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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549



                                    FORM 8-K


                                 CURRENT REPORT
     PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934



       DATE OF REPORT (DATE OF EARLIEST EVENT REPORTED): FEBRUARY 19, 2004


                          LEXICON GENETICS INCORPORATED
             (EXACT NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER)



                                                                                
                DELAWARE                              000-30111                             76-0474169
    (STATE OR OTHER JURISDICTION OF            (COMMISSION FILE NUMBER)                  (I.R.S. EMPLOYER
     INCORPORATION OR ORGANIZATION)                                                   IDENTIFICATION NUMBER)



                          8800 TECHNOLOGY FOREST PLACE
                           THE WOODLANDS, TEXAS 77381
                         (ADDRESS OF PRINCIPAL EXECUTIVE
                              OFFICES AND ZIP CODE)


                                 (281) 863-3000
                         (REGISTRANT'S TELEPHONE NUMBER,
                              INCLUDING AREA CODE)

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ITEM 7. FINANCIAL STATEMENTS AND EXHIBITS

         (c) Exhibits

EXHIBIT NO.        DESCRIPTION
-----------        -----------
  99.1        --   Press Release of Lexicon Genetics Incorporated dated
                   February 19, 2004

ITEM 12. RESULTS OF OPERATIONS AND FINANCIAL CONDITION

         On February 19, 2004, we issued a press release to report our financial
results for the quarter and year ended December 31, 2003. A copy of the press
release is attached to this current report on Form 8-K as Exhibit 99.1.

         The information in this Form 8-K and the Exhibit attached to this Form
8-K shall not be deemed "filed" for purposes of Section 18 of the Securities
Exchange Act of 1934 (the "Exchange Act") or otherwise subject to the
liabilities of that section, nor shall it be deemed incorporated by reference in
any filing under the Securities Act of 1933 or the Exchange Act, except as
expressly set forth by specific reference in such a filing.


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                                   SIGNATURES


         Pursuant to the requirements of the Securities Exchange Act of 1934,
the registrant has duly caused this report to be signed on its behalf by the
undersigned thereunto duly authorized.


                                               LEXICON GENETICS INCORPORATED


Date:  February 19, 2004                       By: /s/ JEFFREY L. WADE
                                                   -----------------------------
                                                   Jeffrey L. Wade
                                                   Executive Vice President and
                                                   General Counsel


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                                INDEX TO EXHIBITS

EXHIBIT NO.         DESCRIPTION
-----------         -----------
   99.1        --   Press Release of Lexicon Genetics Incorporated dated
                    February 19, 2004