PAGE 1
000 A000000 12/31/2016
000 C000000 0000916183
000 D000000 N
000 E000000 NF
000 F000000 Y
000 G000000 N
000 H000000 N
000 I000000 6.1
000 J000000 A
001 A000000 PIMCO STRATEGIC INCOME FUND, INC.
001 B000000 811-08216
001 C000000 8443374626
002 A000000 1633 BROADWAY
002 B000000 New York
002 C000000 NY
002 D010000 10019
003 000000 N
004 000000 N
005 000000 N
006 000000 N
007 A000000 N
007 B000000 0
007 C010100 1
008 A000001 PACIFIC INVESTMENT MANAGEMENT COMPANY LLC
008 B000001 A
008 C000001 801-48187
008 D010001 NEWPORT BEACH
008 D020001 CA
008 D030001 92660
010 A000001 PACIFIC INVESTMENT MANAGEMENT COMPANY LLC
010 B000001 801-48187
010 C010001 NEWPORT BEACH
010 C020001 CA
010 C030001 92660
012 A000001 AMERICAN STOCK TRANSFER & TRUST COMPANY LLC
012 B000001 84-00416
012 C010001 BROOKLYN
012 C020001 NY
012 C030001 11219
013 A000001 PRICEWATERHOUSECOOPERS, LLP
013 B010001 KANSAS CITY
013 B020001 MO
013 B030001 64106
014 A000001 PIMCO INVESTMENTS LLC
014 B000001 8-68686
015 A000001 STATE STREET BANK & TRUST COMPANY
015 B000001 C
015 C010001 KANSAS CITY
015 C020001 MO
015 C030001 64105
015 E010001 X
PAGE 2
015 A000002 BANCO ITAU CHILE
015 B000002 S
015 C010002 SANTIAGO
015 D010002 CHILE
015 E040002 X
015 A000003 BANCO ITAU URUGUAY S.A.
015 B000003 S
015 C010003 MONTEVIDEO
015 D010003 URUGUAY
015 E040003 X
015 A000004 BANCO NACIONAL DE MEXICO S.A.
015 B000004 S
015 C010004 MEXICO CITY
015 D010004 MEXICO
015 E040004 X
015 A000005 BANK HAPOALIM B.M.
015 B000005 S
015 C010005 TEL AVIV
015 D010005 ISRAEL
015 E040005 X
015 A000006 BANK POLSKA KASA OPIEKI S.A.
015 B000006 S
015 C010006 WARSAW
015 D010006 POLAND
015 E040006 X
015 A000007 BNP PARIBAS SECURITIES SERVICES, S.C.A.
015 B000007 S
015 C010007 ATHENS
015 D010007 GREECE
015 E040007 X
015 A000008 CESKOSLOVENSKA OBCHODNI BANKA, A.S.
015 B000008 S
015 C010008 PRAGUE
015 D010008 CZECH REPUBLIC
015 E040008 X
015 A000009 CITIBANK DEL PERU S.A.
015 B000009 S
015 C010009 LIMA
015 D010009 PERU
015 E040009 X
015 A000010 CITIBANK EUROPE PLC
015 B000010 S
015 C010010 BUCHAREST
015 D010010 ROMANIA
015 E040010 X
015 A000011 CITIBANK EUROPE PLC
015 B000011 S
015 C010011 BUDAPEST
015 D010011 HUNGARY
015 E040011 X
015 A000012 CITIBANK RUSSIA
PAGE 3
015 B000012 S
015 C010012 MOSCOW
015 D010012 RUSSIA
015 E040012 X
015 A000013 CITIBANK N.A.
015 B000013 S
015 C010013 SAO PAULO
015 D010013 BRAZIL
015 E040013 X
015 A000014 CITIBANK, N.A.
015 B000014 S
015 C010014 SINGAPORE
015 D010014 SINGAPORE
015 E040014 X
015 A000015 CITITRUST COLOMBIA S.A. SOCIEDAD FIDUCIARIA
015 B000015 S
015 C010015 BOGOTA
015 D010015 COLOMBIA
015 E040015 X
015 A000016 CREDIT SUISSE AG
015 B000016 S
015 C010016 ZURICH
015 D010016 SWITZERLAND
015 E040016 X
015 A000017 DEUTSCHE BANK (MALAYSIA)
015 B000017 S
015 C010017 KUALA LUMPUR
015 D010017 MALAYSIA
015 E040017 X
015 A000018 DEUTSCHE BANK AG
015 B000018 S
015 C010018 PARIS
015 D010018 FRANCE
015 E040018 X
015 A000019 DEUTSCHE BANK AG
015 B000019 S
015 C010019 JAKARTA
015 D010019 INDONESIA
