According to the latest research study, the demand of global Non-Small-Cell Lung Cancer Drug Market size & share was valued at approximately USD 31,614.8 Million in 2023 and is expected to reach USD 34,175.6 Million in 2024 and is expected to reach a value of around USD 68,888.6 Million by 2033, at a compound annual growth rate (CAGR) of about 8.1% during the forecast period 2024 to 2033.

MAIA Biotechnology, Inc. (NYSE American: MAIA), a trailblazer in clinical-stage biopharmaceuticals, revealed impressive efficacy data from the Phase 2 THIO-101 clinical trial of THIO in sequence with the immune checkpoint inhibitor cemiplimab (Libtayo®) for treating advanced non-small cell lung cancer (NSCLC). The latest findings, which were showcased during the American Society of Clinical Oncology (ASCO) 2024 Annual Meeting, demonstrate significant superiority over standard-of-care therapies, particularly in patients who have undergone multiple prior treatments.

The updated trial results revealed a notable overall response rate (ORR) of 38% and a disease control rate (DCR) of 85% with the THIO + cemiplimab combination in third-line treatments—figures that starkly outpace the standard-of-care ORR of 6–10% and DCR of 25–35% typically observed with chemotherapy alone. These data underscore the potential of THIO as a formidable alternative in the NSCLC therapeutic landscape.

Transformative Results in Third-Line Treatment

The THIO-101 trial, which focuses on the safety, tolerability, and efficacy of THIO as both an anticancer agent and an immune system primer, reported encouraging survival metrics. Notably, 65% of participants surpassed the 5.8-month overall survival (OS) benchmark, with a median follow-up time of 9.1 months. Additionally, the optimized dose of 180mg of THIO achieved a median progression-free survival (PFS) of 5.5 months and an OS rate of 78% at six months.

MAIA's Chairman and CEO, Dr. Vlad Vitoc, expressed enthusiasm about the results: "The exceptional measures of efficacy in our trial to date have exceeded our own expectations and significantly outperformed standard of care treatments. The data presented at ASCO advances THIO’s clinical profile as a strong, safe, and highly effective alternative for patients who have progressed following chemotherapy and other available treatments."

THIO: A Novel Approach to Cancer Treatment

THIO (6-thio-dG or 6-thio-2’-deoxyguanosine) is an investigational telomere-targeting agent designed to disrupt the survival mechanisms of cancer cells. By inducing telomerase-dependent DNA damage and activating both innate and adaptive immune responses, THIO shows promise in overcoming the resistance often encountered with current therapies.

The THIO-101 Phase 2 trial represents a pioneering effort to assess the efficacy of THIO when used in conjunction with PD-(L)1 inhibitors like cemiplimab. This approach not only aims to enhance the immune response but also to establish a durable clinical remission in patients with advanced NSCLC who have exhausted other treatment options.

Looking Ahead

With full enrollment completed ahead of schedule, MAIA anticipates further compelling data from the THIO-101 trial in the latter half of this year. This could potentially position THIO as a first-in-class telomere targeting agent in the field of cancer drug discovery and treatment.

MAIA's ongoing commitment to advancing cancer treatment underscores its role as a leader in targeted therapy and immuno-oncology, aiming to significantly improve and extend the lives of those battling cancer. For more information, including access to the poster and updated company presentations, visit [MAIA Biotechnology’s website]

For additional details on the THIO-101 clinical trial, visit [ClinicalTrials.gov] with identifier NCT05208944.

Other biotech companies to keep on top of radar include Vertex Pharmaceuticals (NASDAQ: VRTX), United Therapeutics (NASDAQ: UTHR), Corcept Therapeutics (NASDAQ: CORT), Neurocrine Biosciences (NASDAQ: NBIX), Halozyme Therapeutics (NASDAQ: HALO).

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Sources:

https://finance.yahoo.com/news/latest-global-non-small-cell-073000144.html

https://finance.yahoo.com/news/maia-biotechnology-reveals-clinical-data-124100573.html

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