopher Fuglesang		10/03/2017
**Signature of Reporting Person		Date
Rodney W. Lappe, By: /s/ Rodney W. Lappe, Rodney W. Lappe		10/03/2017
**Signature of Reporting Person		Date
Ivan M. Lieberburg, By: /s/ Ivan M. Lieberburg, Ivan M. Lieberburg		10/03/2017
**Signature of Reporting Person		Date
Neil Reisman, By: /s/ Neil Reisman, Neil Reisman		10/03/2017
**Signature of Reporting Person		Date
Shehan B. Dissanayake, By: /s/ Shehan B. Dissanayake, Shehan B. Dissanayake		10/03/2017
**Signature of Reporting Person		Date
Aaron I. Davis, By: /s/ Aaron I. Davis, Aaron I. Davis		10/03/2017
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	These securities are owned directly by Boxer Capital, LLC ("Boxer Capital"), which may be deemed to be a member of a "group" for purposes of Section 13(d) of the Securities Exchange Act of 1934, as amended, consisting of (i) Boxer Capital, (ii) Boxer Asset Management Inc., (iii) MVA Investors, LLC ("MVA Investors"), (iv) Braslyn Ltd., (v) Joe Lewis, (vi) Christopher Fuglesang, (vii) Rodney W. Lappe, (viii) Ivan M. Lieberburg, (ix) Neil Reisman, (x) Shehan B. Dissanayake, and (xi) Aaron I. Davis (collectively, the "Boxer Group"). Joseph C. Lewis is the sole indirect beneficial owner of and controls Braslyn Ltd.
(2)	These securities are owned directly and solely by MVA Investors, which has sole voting and dispositive power with respect to these securities. Each of Messrs. Fuglesang, Lieberburg, Reisman, Dissanayake and Davis is a member of MVA Investors. Each member of the Boxer Group other than MVA Investors disclaims beneficial ownership of these securities to the extent it or he does not have a pecuniary interest therein.
Remarks: Form 1 of 2 Because the number of Reporting Persons exceeds the Form 4 limit, additional Reporting Persons are included on another Form 4 filed on the same date.

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