015 E040019 X
015 A000020 DEUTSCHE BANK AG
015 B000020 S
015 C010020 SEOUL
015 D010020 REPUBLIC OF KOREA
015 E040020 X
015 A000021 DEUTSCHE BANK AG
015 B000021 S
015 C010021 AMSTERDAM
015 D010021 NETHERLANDS
015 E040021 X
015 A000022 DEUTSCHE BANK AG
015 B000022 S
PAGE 4
015 C010022 MANILA
015 D010022 PHILIPPINES
015 E040022 X
015 A000023 DEUTSCHE BANK AG
015 B000023 S
015 C010023 LISBON
015 D010023 PORTUGAL
015 E040023 X
015 A000024 DEUTSCHE BANK AG, NETHERLANDS
015 B000024 S
015 C010024 BRUSSELS
015 D010024 BELGIUM
015 E040024 X
015 A000025 DEUTSCHE BANK S.A.E.
015 B000025 S
015 C010025 BARCELONA
015 D010025 SPAIN
015 E040025 X
015 A000026 DEUTSCHE BANK S.P.A.
015 B000026 S
015 C010026 MILAN
015 D010026 ITALY
015 E040026 X
015 A000027 DEUTSCHE BANK TURKEY
015 B000027 S
015 C010027 INSTANBUL
015 D010027 TURKEY
015 E040027 X
015 A000028 FIRSTRAND BANK LIMITED
015 B000028 S
015 C010028 JOHANNESBURG
015 D010028 SOUTH AFRICA
015 E040028 X
015 A000029 HSBC BANK (CHINA) COMPANY LIMITED
015 B000029 S
015 C010029 SHANGHAI
015 D010029 P.R OF CHINA
015 E040029 X
015 A000030 HSBC BANK (CHINA) COMPANY LIMITED
015 B000030 S
015 C010030 SHENZHEN
015 D010030 P.R. CHINA
015 E040030 X
015 A000031 NORDEA BANK
015 B000031 S
015 C010031 STOCKHOLM
015 D010031 SWEDEN
015 E040031 X
015 A000032 NORDEA BANK FINLAND
015 B000032 S
015 C010032 HELSINKI
PAGE 5
015 D010032 FINLAND
015 E040032 X
015 A000033 NORDEA BANK NORGE ASA
015 B000033 S
015 C010033 OSLO
015 D010033 NORWAY
015 E040033 X
015 A000034 ROYAL BANK OF CANADA
015 B000034 S
015 C010034 TORONTO
015 D010034 CANADA
015 E040034 X
015 A000035 STATE STREET BANK GMBH
015 B000035 S
015 C010035 FRANKFURT
015 D010035 GERMANY
015 E040035 X
015 A000036 STANBIC IBTC BANK PLC
015 B000036 S
015 C010036 LAGOS
015 D010036 NIGERIA
015 E040036 X
015 A000037 STANDARD CHARTERED BANK (HONG KONG) LTD.
015 B000037 S
015 C010037 HONG KONG
015 D010037 HONG KONG
015 E040037 X
015 A000038 STANDARD CHARTERED BANK (THAI) PCL
015 B000038 S
015 C010038 BANGKOK
015 D010038 THAILAND
015 E040038 X
015 A000039 STATE STREET BANK & TRUST CO., UNITED KINGDOM
015 B000039 S
015 C010039 LONDON
015 D010039 UNITED KINGDOM
015 E040039 X
015 A000040 STATE STREET TRUST COMPANY CANADA
015 B000040 S
015 C010040 TORONTO
015 D010040 CANADA
015 E040040 X
015 A000041 THE HONGKONG & SHANGHAI BANKING CORP., LTD.
015 B000041 S
015 C010041 TOKYO
015 D010041 JAPAN
015 E040041 X
015 A000042 THE HONGKONG & SHANGHAI BANKING CORP., LTD.
015 B000042 S
015 C010042 AUCKLAND
015 D010042 NEW ZEALAND
PAGE 6
015 E040042 X
015 A000043 THE HONGKONG & SHANGHAI BANKING CORP., LTD.
015 B000043 S
015 C010043 SYDNEY
015 D010043 AUSTRALIA
015 E040043 X
015 A000044 UNICREDIT BANK SLOVAKIA A.S.
015 B000044 S
015 C010044 BRATISLAVA
015 D010044 SLOVAK REPUBLIC
015 E040044 X
018 000000 Y
019 A000000 Y
019 B000000 177
019 C000000 PIMCOFUNDS
020 A000001 DEUTSCHE BANK SECURITIES, INC.
020 B000001 13-2730828
020 C000001 1
021 000000 1
022 A000001 CREDIT SUISSE (USA), INC.
022 B000001 13-1898818
