FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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(Print or Type Responses)

1. Name and Address of Reporting Person * BRANCACCIO JOHN P   2. Issuer Name and Ticker or Trading Symbol CALLISTO PHARMACEUTICALS INC [CLSP] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) __X__ Director _____ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) C/O CALLISTO PHARMACEUTICALS, INC., 420 LEXINGTON AVE., SUITE 1609 3. Date of Earliest Transaction (Month/Day/Year) 01/17/2013 (Street) NEW YORK, NY 10170 4. If Amendment, Date Original Filed(Month/Day/Year) 6. Individual or Joint/Group Filing(Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 01/17/2013   D   113,636 D (1) 0 D

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Underlying Securities (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Stock Options	$ 3.2	01/17/2013		D			75,000	(2)	04/06/2014	Common Stock	75,000	(1)	0	D
Stock Options	$ 1	01/17/2013		D			17,123	(3)	06/16/2015	Common Stock	17,123	(1)	0	D
Stock Options	$ 1.17	01/17/2013		D			6,000	(4)	10/20/2015	Common Stock	6,000	(1)	0	D
Stock Options	$ 1.45	01/17/2013		D			8,000	12/23/2006	12/23/2015	Common Stock	8,000	(1)	0	D
Stock Options	$ 0.77	01/17/2013		D			6,000	(5)	10/12/2016	Common Stock	6,000	(1)	0	D
Stock Options	$ 0.83	01/17/2013		D			8,000	10/19/2007	10/19/2016	Common Stock	8,000	(1)	0	D
Stock Options	$ 0.47	01/17/2013		D			6,000	(6)	09/26/2017	Common Stock	6,000	(1)	0	D
Stock Options	$ 0.47	01/17/2013		D			8,000	09/26/2008	09/26/2017	Common Stock	8,000	(1)	0	D
Stock Options	$ 0.08	01/17/2013		D			6,000	(7)	12/18/2018	Common Stock	6,000	(1)	0	D
Stock Options	$ 0.08	01/17/2013		D			8,000	12/18/2009	12/18/2018	Common Stock	8,000	(1)	0	D
Stock Options	$ 0.2	01/17/2013		D			6,000	(8)	12/29/2019	Common Stock	6,000	(1)	0	D
Stock Options	$ 0.2	01/17/2013		D			8,000	12/29/2009	12/29/2019	Common Stock	8,000	(1)	0	D
Stock Options	$ 0.66	01/17/2013		D			6,000	(9)	05/19/2021	Common Stock	6,000	(1)	0	D
Stock Options	$ 0.66	01/17/2013		D			8,000	05/19/2011	05/19/2021	Common Stock	8,000	(1)	0	D

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
BRANCACCIO JOHN P C/O CALLISTO PHARMACEUTICALS, INC. 420 LEXINGTON AVE., SUITE 1609 NEW YORK, NY 10170	X

Signatures

/s/ John P. Brancaccio		01/22/2013
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	Pursuant to the Agreement and Plan of Merger, dated as of July 20, 2012, as amended October 15, 2012, by and between Synergy Pharmaceuticals Inc ("Synergy") and Callisto Pharmaceuticals, Inc. ("Callisto"), Callisto merged with and into Synergy (the "Merger"). Upon the effective time of the Merger, each share of Callisto common stock was cancelled and exchanged for .1799 shares of Synergy common stock (the "Exchange Ratio"). Each stock option exercisable for shares of Callisto common stock that is outstanding at the effective time of the Merger was assumed by Synergy and converted into a stock option to purchase the number of shares of Synergy's common stock that the holder would have received if such holder had exercised such stock option for shares of Callisto common stock prior to the Merger and exchanged such shares for Synergy common stock in accordance with the Exchange Ratio.
(2)	25,000 options vested each year on April 26, 2005, 2006 and 2007, respectively.
(3)	5,707 options vested immediately and 5,708 options vested on June 16, 2006 and 2007
(4)	2,000 options vested each year on October 20, 2006, 2007 and 2008, respectively.
(5)	2,000 options vested each year on October 12, 2007, 2008 and 2009, respectively.
(6)	2,000 options vested each year on September 26, 2008, 2009 and 2010, respectively.
(7)	2,000 options vested on each of December 18, 2009, 2010 and 2011, respectively.
(8)	2,000 options vested on each of December 29, 2010, 2011 and 2012, respectively.
(9)	2,000 options vested on May 19, 2012 and 2,000 options vest on each of May 19, 2013 and 2014, respectively.

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