022 C000001 2737830
022 D000001 2669178
022 A000002 GOLDMAN SACHS & CO.
022 B000002 13-5108880
022 C000002 500105
022 D000002 466007
022 A000003 BARCLAYS, INC.
022 B000003 06-1031656
022 C000003 231058
022 D000003 229066
022 A000004 STATE STREET BANK & TRUST CO.
022 B000004 04-1867445
022 C000004 292412
022 D000004 4649
022 A000005 MORGAN STANLEY & CO., INC.
022 B000005 13-2655998
022 C000005 149101
022 D000005 141040
022 A000006 BNP PARIBAS SECURITIES CORP.
022 B000006 13-3235334
022 C000006 133735
022 D000006 141195
022 A000007 JPMORGAN CHASE & CO.
022 B000007 13-2624428
022 C000007 107878
022 D000007 102575
022 A000008 UBS SECURITIES LLC
022 B000008 13-3873456
022 C000008 80864
022 D000008 81837
PAGE 7
022 A000009 DEUTSCHE BANK SECURITIES, INC.
022 B000009 13-2730828
022 C000009 12651
022 D000009 110664
022 A000010 NOMURA SECURITIES
022 B000010 13-2642206
022 C000010 55330
022 D000010 44615
023 C000000 4449612
023 D000000 4119956
024 000000 Y
025 A000001 JPMORGAN CHASE & CO.
025 B000001 13-2624428
025 C000001 D
025 D000001 17023
025 A000002 MORGAN STANLEY & CO., INC.
025 B000002 13-2655998
025 C000002 D
025 D000002 11673
025 A000003 NOMURA SECURITIES
025 B000003 13-2642206
025 C000003 D
025 D000003 8315
025 A000004 GOLDMAN SACHS & CO.
025 B000004 13-5108880
025 C000004 D
025 D000004 5998
025 A000005 CREDIT SUISSE (USA), INC.
025 B000005 13-1898818
025 C000005 D
025 D000005 3286
025 A000006 DEUTSCHE BANK SECURITIES, INC.
025 B000006 13-2730828
025 C000006 D
025 D000006 3213
025 A000007 BARCLAYS, INC.
025 B000007 06-1031656
025 C000007 D
025 D000007 2851
025 A000008 STATE STREET BANK & TRUST CO.
025 B000008 04-1867445
025 C000008 D
025 D000008 2712
025 A000009 BNP PARIBAS SECURITIES CORP.
025 B000009 13-3235334
025 C000009 D
025 D000009 2015
026 A000000 N
026 B000000 N
026 C000000 N
026 D000000 Y
PAGE 8
026 E000000 N
026 F000000 N
026 G010000 N
026 G020000 N
026 H000000 N
027 000000 N
028 A010000 0
028 A020000 0
028 A030000 0
028 A040000 0
028 B010000 0
028 B020000 0
028 B030000 0
028 B040000 0
028 C010000 0
028 C020000 0
028 C030000 0
028 C040000 0
028 D010000 0
028 D020000 0
028 D030000 0
028 D040000 0
028 E010000 0
028 E020000 0
028 E030000 0
028 E040000 0
028 F010000 0
028 F020000 0
028 F030000 0
028 F040000 0
028 G010000 0
028 G020000 0
028 G030000 0
028 G040000 0
028 H000000 0
030 A000000 0
030 B000000 0.00
030 C000000 0.00
031 A000000 0
031 B000000 0
032 000000 0
033 000000 0
035 000000 0
036 B000000 0
038 000000 0
042 A000000 0
042 B000000 0
042 C000000 0
042 D000000 0
042 E000000 0
042 F000000 0
PAGE 9
042 G000000 0
042 H000000 0
043 000000 0
044 000000 0
045 000000 Y
046 000000 N
047 000000 Y
048 000000 0.955
048 A010000 0
048 A020000 0.000
048 B010000 0
048 B020000 0.000
048 C010000 0
048 C020000 0.000
048 D010000 0
048 D020000 0.000
048 E010000 0
048 E020000 0.000
048 F010000 0
048 F020000 0.000
048 G010000 0
048 G020000 0.000
048 H010000 0
048 H020000 0.000
048 I010000 0
048 I020000 0.000
048 J010000 0
048 J020000 0.000
048 K010000 0
048 K020000 0.000
049 000000 N
050 000000 N
051 000000 N
052 000000 N
053 A000000 N
054 A000000 Y
054 B000000 Y
054 C000000 Y
054 D000000 Y
054 E000000 Y
054 F000000 Y
054 G000000 Y
054 H000000 Y
054 I000000 N
054 J000000 Y
054 K000000 Y
054 L000000 Y
054 M000000 Y
054 N000000 Y
054 O000000 Y
055 A000000 Y
PAGE 10
055 B000000 N
056 000000 Y
057 000000 N
058 A000000 N
059 000000 Y
060 A000000 Y
060 B000000 Y
061 000000 0
062 A000000 Y
062 B000000 4.5
062 C000000 3.4
062 D000000 1.7
062 E000000 0.0
062 F000000 0.0
062 G000000 0.0
062 H000000 0.0
062 I000000 0.0
062 J000000 0.0
062 K000000 0.0
062 L000000 0.0
062 M000000 19.6
062 N000000 176.4
062 O000000 0.5
062 P000000 24.4
062 Q000000 63.9
062 R000000 0.1
063 A000000 0
063 B000000 6.3
064 A000000 N
064 B000000 N
066 A000000 N
067 000000 N
068 A000000 N
068 B000000 N
069 000000 N
070 A010000 Y
070 A020000 Y
070 B010000 Y
070 B020000 N
070 C010000 Y
070 C020000 Y
070 D010000 Y
070 D020000 N
070 E010000 Y
070 E020000 Y
070 F010000 Y
070 F020000 N
070 G010000 Y
070 G020000 N
070 H010000 Y
070 H020000 N
PAGE 11
070 I010000 Y
070 I020000 N
070 J010000 Y
070 J020000 Y
070 K010000 Y
070 K020000 N
070 L010000 Y
070 L020000 Y
070 M010000 Y
070 M020000 Y
070 N010000 N
070 N020000 N
070 O010000 Y
070 O020000 N
070 P010000 Y
070 P020000 Y
070 Q010000 N
070 Q020000 N
070 R010000 Y
070 R020000 N
071 A000000 161838
071 B000000 23552
071 C000000 913082
071 D000000 3
072 A000000 6
072 B000000 16349
072 C000000 7
072 D000000 0
072 E000000 0
072 F000000 1598
072 G000000 0
072 H000000 0
072 I000000 0
072 J000000 0
072 K000000 0
072 L000000 0
072 M000000 29
072 N000000 0
072 O000000 0
072 P000000 732
072 Q000000 0
072 R000000 0
072 S000000 0
072 T000000 0
072 U000000 0
072 V000000 0
072 W000000 1
072 X000000 2360
072 Y000000 0
072 Z000000 13996
072AA000000 0
PAGE 12
072BB000000 6950
072CC010000 3464
072CC020000 0
072DD010000 20274
072DD020000 0
072EE000000 0
073 A010000 0.4800
073 A020000 0.0000
073 B000000 0.0000
073 C000000 0.0000
074 A000000 99
074 B000000 5372
074 C000000 25725
074 D000000 923390
074 E000000 0
074 F000000 333
074 G000000 0
074 H000000 0
074 I000000 0
074 J000000 338330
074 K000000 0
074 L000000 3926
074 M000000 6282
074 N000000 1303457
074 O000000 855503
074 P000000 278
074 Q000000 0
074 R010000 117400
074 R020000 0
074 R030000 0
074 R040000 6016
074 S000000 0
074 T000000 324260
074 U010000 42329
074 U020000 0
074 V010000 7.66
074 V020000 0.00
074 W000000 0.0000
074 X000000 25935
074 Y000000 199688
075 A000000 0
075 B000000 329018
076 000000 8.79
077 A000000 N
078 000000 N
080 C000000 0
081 B000000 0
082 B000000 0
083 B000000 0
084 B000000 0
086 A010000 0
PAGE 13
086 A020000 0
086 B010000 0
086 B020000 0
086 C010000 0
086 C020000 0
086 D010000 0
086 D020000 0
086 E010000 0
086 E020000 0
086 F010000 0
086 F020000 0
087 A010000 COMMON
087 A020000 72200X104
087 A030000 RCS
088 A000000 N
088 B000000 N
088 C000000 N
088 D000000 N
SIGNATURE WILLIAM G. GALIPEAU
TITLE TREASURER